뇌기저부 수막종의 임상분석 및 수술성적

김영욱,정신,김재성,이정길,김태선,김재휴,김수한,강삼석,이제혁,Kim, Young Wook,Jung, Shin,Kim, Jae Sung,Lee, Jung Kil,Kim, Tae Sun,Kim, Jae Hyoo,Kim, Soo Han,Kang, Sam Suk,Lee, Je Hyuk 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.11

저자들은 10년동안 수술을 시행받았던 212례의 수막종 환자중 뇌기저부에 위치한 61례에 대한 임상 분석을 시행한 결과 다음과 같은 결과를 얻었다. 1) 본 연구기간중 뇌기저부 수막종 환자는 61례로 전체의 29%를 차지하였으며, 평균 추적기간은 약 52개월이었다. 2) 성비는 여성이 남성보다 약 2배 많았으며, 평균연령은 52세였다. 3) 위치별로는 후두개와가 가장 많았으며, 전체적으로는 접형골연부, 천막부 및 소뇌교각부가 대부분을 차지하였다. 4) 호발증상 및 징후로는 두통, 뇌신경마비 및 소뇌징후 순으로 나타났다. 5) 종양제거정도는 심슨등급 I, II로 전적출한 경우가 82%이었으며, 심슨등급 III로 아전적출한 경우가 18%이었다. 6) 병리조직결과는 양성이 85%로 대부분을 차지하였으며, 비정형성과 악성은 각각 10%, 5%를 차지하였다. 7) 술후 보조적 치료는 악성, 부분적출 및 재발한 경우에 사용하였다. 8) 술후 합병증으로는 뇌척수액누출, 뇌신경마비 및 간질 발작 순이었다. 9) 술후 사망한 경우는 수술후 사망한 1례와 종양 재발에 의한 사망 2례이었다. 10) 재발은 약 15%로 심슨등급 III와 악성인 경우에 높았으며, 재발 위치는 천막부, 접형골연 및 소뇌교각부 순이었다. 결론적으로 뇌기저부 수막종의 수술은 종양 주변부의 중요한 구조물이 위치함에 따라 낮은 사망률 및 합병증 발생률을 가지고 수술적 적출이 어렵지만, 술전 방사선학적 소견의 정확한 이해와 적절한 접근법의 선택, 뇌기저부 재건술이 술후 합병증의 감소 및 종양적출을 위해 필수라고 생각한다. Objectives : Traditionally intracranial meningiomas are regarded as benign and curable tumors. About half of all intracranial meningiomas locate in the skull base region. However, surgical removal of these tumors may be challenging and require special considerations. Here general aspects of skull base meningiomas including clinical presentation, surgical approaches, complications and their recurrence rate are discussed based on our experiences. Methods : A retrospective analysis of 61 consecutive patients with skull base meningioma among 210 patients of meningioma between 1989 and 1998 were done. Results : There were 41 women and 20 men ranging from 13 to 74 years(mean 52 years). These tumors were divided into seven categories according to location : olfactory groove(n=9), sphenoid ridge(n=16), cavernous sinus(n =2), tuberculum sellae(n=8), tentorium(n=13), cerebellopontine angle(n=12), and foramen magnum meningiomas (n=1). Surgical approaches were selected on the basis of the tumor attachment, size and extension on preoperative radiologic findings. Total removal(Simpson grade I and II) was achieved in 50 cases(82%), and subtotal removal (Simpson grade III) in 11 patients(18%). According to WHO classification, there were 52 of cases of benign meningioma( 86%), 6 atypical cases(10%), and 3 malignant cases(5%). The most common postoperative complications were CSF leakage(23.0%) and cranial nerve injury(8.2%). Three patient died related with tumor(one was due to surgical complication and the other two due to recurrence) but three patients died from other systemic causes. Mean follow-up period was 51.7 months after surgery. Recurrence occurred in six patients(10.9%) ; three with tentorial meningioma, two with sphenoid ridge, and one in cerebellopontine angle. Conclusion : With advances in neuroradiology and microsurgical techniques, the surgical outcome of miningiomas has been markedly improved with acceptable morbidity and mortality rates. Overall, our surgical results of skull base meningiomas is comparable to other reports. Therefore, with the appropriate operative strategy and techniques, these tumors can be completely removed and good surgical results can be expected.

Helicobacter pylori 감염의 유병률과 관련요인에 관한 연구

김영욱,이수일,조병만,고광욱,김영실,강수용,차애리,김돈균,Kim, Yeung-Wook,Lee, Su-Ill,Cho, Byung-Mann,Koh, Kwang-Wook,Kim, Young-Sil,Kang, Su-Yong,Cha, Oae-Ri,Kim, Don-Kyoun 대한예방의학회 1996 Journal of Preventive Medicine and Public Health Vol.29 No.3

Helicobacter pylori 감염은 만성 위염과 소화성 궤양의 원인인자로 작용하며 위암과도 강한 상관관계가 있는 것으로 증명되어 기존의 위 십이지장 질환의 치료와 관리에 많은 변화를 가져오고 있다. 저자들은 Helicobacter pylori 감염의 유병률을 측정하고 유병상태와 관련되는 요인을 조사할 목적으로 부산광역시와 경상남도에 거주하는 소아 몇 청년 552명을 대상으로 1996년 4월부터 6월에 걸쳐 본 연구를 시행했다. 연구 대상자들의 혈청에 존재하는 Helicobacter pylori Ig G 항체는 Enzyme Linked Immunosorbent Assay(ELISA) 방법으로 측정했으며 설문조사를 통해 기본적인 인구학적 특성, 유병상태와 관련되는 요인에 관한 정보를 얻었다. 연구 대상자들의 총 Helicobacter pylori 감염률은 25.7%였고 $1\sim3$세군에서의 5.8%에서 $20\sim29$세군의 44.4%까지 연령이 증가함에 따라 유병률도 비례해 증가하는 양상을 보였다($\chi^2$ for trend=57.9, p<0.0001). 특히 학동기 전 연령인 $4\sim6$세 군에서 초등학교 1, 2, 3학년 연령인 $7\sim9$세 군간에 유병률의 급격한 상승이 관찰되어 이 시기에 Helicobacter pylori 감염이 본격적으로 발생하는 것으로 추측된다. 다변량 로지스틱 회귀 모델에서 연령, 가족수 및 거주하는 주택의 형태가 유병상태와 유의한 상관관계를 보였으며 각각의 교차비(95% 신뢰구간)는 연령 $1\sim9$세를 기준으로 $10\sim19$세 $3.6(2.0\sim6.4)$, $20\sim29$세 $7.3(4.1\sim13.1)$ 였고, 가족수 $1\sim3$명을 기준으로 $4\sim5$명 $2.1(1.3\sim5.4)$, 6명 이상 $2.7(1.3\sim5.4)$였으며 주택의 형태는 아파트 거주를 기준으로 일반주택 및 연립주택 $1.9(1.1\sim3.5)$ 이었다. Helicobacter pylori is now recognized as causative agent of chronic gastritis and peptic ulcer, and strongly associated with development of gastric carcinoma. With development of sensitive and specific serologic tests to identify individuals infected with Helicobacter pylori, the epidemiologic study of this diseases has been investigated. But it's transmission route is not established, yet. The purpose of this study is to measure the prevalence of Helicobacter pylori infection in healthy children and young adults and to evaluate related factors for Helicobacter pylori infection in Korea. The seroprevalence of Ig G antibodies to Helicobacter pylori was determined using a Enzyme Linked Immunosorbent Assay and we obtained the information, such as demographic characteristics, monthly household income, numbers of family members in the house, numbers of persons using same room, type of house, and type of drinking water through the questionnaire survey. The observed overall seropositivity rate was 25.7%. The rate is increased progressively from 5.8% in the age group $1\sim3$ years to 44.4% in the age group $20\sim29$years($\chi^2$ for trend, p<0.001). Especially, the rate increased steeply from 6.5% in the age group $4\sim6$ years to 20.8% in the age group $7\sim9$ years, and this suggested that elementary school age was the major acquisition time of Helicobacter pylori infection. In multivariate logistic regression model, age, numbers of family members in the house, and type of house was statistically significant variables for Helicobacter pylori infection. Each odds ratio(93% CI) were as follows; base to age group $1\sim9$ years, age group $10\sim19$ years $3.6(2.0\sim6.4)$, age group $20\sim29$ years $7.3(4.1\sim13.1)$ and base to group of $1\sim3$ family members, group of $4\sim5$ family members $2.1(1.1\sim4.0)$, group of 6 or more family members $2.7(1.3\sim5.4)$ and base to apartment, single and multihouse $1.9(1.1\sim3.5)$. Sex, monthly household income, numbers of persons using same room, and type of drinking water was not statistically significant for Helicobacter pylori infection.

傳仁容寺址 木簡에 대한 어학적 접근

金永旭(Kim Young-wook) 한국목간학회 2011 목간과 문자 Vol.7 No.-

필자는 이 글에서 難解語句에 대한 語學的分析을 시도하였고, 이것을 바탕으로 전인용사지 목간의 全文을 구조적으로 분석한 후, 그것을 현대국어로 번역하였다. 목간에 기록된 46자의 텍스트는 연결 표현인 ‘亦在(如)/또 있습니다’를 기준으로 아래와 같이 세 부분으로 나눌 수 있다. 大龍王中白主民渙次心阿多乎去/ 대룡왕께 사룁니다. 주민이 갈라져 마음에 많은 것이 사라집니다. 亦在名者所貴公歲?金□公歲?五是二人者歲口中人/ 또 있습니다. 이름은 소귀공으로 나이는 삼십 세이고, 김□공은 나이가 삼십오 세인데 두 사람은 나이가 적당한 사람입니다. 亦在如契?□□右如/ 또 있습니다. (두 사람이) 계약을 맺은 것과 함께 (화해하기를) 비나이다. 또한 필자는 다음과 같은 국어사적 사실도 새롭게 밝혔다. 첫째, ‘大龍王中白’의 中은 현재까지 확인된 국어사 자료 중, 여격 조사 표지로서는 최초의 용례다. 둘째, ‘契?□□右如’에서 ‘-右如/고다’는 ‘고+다’로 분석되며, 이때의 ‘-右/고-’는 신라 이두 자료에서는 처음으로 확인된 先語末語尾로, 그것의 의미 기능은 願望形語尾다. 셋째, 전인용사지 목간은 終結語尾인 ‘-如’로 끝맺는데 이것은 46자로 된 전인용사지 텍스트는 한문이 아니고 新羅語를 표기한 吏讀文이라는 것을 의미한다. 그 외에 전인용사지 목간의 본문에는 처격조사 ‘-阿/아’, 주제격 조사 ‘-者/은’, 서술격 조사 ‘-是/이, 인’, 동명사인 ‘多乎/하온’, 연결 표현인 ‘亦在如/? 겨다’ 등과 같이, 吏讀로 표기된 고대국어 문법 자료들이 다양하게 나타난다. I have discovered several facts on the grammatical systems of Old Korean, based on the studies concentrated on the wooden tablet named Jeon Inyongsaji, which excavated last year at Gyeongju, where at once the capital city of Silla kingdom. My points are as follows. First, the full interpretation of the wooden tablet is, 大龍王中白主民渙次心阿多乎去/ (we) said to Great Dragon God, people are separated and (In our) heart many things are gone. 亦在名者所貴公歲 ?金□公歲?五是二人者歲□中人/ And there is, (his) name is Sogwi Gong, 34 years old (and) Kim□Gong, 35 years old, two men are good for age. 亦在如契?□□右如/ And there is, (We wish two men) be reconcile same as the contract. Second, I discovered new facts on Old Korean: The above ‘-中/keui’ is the first and the oldest dative case marker in Old Korean and -古/ko- is a prefinal ending function as desirative, ‘-右如/koda’ is sentence final ending and that means the text of the wooden tablet is not classic Chinese, but old Korean sentence, so called Idu sentences.

극소 및 극대 곡면 발견의 역사

김영욱,김소영,김지연,Kim, Young-Wook,Kim, So-Young,Kim, Ji-Yean 한국수학사학회 2008 Journal for history of mathematics Vol.21 No.1

극소곡면은 고전미분기하학의 꽃이며 현대에 이르기까지 기하학의 중심을 이루고 있다. 이러한 극소곡면 이론에서 가장 어려운 부분이라고 할 수 있는 극소곡면의 발견 과정을 역사적으로 조명하여 보고 이를 통하여 극소곡면 이론을 소개한다. 한편 최근에 들어 연구가 시작된 로렌츠-민코프스키 공간의 극대곡면의 예를 소개하고 극소곡면 발견 과정과 비교 연구한다. Theory of minimal surfaces has always been in the center of differential geometry. The most difficult part in minimal surfaces is how to find meaningful examples. In this paper we survey the history of search for minimal surfaces. We also introduce examples of recently emerging maximal surfaces in the Lorentz-Minkowski space and compare the processes in the search for the minimal and the maximal surfaces.

Pain Disability Index와 Visual Analogue Scale을 이용한 경항통(頸項痛)에 대한 팔체질침(八體質鍼)의 효과

김영욱,이경민,김성웅,이세연,서정철,정태영,임성철,한상원,Kim, Young-wook,Lee, Kyung-min,Kim, Sung-woong,Lee, Sea-youn,Seo, Jung-chul,Jung, Tae-young,Lim, Sung-chul,Han, Sang-won 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective : This study was designed to compared with the effect of body acupuncture and 8 constitution acupuncture by pain Disability Index(PDI) and Visual Analogue Scale(VAS). Methods : Body acupuncture group consists of 10 patients and 8 Constitution acupuncture group consists of 10 patients. The degree of improvement was evaluated by PDI and VAS after 2 weeks treatment. PDI consists of seven items and they are scored as 10 points per each item. Results : After 2 weeks treatment there was no significant difference between the two groups in PDI scores, each PDI item's score and VAS score. Conclusions : The effect of 8 constitution acupuncture is not statistically different form that of body acupuncture on neck pain. Further study is needed about the effectiveness of 8 constitution acupuncture.

정위적 뇌생검의 임상분석

김영욱,김재휴,서승권,이정길,김태선,정신,김수한,강삼석,이제혁,Kim, Young Wook,Kim, Jae Hyoo,Seo, Seung Kweon,Lee, Jung Kil,Kim, Tae Sun,Jung, Shin,Kim, Soo Han,Kang, Sam Suk,Lee, Je Hyuk 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.1

Objective : This study was undertaken to evaluate the benefits and risks of the stereotactic biopsy in brain lesions. We assessed the diagnostic accuracy and morbidity rate associated with the stereotactic biopsy. Methods : The authors present a review of 47 patients, who underwent stereotactic biopsy using Cosman-Roberts-Wells(CRW) stereotactic apparatus during last six years. Results : Target locations were supratentorial in 36 cases, infratentorial in 9 and multiple in 2. According to pathological diagnosis, the largest group was neoplasm(29) followed by infection(9), infarction(2), cyst(2), and non-specific(5). Definitive diagnosis could be made in 42 of 47 cases(89.4%). When the mass lesion had been suspected as neoplastic condition, the diagnostic rate was 96.7%(29/30). It was being much higher than that of non-neoplastic lesion, 76.5%(13/17). The treatment modality was changed in 15 cases(32%) because the result of stereotactic biopsy was different from clinical diagnosis. Subsequent craniotomy after stereotactic biopsy was then performed in 6 cases, and the pathological diagnoses were precisely coincident in all of these cases. There were two complications(4.3%) : One intratumoral hemorrhage in glioblastoma and a transient hemiparesis in benign astrocytoma. There was no mortality in this series. Conclusion : The precise histological verification is crucial to determine the adequate treatment modality in intracranial lesions. Stereotactic biopsy is a safe and accurate diagnostic procedure for intracranial lesions with a low complication rate.

Polymerase chain reaction에 의한 동물 유래 피부사상균 DNA의 검출

김영욱,여상건,최원필,Kim, Young-Wook,Yeo, Sang-Geon,Choi, Woo-Pil 대한수의학회 2002 大韓獸醫學會誌 Vol.42 No.3

For the development of diagnostic polymerase chain reaction (PCR) to fungal infection by dermatophytes Trichophyton and Microsporum, detection of the fungal DNA by PCR and analysis of the DNA pattern were undertaken in the present study. A total of 15 strains were tested and those consisted of 3 reference strains and 12 isolates such as: reference strains of T mentagrophytes (downy type, ATCC 9533), T rubrum (IFO 6204) and M gypseum (ATCC 9083), and each isolate of T mentogrophytes (powdery type), T mentagrophytes (granular type), T mentogrophytes (purple-red type), T rubrum, T raubitschekii, T tonsurans, T equinum, T ajelloi, T verrucosum, M cookei, M nanum and M gypseum. The DNA were purely isolated from all strains of Trichophyton spp. and Microsporum spp. by a simple method partly consisted of disruption of fungal cells by lyophilization and grinding and extraction of fungal DNA without phenol treatment which is a routine procedure in DNA isolation. For the detection of fungal DNAs, optimal condition of PCR was determined as preheating once at $94^{\circ}C$ for 5 min, 35 cycles of denaturation at $94^{\circ}C$ for 1 min, annealing at $38^{\circ}C$ for 1 min and polymerization at $72^{\circ}C$ for 2 min, and 1 cycle of final extension at $72^{\circ}C$ for 5 min. In PCR using arbitrary primers AP-1 (5' ACCCGACCTG3') and AP-2 (5' ACGGGCCAGT3'), DNAs in various numbers and sizes were detected from different species of Trichophyton and Microsporum, while DNAs in similar size were also detected in all strains of Trichophyton spp. and Microsporum spp. There were unique DNAs observed from certain dermatophytes by AP-1 such as 1,900 bases in T rubrum, 950 and 1,100 bases in T raubitscheldi, 2,100 bases in T equinum, 400 bases in T verrucosum and 1,150 bases in M gypseum. The unique DNAs were also observed by AP-2 such as 1,200 bases in T ajelloi, 250 bases in T verrucosum, 1,150 bases in M cookei and 2,000 bases in M nanum. The results indicated that PCR can detect a specific DNA from certain Trychophyton and Microsporum spp, which can be the information for further development of diagoomc PCR to dennatophytes.

엘리 카르탕과 20세기 리만기하학

김영욱,Yuzi Jin,Kim, Young-Wook,Yuzi Jin 한국수학사학회 2009 Journal for history of mathematics Vol.22 No.2

엘리 카르탕은 20세기 기하학과 대수학의 한 획을 그은 업적을 낸 수학자이다. 이 논문에서 우리는 소수의 전문가에게는 친숙하지만 일반적으로는 생소한 그의 업적을 조명해 보고 그 영향을 알아본다. Elie Cartan is one of the mathematicians whose works marked the development of geometry and algebra of 20th century. We illuminate his mathematical contributions which is familiar to the experts but is alien to most of the mathematicians in general. Also we elucidate some of his influences.

한.일간(韓.日間)의 문자교류(文字交流)에 대하여 -불교(佛敎) 문화(文化)의 흐름 속에서 고대(古代) 한.일관계(韓.日關係)를 조명(照明)함-

김영욱,Kim, Young-Wook 국제언어인문학회 2006 인문언어 Vol.8 No.-

The writing systems of the Silla dynasty, the Kugyol(口訣), had influenced the earlier states of Japanes Kunten(假片) during the 8th century. Japanese developed their own writing system, Kunten(訓点) after the 9th century. The Silla Kugyol was inscribed by Gagpil(角筆), a kind of ancient stylus, which seems to be originated in China and India. There are two main streams of Asian script culture. One is from China: a brush-pen culture for East asian calligraphy, named Seoye(書藝) or Seodo(書道). The other is from India: a tusk-pen culture for inscribing Buddha's words. In Korean peninsular, we can find the traces from Buddist texts inscribed by the Gagpil, a tusk-pen. We can find new writing system in the books of the Silla, penod, Panbilyanglon(判比量論), Hwaeommuneuiyogyol(華嚴文義要訣) etc. The scripts inscribed by gagpil was a totally phonetic system with dots and lines etc., like Hangul strokes was invented by I king Sejong 800 years later. The old system was used until 15th century before the invention of Hangul scripts.

치주염 환자에 있어서 방출 조절성 제제를 이용한 치료에 관한 연구

김영욱,신형식,Kim, Young-Wook,Shin, Hyung-Shik 대한치주과학회 1991 Journal of Periodontal & Implant Science Vol.21 No.1