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대장 용종에서 cyclooxygenase - 2 와 vascular endothelial growth factor ( VEGF ) 의 발현
이창우(Chang Woo Lee),이구(Goo Lee),김동훈(Dong Hoon Kim),전훈재(Hoon Jai Chun),서정일(Jeong Ill Suh),양창헌(Chang Heon Yang),김수근(Soo Keun Kim),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun),김한겸(Han Kyeon Kim) 대한내과학회 2001 대한내과학회지 Vol.61 No.3
N/A Background : Recent studies showed that non-steroidal antiinflammatory drug may reduce the risk of colorectal cancers. So its potential target, cyclooxygenase (COX)-2 in colorectal cancers has been widely investigated. However, the rate and patterns of COX-2 expression in colorectal polyps have been quite variable among study groups. Furthermore, its role has not been established. The study aim is to investigate the expressions of COX-2 and vascular endothelial growth factor (VEGF) and to evaluate the role of COX-2 in colorectal polyps. Methods : Fifty-seven colorectal polyps from endoscopic polypectomy or surgical resection were enrolled. Polyps were as follows; 9 were hyperplastic polyps, 14 mild, 26 moderate dysplasia, 8 high grade adenomas (5 severe dysplasia, a carcinoma in situ, and two intramucosal carcinomas). They were stained for COX-2 and VEGF by immunohistochemistry. The intensity of staining according to histologic grades and size of polyp was semi-quantitatively assessed. Results : COX-2 was expressed in 18 cases (31.8%) by dysplastic epithelium and 29 cases (50.9%) by interstitial cells. Epithelial COX-2 expressions were significantly related to histologic grades and size, and begun at moderate dysplasia actually. Interstitial COX-2 was little related to histologic grades and size. VEGF was expressed in 35 cases (61.4%). There was close relationship between epithelial COX-2 and VEGF expressions. Conclusion : COX-2 is expressed both in dysplastic epithelium and interstitial cells of colorectal polyps. Our results suggest that epithelial COX-2 expression may be playing a role in tumorigenesis of colorectal polyp, possibly involved in angiogenesis with VEGF.(Korean J Med 61:240-248, 2001)
Qi(氣) 운동이 인간의 호흡순환계 변인에 미치는 영향
김수근,주동엽,류훈,정헌택 圓光大學校 附設 體力科學硏究所 1996 體力科學硏究 Vol.19 No.-
This study aimed at the effects both on the cardoirespiratory variables changes and on the motor performance capacity after practicing Qi exercise. The test of basic motor performance capacity was operated by means of stress test(CardiO2 Gas Analyzer). Qi exercise mrthod was as follows; all the subjects practiced Qi exercise of one years. As a result of the changes of cardiorespiratory system, we got to the conclusion as follows; As a result of Qi exercise, maximal heart rate of post-exercise compared with pre-exercise was decreased at the rate of 46%(P>.05). The exercise intensity of Qi exercise was 12.94% level of maximal heart rate by the test of basic motor performance capacity.