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류마티스 관절염에 동반된 빈혈에서 혈청 Transferrin 수용체 측정의 유용성: 골수 저장철과의 비교
김성수 ( Sung Soo Kim ),박원 ( Won Park ),배성권 ( Sung Kwon Bae ),이용환 ( Yong Hwan Lee ),송정수 ( Jung Soo Song ),최종원 ( Jong Weon Choi ),김순기 ( Sun Ki Kim ) 대한류마티스학회 2000 대한류마티스학회지 Vol.7 No.4
Objective: This study was aimed at investigating the usefulness of serum transferrin receptor (sTfR) in anemic patients with rheumatoid arthritis (RA) compared with bone marrow storage iron and other tests for anemia. Methods: Fifty-five anemic RA patients were undergone anemia study including hematologic indices, iron panel, and sTfR. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were also measured. Eighteen patients performed marrow iron stain. The sTfR and serum ferritin levels were compared with bone marrow iron store, hematologic values, iron batteries, and markers of the disease activity. Results: 1) Mean sTfR concentration was 2.68±1.29mg/L in all patients. 2) sTfR correlated significantly with hemoglobin concentration (r=-0.491; p<0.001), hematocrit (r=-0.348; p=0.009), MCV (r=-0.597; p<0.001), RDW (r=0.696; p<0.001), serum iron (r=-0.389; p=0.003), and transferrin saturation (r=-0.451; p=0.001) 3) Ferritin did not correlated significantly with hemoglobin, hematocrit, serum iron/TIBC, MCV and RDW, except reticulocyte count (r=0.295; p=0.032) and total iron binding capacity (TIBC) (r=-0.503; p<0.001). 4) sTfR showed no significant correlation with ESR and CRP, whereas ferritin correlated with CRP (r=0.342; p=0.019). 5) Among the patients who performed iron staining from bone marrow, sTfR was higher in iron-depleted group compared with iron replete group (p=0.040). Conclusion: This study suggests that measurement of sTfR may be useful assay for anemia and the possible substitute for invasive bone marrow study in differentiating iron deficiency anemia from anemia of chronic diseases in patients with RA.
한국인에서 쇼그렌 증후군의 선별 및 추적검사로서 건빵 용해 검사의 개발
김성수 ( Sung Soo Kim ),송정수 ( Jung Soo Song ),박보형 ( Bo Hyoung Park ),이용환 ( Yong Hwan Lee ),배성권 ( Sung Kwon Bae ),박원 ( Won Park ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Objective: To investigate the usefulness of the Hardtack test to screen the Sjogren`s syndrome compared with non-stimulated whole salivary flow (NSWSF) and Schirmer-1 test. Methods: Fifty patients with RA and other connective tissue disease who had complained sicca symptoms (7 males and 43 females) and twenty healthy participant, were undergone the Hardtack test, NSWSF, and Schirmer-1 test. The Hardtrack test were compared with NSWSF and Schirmer-1 test for the screening of Sjogren`s syndrome. And the relationship between the tests were evaluated. Results: 1) The time of dissolution of the hardtack was 88.7sec (Max: 136, Min: 44) in healthy group, and 321 sec (Ma: 900, Min: 92) in patient group (p<0.001). 2) NSWSF was 0.6 ml/min (Max: 1.32, Min: 0.14) in healthy group, and 0.28 ml/min (Max: 0.8, Min: 0.01) in patient group (p<0.001). 3) The lacrimal flow in Schirmer-1 test was 22.0 mm (Max: 30, Min: 8) in healthy groups and 5.26 mm (Max: 21, Min: 0) in patient group (p<0.001). 4) The correlation coefficient between the hardtack test and NSWSF was -0.56 (p<0.001). The correlation coefficient between the hardtack test and Schirmer-1 test was -0.51 (p<0.001). NSWSF was correlated with Shirmer-1 test but not significantly (r=0.254, p=0.075). In the hardtack test, the best balance between sensitivity and specificity was seen with a cut-off value of 120 seconds. Conclusion: The Hardtack test is useful screening test to discriminate between subjects with normal and reduced salivary flow. The Hardtack test is easy to perform, inexpensive, imposes minimal discomfort on the subject with xerostomia and correlated well with the NSWSF and the Schirmer-1 test. So it can also be used as to monitor the Sjogren`s syndrome before the salivary flow measurement or Schirmer-1 test.
김성수 ( Sung Soo Kim ),박원 ( Won Park ),배성권 ( Sung Kwon Bae ),송정수 ( Jeong Soo Song ),문경호 ( Kyung Ho Moon ),이정윤 ( Joung Yoon Lee ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.2
Septic arthritis is a disease that causes a rapid joint destruction by various kinds of bacteria such as Staphylococcus aureus. It affects more frequently the patients with rheumatoid arthritis, diabetes, immunocompromised patients, and chronic steroid users. In patients with rheumatoid arthritis, 1 to 12% of patients are affected by septic arthritis. In these patients, it is very difficult to distinguish between an acute exacerbation of rheumatoid arthritis and a development of septic arthritis if the latter affects more than one joint. Septic arthritis usually affects single joint, especially the knee joint. If the diagnosis and treatment are delayed, it would cause sepsis resulting in high mortality and morbidity. Thus early diagnosis by arthrocentesis, prompt drainage, and antibiotics therapy are essential. We experienced a 46 years-old woman with rheumatoid arthritis who abused the steroids for 10 years and complaining recent aggravation of bilateral knee joint swelling, warmth, and tenderness. Large amount of pus from both knees showed Gram positive cocci. The immediate open surgical drainage of both knees was done. The patient recovered from septic arthritis after 6 weeks of antibiotics therapy. The synovial fluid microbiology study should be done in all joints of the patients with the risk factors of joint infection.
양막과 표피세포 및 골수 간엽세포의 피부 결손 치유 효과
김철홍(Chul Hong Kim),김성수(Sung Soo Kim),손성근(Sung Keun Shon),김달희(Dal Hee Kim),송창근(Chang Geun Song),김현준(Hyun Jun Kim) 대한정형외과학회 2008 대한정형외과학회지 Vol.43 No.3
목적: 피부 결손치료에 있어 양막, 표피세포 및 골수 간엽세포의 상처 치유 효과에 대해 연구하고자 하였다. 대상 및 방법: 토끼의 전충 피부 결손 치료에 있어서 양막(human amniotic membrane: HAM)을 이식한 군, 양막과 배양된 표피세포(epidermal cells)를 주입한 군, 양막과 배양된 간엽세포(mesenchymal stem cells: MSCs)를 주입한 군, 그리고 바세린 거즈로 처리한 군을 각각 A (HAM), B (HAM + epidermal cells), C (HAM + MSCs), D (Vaseline gauze)군으로 하였다. 이식 후 각 군의 상처 치유 기간, 육아 조직 성장 및 상피화 등 상태를 관찰하고 수술 2주 후 치유 면적 백분율을 측정하였다. 결과: 2주 후, 평균 치유 면적 백분율은 A군 67.5%, B군 81.7%, C군 83.2%, D군 49.5%로 관찰되었고, A, B, C군과 D군 간(p<0.01), 그리고 B, C군과 A군 간(p<0.05)에 통계적인 유의한 차이를 보였다. 평균 회복기간은 D군에 비해 A, B, C군이 5.7-6.4일 짧았고 통계적으로 유의한 차이를 보였다(p<0.01). 가피 형성, 삼출물 분비 등 육안적 치유에서도 A, B, C군에서 보다 좋은 결과를 얻었다. 조직학적으로 B, C군은 피부 결손이 신생 상피로 덮여져 있고 육아 조직 성장이 왕성하며 섬유모세포, 미세혈관, 교원세포 함량이 풍부했다. 결론: 양막하 주입한 배양된 표피세포 및 골수 간엽세포 이식은 피부 결손 치료에 있어 효과적이고 조직학적으로도 우수한 결과를 보였다. Purpose: The purpose of this study was to investigate the transplantation results of human amniotic membrane (HAM), epidermal cells, or marrow mesenchymal stem cells (MSCs) in healing a skin defect. Materials and Methods: Defects (full-thickness) in rabbits were treated with HAM alone (group A), HAM injected with cultivated epidermal cells (group B), HAM injected with cultivated MSCs (group C), or Vaseline gauze (group D). Tissue granulation, regeneration, re-epithelization and healing time were measured. Defects and healed area were calculated 2 weeks after surgery. Results: The mean healing area was 67.5%, 81.7%, 83.2% and 49.5% in each group, with all treatment groups significantly different than group D (p < 0.01), and groups Band C compared higher than group A (p<0.05). The healing time of groups A, B, and C was 5.7 to 6.4 days faster than that of group D (p<0.01). Histologic analysis showed that the new epidermis covered nearly the whole wound surface in group Band C, and contained granulated tissue with fibroblasts, capillaries, and collagen. Conclusion: HAM grafts injected with cultivated epidermal cells or MSCs promoted healing of skin defects.
실험연구 : 쥐 배아심장 H9c2세포의 허혈 후 재산소화 시 Propofol 농도가 활성산소 발생에 미치는 영향
김윤홍 ( Yun Hong Kim ),김현수 ( Hyun Soo Kim ),이영재 ( Young Jae Yi ),최원준 ( Won Joon Choi ),송준규 ( Jun Kyu Song ),이선민 ( Seon Min Lee ),최원재 ( Won Chae Choe ),김성수 ( Sung Soo Kim ) 대한마취과학회 2006 Korean Journal of Anesthesiology Vol.51 No.1
Background: Reoxygenation of an ischemic heart causes a decrease in the cardiac function, which is known as reperfusion injury that is associated with an increase in the concentration of reactive oxygen species (ROS). This study examined the effect of the propofol concentration on the generation of ROS during reoxygenation in rat embryonic heart H9c2 cells. Methods: Cultured H9c2 cells were examined in the following sequences: Prehypoxic, Hypoxic and Reoxygenation period. Each period required 60 minutes. The cells were exposed to propofol at the beginning of the prehypoxic period. Thirty minutes later, DCFH-DA (dichlorofluorescin diacetate) 10μM was added to detect the ROS. The propofol concentrations used were 0, 5, 25, 50, 250μM in the first experiment and 0, 1, 2, 3, 4, 5μM in the second experiment. The ROS level was estimated using a fluorometer at 5-minute intervals from 5 to 60 minutes after reoxygenation. Results: When the propofol concentrations was > 5μM, the ROS levels were significantly lower than those of the untreated group (P0) (P < 0.05). At propofol concentrations < 5μM, the ROS levels 35 to 60 minutes after reoxygenation were significantly lower that in the untreated group (P < 0.05). Between 5 and 30 minutes after reoxygenation, the cells exposed to 1, 4 and 5μM propofol also showed lower ROS levels than the untreated group P0. However, 2 and 3μM propofol did not show any significant difference in ROS values to those observed in the untreated group except for 2μM at 25 minutes after reoxygenation. Conclusions: During the reoxygenation period in H9c2 cells, propofol concentrations > 5μM inhibited ROS production over the whole period, and even 1μM showed some inhibition of ROS. (Korean J Anesthesiol 2006; 51: 89~93)