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뽕잎추출물이 콜레스테롤 투여 흰쥐의 혈청지질에 미치는 영향
김선여(Sun-Yeou Kim),이완주(Won-Chu Lee),김현복(Hyun-Bok Kim),김애정(Ae-Jung Kim),김순경(Soon-Kyung Kim) 한국식품영양과학회 1999 한국식품영양과학회지 Vol.27 No.6
뽕잎이 고지혈증에 미치는 영향을 알아보기 위하여 고지혈증이 유도된 흰쥐의 뽕잎추출물을 경구투여한 후 혈청학ㆍ조직학적인 검사를 행하였고, 부가적으로 뽕잎이 인체의 지질대사에 미치는 영향을 조사하였다. 뽕잎추출물을 흰쥐의 각각 0.1g/㎏ of body weight과 1g/㎏ of body weight의 농도로 투여함으로써 총 콜레스테롤과 중성지질 함량을 유의성있게 감소시켰고 또한 총 콜레스테롤 중의 HDL-콜레스테롤이 차지하는 비와 lipase의 활성을 증가시켰다. 이러한 혈청학적인 결과는 조직학적인 검사를 통하여 확인할 수 있었고 인체실험에서도 동물실험에서와 같은 경향을 나타냈고 특히 뽕잎파우더의 투여로 중성지질이 유의적으로 감소하였다. This study was conducted to investigate the effect of mulberry leaves on lipid metabolism in cholesterol-induced hypercholesterolemia rats. The mulberry treatment group showed decreases of serum lipid concentration compared with hyperlipidemic group. Also, Mulberry leaves inhibited the activity of HMG-Co A reductase, increased lipase activity. In histopathological examination, abdominal aorta showed no critical lesions with mulberry leaves treatment. These results suggest that hypolipidemic effects of mulberry leaves on rats were the inhibition of cholesterol synthesis and acceleration of cholesterol catabolism in the liver. For human, serum triglyceride contents were more significantly decreased with treatment of mulberry leaves powder.
사염화탄소에 의하여 유발된 흰쥐의 간 독성에 미치는 비테인의 효과
김선여(Sun Yeou Kim),김홍표(Hong Pyo Kim),이미경(Mi Kyeong Lee),변순정(Soon Jeong Byun),김승희(Seung Hee Kim),문애리(A Ree Moon),한형미(Hyung Mi Han),허훈(Hoon Huh),김영중(Young Choong Kim) 대한약학회 1993 약학회지 Vol.37 No.5
Effects of betaine, a major component of Lycii Fructus, on carbon tetrachloride intoxicated rats were evaluated. Histological studies showed that betaine had improved the typical necrosis around centrilobular area in liver tissue due to the carbon tetrachloride intoxication. Betaine, whether it was administrated simultaneously or prior to carbon tetrachloride, prevented or retarded the elevation of liver-weight/body-weight ratio due to the carbon tetrachloride intoxication. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride intoxication. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride in rat.
일차 배양한 흰쥐의 간세포에서 사염화탄소로 인한 독성에 미치는 비테인의 효과
김선여(Sun Yeou Kim),김홍표(Hong Pyo Kim),이미경(Mi Kyeong Lee),김승희(Seung Hee Kim),문애리(A Ree Moon),한형미(Hyung Mi Han),허훈(Hoon Huh),김영중(Young Choong Kim) 대한약학회 1993 약학회지 Vol.37 No.5
Betaine, a major component of Lycii Fructus, was evaluated for its anti-hepatotoxic activity on carbon tetrachloride-induced hepatotoxicity in primary cultured rat hepatocytes. Betaine was found to attenuate carbon tetrachloride-induced hepatotoxicity both morphologically and biochemically. Typical hepatocyte necrosis due to carbon tetrachloride seemed to be reduced by 50 to 500mcM of betaine under microscopical observation. The value of glutamic pyruvic transaminase released from the hepatocytes into the medium significantly decreased as betaine concentration increased. Betaine also significantly elevated the reduced activities of some enzymes, cytochrome P-450, 7-ethoxycoumarin-O-deethylase and glutathione-S-transferase, involved in xenobiotic metabolism due to carbon tetrachloride-induced hepatotoxicity. These results demonstrate a possible hepato-protective role of betaine against fatty liver that could be easily induced by carbon tetrachloride.
김선여(Sun Yeou Kim),김영중(Young Choong Kim),변순정(Soon Jung Byun),김은(Eun Kim) 한국생약학회 1992 생약학회지 Vol.22 No.4
Liver protective effects of ginsenosides as well as fractions of dammarane glycosides of Panax ginseng were studied using galactosamine (Ga1N)-induced cytotoxicity in primary cultured rat hepatocytes. Preventing effects on Ga1N-induced hepatotoxicity were found both microscopic observation and determination of GPT level with total dammarane glycosides fraction and 20(S)-ginsenoside-Rb₁ as well as 20(S)-ginsenoside-Rg₁ at the concentration of 50 ㎍/㎖. The syntheses of both protein and RNA were significantly increased by the treatment of 50 ㎍/㎖ of total dammarane glycoside fraction, 20(S)-ginsenoside-Rb₁, -Rc, -Re and -Rg₁, respectively in both normal and Ga1N-induced cytotoxic hepatocytes.