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지속형 천식 환자에서 아콜레이트 (R) (Zafirlukast) 투여에 따른 유효성과 안전성 및 내약성 평가를 위한 비대조, 다기관 임상연구
김능수,이양근,조영주,최병휘,최인선,박춘식,민경업,홍천수,박중원,윤호주,박해심 대한알레르기학회 2001 천식 및 알레르기 Vol.21 No.3
Background and Objective:Accolate, one of the cysteinyl leukotriene receptor antagonists, have anti-inflammatory and bronchodilating effects. The clinical indications for LT antagonist are not yet in consensus. We performed a non-comparative multicenter trial to assess the additional responses of Accolate to the current long-term control regimens in persistent asthma. Materials and Methods: Eighty persistent asthmatics from 10 asthma special care clinics were enrolled. Daily 20 mg of Accolate was added 2 times to the current control regimen for 6 weeks and its effects on symptom scores, morning and evening PEFR, FEV₁ and frequency of the short acting 2 agonist usage for relief of asthma were measured. Results: The morning symptom scores significantly improved by addition of Accolate for 1 week (p$lt;0.01) and its effect persisted to the 6th week (p$lt;0.01) of trial. Nocturnal symptom scores also improved at 2nd week (p$lt;0.05) and the effect continued to the end of this trial. Days with morning asthma symptoms deceased by addition of Accolate at 4th week (p$lt;0.05) and 6th week (p$lt;0.05). The frequency of the short acting β₂- agonist inhalations significantly decreased by addition of Accolate from 1st week to the end of this trial. Morning and evening PEFR significantly improved at 1st week and the effects progressively improved to the end of this trial. The FEV1 not improve by addition of Accolate. However, when the asthmatic with obstructed lung function (FEV₁ $lt;80%) were enrolled only for analysis, the FEV₁ significantly improved at 3rd (p$lt;0.05) and 6th weeks (p$lt;0.05). In 21 asthmatics, oral prednisolone was continuously used at the beginning of this trial. It could be discontinued in 4 patients and the dosage of prednisolone was significantly reduced in another 3 patients by addition of Accolate. Their mean administered dosage of prednisolone decreased from 8.6±0.9 mg/day to 6.8±1.1 mg/day at the end of this trial (p$lt;0.05). Conclusions: With these results, we thought that addition of Accolate as a long term control imen in the symptomatic persistent asthmatics would be an effective strategy. For evaluation of steroid sparing effects, further studies will be needed.
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뇌혈관질환 후 실어증의 한의학적 치료에 대한 국내 임상연구에 대한 고찰
고지윤,손아현,신현수 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.6
Objectives: The aim of this review is to investigate clinical studies on Oriental medicine treatment for aphasia after cerebrovascular disease. Methods: Using the keywords ‘Aphasia', ‘Oriental medicine', ‘Stroke' ‘Cerebral infarction', ‘Cerebral hemorrhage', and ‘Clinic', we searched domestic databases, including “NDSL (National Discovery for Science Leaders)", “Korean Traditional Knowledge Portal", “OASIS (Oriental Medicine Advanced Searching Integrated System)", and “RISS (Research Information Sharing Service)". Each keyword was not searched individually, but combined in various ways. To investigate recent trends, we limited our search to papers published after 2000. Papers that did not include a specific treatment method or did not match the subject “Aphasia after stroke" were excluded. Results: Using the searching method, 13 studies were found. Of these, 12 studies were in the form of case reports, while one was in the form of a non-randomized controlled trial. These studies showed positive results for the use of Oriental medicine in terms of the Korean version of the Western Aphasia Battery (K-WAB), the evaluation form on functional performance capability and accuracy of articulatory organs developed by Lee, aphasia screening test refered in ‘Assessment in Speech-Language Pathology' and adapted properly to Korean, the Communicative Ability in Daily Living Test (CADLT), the Korean Version-Boston Naming Test (K-BNT), and language assessment items included in CNS, and NIHSS. Conclusions: Of the 12 case reports, 11 studies showed positive results of the use of Oriental medicine for treatment of aphasia after cerebrovascular disease. However, more sophisticated and large-scale clinical research on aphasia should be conducted.
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