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금앵자(金櫻子) 추출물(抽出物)이 음경해선체(陰莖海線體)의Nitric oxide synthase 활성(活性) 및 항산화효과(抗酸化效果)에 미치는 영향(影響)
김경동,정지천,Kim, Kyung-Dong,Jeong, Ji-Cheon 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.1
Rosae laevigatae Fructus extract (RLF) was tested for the effects on the urethral nitric oxide synthase (NOS) activity and Antioxidation in streptozotocin (STZ) induced diabetic rats. RLF was treated firstly into samples, and then STZ induced diabetic rats were set with them. In vitro, the urethral NOS activity was not noted but the type O activity and type conversion ratio of xanthine oxidase and the level of urethral lipid peroxide were decreased in the level of Dose of extract prepared from RLF. In vivo, after the extract was administered to the animal model for fifteen days, the urethral NOS activity increased in STZ induced diabetic rats to the level of normal rats. The content of urethral nitrite and glutathione followed by RLF pre-medicating administration, increased as highly as normal group in compare with the group treated with STZ. The type O activity and type conversion ratio of xanthine oxidase and the level of urethral lipid peroxide followed by RLF pre-medicating administration, decreased as lowly as normal group in compare with the group treated with STZ. In conclusion, the extract of RLF will be able to restore erectile dysfunction of STZ induced diabetic rats.
김경동(Kim, Kyung-Dong) 한국중어중문학회 2017 中語中文學 Vol.- No.70
Chinese classical works are a valuable humanities heritage for all humanity. To rediscover its value, researchers and ordinary readers are constantly reading classics on different levels of research and appreciation. Creative research and correct appreciation are only possible through accurate interpretation and translation. It is time for us to find a new way of interpreting and translating Chinese classical works, because it is a difficult task for us. This paper aims to solve some misunderstandings in interpretation and translation of some Chinese classical poetry and prose. I hope that it will be the precursor of correct interpretation and translation of Chinese classical works.
연구논문 : 추출시간에 따른 약용식물추출물의 활성변화에 관한 연구
김경동 ( Kyung Dong Kim ) 한국미용학회 2007 한국미용학회지 Vol.13 No.3
When extracting medicinal plant which is used as effective medicine, there`s something to be considered. You should consider the collecting condition like collecting time, place, part and extracting condition like extracting method. Despite the effect differences by collecting and extracting conditions, the differences of efficacy appeared by some condition(extracting time) were not big problem till now. But, as increased interests in standard extracting condition of medicinal plants, more scientific study about extraction time is required. Therefore, this study used the free radical scavenging activity test and absorbance method in ultraviolet-ray area and focused on checking the occurrence of effect difference by extracting time. Moreover, in case of doing extraction test by time difference, we could notice that extracting time is very important factor and effect is varied by time. With this result, we found that proper time condition can make better data and increase the possibility of plant`s extracts standardization.
김경동 ( Kyung-dong Kim ),나민균 ( Min-kyun Na ),김상진 ( Sang-jin Kim ) 대한화장품학회 2006 대한화장품학회지 Vol.32 No.2
본 연구는 한방화장품의 원료로써 사용이 되는 약용식물들의 부위별 및 추출용매에 따른 추출물의 효능효과의 차이를 기술하였다. 기존의 단일성분 분석법 보다 실제로 성분의 복합체인 추출물에 대하여 항산화 관련 효능효과 시험법을 적용하였다. 일차적으로 항산화활성을 가지는 약용식물을 선별한 후, 문헌상 부위별로 사용이 가능한 약용식물 11종을 선정하여 DPPH radical 소거활성 및 hydroxyl radical 소거활성과 같이 널리 알려진 시험법을 통하여 차이를 확인하였다. 예를 들자면 Trachelospermum asiaticum 경우 aerial part와 fruit를 비교하면 DPPH radical 소거활성인 경우 값이 각각 25.2 ± 0.2와 62.4 ± 1.6로 fruit가 2.4배의 높은 효과를 보이며, hydroxyl radical 소거 활성의 경우에는 fruit에서는 효과를 보이지만 aerial part에서는 효과를 확인할 수 없었다. 몇 가지 다른 식물들도 같은 형태를 보여주고 있다. 이 결과로 약용식물 또는 유효성분을 가지는 식물을 추출함에 있어서 부위별 추출이 고려되어야 함을 알 수 있었다. 또한 약용과 염료용으로 많이 사용이 되는 Lithospermum erythrorhizon를 선정하여 추출용매를 변경시킴으로써 용매에 따른 효과 차이를 확인하였다. 실제로 superoxide scavenging activity값을 측정한 결과 용매에 따라 효과 차이가 10~80% 발생함을 확인함으로써 약용식물 추출하여 사용 시 부위별 또는 추출 용매별로 차이가 있음을 고려하여 제품에 적용시 발생 가능한 오차를 줄여야 한다는 것을 보여주었다. This study was to describe the differences in efficacy and effect of herbal extracts by the part and solvent extraction from the medical plants used as materials of oriental herbs cosmetics. And, this study was to apply to the test method of efficacy and effect related to the antioxidation as herbal extracts, complex of actual ingredient, not existing analytical methods of single ingredient. After screening the medical plants with the antioxidative activity primarily and selecting 11 sorts of medical plants to be used by the part in the literature, this study was to confirm the differences through the well-known test methods like DPPH radical scavenging activity test and hydroxyl radical scavenging activity test. For examples, in case of Trachelospermum asiaticum, compared with the aerial part and fruit, the value of DPPH radical scavenging activity test had 25.2 ± 0.2 and 62.4 ± 1.6 each. It has shown that the value of fruit had 2.4 times higher effect than the one of aerial part. In case of hydroxyl scavenging activity test, it was effective in the fruit, but it has shown that there was no effect on the aerial part. It showed the same phenomena in some other plants. From the result above, this researcher could understand that it needed to consider extracting the medical plants or plants with the active principle by the part. Also, this study was to confirm the differences in effect according to the solvent as it changed the solvent extraction after selecting a plant (Lithospermum erythrorhizon) widely used for medicine and dye. As a result of measuring the actual value of superoxide scavenging activity test, this study was to consider that there were differences by the part or solvent extraction in extracting and using the medical plants as it has shown that the effect differences produced 10~80% according to the solvent. When it was applied to the products, this study has shown that it needed to decrease the possible errors.