약침용(藥鍼用) 봉독성분(蜂毒成分) 중(中) Apamin, Melittin의 항암작용(抗癌作用)

권도희,이재동,최도영,Kwon, Do-Hee,Lee, Jae-dong,Choi, Do-Yong 대한침구의학회 2001 대한침구의학회지 Vol.18 No.1

Objectives : To characterize the antitumorigenic potential of three representative bee venom components, Melittin, Apamin, and Phospholipase A2, their effects on cell proliferation and apotosis of the human melanoma cell line SK-MEL-2 were analyzed using molecular biological approaches. Methodes & Results : To determine the doses of the drugs that do not induce cytotoxic damage to this cell line, cell viability was examined by MTT assay. While SK-MEL-2 cells treated with 0.5 - 2.0㎍/㎖ of each drug showed no recognizable cytotoxic effect, marked reductions of cell viability were detected at concentrations over 5.0㎍/㎖. [3H]thymidine incorporation assay for cell proliferation demonstrated that DNA replication of SK-MEL-2 cells is inhibited by Apamin and Phospholipase A2 in a dose-dependent manner. Consistent with this result, the cells were accumulated at the G1 phase of the cell cycle after treatment with Apamin and Phospholipase A2, whereas no detectable change in cell proliferation was identified by Melittin treatment. In addition, tryphan blue exclusion and flow cytometric analyses showed that all of these drugs can trigger apoptotic cell death of SK-MEL-2, suggesting that Melittin, Apamin, and Phospholipase A2 have antitumorigenic potential through the suppression of cell growth and/or induction of apoptosis. Qantitative RT-PCR analysis revealed that Apamin and Phospholipase A2 inhibit expression of growth-promoting genes such as c-Jun, c-Fos, and Cyciin D1. Furthermore, Phospholipase A2 induced tumor suppressors p53 and p21/Wafl. In addition, all three drugs were found to activate expression of a representative apoptosis-inducing gene Bax while expression of apoptosis-suppressing Bcl-2 and Bcl-XL genes was not changed. Taken together, this study strongly suggests that Metittin, Apamin, and Phosphalipase A2 may have antitumorigenic activities, which are associated with its growth-inhibiting and/or apoptosis-inducing potentials.

건성안(乾性眼)에 대한 침료법(鍼療法)의 문헌적(文獻的) 고찰(考察)

권도희,김용석,최도영,Kwon, Do-Hee,Kim, Yong-Suk,Choi, Do-Yong 대한침구의학회 2000 대한침구의학회지 Vol.17 No.3

1. Objectives : Millions of people throuout the world are affected by some form of dry eye disorder. I made researches for more effective treatments for dry eye. 2. Methodes : I refered to occidental and oriental medical records. 3. The results were as follows : Common symptoms of dry eye are dryness, burning, irritation, grittiness, itching, fatigue of eye, photophobia, congestion, mattering and tear. Treatments of dry eye are to clear away heat and fire, remove dampness, replenish Um and promote production of body fluid, tonify the blood and replenish Ki. Acupunctre and moxibustion therapy of dry eye are as follows: Very busy points of traditional regular acupuncture are Sangsong, Chanjuk, Sajukkong, Chongmyong, Sabaek, Tongjaryo, Taeyang, Pungji, Tuimup, Paekoe, Un-gyo, Chonjong, Hapkok, Yangbaek, Kansu, Yanggye, Imup, Chok-samni, Taechung, Kwangmyong, Yang-gok, Uihui, Chohae, Haenggan. Less busy points of it are Oyo, Kuhu, Sungup, Konmyong, Konmyongl, Konmyong2, Sangmyong, SanghaChongmyong, Shinmyong, Osang, Shinjong, Yonghyang, Yaemyong, Chon-yu, Chon-ju, Kwallye, Naebi, Noeho, Tuyu, Mokchang, Ponshin, Shinhoe, Yepung, Okchim, Pungbu, Kokchon, Kollyun, Nae-gwan, Tae-nung, Samumgyo, Sokolkong, Shinsu, Um-gyo, Igan, Chongok, Choktaek, Kyonjungsu, Kokchi, Kongchoe, Kyuum, Kihae, Taekolkong, Taedon, Pino, Pisu, Sabong, Samgan, Kokchi, Shinmun, Shinmaek, Shimsu, Yangno, Aengmun, Yolgyol, Oegwan, Wijung, Chang-gan, Chungjo, Chungdo, Chigu, Chium, Chollyo, Tongni, Pungmun, Haryom. Very busy points of ear-acupuncture are Kan, Bi, Shin, An, Less busy points of it are Shim, Pye, Naebunbe, Mok1, Mok2, Shinmun, Ichom. Useful points of bleeding by needle are Taeyang meridian, Yangmyong meridian, Chono, Chonjong, Paekoe, Sangsong, Chanjuk, Sajukkong, nasal cavity. Useful points of moxibustion are Inchung, Huaryo, Shinchu, Pungmun, Kansu, Shimsu, Kokchi, Kongchoe, Sohae.

셀프리더십과 고객지향성의 관계에서 자기효능감의 매개효과: 항공사 객실승무원 중심으로

권도희,이승해,Kwon, Do-Hee,Lee, Seung-hae 한국품질경영학회 2022 품질경영학회지 Vol.50 No.3

Purpose: The purpose of this study is to analyze the effect of self-leadership on self-efficacy and customer orientation and to verify whether there is a mediating effect of self-efficy on the relationship between self-leadership and customer orientation. Methods: To verify these research problems, the subjects of this study were a total of 300 Korean cabin crew members working for domestic and foreign airlines who received distributed questionnaires and 247 copies wee analysed using the SPSS 20.0 program. Results: First, it can be seen that the self-leadership of airline cabin crew has a significant positive (+) effect on self-efficacy, indicating that self-leadership has a positive effect on the self-efficacy of the members of the organization. Second, it was found that self-efficacy had a positive (+) effect on the customer orientation of airline cabin crew, and it was analyzed that self-efficacy played a partial mediating role in the relationship between self-leadership and customer orientation. Third, it was found that self-leadership had a positive (+) effect on customer orientation, and it was proved that behavior-oriented strategy, constructive accident pattern, and natural compensation strategy, which are three sub-factors of self-leadership of cabin crew, have an influence on customer orientation. Conclusion: based on these findings, the theoretical and practical implications of this study and directions for future research were presented.

중부지역 낙랑계 토기 및 철기에 대하여

권도희(Kwon, Do-hee) 중부고고학회 2017 고고학 Vol.16 No.3

원삼국시대 한반도 중부지역의 토기는 경질무문토기가 표지적인 유물로 이들과 함께 낙랑(계)유물이 일부 확인되어 선진적 문화를 가진 낙랑지역과 교류가 있었음을 짐작할 수 있다. 낙랑계유물은 한강하류역, 임진강유역, 한탄강유역, 북한강유역, 영동지역 등 전 지역에서 확인되며 특히 북한강유역에 집중도가 높은 편이다. 북한강유역에서 낙랑계토기는 1차 타날흔이 관찰되는 타날문단경호, 시루, 분형토기, 완, 반 등이 있으며 타지역에 비해 평저호가 다수 확인된다. 평저호는 낙랑지역에서도 전시기에 걸쳐 확인되나 북한강유역의 평저호는 점차 고속의 물레흔, 사절흔, 암문 등이 사라져 가며, 동체부 전면에 타날을 남기는 등 점차 재지화된 형태로 변화된다. 이외에도 동체부의 형태와 크기는 타날문단경호와 유사하며 목이 좁고 길어지는 세경호 등 낙랑의 제도술에서 벗어난 특징적인 기형이 나타나기도 한다. 철기도 낙랑지역과의 교류관계를 알 수 있는 소형 주조괭이가 다수 보이며, 송풍관, 완형재, 미완성철기 등이 다수 확인되어 점차 지역에서 철기를 생산하는 수준에 이르렀음을 알 수 있다. 낙랑계토기와 철기가 출토되는 유구에서는 방추차의 출토비율도 높은 편으로 낙랑토성 출토품과 유사한 문양이 새겨진 석제방추차가 확인되어, 제도술과 제철술 외에도 방직술에도 낙랑의 영향이 있었음을 알 수 있다. During the proto-three kingdom period in the Korean peninsula, each regional political system is formed in order to be developed into each ancient kingdom. The material culture developed in such kingdoms had some specific features respectively. In the central region, many living sites rather than tomb sites were excavated and the representative artifact was hard-plain pottery. Since some of Nakrang pottery and Nakrang-type pottery together with the artifacts mentioned above were excavated, it explains that there was some exchange relationship with Nakrang region which had some advanced culture. Nakrang-type artifacts are excavad in the whole areas of the downstream area of Han river, Imjin river basin, Hantan river basin, Bukhan River basin and Youngdong region, etc. Especially, such artifacts are mainly excavated in Bukhan River basin. Nakrang-type artifacts excavated in Bukhan River basin are many kinds of padding patterned short-neck jars on which the 1nd padding traces are found, steamers, vessel-shaped potterys, bowls and low basin-shaped pottery, etc., and lots of flat-bottom jars are found compared to the other regions. Such flat-bottom jars are also found during the whole period in the Nakrang region, but the types of pots had changed into the ones made at each pottery-making place on the flat-bottom jars found in Bukhan River basin since high-speed spinning wheel traces, string traces and dark patterns, etc., distinguished gradually and padding patterns were left on the all parts of pottery. In addition, some unique characteristic deformed shapes, such as, ‘Narrow neck Jars’ whose neck gets narrower and longer, similar to the padding-patterned short-neck jars that deviated from the ceramic arts of Nakrang were developed. For ironware, a lot of small casting hoes were excavated, it can be assumed that the region was exchanged with Nakrang region. also, since many kinds of blast pipes, Wansangjae and incomplete iron ware, etc., were excavated, it can be assumed that the region got to reach the level of producing iron ware gradually. At the remains where Nakrang-type pottery and iron ware are excavated, the rate of excavation of spinning wheels is high and some stone-made spinning wheels on which some patterns similar to the artifacts excavated from Nakrang earthen fortress are carved were excavated. Thus, it can be seen that Nakrang influenced the textile-making technique in addition to the ceramic skill and the iron-manufacture skill of the region.

류성룡의 국방정책으로 본 우리의 안보의식

권도희 ( Do Hee Kwon ) 미래군사학회 2015 한국군사학논총 Vol.4 No.1

Presumably, no one can deny that the current security situation of Korea is in total crisis. Besides the possession of the nuclear weapons, North Korea is endlessly forming a risk aspect, such as development of submarine-launched missiles. In comparison, Koreans``s awareness of national security is becoming noticeably low compared to the past; what is worse, the reality is that pro-North Korean elements and followers of North Korea are openly in operation in the country. In addition to this, a wide range of military people from active or retired generals to non-commissioned officers are being investigated or in custody on charges of their involvement in defense industry-related irregularities. This writer daringly diagnoses that this reality is much like the security situation at the time of the Imjin War of 400 years ago. Sadaegyorin Policy(Policy of submission to China combined with peace-keeping relations with Japan and Jurchens), which neglected the martial prowess but put a focus on letters while depending on the Ming Dynasty, together with 200 years of peaceful prosperity, is very similar to the Korean tendency to rely on the USA. When a country is powerless, it will sure face an invasion from abroad. The history of the Imjin War, the late period of the Joseon Dynasty, and the Korean War clearly bear witness to the proposition; however, it``s really regrettable that our awareness of the current security situation seems to overlook such a vivid historical fact. Seoae Ryu, Seong-ryong, who faced the crisis of a country``s ruination at the time of the Imjin War(1592), managed to surmount the national crisis by devoting himself to the guard of the country. Accordingly, through this writing, this writer is intending to put emphasis on the importance of closely adhering to the attitude of providing for a rainy day with military readiness posture through the increase in military strength, and the importance of national security just like air once again by bringing light to the modern implications through the life, national defense idea & policy as well as strategies and tactics of Ryu, Seong-ryong who saved the Joseon Dynasty.

1910년대 창가와 잡가

권도희(Kwon Do Hee) 동악어문학회 2008 동악어문학 Vol.51 No.-

이 글은 서로 다른 태생적 배경을 갖고 있는 창가와 잡가가 1910년대 상황 하에 서로 비슷한 양상으로 한국근대음악사에 기여하고 있음을 밝혀본 것이다. 창가와 잡가는 각각 근대교육, 근대극장이라는 사회문화적 기반으로 성장한 음악이다. 창가와 잡가라는 용어는 근대적 출판물의 유통과 근대 가창문화의 확산과 함께 정착하여 1910년대 세간에 일반화되었다. 창가집의 경우 1910년을 시작으로 노래책이 발간되었고 잡가집의 경우 1910년대를 정점으로 재판이 계속되었다. 1910년대 창가는 장조를 중심으로 하고 잡가의 경우 서울 소리를 중심으로 하지만 이 외에도 세부적으로 서로 다른 음악어법을 사용하는 여러 류의 음악도 포함하여 창가 혹은 잡가라는 통합된 범주를 형성하여 단일한 노래책으로 수용하고 있었다. 1910년대 창가와 잡가는 한국음악사의 전개에서 근대시민의 음악문화의 성취의 단계와 한계를 보여주고 있다. This article elucidates how Chang-ga(唱歌) and Jap-ga(雜歌) contributed in very similar ways to Korean modern musical history in 1910s though they had been born in different background. Chag-ga and Jap-ga were genres of music based respectively on modern education and on modern theater. Their names had been spread into the general population in 1910s with the distribution of modern publications and with the expansion of modern singing culture. However, while the publication of Chang-ga-jips began to publish in 1910s, the publication of Jap-ga-jips culminated in 1910s. Chang-ga of 1910s were based on Major whereas Jap-ga on Seoul Sori Mode. However, in "Chang-ga-jips(or Jap-ga-jips)" it also were included various songs with other kinds of musical language. They all considered in the same category Chang-ga(or Jap-ga). The Chang-ga and Jap-ga of 1910s showed the establishment and limitation of the modern civil musical culture in the progress of Korean music history.

현대 패션에서의 천연 섬유 소재 사용 경향

권도희(Kwon, Do-Hee) 한국조형디자인학회 2005 조형디자인연구 Vol.8 No.2

‘웰빙 붐’의 영향으로 친환경 운동이 전개 되면서, 유기농 농산물에 이어 의류에도 유기농 면 옷인‘오가닉 코튼(Organic Cotton)'제품의 판매를 비롯하여 방향 가공 소재,원적외선 방사소재,항균 섬유,음이온 방출 소재 등 친환경 소재에 대한 관심이 고조 되었다. 본 연구는 국내.외에서 사용 중인 천연 섬유 소재 개발 및 사용 사례를 조사하고,이를 접목시킨 상품 출시 현황 및 앞으로의 실용 방안에 대하여 연구하고자 천연 섬유 소재 종류 및 상품화된 제품 출시현황을 섬유 관련 매체와 신문 등에 기사화된 내용과 패션 및 섬유 정보 회사 인터넷자료 등을 토대로 분석 후 패션 업계 관계자들과 일반소비자를 일대일로 면담하여 질의 내용 및 응답을 축약하여 토대로 분석하였다. 천연 섬유 소재는 여러 패션 브랜드에서 많은 부분은 아니지만 여러 종류가 상품으로 개발되어 다른 브랜드와 차별화 전략으로 판매되고 있었다. 천연 섬유 소재는 소비자가 흔히 접할 수 있는 소재를 제외하고 육안으로는 식별이 어렵다. 따라서,철저한 분석을 통한 제품의 기능과 효능,그에 따른 세탁 및 관리 등 제품에 관한 다양한 정보가 필요하다. As the pro- environment movement widely spread out under the influence of 'Well-Being Trend', the sale of pro- environmental agricultural products have been expanding as well as the products of organic cotton in fashion industry. Furthermore, the fashion industry has been very interested in pro- environmental fabrics with aromatic, far infrared radioactive, antibacterial, and negative ionic characteristics. This paper examines into the development of natural fabric material and it' s usage in Korea & other foreign countries. This paper analyzes into the status of textile commodities in using several natural fabric materials, not only in referring many data in fashion/textile magazines & newspapers and those of fashion/textile companies, but also in summarizing the contents of surveys of fashion industry professionals and the consuming public. The marketing of natural fabric materials in several fashion brands differs from the tactics of other normal brands. The commodities of natural fabric material IS difficult to discriminate from those of norrral material [or the conswning public. Therefore, the conswning public needs all relevant, accurate information of the commodities of its functions including washing/cleaning management etc. and the effects by consistent analysis by experts.

저항과 승리의 기호, 근대 민요 : 음악 양식의 단계적 변화와 그 의미

권도희(Kwon, Do Hee) 국립국악원 2022 국악원논문집 Vol.45 No.-

한국 민요는 현재 한국의 민속을 상징하는 노래로 혹은 한민족을 상징하는 노래로 간주되고 있다. 그런데 19세기 후 반 사회에서 하층민의 “謠”가 20세기 이후 민속의 노래 혹은 민족의 노래로 인식되기까지는 몇 단계로 변화하는 절차를 거쳤다. 갑오 동학 혁명을 계기로 군중의 노래는 역사의 주체가 부르는 공적인 노래로 부상했다. 이후로 도시에 “잡조”도 “잡요(이요)”로 불리며 독립된 범주를 구성하기 시작했고, 대중 매체가 이를 주목하면서 “잡요(이요)”는 “잡가”로 불리면서 “가”의 지위에 도달했다. 이러한 변화는 이러한 음악 양식을 즐기는 근대적 주체, 도시적 주체의 성장을 의미했다. 그런데 도시적 주체의 성장은 여기에 머물지 않았다. 특히 3･1운동 이후 민족주의가 부상하면서 근대화를 갈망했던 도시적 주체는 민족적 주제로서 자기 정체를 노래에 담고자 했다. 이에 적중한 것이 신민요였다. 그간의 음악 연구는 대체로 음고나 박자 같이 기보되기 유리한 것들을 중심으로 시도되었다. 그러나 본고에서는 실연 되는 음악에 관심을 두고 음고나 박절 외에도 음색, 시김새, 창법 등등을 음악적 양식으로 포괄하여 분석해보았다. 이를 위해 1920년대에 소련의 음악학자 아사페브가 제안한 “음악적 억양”이라는 개념을 사용하되 그 논리적 공백은 1970년 대 이후에 문화 연구 및 음악 기호 연구의 성과로 보완하여 한국 근대 민요를 살펴보았다. 그 결과 노래의 양식적 변화 와 그 의미의 변화가 정리될 수 있었다. “요”는 갑오년 이전까지 지방의 음악 양식으로 된 노동 공동체를 호출하는 지 역별 노래였거나 도시의 잡역부가 부르는 “잡조”에 불과했다. 그러나 갑오년 봉기 이후로 이러한 양식으로 된 동학가요는 동일한 이념과 노랫말 그리고 음악 형식을 공유하는 군중의 노래가 되었다. 즉 동학 가요는 역사의 주체로 등장한 민중을 기호화하는 노래가 되었다. 동학 가요의 확산 이후로 도시의 하층민의 “잡조” 역시 재해석되었다. 잡조는 이를 전담한 가수에게 불리면서 양식적 으로 변화되면서 “잡요(이요)”로 호명되었다. “잡요(이요)”가 독립된 범주로 인식된 이후 도시 문화의 급속한 변화 속에서 잡요의 지위는 다시 “잡가”라는, 즉 도시의 주도적 갈래로 상승했다. 잡조로부터 잡가까지의 상승은 이를 지지하는 도시적 주체의 성장을 의미했다. 그런데 3･1운동 이후 민족주의가 부상하면서 도시 대중은 민족적 주제로서 자기 정체를 기호화하고자 했다. 이에 전과 다른 양식, 즉 민요 양식을 중심으로 하되 여타 전통적 음악 양식과 서양의 그것을 절충한 신민요가 등장하여 민족이라는 새로운 이념, 통일된 공동체를 의미하는 새로운 음악 기호를 만들어냈다. 이상과 같은 변화는 기존 사회의 억압이나 한계를 뚫은 결과이기 때문에 근대 민요의 전개는 그 향유 주체의 저항과 적응 혹은 승리의 궤적을 기호화하는 것이라고 할 수 있다. It is commonly considered that Korean urbanity is the product of Korean history and Japanese colonialism. The genres of Korean folk song in modern era, such as japga (雜歌) and sinminyo (新民謠), which are different from folk songs in ritual contexts, represent urbanity and articulate the Korean ethnicity with its musical style. The musical style, including mode, melody, form, and vocal timbre, functions as a signifier representing the Korean identity. The musical style, which articulates the subject who dominates it, means the special idea or thing in a specific epoch and province. This study utilizes the concept of musical intonation that the Russian musicologist Asafiev suggests as a signifier of meaning to communicate in a community. There are two urban styles of Korean folk song in modern era. The first was the traditional genre called japga, which was made of the established musical styles from various provinces of the Korean Peninsula. It was sung at theatres and in ordinary life among the urban people in the 1900s who came to be a subject in history since 1894 when broke out Gabo Reform (甲午改革) and Gabo Peasant Movement (甲午農民戰爭); the lower class sung donghak songs (東學 歌謠). Sinminyo was an eclecticized product of standardized popular genre japga and westernized Korean song changga (唱歌). There was an expectation for a genre that should have a typical Korean timbre and the traditional musical mode and on the other hand show a new, western style. Sinminyo appeared in the early 1930s and was loved by the citizen who had learned the nationalism after 1919. Since the end of the 19th century, japga was shared among ordinary people who enjoyed modern culture institutionally while sinminyo was demanded by the audiences who wanted to articulate their ethnicity with new musical style. Every song style has one’s own musical intonation which makes a meaning of their epoch. The musical style of Korean music as a signifier delivers the meaning of the Korean identity. It is similar to the voice of grain that R. Barthes mentions. Japga signifies the audience in urban society after the interpellation of people in history after the end of the 19th century, sinminyo articulates the Korean nationality with a new style even under the Japanese colonial rule.

유성기 음반 가야금 산조 중모리 연구 평조 유형 간의 상호관계를 중심으로

권도희(Do Hee Kwon) 한국고음반연구회 1996 한국음반학 Vol.- No.6

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심상건의 산조사적 공헌

권도희(Do Hee Kwon) 한국고음반연구회 1999 한국음반학 Vol.- No.9

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