性 Hormone 投與가 家兎摘出子宮의 運動, Cholinesterase 活性度 및 電解質에 미치는 效果

具姬洙,申萬鍊 우석대학교 의과대학 1970 우석의대잡지 Vol.7 No.2

In this experiment, the contractile sensitivity of the excised uterine muscle of non-castrated and castiated rabbits pretreated with estrogen and testosterone to oxytocics (spareng and quinine) is observed respectively. And the cholinesterase activity and electrolytes (Na, K, Ca and Mg) in the uterine muscle of rabbits pretreated with estrogen and testosterone are measured in order to stuff on the relationship with contractile sensitivity and those changes. The results obtained as follows: 1. The contractile effect of spareng on the excised uterine muscle of non-castrated rabbits pretreated with estrogen showed no appreciable changes, but in the rabbits pretreated with testosterone its contractile sensitivity was increased compared with that of the control group. On the other hand, the contractile sensitivity of the castrated rabbits showed markedly increased in estrogen pretreated group, however it was decreased in testosterone pretreated group. 2. The contractile effect of quinine on the uterine muscle of non-castrated rabbits pretreated with estrogen showed decreased, but in the rabbits pretreated with testosterone its contractile sensitivity was increased compared with that of the control group. The contractile effect of quinine on the uterine muscle of castrated rabbits pretreated with estrogen or testosterone showed increased, especially in case of the estrogen pretreated it revealed markedly increased. 3. The cholinesterase activities in the uterine muscle of non-castrated rabbits pretreated with both estrogen and testosterone showed markedly increased, but it was markedly decreased in the castrated rabbits pretreated with estrogen using large doses. 4. Na contents in the uterine muscle of non-castrated rabbits showed markedly increased when it was pretreated with estrogen in small doses. On the contrary, it showed decreased in the group of pretreated with small dose of testosterone, however no any changes in large doses. Na contents in the uterine muscle of castrated rabbits showed increased when it was pretreated with large doses of estrogen, and it also increased in the testosterone pretreated group. 5. K contents in the uterine muscle of both non-castrated and castrated rabbits showed markedly increased in both estrogen and testosterone pretreated group. 6. Ca contents in the uterine muscle of non-castrated rabbits showed decreased when it was pretreated with large doses of estrogen. On the contrary, it showed increased in e testosterone pretreated group with its small doses and it showed markedly increased in its large doses. Ca contents in the uterine muscle of castrated rabbits showed decreased in both estrogen and testosterone pretreated group. 7. Mg contents in the uterine muscle of non-castrated rabbits showed increased in both estrogen and testosterone pretreated with its small doses, especially it showed significantly increased in the estrogen pretreated group. On the contrary, it showed markedly decreased when it was pretreated with large doses of testosterone. Mg contents in the uterine muscle of castrated rabbits showed decreased in both estrogen and testosterone pretreated group, especially it showed markedly decreased in the testosterone pretreated group.

A study on Kudoa septempunctata infection from sashimi and sushi of olive flounder Paralichthys olivaceus in Busan, South Korea

구희수,Ji-young Park,Gyung-hye Sung,Eun-hee Park,Pyeong-tae Ku,Mi-ok Lee 한국수산과학회 2021 Fisheries and Aquatic Sciences Vol.24 No.8

Kudoa septempunctata has been reported as a new parasite in aquacultured olive flounder Paralichthys olivaceus, and also as a causative agent of food poisoning in humans. This paper investigated the infection of K. septempunctata in 216 sashimi and 20 sushi made of olive flounders in Busan, Korea. Among 236 samples, K. septempunctata was detected in eleven sashimi with 6–7 polar capsules by the microscopy. Among eleven sashimi, five sashimi were positive in Polymerase Chain Reaction (PCR) assay with the targets of 18S rDNA and 28S rDNA. The genotype of all the five PCR results is identified as the genotype ST3 which is common in Korea. K. septempunctata was found in olive flounders sashimi from Samcheonpo and Wando outside of Jeju Island. These findings would contribute to establish the standard of K. septempunctata for preventing food-borne outbreaks in advance and providing further preventive management for the seafood safety.

일본 개호비즈니스의 사업성 분석-후꾸오까의 한 의료법인을 중심으로-

구희수,남은우 한국보건복지학회 2001 보건과 복지 Vol.4 No.-

性 Hormone 投與가 家兎摘出子宮의 運動, Cholinesterase 活性度 및 電解質에 미치는 效果

具姬洙 우석대학교 의과대학 1970 우석의대잡지 Vol.7 No.2

판토그래프 Auto Drop Operation Logic

구희수 한국철도학회 2013 한국철도학회 학술발표대회논문집 Vol.2013 No.5

우크라이나 현지 가선 자체의 불량 또는 외부의 충격으로부터 판토그래프를 보호하기 위하여 Auto Drop 로직을 적용하였다.

유통 화장품 중 내분비계 장애물질 탐색 및 규명에 관한 연구

구희수(Heesoo Koo),나영란(Youngran Na),이승주(Seungju Lee),민상기(Sangkee Min),강정미(Jungmi Kang),진성현(Sung Hyun Jin) 한국분석과학회 2015 분석과학 Vol.28 No.3

교직절환 스위치 동작 점검 회로

구희수(Hee Soo Koo) 한국철도학회 2015 한국철도학회 학술발표대회논문집 Vol.2015 No.10

본 논문은 AC,DC 겸용 차량에 설치되는 교직 절환스위치의 유지보수를 위한 회로를 별도로 구현하여 편리성을 증대하기 위함이다. 기존 제어 방식의 경우, 판토그래프가 가선에 접촉하면 AC 또는 DC 전원임을 감지하는 릴레이가 동작을 하고 해당 릴레이의 접점을 이용하여 교직 절환 스위치가 동작을 하도록 되어있다. 우크라이나와 같이 결빙이 수시로 이루어지는 열악한 기후환경에서 전동차 운행을 할 경우, 교직 절환 스위치의 물리적 결빙으로 인한 고장은 영업운행중 교직 절환이 이루어지는 시점에서야 파악을 할 수가 있다. 이는 영업중단이라는 중대한 사고와도 직결될 수 있으므로 이를 방지하기 위한 사전 점검을 증대시킬 필요성이 있다. This paper is to propose the testing circuit for AC/DC changeover switch which is used in the train having AC/DC power sources. In before logic, when pantograph touches the high voltage catenary, ACVR or DCVR relay detects the power source is AC or DC and its contact makes it possible AC/DC changeover switch operates. This is the sequence AC/DC changeover switch operates. But one day, a problem had been occurred. It was winter season in Ukraine, cold weather made AC/DC changeover switch frozen. Even ACVR and DCVR were normally operated but AC/DC changeover switch wasn’t. Due to this accident, service operation was canceled and many passengers had experienced inconvenience. To prevent such an accident, one point should be considered before service operation. This paper describes the method to check the condition of AC/DC changeover switch logically. It shall be useful and efficient in railway industry.

Testosterone 및 Estrogen 투여(投與)가 자궁수축약(子宮收縮藥)의 적출자궁(摘出子宮) 수축성(收縮性)에 미치는 영향(影響)과 자궁근내(子宮筋內) Cholinesterase 활성도(活性度) 및 전해질(電解質)에 미치는 효과(効果)

구희수(Koo, Hee-Soo),공화순(Kong, Wha-Soon),김순영(Kim, Soon-Yeung),송현섭(Song, Hyun-Sub),이증자(Lee, Jeung-Ja) 대한약리학회 1970 대한약리학잡지 Vol.6 No.1

It is well known that the uterine contractility is affected by sexual hormone. In this experiment, the authors attempted to study the influences of testosterone and estrogen or the uterine contractility to oxytocics. The contractile sensitivity of the excised uterine muscle of non-castrated and castrated rabbits with testosterone and estrogen 24 hours before experiment is observed respectively. And the cholinesterase activity and electrolytes (Na, K, Ca and Mg) in the uterine muscle are measured in order to study the relationship with contractile sensitivity and those changes. The results obtained were summarized as follows: 1. The contractile effect of spareng on the excised uterine muscle of non-castrated rabbits pretreated with estrogen was markedly increased in small dose, but that of rabbits pretreated with testosterone was significantly increased in large dose, comparing with that of the control group. In castrated rabbits, the contractile sensitivity of the uterine muscle to spareng was significantly increased by pretreatment with estrogen in large dose but it was markedly decreased by pretreatment with testosterone in small dose. 2. The contractile effect of quinine on the excised uterine muscle of non-castrated rabbits pretreated with estrogen was significantly decreased but that of castrated rabbits pretreated with both estrogen and testosterone were markedly increased comparing with that of the control group. 3. The cholinesterase activity in the uterine muscle of non-castrated rabbits was significantly increased by pretreatment with small dose of estrogen or large dose of testosterone, but that of castrated rabbits was markedly decreased by pretreatment with large dose of estrogen. 4. Na and K contents in the uterine muscle of non-castrated rabbits were markedly increased by pretreatment with both estrogen and testosterone, but that of castrated rabbits was significantly increased by pretreatment with small dose of estrogen. 5. Ca content in uterine muscle of non-castrated rabbits was significantly decreased by pretreatment with both large dose of estrogen and testosterone but increased by pretreatment of testosterone. In castrated rabbits, Ca content was significantly decreased by pretreatment with both estrogen and testosterone. 6. Mg content in the uterine muscle of non-castrated rabbits was markedly increased by pretreatment with estrogen and small dose of testosterone, but that of castrated rabbits was significantly decreased by pretreatment with both large dose of estrogen and testosterone.

부산지역 집단 식중독 발생에서 검출된 노로바이러스의 유행양상

구희수(Hee Soo Koo),구평태(Pyeong Tae Ku),이미옥(Mi Ok Lee),백형석(Hyung Suk Baik) 한국생명과학회 2016 생명과학회지 Vol.26 No.8

최근 4년 동안 부산지역에서 2인 이상 발생된 식중독 사례를 대상으로 급성 위장관염 증상을 보인 환자 472건와 조리종사자 109건을 대상으로 유전자 분석을 한 결과 총 581건 중 71건(12.2%)에서 노로바이러스를 확인하였다. 연도별 검출현황은 2012년 18.3%(30/164건), 2013년 5.6%(6/107건), 2014년 8.0%(6/75건), 2015년 12.3%(29/235)으로 2012년과 2015년이 Norovirus 식중독에 의한 유병률이 가장 높았다. 월별 발생양상은 2월에 20건(28.2%)으로 가장 많이 발생했으며, 11월 18건(25.4%), 12월 12건(16.9%) 순이었고, 5월~8월에는 노로바이러스 환자 발생이 없어, 비교적 추운 계절에 높은 검출율을 보이는 계절적인 특징을 나타내었다. 연령별 분포는 11세~20세의 검체가 269건으로 10대의 초, 중, 고등학생의 검체가 전체의 46.3%를 차지하였다. ANOVA Scheffe 검정 결과를 통해, Norovirus의 예방 및 확산 방지를 위해 10대를 위한 위생 교육 및 식중독 예방교육을 더욱 철저히 실시해야 할 시사점을 얻었다. Norovirus genotype 분석 결과, GI genogroup은 GI-1형, GI-2형, GI-3형, GI-5형, GII genogroup은 GII-1형, GII-4형, GII-5형, GII-6형, GII-17형으로 다양한 genotype이 분포되었다. 연도별 유행하는 유전형은 2012년 GII-6형(17건), 2013년 GII-6형(3건), 2014년 GII-4형(5건), 2015년 GII-6형(18건)이 가장 우세했다. 그러나 최근 국내 뿐 아니라 전 세계적으로 GII-4형이 매우 유행하고 있으나, 부산지역은 2014년을 제외하고는 GII-6형이 우세한 genotype이라는 매우 특징적 결과를 얻었다. Norovirus is the most common causative agent of acute gastroenteritis. This study was carried out to investigate molecular epidemiology of norovirus infections from outbreaks in Busan from 2012 to 2015. Total of 581 stool specimens were collected from diarrhea patients in outbreaks in Busan, 71 samples were resulted in positive to norovirus. The data were analyzed according to seasonality, patient, age and gender. Noroviruses were detected most frequently during the winter season from November (25.4%) to February (28.2%). The age group from teens was the most susceptible to norovirus infections. To obtain the molecular genetic information of norovirus, we performed sequencing analyses of the strains detected. Norovirus genotypes have been reported to show high genetic diversity. Four kinds of GI genotypes (GI-1, GI-2, GI-3, GI-5) and five kinds of GII genotypes (GII-1, GII-4, GII-5, GII-6, GII-17) were indentified in outbreaks in Busan. Other previous studies have shown that GII-4 is the most predominant circulating in Korea and worldwide. The most prevalent norovirus genotypes of each year were GII-6 in 2012, GII-6 in 2013, GII-4 in 2014 and GII-6 in 2015. Except for 2014, GII-6 genotype was the most prevalent and predominant in Busan. We described the epidemiological analysis of the noroviruses in outbreaks in Busan. The result of this study will contribute to update the epidemiological data and improve hygiene and public health via sustainable surveillance.

연장급전 회로 고안

구희수(Hee Soo Koo) 한국철도학회 2020 한국철도학회 학술발표대회논문집 Vol.2020 No.11

본 논문은 통상적으로 연장급전 회로용 박스를 차량 하부에 별도로 설치하는 방안에서 해당 기능을 차량 실내 배전반에 회로적으로 구현함으로써 비용적 측면 및 유지보수 측면에서 보다 용이하도록 하기 위함이다. This paper is intended to make it easier in terms of cost and maintenance by implementing the function as a circuit in the vehicle interior ‘Electric Distribution Board’ instead of installing the box for the extension power supply circuit separately under the vehicle.