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2-알킬-2,3-다이하이드로-1H-2-아자사이클로펜타[b]안트라센-5,10-디온계 유도체 합성 및 세포독성
곽재환,정은경,오주훈,정재경,홍진태,이희순,Kwak, Jae-Hwan,Jeong, Eun-Kyeong,Oh, Ju-Hoon,Jung, Jae-Kyung,Hong, Jin-Tae,Lee, Hee-Soon 대한약학회 2009 약학회지 Vol.53 No.1
A series of 2-alkyl-2,3-dihydro-1H-2-azacyclopenta[b]anthracene-5,10-diones ($3a{\sim}h$) were synthesized and evaluated in vitro cytotoxicity against colon cancer cell lines (HCT116 and SW620) and nuroblastoma cell lines (SK-N-SH and SK-N-MC). Among them, compound 3f showed significant cytotoxic activity ($IC_{50}$ against SK-N-SH; $14.8{\mu}M$, $IC_{50}$ against SK-N-MC; $11.3{\mu}M$).
6-하이드록시-7-메톡시크로만-2-카복실산 디알킬아미노알킬아마이드 합성
곽재환,이금호,정재경,조정숙,이희순,Kwak, Jae-Hwan,Lee, Keum-Ho,Jung, Jae-Kyeong,Cho, Jung-Sook,Lee, Hee-Soon 대한약학회 2006 약학회지 Vol.50 No.5
In the course of developing novel antioxidants, we synthesized four of 6-hydroxy-7-methoxy-4-oxochroman-2carboxylic acid dialkylamides (3a-d) $(13{\sim}18%)$ and four of 6-hydroxy-7-methoxychroman-2-carboxylic acid dialkylamides (4a-d) $(52{\sim}89%)$, incorporating the basic amine functionality. None of these compounds exhibited significant antioxidant activity possibly due to the hydrophilic character of the basic amine side chains.
곽재환 ( Jae Hwan Kwak ),김홍균 ( Hong Gyun Kim ),김열 ( Youl Kim ),김만일 ( Man-il Kim ),이문세 ( Moon Se Lee ) 대한지질공학회 2018 지질공학 Vol.28 No.3
탐방로의 전체적인 환경은 크게 탐방로 상부, 탐방로 자체, 탐방로 하부로 나누어진다. 본 연구에서는 현장조사를 기반으로 하여 3가지의 탐방로 환경과 인문/사회 요인을 결합하여 탐방로 위험지수를 개발하였다. 탐방로 현장조사를 위해 체크리스트를 개발하였으며, 체크리스트 항목들은 상대적인 중요도 분석과정을 거쳐 점수화 되었다. 항목들의 상대비중 분석은 AHP 기법을 활용하였다. AHP 분석 결과, 탐방로 상부 환경이 나머지 환경들에 비해 2배 중요한 것으로 나타났으며, 각 환경들에 속한 항목들의 중요도 및 배점이 정해졌다. 위험지수는 항목들의 총합으로 계산되었으며, 기조사 자료를 이용한 가중치가 더해졌다. 위험지수는 총점 200점으로 설정하였으며, 최대 159점, 최소 64.2점으로 산출되었다. 현장 상황과 위험지수의 비교 분석 결과, 위험성이 낮은 구간은 대부분 100점 이하의 값을 보였으며, 위험성이 매우 높거나 사고이력을 가지는 구간은 140점을 초과하는 것으로 나타났다. A walking trail environment can be divided into the upper part of the trail, the trail itself, and the lower part of the trail. In this study, based on field investigations, we developed a risk index for trails by considering human/societal factors that affect each of these three trail environments. A checklist was developed for field investigations, and checklist items were scored through relative importance analysis. The relative weights of items were analyzed using the AHP (Analytic Hierarchy Process) technique, revealing that the upper environment of a trail is twice as important as the rest of the environment. The importance and score of items belonging to each environment were determined. We define the risk index as the sum of the item scores. Weights were added using data from existing investigations including landslides risk rating and designated risk steep slopes. The risk index has a maximum value of 200, and the maximum and minimum calculated scores of 335 risk sections were 159 and 64.2, respectively. As a result of comparative analysis between field observations and risk index calculations, most sections at relatively low risk had risk values less than 100, and sections with high risks or that had been the site of accident yielded scores that exceeded 140.
EGFR 과발현 세포인 A431과 MDA-MB-468에 대한 1-옥소-1,2,3,4- 테트라하이드로피라지노[1,2-a]인돌-3-카르복사마이드 유도체의 항암 활성
곽재환(Jae Hwan Kwak),정영석(Young Suk Jung) 대한약학회 2018 약학회지 Vol.62 No.5
Previous our study showed that 1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide analogs had more potent anti-cancer activity than that of gefitinib, which is representative EGFR-TKI, in MDA-MB-468 human breast cancer cells expressing abnormally high level of EGFR. Especially, they more strongly inhibited the phosphorylation of Akt being in the EGFR signaling pathway compared with gefitinib. In this study, we compared their anticancer effect between MDA-MB-468 and A431 epidermoid carcinoma cells which is another model having high level of EGFR. Although the tissue origin is different, they showed similar anticancer activity in both EGFR overexpressing cell lines. These results suggest that 1-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indole-3-carboxamide analogs could be promising agent to overcome EGRF overexpressing cancer cells.