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건강검진 수진자에서 간세포암종 진단에 관한 혈청 알파태아단백질 측정의 의의
고영선 ( Young Sun Ko ),배주환 ( Joo Hwan Bae ),신동현 ( Dong Hyun Sinn ),곽금연 ( Geum-youn Gwak ),강원석 ( Wonseok Kang ),백용한 ( Yong-han Paik ),최문석 ( Moon Seok Choi ),이준혁 ( Joon Hyeok Lee ),고광철 ( Kwang Cheol Koh ) 대한소화기학회 2017 대한소화기학회지 Vol.69 No.4
Background/Aims: Serum alpha-fetoprotein (AFP) measurement is commonly included in a health check-up program in Korea. However, its benefits remain uncertain. We analyzed whether AFP measurement should be included in a general health check-up program to screen for hepatocellular carcinoma (HCC). Methods: A total of 36,552 adults aged 18 years or older―who participated in a routine health examination including AFP determination between January 2009 and December 2009 at the Health Promotion Center, Samsung Medical Center, South Korea―were analyzed. High risk of HCC was defined as positivity for hepatitis B surface antigen, anti-hepatitis C virus antibody or having liver cirrhosis. Results: AFP level >10 ng/mL was observed in 27 participants (0.1%) and primary liver cancer was diagnosed in 9 patients (6 HCC and 3 cholangiocarcinoma). Among 1,619 participants with high risk factors of HCC, AFP level >10 ng/mL was observed in 16 participants, of which, 4 diagnoses were made. Sensitivity, specificity, positive predictive value, and negative predictive value of AFP for HCC was 0.66, 0.99, 0.25 and 0.99, respectively, for high risk participants. Among 34,933 participants without risk factors for HCC, 11 patients (<0.1%) showed elevated AFP levels above 10 ng/mL, and no case was diagnosed with primary liver cancer during a median follow-up period of 36 months (range: 0-48 months). Conclusions: AFP elevation was rare in participants without risk factors for HCC, and was unable to screen for HCC in this population. We discourage routine AFP measurements for asymptomatic adults without risk factors of HCC. (Korean J Gastroenterol 2017;69:232-238)
항생물질을 생성하는 토양균의 대량 검색을 위한 새로운 방법
구양모(Yang MoGoo),이윤영(Youn Young Lee),조영애(Young Ae Joe),이영복(Young Bok Lee),정원윤(Won Yun Chung),이창훈(Chang Hoon Lee),고영선(Young Sun Koh),조희영(Hee Yeung Joe),정연숙(Youn Sook Chung) 대한약학회 1991 약학회지 Vol.35 No.4
A new agar-disk method was developed from the fast selection and characterization of antibiotic producing organisms.
항생물질 생산 토양 Actinomycetes 균주 선별과 항생물질 생산특성 조사
구양모(Yang Mo Goo),이윤영(Youn Young Lee),정연숙(Youn Sook Chung),이영복(Young Bok Lee),조영애(Young Ae Joe),조희영(Hee Yeong Cho),고영선(Young Sun Koh),이창훈(Chang Hoon Lee) 대한약학회 1991 약학회지 Vol.35 No.3
Selective culture of actinomycetes from soil microbes and their antibiotic producing characters by agar-disk method were examined. Some of the organisms which produced antibiotics on agar disk did not produce antibiotics in liquid culture. Further examination indicated that production of antibiotic was dependent on the composition of medium. Many streptomycestes produced antibacterial substances in tryptic soy broth but others produced antifungal antibiotics in V-8 broth. Production of antibacterial substances by Streptomyces sp. was also dependent on the medium composition.
이성종,이석하,고영선,김택선,심재익,유창무 대한골절학회 1995 대한골절학회지 Vol.8 No.1
The incidence of intertrochanteric fracture of femur is increasing because of increasing number of old-aged people. The goal in the treatment of an elderly patient with an intertrochanteric fracture is to restore the patient to his prefracture activity as soon as possible. The purpose of this report is to review of the difficulty of treating the intertrochanteric fracture of femur in elderly patients. The authors treated 213 cases of intertrochanteric fracture from Jan, 1980 to Dec. 1993. We analyzed the clinical result of 73 cases intertrochanteric fracture with minimum 1 year follow up retrospectively. The results were as follows. l. The degrees of osteoporosis by Singh index were 27 cases in Grade g, 22 Cases in Grade II, 14 cases in grade N, 5 cases in Grade I and 5 cases in Grade V. 2. By Tronzo classification of fracture, the most common type was 38 cases in type g, 17 cases in type II and 8 cases in type IY. 3. The operation method were compression hip screw(38 cases), Jewett nail (12 cases), Ender nail(17 cases), multiple pinning (5 cases), and primary hemiarthoplasty(3 cases). 4. Average bony union time was 13.2 weeks in compression hip screw group, 14.5 weeks in Jewett nail group, 14.7 weeks in Ender nail group and 15.4 weeks in multiple pinning group.