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재발 진행성 위암 환자의 FOLFOX 유발 부작용 개선에 대한 한의 치료 1례
고명현,양재호,전형준,조종관,이연월,박소정,유화승 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.1
Objective: The purpose of this study was to report the clinical effectiveness of Korean medicine treatment on FOLFOX-induced symptoms such as nausea and dizziness in a patient with recurrent advanced gastric adenocarcinoma. Methods: The patient was diagnosed with recurrent advanced gastric cancer and had FOLFOX-induced nausea and dizziness. The patient was treated with Samchulgunbi-tang and Banhasashim-tang for symptom management. The clinical outcomes were measured by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI CTCAE) and a numeral rating scale (NRS). Results: After treatment, the patient's nausea and dizziness were relieved from NRS 9 to 2 and NRS 8 to 2 respectively. During and after treatment, no severe toxicities were detected on laboratory findings. Conclusion: This case study suggests that Samchulgunbi-tang and Banhasashim-tang may relieve symptoms of FOLFOX-induced nausea and dizziness.
알렉티닙과 삼칠충초정을 병용하여 호전된 진행성 비소세포성 폐암환자 1례
고명현,명지수,박소정,전형준,이연월,조종관,유화승,Ko, Myung-hyun,Myong, Ji-soo,Park, So-jung,Jeon, Hyung-joon,Lee, Yeon-weol,Cho, Chong-kwan,Yoo, Hwa-seung 대한암한의학회 2019 大韓癌韓醫學會誌 Vol.24 No.1
Objective: The purpose of this study is to report the clinical effectiveness of advanced non-small cell lung cancer (NSCLC) with Samchilchoongcho-Jung (HAD-B1) in conjunction with Alectinib. Methods: The patient was diagnosed with Anaplastic lymphoma kinase (ALK) mutated (2+) non-small cell lung cancer adenocarcinoma stage IV, suffering from edema of lower extremities, dyspnea, pleural effusion, general weakness, insomnia. The patient being treated with Alectinib was treated with Samchilchoongcho-Jung (HAD-B1) for disease control and symptom management. The clinical outcomes were measured by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Numeral rating scale (NRS) and Eastern Cooperative Oncology Group (ECOG). Results: After treatment, dyspnea and edema of lower extremities was relieved from NRS 7 to 5, and 6 to 1 respectively. And ECOG score of the patient was improved from grade 3 to 2. During and after treatment, we didn't find any severe toxicities on laboratory findings. Conclusion: This case study suggests that Samchilchoongcho-Jung (HAD-B1) may improve symptom relief and life quality of NSCLC patient in conjunction with Alectinib.
사람의 유방암 세포주인 MDA MB-231 세포에서 CpG 메칠화에 의한 Disabled-2유전자의 발현억제
고명현,오유미,박준호,전병훈,한동민,김원신,Ko Myung Hyun,Oh Yu Mi,Park Jun Ho,Jeon Byung Hoon,Han Dong Min,Kim Won Sin 한국생명과학회 2005 생명과학회지 Vol.15 No.5
사람의 Disabled-2 (Dab2)는 정상세포에서 c-Fos의 발현을 억제하여 세포 성장을 조절하는 암억제 유전자로 추정되어 지고 있다. 많은 암세포에서 Dab2는 유방과 난소의 정상세포에서는 발현이 되지만, 약 $85\%$의 유방과 난소의 종양세포에서는 발현이 줄어들거나, 발현이 억제되는 것으로 알려져 있다. 본 연구에서는 bisulfite 반응에 의한 염기서열 분석법과 MSP방법 등을 이용하여 유방암 세포주인 MDA MB-231세포에서 Dab2 유전자의 promoter상에 존재하는 Cpg island의 methylation된 상태를 분석하였다. 그 결과, 사람의 정상 자궁내막세포에서는 Dab2 promoter 부위가 완전하게 methylation되어 있지 않았다. 그러나 MDA MB-231세포에서는 TATA box 근처 의 CpG dinucleotide에서 비정상적으로 methylation되어 있었다. 이런 비정상적인 CpG dinucleotide의 methylation은 MDA MB-231세포를 5-azacytidine으로 처리하였을 때 methylation이 풀리고, Dab2의 발현이 회복되는 것으로 나타났다. 따라서 인간 유방암 세포주인 MBA MB-231세포에서 Dab2의 발현억제는 Dab2 유전자의 promoter부위의 CpG island의 비정상적인 methylation과 관련이 있는 것으로 여겨진다. Human Disabled-2 (Dab2) is a candidate tumor suppressor gone that regulates cell growth by c-Fos suppression in normal cells. In many cancer cells, Dab2 expression is lost or greatly diminished in $\∼85\%$ of the breast and ovarian cancers. In this study, we have examined the methylation status of CpG island on Dab2 gene promoter using bisulfite-assisted genomic sequencing and methylation specific PCR (MSP) method in human breast cancer cell line, MDA MB-231 cells. In normal human uterus endometrial cells, Dab2 was completely unmethylated. In contrast, Dab2 was methylated on CpG dinucleotides near the TATA_ box in MDA MB-231 cells. following MDA MB-231 cells by treatment with 5-azacytidine, Dab2 gene were demethylated and reexpressed. Result of this study suggested that silencing of Dab2 gene is correlated to CpG island methylation in human breast cancer cell line, MBA MD-231 cells.
고명현 북한연구소 2016 北韓 Vol.- No.539
90년대 북한경제 붕괴 이후 시장화가 급격히 진행되었다는 사실은 이미 널리 알려져 있다. ‘장마당’이라고 불리는 북한시장은 국가중심의 공급제도가 무너진 1990년대 중반부터 등장하였다. 처음에는 농민들이 자가적으로 형성한 1일장, 3일장들이었으나 점차 상설화되었다. 그러나 국가중심의 계획경제체제 아래서 이들 시장은 기본적으로 불법경제행위였다. 따라서 북한당국의 갈취와 압수 위협에 항상 놓여 있었다. 그러나 2003년 당국이 시장을 합법화하면서 장마당은 북한경제내에서 확고히 자리 잡게 되었다
고명현,임정희,김지연 중국지역학회 2023 중국지역연구 Vol.10 No.4
China is actively using cyber platforms as a propaganda tool to spread its cultural and socialist values, and has expanded its influence on mobile games. IT companies or the online game industry are closely involved in China's cyber influence operations. The companies are in close cooperation with the Chinese government’s Internet censorship policies and in support of the Communist Party leadership. This research found that Chinese online game companies control Korean users' chats, usernames, and messages based on the top-ranked Chinese game lists in Korea. China's censorship of keywords in online games focuses on the language and words such as Taiwan, Hong Kong, Tibet, and Xinjiang, which are classified as sensitive words in China, as well as historical events and national hate speech. These keywords were closely in line with the list of prohibited content in the terms of service. In addition, our analysis of the game's privacy policy revealed that there was extensive collection of the private information of game users. Some of the games explicitly state that chat content may be subject to monitoring. In particular, national security and government requests are cited as justifications for sharing data with third parties under Chinese regulations. As China tightens its control over the Internet, especially as it extends to data and algorithmic control, it may pose even more serious threats to digital authoritarianism, data security, individual privacy, Internet freedom, and human rights.