The Impact of Masticatory Function on Cognitive Impairment in Older Patients: A Population-Based Matched Case-Control Study

고경아,박진영,이중석,예병석,정의원,최성호,차재국 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.8

Purpose: The aim of this study was to investigate the association between the changes in masticatory function and cognitive im pairment by analyzing longitudinal data of older Korean patients. Materials and Methods: Patients aged over 60 years with dental records between 2005 to 2010 (baseline; T1) and 2014 to 2020(follow-up; T2) were selected in a single medical center. Based on the dementia diagnosis after T2, the cohort was classified intotwo groups, the dementia group (n=122) and the control group (n=366). Changes in masticatory function were calculated using thetotal functional tooth unit (T-FTU) in both groups. The incidence of tooth extraction (%) and the subsequent rehabilitation duringthe observation period were also evaluated. Results: In the dementia group, T-FTU significantly decreased from T1 to T2 (9.81±2.78 to 9.11±3.16, respectively, p=0.008), whileno significant change was observed in the control group. During the mean observation period of 9 years, significantly more teethwere extracted and neglected to be prosthetically restored in the dementia group than in the control group. Regression analysis re vealed that the number of missing teeth neglected [odds ratio (OR)=1.195, 95% confidence interval (CI)=1.025–1.393, p=0.023] andprevious alcohol consumption (OR=4.445, 95% CI=1.831–1.795, p=0.001) were the most significant risk factors of dementia. Conclusion: There might be a causative relationship between the neglected missing dentition and the onset of dementia.

추출조건에 따른 블루베리 열수추출물의 항산화 활성 비교

고경아,손모아,강혜림,임지희,임근형,김소미 한국식품저장유통학회 2015 한국식품저장유통학회지 Vol.22 No.3

Five extraction conditions (AE, autoclave extraction; OE, oven extraction; HWSE, hot water and sonication extraction; HWASE, hot water acidified with 0.5% (v/v) acetic acid and sonication extraction; and BE, boiling extraction) were examined to compare the effects of different hot water extraction methods on the antioxidant properties of blueberries. The extraction yields of the AE, OE, HWSE, HWASE, and BE were 7.94%, 8.35%, 8.55% 9.15%, and 8.50%, respectively. The polyphenol and flavonoid contents of AE were 3.47 mg GAE/g and 1.59 mg RE/g, respectively, which were highest centents among others. Those of OE were ranked second to the highest. The total anthocyanin content of HWSE (5.29 mg/g) was significantly higher than that of others whereas that of AE showed the lowest content (0.96 mg/g). The order of ABTS radical and alkyl radical scavenging activities was as follows: AE > BE > OE > HWSE > HWASE. The antioxidant properties were considerably correspondent with the total polyphenol and flavonoid content. DPPH radical scavenging activity was quite high in HWSE, AE, and BE extraction, however, there were no significant differences among the five extraction methods in the aspect of Fe2+ ion chelating activities. Moreover, AE showed the highest SOD activity, and protected the dermal fibroblast the best against H2O2-induced cytotoxicity. In conclusion, it was suggested that the autoclave extraction (AE) would be the most effective method for preparing blueberry hot water extracts with relatively high antioxidant activities.

소신 소비 척도 개발 및 타당성 검증

고경아 한국PR학회 2023 한국PR학회 학술대회 Vol.2023 No.11

Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway

고경아,김소미 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.1

Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent. In this study, we investigated the effect of ethyl linoleate on the melanogenesis and the mechanism underlying its action on melanogenesis in B16F10 murine melanoma cells. Our results revealed that ethyl linoleate significantly inhibited melanin content and intracellular tyrosinase activity in α-MSH-induced B16F10 cells, but it did not directly inhibit activity of mushroom tyrosinase. Ethyl linoleate inhibited the expression of microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase related protein 1 (TRP1) in governing melanin pigment synthesis. We observed that ethyl linoleate inhibited phosphorylation of Akt and glycogen synthase kinase 3β (GSK3β) and reduced the level of β-catenin, suggesting that ethyl linoleate inhibits melanogenesis through Akt/GSK3β/β-catenin signal pathway. Therefore, we propose that ethyl linoleate may be useful as a safe whitening agent in cosmetic and a potential therapeutic agent for reducing skin hyperpigmentation in clinics.

생태교통 수원 2013을 통해 본 환경문제 인식과 실천

고경아 한국환경사회학회 2015 한국환경사회학회 학술대회 자료집 Vol.2015 No.4

Comparative evaluation of free radical scavenging activities and cytotoxicity of various solvent fractions of Sandong Sageretia thea (Osbeck) M.C. Johnst. branches

고경아,손모아,김소미 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.6

Sageretia thea (Osbeck) M.C.Johnst., an evergreen tender shrub of the Rhamnaceae, has been used as folk medicine and in traditional tea. To the best of our knowledge, this is the first study that investigates the free radical scavenging activity and cell cytotoxicity of S. thea branches. The ethyl acetate fraction and n-butanol fraction were identified to be rich in phenolic compounds exhibiting impressive antioxidant activity after stepwise partitioning of solvent fractions of the methanol extracts of S. thea branches (MB). Among the different human cancer cells tested, maximum cytotoxicity was found in MDA-MB-231 human breast cancer cells with MB, chloroform, ethyl acetate, n-butanol and water fraction. A significant (p<0.05) correlation between antioxidant activities and cytotoxicity exists in each fraction. These results suggest the branches of S. thea can be a valuable source of antioxidants, and they can serve as natural anticancer constituents in nutraceutical and pharmaceutical applications.

제주지역 고등학생의 제주4・3 인식과 평화・인권교육 방안

고경아 제주4.3연구소 2020 4.3과 역사 Vol.20 No.-

A case of disappeared Rasmussen’s aneurysm after the treatment of pulmonary tuberculosis

고경아,한민수 대한내과학회 2021 대한내과학회 추계학술대회 Vol.2021 No.1

청소년 의식구조의 형성에 대한 정치경제학적 분석 : 개인주의 의식을 중심으로

고경임 숙명여자대학교 대학원원우회 1993 원우논총 Vol.11 No.-

제주산 블루베리와 상동열매의 일반성분, 항산화 및 항증식 활성 비교

고경아 ( Gyeong-a Ko ),고소예 ( So Yae Koh ),류지연 ( Ji-yeon Ryu ),김소미 ( Somi Kim Cho ) 한국응용생명화학회 2017 Journal of Applied Biological Chemistry (J. Appl. Vol.60 No.2

본 연구에서는 블루베리의 형태 및 풍미와 유사한 상동열매의 일반성분과 항산화 활성을 비교하였다. 열량, 조단백, 조회분, 탄수화물 및 유리당은 상동열매가 블루베리에 비해 더 높았으며 수분은 블루베리가 더 높은 것으로 나타났다. 상동열매의 주요 유리당은 fructose, glucose 및 maltose로 나타난 반면, 블루베리에서는 maltose가 검출되지 않았다. 상동열매와 블루베리를 각각 80% 메탄올로 추출한 후, 헥산, 클로로포름, 에틸아세테이트, 부탄올 및 물층으로 용매 분획하여 이들의 폴리페놀 및 안토시아닌 함량과 항산화 활성을 비교하였다. 상동열매 메탄올추출물이 블루베리 메탄올 추출보다 폴리페놀 함량과 안토시아닌 함량 모두 높게 나타났으며, 아울러 DPPH, alkyl, 및 ABTS라디칼 소거 활성 또한 더 우수하였다. 용매 분획물들을 대상으로 항산화 효능을 비교했을 때, 상동열매와 블루베리 모두 폴리페놀 함량이 상대적으로 높았던 에틸아세테이트 분획물의 DPPH와 alkyl radical 소거 활성이 가장 우수했으며, 안토시아닌 함량이 높은 부탄올 분획물의 ABTS radical 소거 활성이 상대적으로 우수하였다. 특히, 안토시아닌 함량이 상대적으로 높았던 상동열매 부탄올 분획물의 ABTS 라디칼 소거 활성은 블루베리 부탄올 분획물에 비해 상대적으로 우수하였다. 상동열매와 블루베리 메탄올 추출물은 피부세포에서의 H2O2로 유도된 산화적 스트레스로부터 세포 보호 효과를 나타냈으며, 블루베리와 비교하여 상동열매에서 그 효능이 더 우수한 것으로 나타났다. 또한 상동열매와 블루베리의 헥산 분획물과 클로로포름 분획물이 위암(AGS)와 유방암(MDA-MB-231)세포에 대한 증식억제 활성이 확인되었다. 본 연구에서는 최초로 상동열매와 블루베리의 일반성분, 항산화 및 항암 활성을 비교하였으며, 상동열매가 블루베리보다 상대적으로 높은 함량의 폴리페놀과 안토시아닌을 함유할 뿐만 아니라 블루베리보다 우수하거나 그에 필적한 항산화 및 항암 활성을 나타내고 있어, 항산화 식품 및 천연 항산화 소재 로서의 활용가치가 클 것으로 사료된다. This study was aimed to evaluate and compare the proximate composition, antioxidant and antiproliferative activities of Sageretia thea (Osbeck) M.C.Johnst (S. thea) fruit and blueberry. The calorific value, crude protein, crude fat, crude ash, and carbohydrate were higher in S. thea fruit than in blueberry. S. thea fruit and blueberry have different profile of free sugars, in which amounts of fructose, glucose, and maltose were much higher in S. thea fruit than in blueberry. The methanol extracts of S. thea fruit contain higher amounts of total polyphenol and anthocyanin compared to those of blueberry extracts. In additions, 2,2-diphenyl-1-picrylhydrazyl (DPPH), alkyl, and 2,2`-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging activities are greater in S. thea fruit extracts. Ethyl acetate fractions and n-butanol fractions of S. thea fruit and blueberry show the most potent scavenging activity in DPPH-, alkyl-, and ABTS-radical scavenging assay. The ethyl acetate fractions of S. thea fruit and blueberry are the richest fraction in polyphenol contents while the n-butanol fractions of those are the highest fraction in anthocyanin contents. Furthermore, both S. thea fruit and blueberry extracts protect human dermal fibroblast cells against a H₂O₂-induced oxidative stress. The antiproliferative activities of n-hexane and chloroform fraction from S. thea fruit and blueberry were observed in AGS human gastric cancer and MDA-MB-231 human breast cancer cells. Therefore, our results suggest for the first time that the antioxidant and antiproliferative activities of S. thea fruit is comparable to that of blueberry and the nutritional value of the former is even superior to that of the latter.