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간세포암 환자에서 DNase , RNase 및 Rnase inhibitor 측정의 의의
계세협(Sea Hyub Kae),정유선(Yoo Sun Chung),장현주(Heon Ju Jang),정선화(Sun Wha Jung),김용태(Yong Tae Kim),강승식(Seung Sik Kang),이진(Jin Lee),곽상택(Sang Taek Kwak),주상언(Sang Aun Joo),유재영(Jae Young Yoo) 대한내과학회 1998 대한내과학회지 Vol.54 No.5
N/A Objective Activities of nucleases (acid DNase and neutral RNase) and RNase inhibitor 1mown to be involved in carcinogenesis and suppression of cancer were determined in cancer tissue, serum and ascitic fluid of patients with hepatocellular carcinoma and were compared with those of the controls. Also studied were nucleases and RNase inhibitor isolated from hepatocellular carcinoma tissue and ascitic fluid of the cancer patients to evaluate the properties and interactions between them. Method: Activities of nucleases and RNase inhibitor were measured in cancer tissue, serum and ascitic fluid of patients with hepatocellular carcinoma by ultraviolet spectrophotometry. Nucleases and RNase inhibitor were isolated from hepatocellular carcinoma tissue and ascitic fluid of the cancer patients by DEAE-cellulose column chromatography. As controls, normal tissue of the cancer patients, serum of healthy persons and ascitic fluid of cirrhotic patients were used. Result: Activities of DNase, RNase and RNase inhibitor were significantly increased in hepatocellular carcinoma tissue. DNase activity was not detected, RNase activity was increased and RNase inhibitor activity was unchanged in both serum and ascitic fluid of the hepatocellular carcinoma patients. DNase was isolated as a single enzyme and RNase as seven isozymes from the hepatocellular carcinoma tissue. The DNase isolated preferentially cleaved ds DNA over ss DNA and was endonuclease in nature (majority of hydrolytic products of DNA by the DNase were oligodeoxyribonucleotides). Of seven RNase isozymes isolated from the hepatocellular carcinoma tissue, isozyme I exhibited nonsecretory nature of RNase and other six isozymes secretory nature of the enzyme. Activity of RNase isozyme V was greatly increased and the activity of inhibitor complexed with the isozyme V was also increased. RNase in ascitic fluid of the cancer patient was separated into four isozymes, of which isozyme I exhibited mixed form of secretory and nonseretory nature and greatly increased in its activity. RNase isozyme V isolated in the hepatocellular carcinoma tissue was not detected in the ascitic fluid, Conclusion: The use of the nucleases and the inhibitor in the cancer tissue as biochemical markers for the hepatocellular carcinoma was suggested. RNase was released into the body fluid from the cancer tissue and could be used as a diagnostic marker for the hepatocellular carcinoma. An important rale of the DNase in carcinogenesis of the liver was suggested. RNase isozyme V was limited in the cancer tissue and RNase isozyme I and V and inhibitors associated with these isozymes might be involved in carcinogenesis processes, suppression of cancer and maintenance of tocellular carcinoma through their interactions.
장현주 ( Hyun Joo Jang ),김정한 ( Jung Han Kim ),홍수진 ( Su Jin Hong ),계세협 ( Sea Hyub Kae ),이진 ( Jin Lee ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<증례> 28세 여자가 1주전부터 시작된 소양감과 오심을 주소로 내원하였다. 환자는 임신 7주였으며 임신입덧이 의심되어 산부인과로 입원하였고, 입원 후 시행한 검사에서 고빌리루빈혈증 및 간기능검사의 이상이 있어 임신 9주에 치료적 유산을 시행한 후 내과로 전과되었다. 과거력에서 2명의 자녀를 자연분만으로 출산하였으며 임신기간 동안 특이 병력은 없었고 사회력, 가족력, 약물 복용력에서도 특이사항은 없었다. 두경부 검진에서 공막에 황달이 있었으며 복부검진에
장현주(Hyun Joo Jang),김정한(Jung Han Kim),홍수진(Su Jin Hong),계세협(Sea Hyub Kae),채승완(Seoung Wan Chae),손진희(Jin Hee Sohn),이진(Jin Lee) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.3
Idiopathic adulthood ductopenia (IAD), named about 10 years ago, is a chronic cholestatic entity of unknown origin that affects predominantly young and middle-aged adult. IAD should be considered in patients with ductopenia who manifest cholestatic liver disease of unknown cause. Ductopenia is characterized by the ratio of interlobular and septal bile ducts to the portal tract less than 0.5. We recently experienced one case in a 28-year-old woman who presented with pruritus and jaundice. Laboratory findings revealed intrahepatic cholestasis and negative results in all serological markers of viral hepatitis and circulating autoantibodies. Endoscopic retrograde cholangiography showed normal cholangiogram. Histological examination of two liver specimens showed severe canalicular cholestasis and ductopenia. IAD is very rare, and there has been no report of IAD in Korea. We report a case of idiopathic adulthood ductopenia with a brief review of literature. (Korean J Gastroenterol 2002;39:233-237)
간경변증 환자의 수분 전해질 평형 및 신기능에 있어서 혈청 Endothelin - 1 의 역할
이진(Jin Lee),박철수(Cheol Soo Park),박철희(Cheol Hee Park),계세협(Sea Hyub Kae),곽상택(Sang Taek Kwak),주상언(Sang Aun Joo),김호중(Ho Jung Kim),기춘석(Choon Suhk Kee) 대한내과학회 1997 대한내과학회지 Vol.52 No.4
N/A Objectives: It has been recently known that endotheUn-1 is a potent vasoconstrictor. The purpose of the present study was to clarify the possible correlation of endothelin-1 with other vasoactive neurohormonal activities and its effects on fluid- electrolyte balance and renal function in patients with liver cirrhosis. Mcthods: In 35 patients of liver cirrhosis with (n=19) and without (n=16) ascites and in 12 normal controls, plasma and urine levels of endothelin-1 were measured by specific radioimmunoassay, and serum sodium, serum albumin and other blood chemistries, renal functions with creatinine clearance, urinary sodium excretion, plasma renin activity, plasma aldosterone and plasma norepinephrine were measured at the same time. Results: The plasma endothelin-1 level was significantly higher in ascitic group than nonascitic group (mean±SD; 16.4±10.6 VS. 7.5±4.1pg/mL, p=0.0000), and there was no significant difference in plasma endothelin-1 level between nonascitic group and normal controls(4.8±1.9pg/mL). The urine endothelin-1 level also was significantly higher in ascitic group than non-ascitic group (140.3±74.3 VS. 58.5±37.4 pg/mL, p=0.0000), there was no significant difference in urine endothelin-1 level between nonascitic group and normal controls (19.5±112pg/mL). In patients with cirrhosis, the plasma endothelin-1 concentration showed significant negative correlation with creatinine clearance (r=-0.55), serum albumin (r=-0.56%) and serum sodium concentrtion (r=-0.62), and significant positive correlation with plasma renin activity (r=0.63), plasma aldosterone (r=0.68) and norepinephrine (r=0.70). The factors that influence on plasma concentration of endothelin-1 were plasma norepinephrine (p=0.0000), serum sodium (p=0.0169), plasma aldosterone (p=0.0176), serum albumin (p=0.0213) and plasma renin activity (p=0.0329) in statistically significant order. Conclusion: The elevated plasma endothelin-1 level along with the increased activity of other neurohormonal substances including plasma renin, aldosterone and norepinephrine induces sodium and water retention in decompensated liver cirrhosis. Thus, the plasma endothelin-1 level seems to have an important role in the development of functional renal impairment in decompensated liver cirrhosis by inducing renal vasoconstriction.
장현주(Hyun Joo Jang),김정한(Jung Han Kim),홍수진(Su Jin Hong),계세협(Sea Hyub Kae),이진(Jin Lee),이명석(Myung Seok Lee),김우중(Woo Joong Kim),김동준(Dong Joon Kim),김학양(Hak Yang Kim),박충기(Choong Kee Park),유재영(Jae Young Yoo) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.2
Background/Aims: There is little information on the effect of Helicobacter pylori (H.pylori) eradication in patients with reflux esophagitis (RE). This study was performed to investigate the effect of H. pylori eradication in patients with and without RE. Methods: We retrospectively reviewed 217 patients with H. pylori infection who received upper endoscopy and biopsies between March 1997 and February 2000. Among them, 77 patients with RE and 140 patients without RE were involved in this study. Their H. pylori infection was assessed by rapid urease test and histology. RE was graded according to Savary-Miller classification. Results: Forty-three of 77 patients with RE and the 140 patients without it were treated by eradication regimen (omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg, twice daily) for 14 days. In 37 of the 43 patients with RE and 115 of the 140 patients without RE, H.pylori was eradicated successfully. Among the patients with RE, there was no significant difference in the course of the RE between the eradicated group and the non-eradicated group. However, RE was newly developed after H. pylori eradication in 12.1% (14 of 140) of the patients without RE. Conclusions: H. pylori eradication may not deteriorate RE in the patients with RE. (Korean J Gastroenterol 2002;39:88-92)
김철홍(Cheol Hong Kim),박철수(Cheol Soo Park),이문희(Moon Hee Lee),계세협(Sea Hyub Kae),이진(Jin Lee),곽상택(Sang Taek Kwak),주상언(Sang Aun Joo) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3
Anthrax is an acute bacterial infection caused by Bacillus anthracis, which is a spore-forrning, aerobic, Gram-positive bacillus. It occurs most frequently in herbivores when they are foraging for food in areas contamioated with spores of Bacillus anthracis under appropriate climatic conditions. Humans become infected when spores of Bacillus anthracis are introduced into the body by contact with infected animals or contaminated animal products, insect bites, inhalation, or ingestion. The disease occurs primarily in three forms; cutaneous, respiratory and gastrointestinal. Bacillus anthracis bacteremia can develop in any form of anthrax and is fatal in almost all cases. We experienced two cases of human gastrointestinal anthrax, which resulted frorn consumption of contaminated meat. Here we report 2 cases of human gastrointestinal anthrax with a brief review of literature. (Korean J Gastroenterol 1997;29:404-410)
위의 양성 및 전암성 병변에서 Telomerase 활성화와 Helicobacter pylori 감염의 연관성
장현주(Hyun Joo Jang),김정한(Jung Han Kim),홍수진(Su Jin Hong),강승식(Seung Sik Kang),계세협(Sea Hyub Kae),이 진(Jin Lee),주상언(Sang Aun Joo) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1
Background/Aims: It has been considered that motor abnormalities of the oropharynx might play a role in the pathogenesis of oropharyngeal dysphagia. This study aimed to evaluate the motility change in patients with oropharyngeal dysphagia using circumferential solid state manometry. Methods: Nineteen patients with oropharyngeal dysphagia and 12 healthy volunteers of similar age underwent circumferential solid state manometry and lateral videofluoroscopic studies to assess oropharyngeal motility. The patients were divided into 3 groups by videofluoroscopic findings: group 1, patients with delayed oral transit; group 2, patients with increased pharyngeal residue; group 3, patients with aspiration alone. Results: The group 2 showed less upper esophageal sphincter relaxation and lower amplitude of hypopharyngeal contractions. The time interval from the onset of hypopharyngeal contractions to the onset of complete upper esophageal sphincter relaxation was delayed in the group 3. Post-swallow aspiration was caused by high pharyngeal residue in patients with oropharyngeal dysphagia. Conclusions: These results suggest that a high pharyngeal residue is related to a weak contraction of the hypopharynx, and aspiration is related to a slowed swallow response, presumably with delayed laryngeal closure. (Korean J Gastroenterol 2001;38:9-14)
간경변증 환자의 나트륨대사에 있어서 혈장 Renin 및 교감신경활동도의 역할
이진(Jin Lee),최용석(Young Suk Choi),강승식(Seung Sik Kang),정용영(Yong Young Jung),윤석부(Seok Boo Yoon),계세협(Sea Hyub Kae),곽상택(Sang Taek Kwak),주상언(Sang Aun Joo),김호중(Ho Jung Kim),기춘석(Choon Suhk Kee) 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: We studied to determine the changes of sodium metabolism and to evaluate the role of plasma renin and sympathetic activities in liver cirrhosis with hyponatremia. Methods: We performed measurement of serum sodium, serum albumin and other blood biochemistries, creatinine and creatinine clearance, daily urinary sodium excretion, plasma renin and aldosterone, and plasma norephinephrine level for sympathetic activity in 24 cirrhotic patients with (n;8) and without ascites(n; 16) on day 1 after admisson. We checked body weight, serum sodium and creatinine clearance again on day 10 after admission. Results: 1) The serum sodium level of the ascitic group was lower than that of the non-ascitic group(136±1.0 vs. 138±2.4 mEq/L, p<0.01). There were also significant lower values of serum albumin, creatinine clearance and 24hr urinary sodium excreation in the ascitic group as compared with non-ascitic group. 2) The plasma renin activity and norepinephrine level of the ascitic group were higher than that of the non-ascitic group(renin=3.8±1.1 vs. 557±50 pg/ mL, p<0.05). 3) On day 10 after admission, the serum sodium concentration was decreased more prominently to 132±2.6 mEq/L along with significant reduction of body weight and creatinine clearance in the ascitic group, whereas there was no change of serum sodium level in the non-ascitic group, 4) In total 24 patients, a significant positive correlation between serum sodium and albumin concentration(R=0.6, p=0.004) as well as a significant negative correlation between serum sodium concentration and plasma renin activity(R=0.7, p=0.001). Conclusion: These results suggest that changes of serum sodium concentration in cirrhotic pathents correlate closely with changes of renal function related to the presence or absence of ascites, serum albumin level, changes of body weight, increased plasma renin activity and sympathetic activity, and with alteration of sodium and water delivery to the diluting segment of renal tubules.
위암에서 Telomerase 활성화와 Helicobacter pylori 감염의 연관성
강승식 ( Seung Sik Kang ),장현주 ( Hyun Joo Jang ),김정한 ( Jung Han Kim ),은창수 ( Chang Soo Eun ),계세협 ( Sea Hyub Kae ),이진 ( Jin Lee ) 대한내과학회 2002 대한내과학회지 Vol.63 No.6
목적: Telomere는 염색체의 안정구조를 유지시키며 세포에 유해한 유전자의 재조합을 방지하는 기능을 갖는다. 이러한 telomere의 합성을 촉매하는 telomerase 활성이 각종 암종 및 전구암 병변에서 관찰되면서 이 효소의 활성화는 발암과정의 초기현상으로 암화과정에 기여하는 것으로 생각되고 있다. 또한 최근에는 H. pylori감염이 위암의 중요한 원인으로 밝혀지고 있으므로 H. pylori 감염과 telomerase의 활성화 사이에 어떤 연관 Background: Telomerase, an enzyme synthesizing telomere, plays an important role in cell immortalization and carcinogenesis. Telomerase activity is detected in large number of malignant tumors and also in precancerous lesions, such as intestinal metaplasi