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강석연,한형미,정기경,김태균,안향숙,허인회,김승희 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-
Alzheimer's disease(AD) is ass☞ciated wit31 feature of extracellutar deposition of firoos protein aggregation in the form of amyloid plaque and a loss of choliBergic neurons. This study'as designed to evaluate the effects of docosahexaenoir acid(DHA ) and dehydroepiandrosteroneDHEA) in animal models of dementia which wa:T induced by neurotoxin(iboteni acid ) and of alcohot(16) ethanol). Ibotenic acid was injected into the nucleus basalis meynert region of the rat brain byfreotarically. The oral doses of DHA (675mg/kg) and DHEA (130rng/kg) were given respectively dur-lg 24 days daily, and ibotenic acid was injected at 33th day and of alcohol was given during 48 weeks.he effects of DHA and OHEA were tested the active avoidance and activity of acetylcholinesterasetchs), AChB distrib'ution, amyloid protein distribution, synaptophysin distribution and lipidfroxidatfDn in the brfin. There were Bo differences in active avoidance, amyloid distribution,rnaptofsj,sin dist,ibution and lipid pe,oxidation by DHA, DHEA in the rat b.sin. The rats we.e3ministered DHEA only showed decrease body weight significantly. Alcohol had no e(fect on activeroidance. These findinB proposed that DHA and DHEA Irvels may not be related to the memory im-tirment induced by ibotenic acid.
무선 통신 기술 활용 SK텔레콤 Location 기술/서비스 동향
강석연,조채환,윤종필 한국통신학회 2015 정보와 통신 Vol.32 No.8
이동 통신 사업자는 위성 및 이동통신망을 활용하여 Location 기술 및 서비스를 제공하여 왔다. 최근 스마트폰 보급에 따라 Wi-Fi, Bluetooth 등 근거리 통신망 신호를 활용하여, 실내에서 보다 정확한 위치 파악이 가능해지고 있다. 또한, UWB(Ultra Wide Band)신호를 활용한 초정밀 위치 확인 기술, BLE(Bluetooth Low Energy) 및 센서 활용 기술 등 저전력/비용 효율적인 서비스 제공을 위한 다양한 시도가 진행 중에 있다.
정향 , 마황 , 계피의 간염 B 형 바이러스 증식 억제 효과
강석연(Seog Youn Kang),김태균(Tae Gyun Kim),박민수(Min Su Park),한형미(Hyung Mee Han),정기경(Ki Kyung Jung),강주혜(Ju Hye Kang),문애리(A Ree Moon),김승희(Seung Hee Kim) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.2
This study was undertaken to test for anti-Hepatitis B virus (HBV) activity of the aqueous extracts prepared from Eugenic caryophyllate, Ephedra sinica, Cinnamomum cassia. Aqueous extracts were assayed for the inhibition of HBV replication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 128 to 256 ㎍/㎖ and inhibited the production of HBsAg dose-dependently. Our findings suggest that these three hebal medicinal plants may have potential to develop as specific anti-HBV drugs in the future.
Docosahexaenoic Acid가 Ibotenic Acid 혹은 Scopolamine으로 유발된 흰쥐의 기억력감소에 미치는 영향
강석연(Seog Youn Kang),김승희(Seung Hee Kim),정기경(Ki Kyung Jung),김태균(Tae Gyun Kim),한형미(Hyung-Mee Han),허인회(In Hoe Huh) 한국독성학회 1999 Toxicological Research Vol.15 No.2
The effect of docosahexaenoic acid (DHA) on the memory loss was investigated in two different animal models of dementia (active and passive avoidance models). In the active avoidance retention performance, DHA was administered to experimental animals for 24 days and ibotenic acid, a neurotoxin known to cause destruction of cholinergic nerve terminals, was injected into the nucleus basalis meynert on the 12th day. In the passive avoidance retention performance, DHA was administered to experimental animals for 24 days and either ibotenic acid or scopolamine was injected 24 hours (ibotenic acid) or 30 min (scopolamine) before the experiment. All animals were tested for the active and passive avoidance by the shuttle box and the reflex system, acetylcholinesterase (AChE) activity, AChE distribution by histochemical staining, amyloid protein and synaptophysin distribution by immunohistochemical staining and the degree of lipid peroxidation in the brain. DHA did not have any effect on the inhibition of the active and passive avoidance induced by ibotenic acid. On the other hand, scopolamine-induced inhibition of passive avoidance was partially reversed by DHA, indicating the implication of DHA in potentiation of cholinergic transmission. No differences were observed in AChE activity, AChE distribution, amyloid protein deposition synaptophysin distribution and the degree of lipid peroxidation between DHA-treated and vehicle (10% corn oil)-treated groups. These results demonstrated that administration of DHA for 24 days did not have any effect on the memory loss induced by ibotenic acid whereas scopolamine-induced memory loss was partially reversed by DHA. The precise role of cholinergic transmission potentiating effect of DHA in term of improving memory and/or learning ability remains to be elucidated.
CDMA를 기반으로 한 도심환경 마이크로셀룰러 시스템에서의 치국 계획
권준혁,강석연,정종민,차동완 한국경영과학회 1998 한국경영과학회 학술대회논문집 Vol.- No.1
This paper addresses a radio network design problem in an urban micro-cellular CDMA system. Given the data of potential sites of base stations and path loss value between the base station and mobile stations, the objective of this problem is to locate base stations so as to minimize the siting cost while keeping the acceptable path loss value on the service area. We develop an efficient algorithm for solving the problem, and computational experiments are conducted to show the practicality of the proposed design method.