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조두신,신동운,박소정,배지은,감준범,박나연,김재성,오정수,신정원,조동형 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.8
Mitochondrial dynamics control mitochondrialmorphology and function, and aberrations in these areassociated with various neurodegenerative diseasesincluding Alzheimer’s disease and Parkinson’s disease. Toidentify novel regulators of mitochondrial dynamics, wescreened a phytochemical library and identified liquiritigeninas a potent inducer of mitochondrial fusion. Treatmentwith liquiritigenin induced an elongatedmitochondrial morphology in SK-N-MC cells. In addition,liquiritigenin rescued mitochondrial fragmentation inducedby knockout of mitochondrial fusion mediators such asMfn1, Mfn2, and Opa1. Furthermore, we found that treatmentwith liquiritigenin notably inhibited mitochondrialfragmentation and cytotoxicity induced by Ab in SK-NMCcells.