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金石植,韓弘武 大韓神經精神醫學會 1964 신경정신의학 Vol.3 No.1
The authers has field survey during 20th July 1063 to 24th July 1963 at Ko-Koom-Myun in the Island Chin-Do, which had 10517 of population. We investigated for the incidence of main psychosis in that population. The general incidence and corrected incidence by Weinberg's method are as following. -------------------------------------------------------------------------- Number General Most Affected Corrected of Cases Incidence(%) Range of Age Incidence(%) -------------------------------------------------------------------------- Schizopnrenic 16-40 0.47 Reaction 20 0.19 21-40 0.54 Manic Depressive 21-50 0.03 Reaction 1 0.01 16-50 0.03 General 0 0.0 31-50 0.0 Eqilepsy 19 0.18 5-30 0.3 5-20 0.26 -------------------------------------------------------------------------- We also could notice following facts ① Nearly half of epileptics in this area had its onset age more older than usual. ② Most of schizophrenics were chronic cases and half of them were older than 10 years. ③ At least 30% of schizophrenics had hereditary back ground. ④ Those who have religion seemed more prevalent in schizophrenics than in general population. ⑤ Only 1/8 of total patient was treated in reasonable way. ⑥ 72.5% of total patient could maintain social and/or home life in this rural area.
Aspergillus candidus F1484 균주가 생산하는 항진균 화합물의 분리 및 특성
김성옥,이소영,김성규,손광희,김영국,문석식,복성해 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.5
Candida albicans의 효모형태에 대해 활성을 나타내는 항진균 물질의 탐색 중에 Aspergillus candidus F1484 균주의 발효액으로부터 항진균 화합물 F1484를 단리하고 ethyl acetate 추출, silica gel column chromatography, ODS column chromatography 및 preparative HPLC를 행하여 분리정제하였다. F1484 화합물은 EI-MS, ^13C-, ^1H-NMR, DEPT, HMQC 및 HMBC에 의한 구조분석을 행한 결과 이 화합물은 항진균 물질인 chloroflavonin과 동일한 구조를 나타내었으며 효모형태의 Candida albicans에 대한 항진균 활성뿐만 아니라 여러 종류의 인체 종양 세포주에 대해서도 세포독성을 나타내었다. In the course of screening for the antifungal compounds against Candida albicans, an antifungal compound (F1480) was isolated from the culture broth of Aspergillus candidus F1484. Isolation and purification of compound F1484 were performed using ethyl acetate extraction, silica gel column chromatography, ODS column chromatography, and preparative HPLC. The structure of compound F1484 was determined by the spectroscopic analyses of EI-MS, ^13C-, ^1H-NMR, DEPT, HMQC, and HMBC. This compound appeared to have a structure of antifungal agent, chloroflavonin. In addition to antifungal activities against the yeast phase of Candida species, compound F1484 showed cytotoxic effect against various human tumor cell lines.
Chlorpromazine의 副作用과 Sustained Trihexiphenidyl Hcl(Antane)에 依한 錐體外路系 反應의 調節
南命錫,金石植,鄭有碩 大韓神經精神醫學會 1966 신경정신의학 Vol.5 No.1
The authors tried to study on the side effects of Chlorpromazine, evaluate the effect of Artane(Trihexyphenidyl Hcl) and observe the recurrence rate of extrapyramidal reaction after the withdrawal of maintenance doses of Artane. This study includes 28 patients who were hospitalized in Psychiatric ward SNUH and 55 patients in Kaejoug Mental Hospital, Cholla Pukdo Province. (Total; 83 patients) The results are as follows. 1. Most of patients showed muscular weakness and drowsiness, though they were rarely volunteered symptoms. Dizziness and dryness of mouth were observed in more than an half of cases. Nasal stuffness and extrapyramidal reactions were developed among 49% of cases. 2. Extrapyramidal symptoms were appeared one days later the initial administration of chiorpromazine. The authors could observe that torticollis was relatively early appeared symptom and tremor tended to be appeared later. 3. The authors were impressed that the amount of chlorpromazine did not determined the appearance of extrapyramidal symptoms. 4. Artane was administered to 44 cases. But 3 cases of neurologic illness, 5 cases, from whom significant data were not obtainable because of discharge within 10 days without being managed, and 4 cases, for whom Artane was supplied irregularly, were excluded from this study. 5. 85% of extrapyramidal symptoms were managed successfully with Artane. To manage them, successive 4 days of Artane administration (5-10㎎ daily) were needed. 6. Artane was more effective in rigidity than in tremor and especially highly effective in the management of torticollis and oculogyric crises. 7. The side effects of Artane were not significant. 8. Extrapyramidal symptoms were reappeared in 11 cases among 15 cases within 20 days after the withdrawal of daily maintenance doses of Artane (5-10㎎). 9. Among three neurological cases, two cases revealed the much improvement.
Chlorpromazine 의 副作用과 Sustained Trihexiphenidyl Hcl(Antane)에 依한 雜體外路系 反應의 調節
南命錫,金石植,鄭有碩 대한신경정신의학회 1966 신경정신의학 Vol.5 No.1
The authors tried to study on the side effects of Chlorpromazine, evaluate the effect of Artane (Trihexyphenidyl Hcl) and observe the recurrence rate of extrapyramidal reaction after the withdrawal of maintenance doses of Artane. This study includes 28 patients who were hospitalized in Psychiatric ward SNUH and 55 patients in Kaejoug Mental Hospital, Cholla Pukdo Province. (Total; 83 patients) The results are as follows. 1. Most of patients showed musuclar weakness and drowsiness, though they were rarely volunteered symptoms. Dizziness and dryness of mouth were observed in more than an half of cases. Nasal stuffness and extrapyramidal reactions were developed among 49% of cases. 2. Extrapyramidal symytoms were appeared one days later the initial administration of chlorpromazine. The authors could observe that torticollis was relatively early appeared symptom and tremor tended to be appeared later. 3. The authors were impressed that the amount of chlorpromazine did not determined the appearance of extrapyramidal symptoms. 4. Artane was administered to 44 cases. But 3 casesof neurologic illness, 5 cases, from whom significant data were not obtainable because of discharge within 10 days without being managed, and 4 cases, for whom Artane was supplied’ irregularly, were excluded from this study. 5. 85% of extrapyramidal symptoms were managed successfully with Artane. To manage them, successive 4 days of Artane administration (5-lOmg daily) were needed. 6. Artane was more effective in rigidity than in tremor and especially highly effective in the management of torticollis and oculogyric crises. 7. The side effects of Artane were not significant. 8. Extrapyramidal symptoms were reappeared in 11 cases amang 15 cases within 20 days after the withdrawal of daily maintenance doses of Artane (5-lOmg). 9. Among three neurological cases, two cases revealed the much improvement.