http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국 영유아를 위한 일과기반 발달검사 MEISR 타당화
김주현,김주현,박혜원 인지발달중재학회 2024 인지발달중재학회지 Vol.15 No.1
Objective: The Measure of Engagement, Independence, and Social Relationships (MEISR) is a tool designed to assess the engagement, independence, and social interactions of infants and toddlers during daily activities. This study aimed to develop Korean version of MEISR (K-MEISR) and evaluate its reliability and validity. Methods: Korean version of MEISR was developed through the translation and modification of items of the MEISR following a pilot study (N = 44). Two studies were conducted with parents of infants and toddlers up to 36 months old using online (N = 124) and offline (N = 134) versions. Data were analyzed using SPSS 27.0 and AMOS 25.0. Item difficulty and discrimination, as well as passing rates were calculated; and internal consistency, correlations among the routine and total scales, factor analyses, and correlations with K-DST ratings were analyzed to determine the reliability and validity of K-MEISR. Results: Analyses of item difficulty and passing rates identified characteristics of items for determining the item order for K-MEISR. High correlations between the total of each routine and the total of all items were found in both the online (r = .896~.992) and the offline (r = .874~.988) versions. Reliabilities of all total scale items were high for both the online (r = .998) and the offline (r = .997) versions. Reliabilities of routine items were also high, ranging from .913 to .985 for the online and .914 to .985 for the offline version. Correlations between K-DST and K-MEISR were high for both the online (r = .981) and offline (r = .959), showing high concurrent validity. Conclusions: The items of the total scale, and routines and functional domains showed high internal consistency and high correlations with K-DST, revealing the concurrent validity of K-MEISR. Recommendations for further research and clinical use of the assessment tool are discussed.
김주현,권미화,권순상,김영목,홍성운,연성흠,송임숙,이혜숙 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.1
Concurrent administration of herbal drugs that modulate drug transporter activities can cause herb–drug interactions in the process of the absorption, distribution, and elimination of drugs and thereby, modulate drug efficacy and toxicity. For this reason, regulatory agencies have instituted guidelines for the investigation of potential herb–drug interactions during the drug development process. Therefore, the purpose of this study was to investigate the herb–drug interaction potential of HS-23, an extract of the dried flower buds of Lonicera japonica, which is being evaluated for use in the treatment of sepsis in a phase II clinical study. The inhibitory effects of HS-23 on the transport functions of organic cation transporter (OCT)1, OCT2, organic anion transporter (OAT)1, OAT3, organic anion transporting polypeptide (OATP)1B1, OATP1B3, P-glycoprotein (P-gp), and breast cancer resistance protein (BCRP) were investigated in HEK293 and LLC-PK1 cells. The effects of HS-23 on the pharmacokinetics of ceftriaxone and levofloxacin, common combination drugs for sepsis treatment were also examined in rats.HS-23 (up to 100 lg/mL) did not inhibit the in vitro transport activities ofOCT1/2,OAT1/ 3, OATP1B1/1B3, P-gp, and BCRP or the pharmacokinetics of ceftriaxone and levofloxacin in vivo after a single intravenous dose of 40 mg/kg. In conclusion, HS-23 may not have significant herb–drug interactions with the prevalently used ceftriaxone and levofloxacin, in rats even at its effective dose.
김주현 한국어문학회 2006 語文學 Vol.0 No.91
]This paper has the aim to explain the feature of Cheonheedangsihwa and to adjust the place of it. Cheonheedangsihwa is one of the most important poetics at Korea in 1900s. It had been appeared anonymously in The Korea Daily News from November 09, 1909 to December 04, 1909. Cheonheedangsihwa is a talk and an essay on poetry, not so much as poetics. I have especially concern about the historical meaning of Danjae's Cheonheedangsihwa. Danjae established Cheonheedangsihwa by succeeding to nationalism of Yi Gyu-bo and identities of Korean pragmatists for instance, Hong Dae-yong, Park Ji-won, Yi Ik, etc. and by acepting Liang Ch'ich'ao's Eumbingsilsihwa. So, he created greatly characteristic poetics. Cheonheedangsihwa is the practical literary theory that makes a writer's responsibility clear in a turbulent period. Also it is an great essay on poetry that has an insight into a history of Korean poetry.
Inheritance and Characteristics of a New Dwarf Mutant in Lettuce
김주현 한국원예학회 2004 Horticulture, Environment, and Biotechnology Vol.45 No.6
One spontaneous dwarf mutant of lettuce was found in the segregating population derived from the cross 86-197-2-1-4 × Prizehead. This mutant has shrunken, dark red cotyledons and very short hypocotyls. The stems and leaves were very soft and weak. The leaf size was smaller than 1/2 of that of the normal plant, and the flower stem was much shorter. The mutant was crossed with normal lettuce lines of 87-25M-2M and D24. The F1 plants were normal, and the F2 populations segregated in a 3:1 of normal and dwarf, showing that this dwarf characteristic is controlled by a single recessive gene. The results from the F3 families confirmed the F2 results, and the gene was named dwarf-5. The correlations of dwarf character between true second leaf length and width, number of internodes on cauline stem, three internodes length, the largest leaf length, width, and area were investigated. Dwarfing type plants could be found easily by selecting the plants having short second leaf at seedling stage.