천추(天樞) 및 상거허(上巨虛)의 침자극(針刺棘)이 대장(大腸) 통과시간(通過時間)에 미치는 영향(影響)

김동웅,이상용,이창현,Kim Dong-Woung,Lee Sang-Yung,Lee Chang-Hyun 대한침구의학회 1998 대한침구의학회지 Vol.15 No.2

Amis:ST25(Chonchu) and ST37(Sanggoho) are usually used acupoints to management several disease which induced to abnormal intestinal motility as diarrhea, constipation. Colonic transit time by radio opaque marker is able to study easily and useful method for evaluation of colonic motility. The aim of this study was to assess the effect on colonic transit time by manual acupuncture or electroacupuncture stimulation of ST25, ST37 in normal adult. Method: Colonic transit time, including Rt colon, Lt colon, rectosigmoid colon was measured by radio opaque marker in 11 normal adults. Colon transit time was measured before stimulation and after stimulation on ST25, ST37 by manual acupuncture and electroacupuncture. Each person was treated manual acupuncture or electroacupuncture stimulation for 3 days before colonic transit time measurement with 1 week interval. Result: Colon transit time before stimulation was measured $10.60{\pm}12.11$, $3.92{\pm}7.72$, $3.27{\pm}6.37$, $3.41{\pm}5.57$ hours total colon, Rt colon, Lt colon, rectosigmoid colon, respectively. Colon transit time after manual acupuncture is measured $10.48{\pm}12.35$, $3.72{\pm}7.52$, $3.37{\pm}6.76$, $3.39{\pm}5.84$ hours total colon, Rt colon, Lt colon, rectosigmoid colon, respectively. Colon transit time after electroacupuncture stimulation is measured $10.30{\pm}13.21$, $3.92{\pm}8.02$, $3.07{\pm} $, $3.31{\pm}5.49$ hours total colon, Rt colon, Lt colon, rectosigmoid colon, respectively. Significant change was observed Lt colon transit time after electroacupuncture as compared before acupuncture(P<0.05). Conclusion: Theses results suggest that manual acupuncture and electroacupuncture of ST25, ST37 in normal adults does not change colonic transit time.

장기간 한약투여가 B형 바이러스 간염 표면항원 양성자의 간기능에 미치는 영향

金寬植,金東雄 大韓東醫病理學會 1999 동의생리병리학회지 Vol.13 No.2

B형 간염 표면 항원 양성자에 장기간의 한약을 투여하였을 경우 이에 따른 간기능의 변화와 B형 간염 항원 및 항체에 미치는 영향을 살펴보기 위하여 간질환이외의 질환으로 입원하여 장기간의 한약 투여를 하였던 환자들중 B형 간염 바이러스 표면항원(HBsAg)이 양성이고 간기능이 정상이었던 21명(남자 14명, 여자 7명, 평균연령 63.71±8.42세)의 환자들에게 주기적인 간기능 및 B형 간염 바이러스 표면항원을 검사한후 다음과 같은 결과를 얻었다. 대상환자의 내원당시 혈청 ALP AST ALT치는 각각 평균 10.98±2.81 KAU 37.63±7.25 IU/L 39.±5.68 IU/L, 2주간의 한약 투약후의 ALP AST ALT치는 각각 평균 13.45±3.91 KAU 36.71±8.51 IU/L 37.96±7.51 IU/L으로서 투약전과 비교하여 유의한 변화를 보이지 않았다(P>0.05). B형간염의 표면항원은 투약전과 비교하여 변화 없이 21예전예에서 양성이었고 표면 항체는 전예에서 음성이었다. 한약 투여기간 동안 내원당시 정상이었던 ALP AST ALT 치가 상승하여 비정상적인 수치를 부였던 환자들은 5예로서 투약전 각각의 평균치는 12.63±3.31 KAU 35.01±8.97 IU/L 32.71±7.81 IU/L이었다. 투약후의 변화는 1주후 17.15±5.37 KAU 62.51±10.34 IU/L 57.86±12.49 IU/L였으며 2주후 15.61±5.47 KAU 47.82±7.34 IU/L 49.17±9.52 IU/L로서 투약 1주후에 상승하고 2주째에는 하강하는 양상을 관찰할 수 있었다. 이상과 같은 결과로 B형 간염 바이러스 표면항원을 가지고 있으면서 정상 간기능 수치를 보인 21예의 환자들에게 한약을 2주간 투여했을 경우 5예의 환자에서 혈청 AST ALT치가 정상수치의 약 1.5배 상승후 정상화 되는 경향을 보임으로서, 이전의 연구에서 밝혀진 B형 간염 바이러스 표면항원을 가지고 있으면서 정상 간기능 수치를 보인 환자에게 투여시 우려할 만한 간기능 손상을 초래하지 않을 것으로 사료된다. I In order to investigate the commonly used herb medicine formular's effects on the liver with HBsAg positive state and normal serum transaminase level, We examined serum ALT, ALP, AST level, and HBsAg, HBsAb in 21 patients(male 14, female 7) who admitted consecutively for other diseases except liver diseases. ALT, ALP, AST level was investigated on admission, 1 week and 2weeks after admission. HBsAg and HBsAb was examined on admission and 2 weeks after admission. ALP, AST and ALT level on admission was 12.56±4.87 KAU, 35.12±6.75 IU/L, and 32.82±5.29 IU/L, respectively. Those level 1 week after administering herd medication was 10.98±2.81 KAU, 37.63±7.25 IU/L, 39.0±5.68 IU/L and 2 weeks after was 13.45±3.91 KAU, 36.71±8.71 IU/L, 37.96±7.51 IU/L, respectively. There were no significant changes in those levels on each checking time(P>0.05). Also, after 2 weeks after administering herb medication, HBsAg was positive and HBsAb was negative in all 21 cases. The 5 patients had abnormal elevation in serum ALP, AST and ALT level which was normal on admission ALP, AST and ALT level was 12.63±3.31 KAU, 35.01±8.97 IU/L, 32.71±7.81 IU/L on admission, 17.15±5.37 KAU, 62.51±10.34 IU/L, 57.86±12.49 IU/L 1 week after admission, and 15.61±5.47 KAU, 47.82±7.34 IU/L, 49.17±9.52 IU/L 2 weeks after admission, respectively. There was a tendency that serum ALP, AST and ALT level increased 1 week after herd medication and decreased 2 weeks after that. Above results show that, after administering herbs for 2 weeks, Transaminase level change pattern in HBsAg positive patients with normal transaminase level was similar to that pattern shown in HBsAg positive patients with normal transaminase level, not having herbs. So, we suppose that commonly used herb formulars does not incur remarkably liver function injury in HBsAg positive patients with normal transaminase level.

腦血管 疾患에 의한 偏麻痺 患者에서 補陽還五湯의 效果

鄭用埈,金東雄 대한동의병리학회 1999 동의생리병리학회지 Vol.13 No.2

卒中風이 後遺障碍로 因한 偏麻痺의 代表的인 處方인 補陽還五湯의 效果를 알아보기 위하여 2週이상 補陽還五湯을 投與하였던 患者들의 上下肢筋力의 變化를 後向的 調査하였다. 對照藥은 本院에서 投藥頻度가 많았던 固眞飮子로 하였다 全體患者는 47名 이었으며 이들중 補陽還五湯을 投與하였던 患者는 24名으로 腦硬塞 13例 腦出血 11例이었으며, 固眞飮子를 投與하였던 患者는 23例로 腦硬塞 10例 腦出血 13例이었다. 平均 投藥期間은 15.73±1.28日이었으며 補陽還五湯과 固眞飮子를 投與後 2週 經過하였을 때 補陽還五湯 投與群과 固眞飮子 投與群의 運動能力 好轉 程度 測定에서 모두 投藥前에 比하여 上下肢 運動場碍가 有意한(P<0.05) 好轉을 보였다. 두 投藥群의 運動能力 好轉 程度 比較에서 上肢의 경우 두 投藥群 사이에는 有意性(P<0.05)이 없었으나 下肢의 경우 補陽還五湯 投與群이 固眞飮子 投與群에 比較하여 有意한(P<0.05) 筋力增加가 있었다. 以上과 같은 結果로 補陽還五湯은 卒中風 後遺障碍로 因한 偏麻痺 患者의 運動能力 回復에 도움을 주며 특히 上肢보다 下肢의 筋力向上에 더욱 效果가 있을 것으로 思料되었다. To know the effect of Boyanghwanotang used for hemiplegia patients caused by cerebral vascular attack(CVA), We retrospectively investigated the motor weakness change of the upper and lower extrimities in the patients who was given Boyanghwaotang for 2 weeks over. We used, in comparative group, Gonzinumza which has been frequently given in oriental medicine. The total patients was 47. Boyanghwanotang was given to the 24 patients. In the 24 patients, cerebral vascular infarction was 13 and cerebral vascular hemorrhage was 11. Gozinumza was administered to the 23 patients. In the 23 patients, the cerebral vascular infartion was 10 and cerebral vascular hemorrhage 13. The mean administered period was 15.73±1.28 days. 2 weeks after administering Boyanghwanotang, I could find significance motor power improvement(p<0.05) in the upper and lower extrimities in both the experimental group and comparative group. In comparison with the motor power improvement of both the two groups, there was not a significance(P<0.05) in the upper extrimity but was a significance(P<0.05) in lower extrimity. From the above results, We think that Boyanghwanotang helps recover motor weakness in the hemiplegia patients having CVA sequela, especially in the lower extrimity.

中風 患者 34例의 舌診에 對한 臨床的 觀察

金東雄 대한동의병리학회 1998 동의생리병리학회지 Vol.12 No.1

1997年 2月부터 1997年 8月까지 圓光韓醫大 全州韓方病院에 中風으로 來院하여 治療한 34名(平均年齡:65.07歲, 男:19 女:15名)을 對象으로 舌診을 시행하였고, 관찰된 결과는 다음과 같다. 1. 中風原因에 대한 변증결과는 陰虛, 氣虛, 濕痰/痰火, 瘀血이 각각 13, 10, 7, 4例를 보였다. 2. 腦 電算化斷層 撮影 結果 腦出血로 診斷된 16例의 患者에서 舌質은 紅色, 絳色, 淡紅色, 靑紫色, 淡白色이 각각 6, 4, 4, 1, 1例를 보였다. 그리고 腦梗塞의 境遇는 18例중 舌質이 淡紅色, 淡白色, 紅色, 絳色, 靑紫色이 각각 7, 5, 3, 2, 1例를 보였다. 3. 入院當時 觀察한 顔面과 眼色은 面紅目赤한 境遇가 舌質이 紅, 絳한 경우에서 더 頻度가 높았으며, 面紅이 있는 患者는 程度의 差異는 있지만 모든 例에서 目赤을 같이 同伴하였다. 또한 腦 電算化斷層撮影 所見上 腦出血患者에서 腦梗塞이 있는 환자에서 보다 面紅과 目赤이 훨씬 더 많이 관찰되었다. A clinical observation by the tongue change as a diagnostic method was made on 34 acute stage (in 24 hours from the onset) cerebrovascular accident patients admitted to Wonkwang University, Chonju Oriental Medical Hospital from February, 1997 to August, 1997 and the observed results were summarized as follows. 1. The observed results with the differentiation of symtoms and signs for the cerebrovascular cause were that deficiency of yin(陰), deficiency of qi(氣), clamp phlegm or phlegm fire(濕痰, 痰火) and blood stasis(瘀血) was 13, 10, 7, 4 case(s), respectively. 2. The texture of tongue in 16 patients diagnosed intracranial hemorrhages on the brain CT was that red, dark red, pink, cyanosis color, and whitish color was 6, 4, 4, 1, 1 case(s), respectively. And the one in 18 cases diagnosed intracranial infarctions was that pink, whitish color, red, dark red, and cyanosis color was 7, 5, 3, 2, 1 case(s), respectively. 3. As the face color and the eyeball color of the observed patients in the first admission day, The flush and reddish eyes cases were more frequently occurred. Among the patients with red, dark red texture of tongue, All of the cases had reddish eyes in the flushed patients more or less. And The observed results in the intracranial hemorrhages were detected more frequently than one in the intracranial infarctions on the brain CT studys.

Study on the Changes in the Blood Lipid Profile Levels of Patients with Metabolic Syndrome while Receiving Oriental Medicine Treatments for Various Diseases

김동웅 한의병리학회 2009 동의생리병리학회지 Vol.23 No.2

Among patients who visited each clinical department for oriental medical treatments, anthropometric measurement, blood pressure, fasting blood glucose and blood lipid profile level were measured at their first initial visit. 55 subject patients who were diagnosed as having metabolic syndrome and 150 mg/dL or more of triglyceride were selected as subjects whose fasting blood glucose, triglyceride, total cholesterol, HDL cholesterol and LDL cholesterol were measured after fasting. According to each patient’s disease, the subject received treatments such as herb medicine, acupuncture, moxibustion, cupping therapy, physical therapy and rehabilitation therapy from each clinical department, and after an average of 4.10±0.31 weeks, another test was performed yielding the following results. Serum triglyceride was 243.72±13.05 mg/dL before the oriental medical treatment and 188.11±12.17 mg/dL after the treatment where although it continued to show an abnormal value even after the treatment, there was statistically significant decrease compared to pre treatment(P<0.05). Serum total cholesterol was 207.50±5.89 mg/dL before the oriental medical treatment and 192.37±5.53 mg/dL after the treatment which was statistically insignificant compared to pre treatment(P>0.05). Serum HDL cholesterol was 51.19±3.95 mg/dL before the oriental medical treatment and increased to 52.53±1.49 mg/dL after the treatment although it was statistically insignificant compared to pre treatment(P>0.05). Serum LDL cholesterol was 110.66±5.86 mg/dL before the oriental medical treatment and decreased to 106.12±4.82 mg/dL after the treatment although it was statistically insignificant compared to pre treatment(P>0.05). In regards to the change of triglyceride for each sex, it was 221.84±14.01 mg/dL before the treatment and 187.00±15.47 mg/dL after the treatment for men, and it was 271.50±22.78 mg/dL and 189.53±19.76 mg/dL respectively for women where even though men and women showed the decrease of 34.84±12.79 mg/dL and 81.96±20.01 mg/dL respectively, both men and women continue to show abnormal values after the treatments. However, there was statistically significant decrease compared to pre‐treatment(P<0.05). In regards to the change of total cholesterol for each sex, with 198.24±7.60 mg/dL for men before the treatment and 188.93±7.45 mg/dL after the treatment, values for both before and after the treatment were within the normal range where the change value was 9.30±5.86 mg/dL and statistically insignificant(P>0.05). For women, it was 219.26±8.87 mg/dL and 196.73±8.43 mg/dL respectively for women where with 22.53±7.60 mg/dL, it decreased to the normal level after the treatment, and there was a statistically significant decrease compared to pre‐treatment(P<0.05). With such results, serum triglyceride and cholesterol levels of patients who have been diagnosed as having metabolic syndrome were observed to decrease after the oriental medical treatment. Especially, for both men and women, abnormally high triglyceride level decreased while the effect of lipid profile improvement for women was more significant compared to men.

Endoscopy Finding of Patients Who Complained of the Upper Digestive Symptoms after Taking Oriental Herb Decoctions

김동웅 한의병리학회 2008 동의생리병리학회지 Vol.22 No.4

This study was carried out to understand the macroscopic aspects of the digestive system symptoms occurring after taking oriental herb complex decoction as observing morphological changes in esophagus, stomach and duodenal bulb by endoscopy of upper gastrointestinal tract when these symptoms developed. The subjects of this study were 46 patients (male 22, female 24, mean age : 54.72±14.26 years) who were chosen among ones who took oriental herb complex decoction for medical care and developed symptoms related to the gastrointestinal tract while taking an oriental herb decoction, which were assumed that the digestive symptoms were newly developed because of administration. The subjects were given morphological examination by endoscopy of the upper gastrointestinal tract. As a result of the endoscopy operated due to the digestive symptoms developed during the administration of oriental herb decoction, there were 2 cases of esophagitis, 5 cases of acute gastritis, 1 case of chronic gastritis A type, 15 cases of chronic gastritis B type, 1 case of duodenitis, 1 case of gastric ulcer, 1 case of gastric polyp, 2 cases of intestinal metaplasia, 1 case of gastric ptosis and 17 cases of normal findings which didn’t have any abnormality macroscopically with endoscopy. With regards to the patients who complained of the digestive symptoms after taking oriental herb decoction, it has been found that the symptoms occurred as the oriental herbal medicine taken by the patients who had the digestive symptoms at ordinary times influenced on the gastrointestinal tract. Especially, many of them were had chronic gastritis and functional dyspepsia in the past. The disease accompanying macroscopic lesions at endoscopy which occurred due to the oriental herb decoction as direct cause, was acute gastritis, and it was the prescription to cure the pains and inflammations of skeletomuscular disease.

한의학적 응급치료를 받은 급성기 뇌경색환자의 혈압변화에 대한 임상적 고찰

金東雄 한국전통의학연구소 1997 한국전통의학지 Vol.7 No.2

뇌혈관 질환은 심혈관질환과 악성종양과 더불어 주요한 사망원인으로서 뇌혈관 질환을 발생시키는 요인 중 고혈압은 주된 위험인자이며 많은 급성 뇌졸중환자에서 고혈압을 관찰할수 있다. 따라서 고혈압의 치료는 뇌혈관 질환을 예방할 수 있는 효과적인 방법이나 뇌졸중 발생후 고혈압의 치료는 아직 논란의 여지가 있으며 특히 뇌경색에 있어서는 초기의 과도한 혈압 강하가 뇌혈류의회복에 도움이 되지 않는다는 것이 밝혀졌다. 한의학에서 뇌혈관질환 즉 中風은 本虛表實하고 上盛下虛한 증상으로,급성기에는 本虛의 증상이 있으나 表寶의 증상이 위주가 되고 病程의 변화가 급격하므로 治表하는 것이 원칙으로 調氣,順氣,割痰,疏風,滋陰시키는 治法이 응용된다. 본 연구는 원광한의대 전주 한방병원에 입원치료 하였던 급성 뇌경색 환자들중 WHO 기준에 의하여 고혈압으로 진단된 53명(남:55 명,여 28명,평균연령 65.77세)의 환자들을 대상으로 한의학적인 응급치료를 하며 4주간 혈압의 변화를 관찰하였다. 결과:입원후 24시간 안정후의 혈압은 평균 수축기 150.18± 10.46mmHg,이완기 94.77± 4.89mmHg였으며 이후 일주일간씩의 수축기 및 이완기의 혈압 평균은 1주 수축기 135.90±13.25mmHg 이완기 85.28±7.19mmHg,2주 수축기 134.17±11.07mmHg 이완기 84.85±6.37mmHg, 3주 수축기 133.47±10.nmmHg 이완기 84.44±6.89mmHg,4주 수축기 135.25 ± 12.44mmHg 이완기 85.01 ±7.10mmHg으로서 입원후 24시간 안정후의 혈압과 비교하여 수축기와 이완기 혈압 모두에서 유의한 (P<O.05)저하를 보였으나 2주이후의 혈압의 저하는 유의하지 않았으나(P>0.05) 정상 범위내의 혈압으로 하강하였다. 이상의 결과로 한의학적 응급치료를 시행하는 뇌경색 초기의 환자는 과도한 혈압의 강하를 위한 치료는 1주일이상 환자의 혈압을 면밀히 관찰한후 시행되어 져야 할것으로 사료되었다. Cerebrovascular diaease is the third leading cause of mortality following coronary heart disease and malignancies. Cerebrovascular disease is a common cause of morbidity and mortality, espedally in the elderly. Hypertension is one of the most important cerebrovascular risk factors. Hypertension is seen in 80% of acute stroke patients. Treatment of hypertension is effective in the primary prevention of stroke. By increasing the number of treated hypertensive patients and by increasing the effectiveness of treatment it is possible to achieve a decline of the cerebrovascular mortality. But the dinical significance of post-stroke hypertension is uncertain and its management is a contentious issue. In 53 patients from the Won Kwang Oriental hospitals with acute cerebral infarction(25 men; 28 woman; median age, 65.77 years) , we prospectively studied BP changes between admission and 4 weeks. In this study patients receiving no antihypertensive medication after stroke and they were treated with oriental medical emergency care include herb medicine and acupuncture. RESULTS: Systolic and diastolic BP at admission is 150.18±10.46mmHg and 94.77±4.89mmHg. Systolic and diastolic BP fell by 14.28 mm Hg (95% confidence interval [Cl]) and 8.49 mm Hg (95% CI) respectively, in the first week but no further thereafter. CONCLUSIONS: We have demonstrated a marked fall in systolic and diastolic BP levels during the first 7 days in cerebral infarction patients who were treated with oriental medical emergency care, with little change thereafter. This study suggest that antihypertensive medication should be avoided in patients with acute cerebral infarction unless vital organs are compromised, the diastolic BP rises to 130 mm Hg or greater, or the patient has hypertensive encephalopathy.

Clinical Review on Complications of Stroke Patients Admitted Oriental Medical Hospital

김동웅 한의병리학회 2003 동의생리병리학회지 Vol.17 No.1

Biphenyl Dimethyl Dicarboxylate의 저용량 단기 투여가 만성 간염환자의 상승된 Aspartate Aminotransferase와 Alanine Aminotransferase의 저하 효과에 관한 임상적 연구

김동웅,강병기 한국임상약학회 1993 한국임상약학회지 Vol.3 No.1

Biphenyl Dimethyl dicarboxylate(DDB) has been regarded as a safe, effective drug for decreasing serum aminotransferase levels from elevated serum aminotransferase levels, which cause acute or chronic hepatitis and chronic liver diseases. This study was designed to low dose(22.5mg/day) & short-term therapy effectiveness for 4 weeks of DDB in 30 chronic hepatitis patients with elevated serum aminotransferases. The following results were observed. 1. Serum alanine aminotransferase(ALT) levels significantly decresed from 173. of pretreatment level to after treatment for 4 weeks(p<0.00l) and normalized patients by 2. Serum aspartate (AST) aminotransferase levels significantly decreased from of pretreatment level to after treatment(p0<0.01). 3. However, no significant effects in the serum AST & ALT changes by which cause hepatitis and hepatitis duration (p>0.05). 4. No significant adverse effects were observed except for mild epigastric discomfort in one patient during DDB treatment It is suggested that DDB small dosage administration can result effectively decreasing serum aminotransferase levels from chronic hepatitis patients with elevated serum aminotransferase levels.

화력발전소 신설 보일러의 과열기 열부하 편차 연구

김동웅 한국연소학회 2010 KOSCOSYMPOSIUM논문집 Vol.- No.40