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      • 활성화 항원 CD30의 발현과 그 기능

        조경,허영문,남상윤 전주대학교 1999 論文集 Vol.24 No.2

        CD30 is a member of the tumour necrosis factor receptor(TNFR) superfamily, and was originally recognized on Reed-Sternberg cells of Hodgkin's disease and, subsequently, on neoplastic cells of non-Hodgkin's disease and normal activated T, B, NK cells and macrophages. Several studies on CD30 expression of malignant cells suggest that CD30 may define relevant subgroups within the main tumor or lymphoma categories. Despite many controversial reports, it is noteworthy that CD30 is expressed solely on Th2 cells but not on Th1 cells after complete differentiation, because, so far, any specific markers of Thl or Th2 cells have not been demonstrated. Expression and its maintenance of CD30 is also dependent upon IL 4 which is a pivotal cytokine for Th2 differentiation and downregulated by FNv, a Thl type cytokine. These observations implicate that CD30 may regulate Th2 cell differentiation or proliferation. At the clonal level, CD30 was revealed to promote Th2 differentiation. Various functions of CD30 from in vitro studies have been described: induction of cell proliferation, apoptosis and cytokine production, inhibition of cell cytotoxicity, enhancement of B cell growth and Ig secretion, induction of NF-KB activation and induction of HIV expression in chronically infected T cells. Although the function of CD30 in vivo is largely unknown, several exciting findings are emerging from recent studies. Mice deficient in CD30 showed a mild impairment in thymic negative selection. Recently, it has been suggested that CD30 protects the body from autoimmunity by limiting the proliferative potential of autoreactive cytotoxic T cells. Taken together, CD30 studies may provide important knowledge for elucidation of the immunopathogenesis of and development of therapeutic regimen of AIDS, autoimmunity and other Th2-related diseases.

      • KCI등재
      • KCI등재

        자연유산 경쟁구조 분석과 관리적 시사점

        조경,엄서호 국립문화재연구원 2013 헤리티지:역사와 과학 Vol.46 No.3

        The purpose of this study is to analyze college students?perception of national natural heritages, including natural monumentsand scenic sites, in comparison with the similar concepts of national parks and eco-landscape preservation areas, to suggest managerial implications to enhance competitiveness. The first objective of this study is to measure their attitude toward traveling each type of natural heritage and to rate the relative importance of the four types of heritages in terms of preservation. Natural monuments were perceived as the most strongly preserved type, while scenic sites were perceived as the least strongly preserved type. The second objective is to conduct a correspondence analysis to match the concepts of four types of natural heritages with 10 tourist attractions representing the types. It was found that college students have difficulty appropriately identifying the types of 10 tourist attractions. In addition, multi-dimensional scaling (MDS) was implemented to identify the similarities and differences of the four types of natural heritages and to produce a positioning map matching the four types of natural heritages with the six attributes representing each type as a tourist attraction. Natural monuments were perceived very differently from scenic sites and not very differently from eco-landscape preservation areas. There were a few associations between the four types of natural heritages and the six tourism attributes, implying that little effort is made to promote and position each type of natural heritage in terms of tourism. In conclusion, a public awareness program is required to enhance the brand image of natural monuments and scenic sites in comparison to national parks and eco-landscape preservation areas. In addition, local residents who live near the natural heritages should be bolstered to play a managerial role as supporters and contents providers for sustainability 본 연구는 자연유산의 미래의 수요자인 대학생들을 대상으로 천연기념물, 명승으로 대별되는 자연유산과 국·도립공원, 생태·경관보전지역과 같은 유사 개념을 얼마만큼 올바르게 인식하고 있는지를 알아보고, 보존 중요성 등 태도차원에서 각 개념 간의 경쟁구조를 분석하고자 하였다. 연구 결과, 보존의 중요도는 ‘천연기념물〉생태·경관보전지역〉국·도립공원〉명승’의 순으로 나타나 천연기념물보다는 명승을 상대적으로 덜 보존적으로 인식하고 있다는 것을 알 수 있었다. 또한 순천만, 설악산, 창녕 우포늪, 홍도, 독도, 문경새재, 한라산, 성산일출봉, 영월 고씨굴, 태안 신두리 해안사구 포함 관광명소 10개소를 대상으로 자연유산 유형을 올바르게 인식하고 있는지를 대응분석한 결과, 전반적으로 응답자들은 자연유산에 대한 개념을 바르게 인식하고 있지 않다는 것을 파악할 수 있었으며, 이러한 문제점을 해결할 수 있도록 인식제고 프로그램 마련이 필요하다. 다차원 척도법을 활용하여 자연유산 유사개념 경쟁구조(유사성)를 파악한 결과, 포지셔닝 맵에서 천연기념물과 명승이 비교적 멀리 떨어져 나타난 것을 볼 때 각기 차별화되는 방문자 관리가 요구된다. 포지셔닝 맵 상에 나타난 자연유산 유사개념 경쟁구조와 각 개념에 대한 태도를 구성하는 속성결합의 결과를 살펴보면, 자연유산을 비롯한 네 개념 모두가 뚜렷한 차이를 보이지 않은 것으로 보아 향후 차별화된 홍보전략이 필요하다. 응답자들도 자연유산을 활용보다는 보존의 대상으로 생각하는 경향이 있는 것으로 파악되며, 다양한 관리주체 때문에 천차만별인 관리 수준을 체계화할 필요가 있다고 여겨진다

      • KCI등재

        勤勞時間의 彈力的 規制

        조경 한국기업법학회 2001 企業法硏究 Vol.8 No.-

        This thesis reviews the standardization of normal working time and exceptional working time under the current Korean Labor standards Act and compares with those of foreign standards and then analyzes the problems for improvements in legislation. Trends of reduction in working time and the increasing phenomena of adopting the new system of working time such as elastic working time, flexitime are also reviewed. After studying the system of standard working time on the Korean Labor Standards Act, the author surveys the present condition, basic principles and exceptions of the standard working time system and then points out some problems of interpretation and proposes a better framework with which it could be interpreted. It investigates various theories on determination of the party concerned, in the overtime work by the mutual agreement, forms of the mutual agreement, requirement to report to the authorities and the civil effect of the mutual agreement. Then the meaning of legal overtime working system nd the rationale of obligation to work are discussed. The comparative study of various regulations on working time systems of advanced countries, especially England, France, Germany, United States of America and Japan is one of approaches of this study. The causes of changes in normal working time from 10 hours a day to 8 hours a day and 40 hours or 5 days a week are studied. In this chapter is also studied the history of the regulation of working time in Korea. Chapter Ⅳ investigates the elastic regulation of working time. First reviews it the definition and necessity of elasticity in the regulation of working time and then examines the types of the regulation of working time. First of all reviews it the definition of the elastic working time. First of all reviews it the definition of the elastic working time system and the legal problems of working time in other advanced countries, especially United States of America, Germany, France, England and Japan., this thesis reviews the introduction and the abolition of the elastic working time systems under the current Korean Labor Standards Act and then the points at issue in the elastic working time systems. This chapter investigates the necessity, legislation, definition, types, necessary condition of establishment, effectuation, introduction and legal problems of flexitime system. For the last time the final chapter deals with the interpretational problems and deficiency in the elastic regulation of working time under the current Korean Labor Standards Act and presents the author's proposals for solving the problems.

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