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張大植,吳益秀 영남이공대학 1975 論文集 Vol.4 No.-
Stress distribution in a pare frame (portal frame with side spans freely supported) is analysed by finite element method; when the results are compared with those calculated by classic Castigliano's Theorem and Slope-Deflection Method, a significant discrepancy is noted between these results in the magnitude of the former's horizontal reaction which gives a totally different stress distribution over the major portion of the frame from those given by latter methods. The discrepancy will be due to the approximate nature of the latter; however, the true extent and the explanation of such a discrepancy will deserve a further investigation.
최정미,김종길,장대식 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.4
Tardive dystonia is rare late-onset side effect of neuroleptics. This report presents a parevalence study of 1520 inpatients conduced in 4 mental sanatoriums in Pusan City and Kyung Nam province. Our criteria for diagnosing tardive dystonia(by Burke et. 1982) were 1) presence of chronic dystonia 2) history of antipsychotic drug treatment preceding or concurrent with the onset of dystonia 3) exclusion of known causes of secondary dystonia by appropriate clinical and laboratory evaluation 4) a negative family history of dystonia. Tardive dystonia was also assessed using Simpson rating scale for Tardive dyskinesia. For exclusion of other known causes of secondary dystonia, several studies(liver function test, thyroid function test, determination of serum copper & ceruloplasmin level, observation of Kayser-Fleisher ring) were performed. The results were as follows : 1) Twenty-one of the 1520 assessed patients have been suffered from manifestation of tardive dystonia(1.38%) ; sixteen of 1009 men (1.59%) and five of 511 women(0.98%). Sexual prevalence rate was not tatistically significant(χ²=0.92). 2) Eighteen patients among 347 patients less than 40 years old developed tardive dystonia (5.2%) as compared to 3 patients of 1173 over the age of 40(0.3%). This remarkable difference among young aged before 40 years old is highly significant(χ²=with Yate's correction=44.25)(p<0.001). 3) The most frequently affected site was neck(90.5%) the next, head (61.9%), trunk(33.3%) and extrimities(4.8%). 4) Five patients had concurrent tardive dyskinesia(28.5%) : head nodding, eye blinking, finger tremor, stamping movement, puckering and smacking were observed. The severity of tardive dystonia fluctuated without uniform pattern and aggravated when anxious or tense. 5) Duration of exposure to antipsychotics was varied from 3 months to 24 years(mean 5.6±1.60 years). Seventeen of 21 patients have been taken chloropromazine.
장대식,Nam Hee Yoo,Jong Min Kim,Yun Mi Lee,Jeong Lim Yoo,김영숙,Jin Sook Kim 한국생약학회 2007 Natural Product Sciences Vol.13 No.2
glycosides, rosamultin (1), tetracentronside B (2), 4-O-methylellagic acid 3-O-α-L-rhamnopyranoside (3), and vanillic acid 4-O-β-D-glucopyranoside (4), isolated from the roots extract of Potentilladiscolor, were subjected to in vitro bioassays to evaluate the inhibitory activity on advanced glycation endproducts (AGEs) formation and rat lens aldose reductase (RLAR). Compound 3 exhibited a significant inhibitory50 values of 79.5 and 8.03M, respectively. All thecompounds (1 -4) were isolated for the first time from this plant.KeywordsPotentilla discolor, Rosaceae, diabetic complications, AGEs, aldose reductase.
장대식,유남희,이윤미,유정림,김영숙,김진숙 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
Seven phenolic compounds, caffeic acid (1), 4-hydroxybenzoic acid (2), 4-methoxybenzoic acid (3), protocatechuic acid (4), eugenol O-β-D-glucopyranoside (5), 3,6-di-O-feruloylsucrose (6), and 3,5-di-O-caffeoylquinic acid methyl ester (7), were isolated from an EtOAc-soluble partition of the flowers of Erigeron annuus. The structures of 1-7 were determined by spectroscopic data interpretation, particularly 1D and 2D NMR studies, and by comparison of their data with those published in the literature. All the isolates were subjected to in vitro bioassays to evaluate their inhibitory activities against the formation of advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR). Of the compounds, 1, 6, and 7 exhibited potent inhibitory activities against the formation of AGEs. In the RLAR assay, compound 7 showed the most potent inhibitory activity.
수종의 국화과 식물에서 분리한 Sesquiterpene Lactone들의 생리활성(제3보) -Nitric oxide 방출 및 ACAT 저해활성-
장대식,박기훈,고학룡,이현선,권병목,양민석,Jang, Dae-Sik,Park, Ki-Hun,Ko, Hack-Lyong,Lee, Hyun-Sun,Kwon, Byoung-Mog,Yang, Min-Suk 한국생약학회 1999 생약학회지 Vol.30 No.1
Nine sesquiterpene lactones, which were isolated from Hemisteptia lyrata Bunge, Chrysanthemum zawadskii Herbich var. latilobum Kitamura and Chrysanthemum boreale Makino were evaluated for the inhibition upon the nitric oxide release from the Raw cell and for the ACAT (acyl Co A: cholesterol acyltransferase) inhibitory assay. In the nitric oxide release inhibitory experiment, hemistepsin B $(IC_{50}\;=\;0.05\;{\mu}g/ml,\;0.15\;{\mu}M),$ cumambrin B, tulipinolide and costunolide exhibited strong inhibition with $IC_{50}$ values $0.05\;{\mu}g/ml\;(0.15\;{\mu}M),\;0.1\;{\mu}g/ml\;(0.38\;{\mu}M),\;0.2\;{\mu}g/ml\;(0.69\;{\mu}M)$ and $0.2\;{\mu}g/ml(0.86\;{\mu}M),$ respectively. In the ACAT inhibitory assay, angeloylcumambrin B, tigloylcumambrin B, tulipinolide and costunolide exhibited strong inhibition with $IC_{50}$ values $33\;{\mu}g/ml\;(95.4\;{\mu}M),\;22\;{\mu}g/ml\;(63.6\;{\mu}M),\;38\;{\mu}g/ml\;(151\;{\mu}M)$ and $17\;{\mu}g/ml(73.3\;{\mu}M),$ respectively, whereas other compounds did not exhibit significant activity against ACAT above $100\; {\mu}g/ml.$.
A New Pancreatic Lipase Inhibitor Isolated from the Roots of Actinidia arguta
장대식,이가영,김정현,Yun Mi Lee,Jong Min Kim,김영숙,Jin Sook Kim 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
A new coumaroyl triterpene, 3-O-trans-p-coumaroyl actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1-6) were evaluated in vitro for their inhibitory activities on pancreatic lipase (PL). Of the isolates, the new compound 1 possessed the highest inhibitory activity on PL, with an IC50 of 14.95 μM, followed by ursolic acid (2, IC50 = 15.83 μM). The other four triterpenes (3-6) also showed significant PL inhibitory activity, with IC50 values ranging from 20.42 to 76.45 μM.
장대식,Yun Mi Lee,Il Ha Jeong,김진숙 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6
In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines, fifteen compounds, apigenin (1), apigenin-7-O-β-D-glucopyranoside (2), apigenin-7-O-(6''-O-acetyl)-β-D-glucopyranoside (3), luteolin (4), luteolin-7-O-β-D-glucopyranoside (5), luteolin-7-O-(6''-O-acetyl)-β-D-glucopyranoside (6), isorhamnetin-3-Oneohesperidoside (7), 4-O-caffeoylquinic acid (8), chlorogenic acid methyl ester (9), 4-O-β-Dglucopyranosylcaffeic acid (10), lobetyolin (11), cordifolioidyne C (12), isomultiflorenyl acetate (13), β-sitosterol glucoside (14), and α-spinosterol (15), were isolated from an EtOAc-soluble fraction of the flowers of Platycodon grandiflorum (balloonflower; Campanulaceae). The structures of the compounds were identified by physical and spectroscopic methods, as well as by comparison of their data with literature values. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products and rat lens aldose reductase.