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수종의 국화과 식물에서 분리한 Sesquiterpene Lactone들의 생리활성(제1보) - 암세포주에 대한 세포독성 -
장대식,박기훈,김환묵,홍동호,전효곤,고영희,양민석,Jang, Dae-Sik,Park, Ki-Hun,Kim, Hwan-Mook,Hong, Dong-Ho,Chun, Hyo-Kon,Kho, Yung-Hee,Yang, Min-Suk 한국생약학회 1998 생약학회지 Vol.29 No.3
A diverse panel of human tumor cell lines and a mouse melanoma cell line (B16-F1) were used for the cytotoxicity test of the nine sesquiterpene lactones with ${\beta}-methylene-{\gamma}-lactone$ group isolated from Hemisteptia lyrata, Chrysanthemum zawadskii and Chrysanthemum boreale. In the cell adhesion inhibitory activity test against B16-F1 mouse melanoma cell, hemistepcin B, cumambrin B, costunolide and tulipinolide were shown significant activities with $IC_{50}$ range of 2.2, 4.1, 0.9 and $0.3\;{\mu}g/ml$, respectively. In the cytotoxicity test against human tumor cells, the most active compound was costunolide having $IC_{50}$ values of below $0.3\;{\mu}g/ml$ against all the tested cell lines except for UACC62. Cumambrin A, hendelin and costunolide exhibited more strong activity against HCT15 and UO-31 cell lines than a positive control, adriamycin. All tested compounds showed an $IC_{50}$ values of below $5.0\;{\mu}g/ml$ against all the tested cell lines.
張大植,吳益秀 영남이공대학 1975 論文集 Vol.4 No.-
Stress distribution in a pare frame (portal frame with side spans freely supported) is analysed by finite element method; when the results are compared with those calculated by classic Castigliano's Theorem and Slope-Deflection Method, a significant discrepancy is noted between these results in the magnitude of the former's horizontal reaction which gives a totally different stress distribution over the major portion of the frame from those given by latter methods. The discrepancy will be due to the approximate nature of the latter; however, the true extent and the explanation of such a discrepancy will deserve a further investigation.
장대식,유남희,이윤미,유정림,김영숙,김진숙 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
Seven phenolic compounds, caffeic acid (1), 4-hydroxybenzoic acid (2), 4-methoxybenzoic acid (3), protocatechuic acid (4), eugenol O-β-D-glucopyranoside (5), 3,6-di-O-feruloylsucrose (6), and 3,5-di-O-caffeoylquinic acid methyl ester (7), were isolated from an EtOAc-soluble partition of the flowers of Erigeron annuus. The structures of 1-7 were determined by spectroscopic data interpretation, particularly 1D and 2D NMR studies, and by comparison of their data with those published in the literature. All the isolates were subjected to in vitro bioassays to evaluate their inhibitory activities against the formation of advanced glycation end products (AGEs) and rat lens aldose reductase (RLAR). Of the compounds, 1, 6, and 7 exhibited potent inhibitory activities against the formation of AGEs. In the RLAR assay, compound 7 showed the most potent inhibitory activity.
A New Pancreatic Lipase Inhibitor Isolated from the Roots of Actinidia arguta
장대식,이가영,김정현,Yun Mi Lee,Jong Min Kim,김영숙,Jin Sook Kim 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
A new coumaroyl triterpene, 3-O-trans-p-coumaroyl actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1-6) were evaluated in vitro for their inhibitory activities on pancreatic lipase (PL). Of the isolates, the new compound 1 possessed the highest inhibitory activity on PL, with an IC50 of 14.95 μM, followed by ursolic acid (2, IC50 = 15.83 μM). The other four triterpenes (3-6) also showed significant PL inhibitory activity, with IC50 values ranging from 20.42 to 76.45 μM.
수종의 국화과 식물에서 분리한 Sesquiterpene Lactone들의 생리활성(제3보) -Nitric oxide 방출 및 ACAT 저해활성-
장대식,박기훈,고학룡,이현선,권병목,양민석,Jang, Dae-Sik,Park, Ki-Hun,Ko, Hack-Lyong,Lee, Hyun-Sun,Kwon, Byoung-Mog,Yang, Min-Suk 한국생약학회 1999 생약학회지 Vol.30 No.1
Nine sesquiterpene lactones, which were isolated from Hemisteptia lyrata Bunge, Chrysanthemum zawadskii Herbich var. latilobum Kitamura and Chrysanthemum boreale Makino were evaluated for the inhibition upon the nitric oxide release from the Raw cell and for the ACAT (acyl Co A: cholesterol acyltransferase) inhibitory assay. In the nitric oxide release inhibitory experiment, hemistepsin B $(IC_{50}\;=\;0.05\;{\mu}g/ml,\;0.15\;{\mu}M),$ cumambrin B, tulipinolide and costunolide exhibited strong inhibition with $IC_{50}$ values $0.05\;{\mu}g/ml\;(0.15\;{\mu}M),\;0.1\;{\mu}g/ml\;(0.38\;{\mu}M),\;0.2\;{\mu}g/ml\;(0.69\;{\mu}M)$ and $0.2\;{\mu}g/ml(0.86\;{\mu}M),$ respectively. In the ACAT inhibitory assay, angeloylcumambrin B, tigloylcumambrin B, tulipinolide and costunolide exhibited strong inhibition with $IC_{50}$ values $33\;{\mu}g/ml\;(95.4\;{\mu}M),\;22\;{\mu}g/ml\;(63.6\;{\mu}M),\;38\;{\mu}g/ml\;(151\;{\mu}M)$ and $17\;{\mu}g/ml(73.3\;{\mu}M),$ respectively, whereas other compounds did not exhibit significant activity against ACAT above $100\; {\mu}g/ml.$.
장대식,박기훈,양민석,Jang, Dae-Sik,Park, Ki-Hun,Yang, Min-Suk 한국생약학회 1998 생약학회지 Vol.29 No.2
Two sesquiterpene lactones were isolated from the flowers of Chrysanthemum boreale Makino by the silica gel column chromatography and recrystallization. On the basis of spectrometric studies including $^1H-NMR,\;^{13}C-NMR,\;DEPT,\;^1H-^1H\;COSY,\;{13}C-^1H\;COSY$, IR and Mass, compounds 1 and 2 were identified as germacranolide, tulipinolide and costunolide, respectively. And they showed antibacterial activity against Vibrio parahaemolyticus, Bacillus subtilis, Bacillus cereus and Staphylococcus aureus. This is the first report that Chrysanthemum boreale contained tulipinolide and costunolide.
수종의 국화과 식물에서 분리한 Sesquiterpene Lactone들의 생리활성(제2보) -FPTase 저해활성-
장대식,권병목,양민석,Jang, Dae-Sik,Kwon, Byong-Mog,Yang, Min-Suk 한국생약학회 1999 생약학회지 Vol.30 No.1
Nine sesquiterpene lactones, which were isolated from Hemisteptia lyrata Bunge. Chrysanthemum zawadskii Herbich var. latilobum Kitamura and Chrysanthemum boreale Makino were evaluated for the farnesyl-protein transferase (FPTase) inhibitor, conducted by the scintillation proximity assay (SPA). The angeloylcumambrin B and tigloylcumambrin B inhibited a recombinant rat FPTase with $IC_{50}$ value of $78\;{\mu}g/ml$ $(225\;{\mu}M)$ and $90\;{\mu}g/ml$ $(260 \;{\mu}M)$, respectively.
장대식,Yun Mi Lee,Il Ha Jeong,김진숙 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6
In an ongoing project directed toward the discovery of novel treatments for diabetic complications from traditional herbal medicines, fifteen compounds, apigenin (1), apigenin-7-O-β-D-glucopyranoside (2), apigenin-7-O-(6''-O-acetyl)-β-D-glucopyranoside (3), luteolin (4), luteolin-7-O-β-D-glucopyranoside (5), luteolin-7-O-(6''-O-acetyl)-β-D-glucopyranoside (6), isorhamnetin-3-Oneohesperidoside (7), 4-O-caffeoylquinic acid (8), chlorogenic acid methyl ester (9), 4-O-β-Dglucopyranosylcaffeic acid (10), lobetyolin (11), cordifolioidyne C (12), isomultiflorenyl acetate (13), β-sitosterol glucoside (14), and α-spinosterol (15), were isolated from an EtOAc-soluble fraction of the flowers of Platycodon grandiflorum (balloonflower; Campanulaceae). The structures of the compounds were identified by physical and spectroscopic methods, as well as by comparison of their data with literature values. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products and rat lens aldose reductase.