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간(肝)디스토마증(症) 치료약투여후(治療藥投與後) 간장(肝臟) 변화(變化)에 관(關)한 실험적(實驗的) 연구(硏究)
강신완,Kang, Shin-Wan 대한약리학회 1966 대한약리학잡지 Vol.2 No.2
An experimental study was done on rabbits to observe the effects of several anticlonorchial drugs on the pathology of the liver infested with Clonorchis sinensis. After two months of infestation with Clonorchis sinensis by giving $400{\sim}500$ metacercariae by mouth, hexachlorophene, chloroquine 2,2' methylenebis (3,4,6 trichlorophenoxy acetic acid) and Hetol were administered orally and follow up macro-and microscopic studies of the liver pathology were done in 2 to 3 days, one month, 2 months and 3 months after the completion of medications. The results obtained in this study are as follows: 1. In both groups which were administered hexachlorophene piperazine 20mg/kg for seven days or 8mg/kg for 18 days, the macroscopic findings of the liver after 3 months revealed only minimal changes of the color and consistency The histopathological findings were the reduction of fibrosis, pseudolobulation, proliferation and adenomatous hyperplasia of bile ducts, and regeneration of liver parenchyma. 2. In groups which were administered chloroquine phosphate 20mg/kg for 18 days or 40mg/kg for 5 days, and also in groups which were administered dithiazanine iodide 30mg/kg for 18 days or 60mg/kg for 5 days, no significant findings of recovery were observed either macroscopically or microscopically. 3. In the group which was given 20mg/kg of 2,2' methylenebis(3,4,6 trichlorophenoxy acetic acid) for 5 days, prominent healing of the damaged tissues was observed after 2 months, revealing the decrease of fibrous tissue, caliber of bile ducts and adenomatous hyperplasia of the epitherial cells of the bile ducts, and regenerationof liver parenchyma. 4. In the group which was given Hetol 200mg/kg for 5 days, swelling, congestion and eddish-brown discoloration of the liver were noted macroscopically after 3 days of completion of drug administration. Hemorrhage, congestion, necrosis and degeneration of the parenchyma were observed microscopically After 10 days, liver appeared almost normal macroscopically, but marked fat degeneration was noted microscopically. After 2 months, the liver was almost normal in gross appearence with only slight atrophy and also marked healing was observed microscopically, i. e. decrease of fibrous tissue and reduction of the previously enlarged bile duct and the regeneration of the liver parenchyma.
Trichlorophenoxy alkylene ammonium 유도체(誘導體)의 합성(合成) 및 살균작용(殺菌作用)에 관(關)한 연구(硏究)
강신완,차충석,윤희정,김화웅,김중영,이대수,Kang, Shin-Wang,Cha, Choong-Suk,Yun, Hea-Chung,Kim, Hwa-Woong,Kim, Chung-Yung,Lee, Dae-Soo 대한약리학회 1966 대한약리학잡지 Vol.2 No.2
The bacteriostatic action of trichlorophenoxy alkylene ammonium derivatives, 2(2,4,5-trichlorophenoxy) ethylene N-triethyl ammonium bromide; (2,4,5-TETB), 2(2,4,6-trichlorophenoxy) ethylene N-triethyl ammonium bromide; (2,4,6-TETB), 2,4,5-triphenoxy ethylene pyridinium bromide; (2,4,5-TEPB), and 2,4,6-trichlorophenoxy ethylene pyridinium bromide:(2,4,6-TEPB) were observed by Jackson and Finland's and Finland's and Pak's on Staphylococcus aureus, E. coli, Salmonella typhi, Shigella flexneri, and Bacillus subtilis, comparing with those of phenol and trichlorophenol. The following results were obtained. 1) Phenol is bacteriostatic in a concentration of $10^{-3}$ for all above species. 2) Trichlorophenol is bacteriostatic in concentration of $10^{-4}$ to $5{\times}10^{-5}$ for all above species(Table 7), 3) 2,4,5-TETB and 2,4,6-TETB are bacteriostatic in a concentration of $10^{-4}$ and $5{\times}10^{-5}$ for Staphylococcus aureus, Salmonella typhi, and Shigella flexneri, but do not for E. coli and Bacillus subtilis(Table 8 and 9). 4) 2,4,5-TEPB and 2,4,6-TEPB are bacteriostatic in a concentrationof $10^{-4}$ and $5{\times}10^{-5}$ only for Staphylococcus aureus among four species(Table 10 and 11).
Hexachlorophene 유도체(遺導體)의 간(肝)디스토마증(症) 치료작용(治療作用)에 관(關)한 연구(硏究) (제 2 보)(第 2 報)
김화웅,차충석,강신완,김중영,Kim, Hwa-Woong,Cha, Choong-Suk,Kang, Shin-Wan,Kim, Chung-Yung 대한약리학회 1966 대한약리학잡지 Vol.2 No.2
The experimental rabbits were infested with 300 of metacercariae of Clonorchis sinensis. The therapeutic effects of following 6 kinds of hexachlorophene derivatives on infected rabbits were compared with those of hexachlorophene and 2,2-methylenebis (3,4,6-trichlorophenoxy acetic acid) (MTPA). The drugs were medicated by mouth for 7 days after infection of 40 days, and the following results were obtained. 1) The therapeutic effects of following four hexachlorophene derivatives are less potant than those of hexachlorophene and MTPA. 2) Among hexachlorophene derivatives, 2,2-methylenebis (3,4,6-trichlorophenoxy benzoylate) and 2,2-methylenebis (3,4,6-trichlorophenoxy ${\beta}-ethly$ alcohol) are more effective than 1,1-dihydroxy ethyl ether, 2,2-methylenebis (3,4,6-trichlorobenzene) (Table 1).
Bis(trichlorophenoxy) ethane(BTPE)의 合成 및 殺蟲效力에 關한 硏究 1
金鍾石,金和雄,金明燁,姜信完,李大秀,李義淳 한국응용곤충학회 1965 한국응용곤충학회지 Vol.4 No.-
이화명충에 대한 수도의 저항성 요인과 척도를 구명하기 위하여 여러 가지 품종에 접종 및 방사를 하였으며 그 영향에 따라 도체의 주요성분을 분석한 바 아래와 같은 결과를 얻었다. (1) 수도품종간에 이화명충의 유충 생육이 현저하게 큰 차를 나타내었다. 품종에 따른 체중증가량에 있어서도 부화 후 25일에 유충의 체중은 최고 45.77mg, 최저 21.23mg였는데 대체로 Indica type은 Japonica type 보다 유충체중의 증가가 컸다. (2) 수도품종에 있어서 여러 가지 저항성요소중 상관관계를 보면 유충의 생존율은 ㅊ중증가, 분화, 피해경율 및 산란선택성들과 정의 상관을 나타내었다. 따라서 유층의 생존율은 이화명충에 대한 도체의 저항성요소의 척도로 이용될 수 있다고 생각되었다. (3) 저항성 및 감수성 품종의 화학적 분석 결과에 의하면 몇몇 저항성요소와 질소함량간에는 정, 그리고 규산의 함량과는 부의 상관을 나타내었으며 특히 유충의 추성에는 질소, 천공성에는 규산의 함량이 관련됨을 알 수 있었고 탄소의 함량과는 유의한 상관을 나타나지 않았다. (4) 유충의 추성 및 천공성도 저항성 척도인 생존율과 정의 상관을 나타내었으므로 저항성은 여러 가지 요소들의 복합적인 작용으로 나타난다고 생각되었다. The study was initiated to investigate the nature of varietal resistance to the rice stem borer (Chilo suppressalis WALKER), specially the rotation of the resistance to the silica and nitrogen content of the host Plants. 1. The body freight of the larvae, reared on the stem of the various varieties of rice plants, when weighed at the age of 25 days old, showed great variation, and ranged from 21.24 mgrs. to 45.77 mgrs. depending on the used varieties of tile rice plants. And generally the varieties of Indica types were showed greater body weight than that of Japonica types in this experiments. 2. The positive correlation coefficients of percent survivals to body weight, developement, oviposition preference and rate of damage to host plants were significant, and consequently the percent survival could be used as a criteria of resistance. 3. The content of silica in the host plants was significantly correlated with both the degree of boring on the leaf and attractovemess of larvae, and the total nitrogen content of plants showed significant positive correlation coefficient with larval attractivenes, but not significant with the degree of boring on the leaf. 4. Since the attractiveness and boring manner were significantyly correlated to resistance criteria of rice plant to the pest, it could be considered that the resistance is the results of chain reaction of the factors mentioned above
2.2 -Methylene bis (3.4.6 Trichlorophenoxy Acetic acid)의 肝디스토마 治療效果에 關한 實驗的 硏究
金鍾石,金兌洙,安志烈,姜信完,허근 慶北大學校 醫科大學 1966 慶北醫大誌 Vol.7 No.2
In order to obtain a therapeutic agents which have larger therapeutic index than hexachlorophene on the Clonorchiasis, 2,2'-methylene bis (3,4,6 trichlorophenoxy acetic acid) (MTPA) was synthesized from hexachlorophene, and its therapeutic effects were compared with those of hexachlorophene, 2,2'-methylene bis (3,4,6 trichlorophenoxy sulfonic acid) (MTPS) and 2,2'-methylene bis (3,4,6 trichlorophnoxy methylate) (MTPS) on clonorchis sinensis in vitro and on infected rabbits. The results were as follows. 1) The parasiticidal effect of MTPA in vitro was less than that of hexachlorophene and HCPP while more effective than that of MTPS and MTPM (Table 2). 2) Rabbits were medicated with MTPA, daily dose of 5㎎/㎏, 10㎎/㎏, 15㎎/㎏, and 20㎎/㎏ for 5 days respectively. 5㎎/㎏ appeared to be a little effect while from 10㎎/㎏ were remarkable. (Table 3). 3) The effect of hexachlorophene, HCPP, MTPA, MTPS and MTPM were compared each other with dose of 5㎎/㎏, 10㎎/㎏, 20㎎/㎏ and 50㎎/㎏ for 10 days respectively. The effect of hexachlorophene, HCPP and MTPA was almost the same and they were more effective than that of MTPS and MTPM. (Table 4).