Ethylenediaminetetraacetic Acid Disodium (EDTA)의 尿量 및 尿中電解質에 미치는 影響

金和雄 慶北大學校 醫科大學 1968 慶北醫大誌 Vol.9 No.1

Under the infusion of physiological saline solution containing 0,2% inulin(Inulin-Saline) into the femoral vein, EDTA, a chelating agent, and Lasix (Furosemide), a saluretic agent, were added to the solution and the glomerular filtration rate (GFR) and changes on urinary outflow and electrolytes were observed. Experimental animals were divided into five groups: control; infused with solution of Inulin-Saline-EDTA; of Inulin-Saline+EDTA; of Inulin-Salin+Lasix; and of Inulin-Saline-EDTA+Lasix. The results were as follows: 1. There were no significant changes in urinary outflow and GFR between the groups of Inulin-Saline and Inulin-Saline+EDTA. In Inulin-Saline+EDTA groups, however, urinary sodium, potassium and calcium were considerably increased but chloride was not. 2. The rate of increase in the urinary sodium and potassum were lowered in Inulin-Saline+EDTA group, while calcium was more prominant compared with Inulin-Saline+Lasix group. 3. When EDTA was combined with Lasix, urinary excretion of potassium, calcium were additive and sodium was potentiative.

Diphenylhydantoin의 家兎摘出心房에 對한 作用

金和雄,姜鎬均,孫重鎬 慶北大學校 醫科大學 1970 慶北醫大雜誌 Vol.11 No.2

Diphenylhydantoin의 家兎摘出心房에 對한 作用

金和雄,姜鎬均,孫重鎬 慶北大學校 醫科大學 1970 慶北醫大誌 Vol.11 No.2

Efects of diphenylhydantoin and diphenylhydantoin with dichloroisoproterenol, propranolol, histamine or epinephrine on isolated atrium of rabbit were studied respectively. Atrium of rabbit weighing about 2㎏ body weight were isolated. Contraction of spontaneously beating atrium in 29℃ of oxygenated Ringer-Locke solution were recorded on kymograph and above drugs were added in these solution respectively. The results obtained in this study were as follows: 1. In 2×10 exp(-5)gm/ml of diphenylhydantoin and 5×10 exp(-5)gm/ml of propranolol, the amplitude and the rate of contraction of atrium were inhibited, and inhibitory effects of both drugs on the atrium were additive. 2. Diphenylhydantoin inhibit the positive inotropic effect of dichloroisoproterenol and in their high concention, the inhibitory effects of both drugs were additive. 3. Histamine and epinephrine antagonized the inhibitory effect of diphenylhydantoin.

Hexachlorophene 유도체(遺導體)의 간(肝)디스토마증(症) 치료작용(治療作用)에 관(關)한 연구(硏究) (제 2 보)(第 2 報)

김화웅,차충석,강신완,김중영,Kim, Hwa-Woong,Cha, Choong-Suk,Kang, Shin-Wan,Kim, Chung-Yung 대한약리학회 1966 대한약리학잡지 Vol.2 No.2

The experimental rabbits were infested with 300 of metacercariae of Clonorchis sinensis. The therapeutic effects of following 6 kinds of hexachlorophene derivatives on infected rabbits were compared with those of hexachlorophene and 2,2-methylenebis (3,4,6-trichlorophenoxy acetic acid) (MTPA). The drugs were medicated by mouth for 7 days after infection of 40 days, and the following results were obtained. 1) The therapeutic effects of following four hexachlorophene derivatives are less potant than those of hexachlorophene and MTPA. 2) Among hexachlorophene derivatives, 2,2-methylenebis (3,4,6-trichlorophenoxy benzoylate) and 2,2-methylenebis (3,4,6-trichlorophenoxy ${\beta}-ethly$ alcohol) are more effective than 1,1-dihydroxy ethyl ether, 2,2-methylenebis (3,4,6-trichlorobenzene) (Table 1).

Ethylenediamineteraacetic Acid Disodium(EDTA)의 尿量 및 尿中電解質에 미치는 影響

金和雄 慶北大學校 醫科大學 1968 慶北醫大雜誌 Vol.9 No.1

배양액(培養液)의 성분(成分) 및 배양시간(培養時間)의 변화(變化)에 따른 간흡충(肝吸䖝)의 산소소비(酸素消費)에 미치는 영향(影響)

김화웅(Kim, Hwa-Woong),최형곤(Choi, Hyung-Kon),윤병오(Yun, Byung-Oh),하영호(Ha, Young-Ho) 대한약리학회 1969 대한약리학잡지 Vol.5 No.1

Oxygen consumption by Clonorchis sinensis (C.S.) was observed in a medium of valuable pH of KRP, lack of certain electrolytes of KRP and of glucose, acetic acid or propionic acid was added to KRP. The results were as follows. 1. In a different solutions, KRP with or without 0.4%-glucose, 0.9%-saline solution, the variation of oxygen consumption by C.S. was not significant. 2. Oxygen consumption by C.S. was inhibited by the solution of KCI, CaCl₂, or MgSO₄ in a 0.9% solution of saline. 3. Under the acidity, oxygen consumption was enhanced but under the alkality, it was inhibited. 4. Oxygen consumption by C.S. was inhibited by acetic acid or propionic acid in KRP solution. 5. C.S. keeping in KRP solution for a long duration, oxygen cosumption was reduced in the course of time.

2, 2 Methylene bis (3,4,6 trichlorophenoxy Acetic Acid) 및 Sodium Cholate의 간흡충(肝吸䖝) 산소소비(酸素消費) 및 살충작용(殺䖝作用)

김화웅(Kim, Hwa-Woong),김중영(Kim, Choong-Young),윤병오(Yun, Byung-Oh),하영호(Ha, Young-Ho) 대한약리학회 1969 대한약리학잡지 Vol.5 No.1

The inhibitory action of oxygen consumption and parasiticidal action of hexachlorophene or MTPA combined with or without sodium cholate in Clonorchis sinensis (C.S) have been observed. The results were obtained as follows. 1. In low concentration of MTPA or Hexachlorophene, they inhibited the oxygen consumption of C.S and in high concentration, inhibition of oxygen consumption and parasiticidal action was more remarkable. 2. The oxygen consumption was inhibited also in the concentration of 10^-2 and 2 X 10^-3g/ml of sodium cholate. 3. In the presence of sodium cholate, oxygen consumption of C.S was more remarkably inhibited by MTPA or Hexachlorophene than the absence of sodium cholate. 4. From those results, it may be considered that sodium cholate combined with MTPA or Hexachlorophene produced potentiation in its action.

Bis(trichlorophenoxy) ethane(BTPE)의 合成 및 殺蟲效力에 關한 硏究 1

金鍾石,金和雄,金明燁,姜信完,李大秀,李義淳 한국응용곤충학회 1965 한국응용곤충학회지 Vol.4 No.-

이화명충에 대한 수도의 저항성 요인과 척도를 구명하기 위하여 여러 가지 품종에 접종 및 방사를 하였으며 그 영향에 따라 도체의 주요성분을 분석한 바 아래와 같은 결과를 얻었다. (1) 수도품종간에 이화명충의 유충 생육이 현저하게 큰 차를 나타내었다. 품종에 따른 체중증가량에 있어서도 부화 후 25일에 유충의 체중은 최고 45.77mg, 최저 21.23mg였는데 대체로 Indica type은 Japonica type 보다 유충체중의 증가가 컸다. (2) 수도품종에 있어서 여러 가지 저항성요소중 상관관계를 보면 유충의 생존율은 ㅊ중증가, 분화, 피해경율 및 산란선택성들과 정의 상관을 나타내었다. 따라서 유층의 생존율은 이화명충에 대한 도체의 저항성요소의 척도로 이용될 수 있다고 생각되었다. (3) 저항성 및 감수성 품종의 화학적 분석 결과에 의하면 몇몇 저항성요소와 질소함량간에는 정, 그리고 규산의 함량과는 부의 상관을 나타내었으며 특히 유충의 추성에는 질소, 천공성에는 규산의 함량이 관련됨을 알 수 있었고 탄소의 함량과는 유의한 상관을 나타나지 않았다. (4) 유충의 추성 및 천공성도 저항성 척도인 생존율과 정의 상관을 나타내었으므로 저항성은 여러 가지 요소들의 복합적인 작용으로 나타난다고 생각되었다. The study was initiated to investigate the nature of varietal resistance to the rice stem borer (Chilo suppressalis WALKER), specially the rotation of the resistance to the silica and nitrogen content of the host Plants. 1. The body freight of the larvae, reared on the stem of the various varieties of rice plants, when weighed at the age of 25 days old, showed great variation, and ranged from 21.24 mgrs. to 45.77 mgrs. depending on the used varieties of tile rice plants. And generally the varieties of Indica types were showed greater body weight than that of Japonica types in this experiments. 2. The positive correlation coefficients of percent survivals to body weight, developement, oviposition preference and rate of damage to host plants were significant, and consequently the percent survival could be used as a criteria of resistance. 3. The content of silica in the host plants was significantly correlated with both the degree of boring on the leaf and attractovemess of larvae, and the total nitrogen content of plants showed significant positive correlation coefficient with larval attractivenes, but not significant with the degree of boring on the leaf. 4. Since the attractiveness and boring manner were significantyly correlated to resistance criteria of rice plant to the pest, it could be considered that the resistance is the results of chain reaction of the factors mentioned above

2, 2'-Methylene-bis-(3,4,6,-trichlorophenoxy acetic acid)(MTPA)의 肝디스토마症의 治療效果(第一報)

金鍾石,金和雄,金重暎 慶北大學校 醫科大學 1972 慶北醫大誌 Vol.13 No.2

The effect of MTPA was observed in 173 clonorchiasis patients who visited to the department of pharmacology, Kyungpook national university, school of medicine, from Sep., 1969 to Jun,, 1971 and 20, Mar. , 1972. In 173 patients, 162 patients had normal liver function, 10 patients were complicated with acute hepatitis and one of the patients had been inserted T tube into his common bile duct since 7 months after operation for bile stone. MTPA was administered oraly in daily dose of 7∼15㎎/㎏, which was divided into three equal part and given after each meal. To each patient the drug was given for 4 or 5 cures and one cure was composed of 6 days of drug administration and the interval between each cure was 10 days. The effect of drug was estimated with counting the number of eggs of clonorchis in the feces by the MGL method, the results were expressed as "negative", completly disappeared, and "80% diminution", number of the eggs reduced more than 80% than before treatment. Besides egg count, general symptoms and liver function before and after medication, and side effects induced by drug were also observed. The results obtained as follows. 1) In 51 patients treated with 10㎎/Kg/day for 4 or 5 cures, egg-negative rate was 49% and 80% diminution was 37%. 2) In 31 patients treated with 7 ㎎/Kg/day for first cure and than 15㎎/Kg/day for 3 or 4 cures, egg-negative rate was 58.1% and 80% diminution was 35.5%. 3) In 80 patients given in dose of 10㎎/Kg/day for first cure and then 15㎎/Kg/day for 3 cures or 15㎎/Kg/day for 4 cures, the egg-negative rate were 64.7%, and 69.5% and 80% diminution rate were 29.4%, and 23.9% respectively. 4) In the patients administered with MTPA, the gerneral symptoms and signs such as fatigue, anoraxia, indigestion etc. and hepatomegaly were improved. 5) In 10 patients complicated with acute hepatitis and administered with 3㎎/Kg/day for first cure and continued by 7㎎/Kg/day second cure and then 15㎎/Kg/day for 3 cures, 7 of them were egg-negative, 2 of them were 80% diminution. 6) Side effects induced by drug were gastric pain, abdominal pain, diarrhea, dizziness, headache, fatigue and fever, But the side effects were so mild that discontinuance of administration of drug was not necessary in most cases. 7) In the patient inserted with T tube while administered with 7㎎/Kg/day of MTPA, clonorchis sinensis flew out from the T tube in living, but with 15㎎/Kg/day, clonorchis sinensis flew out in dead. From above results we think that MTPA is a useful drug for treatment of clonorchiais, and 15㎎/Kg/day is enough to kill clonorchis sinensis in the body.

2,2'-Methylene-bis-(3,4,6-trichlorophenoxyacetic acid) (MTPA)의 肝디스토마症의 治療效果 : 弟一報 No.Ⅰ

金鍾石,金和雄,金重暎 慶北大學校 醫科大學 1972 慶北醫大雜誌 Vol.13 No.2