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Genome and chromosome wide association studies for growth traits in Simmental and Simbrah cattle
Calderón-Chagoya René,Vega-Murillo Vicente Eliezer,García-Ruiz Adriana,Ríos-Utrera Ángel,Martínez-Velázquez Guillermo,Montaño-Bermúdez Moisés 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.1
Objective: The objective of this study was to perform genome (genome wide association studies [GWAS]) and chromosome (CWAS) wide association analyses to identify single nucleotide polymorphisms (SNPs) associated with growth traits in registered Simmental and Simbrah cattle. Methods: The phenotypes were deregressed BLUP EBVs for birth weight, weaning weight direct, weaning weight maternal, and yearling weight. The genotyping was performed with the GGP Bovine 150k chip. After the quality control analysis, 105,129 autosomal SNP from 967 animals (473 Simmental and 494 Simbrah) were used to carry out genotype association tests. The two association analyses were performed per breed and using combined information of the two breeds. The SNP associated with growth traits were mapped to their corresponding genes at 100 kb on either side. Results: A difference in magnitude of posterior probabilities was found across breeds between genome and chromosome wide association analyses. A total of 110, 143, and 302 SNP were associated with GWAS and CWAS for growth traits in the Simmental-, Simbrahand joint -data analyses, respectively. It stands out from the enrichment analysis of the pathways for RNA polymerase (POLR2G, POLR3E) and GABAergic synapse (GABRR1, GABRR3) for Simmental cattle and p53 signaling pathway (BID, SERPINB5) for Simbrah cattle. Conclusion: Only 6,265% of the markers associated with growth traits were found using CWAS and GWAS. The associated markers using the CWAS analysis, which were not associated using the GWAS, represents information that due to the model and priors was not associated with the traits.
Expression of heat shock protein genes in Simmental cattle exposed to heat stress
Guzmán Luis Felipe,Martínez-Velázquez Guillermo,Villaseñor-González Fernando,Vega-Murillo Vicente Eliezer,Palacios-Fránquez José Antonio,Ríos-Utrera Ángel,Montaño-Bermúdez Moisés 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.5
Objective: In tropical, subtropical and arid zones, heat stress is the main cause of productivity reduction in cattle. When climate stressors occur, animals become thermal adapted through differential expression of some genes, including heat shock proteins (HSP) family. The aim of this study was to determine levels of expression of HSP60, HSP70, and HSP90 genes in Simmental cattle raised in tropical environments of Mexico. Methods: In this study, expression of HSP60, HSP70, and HSP90 genes was analyzed in 116 Simmental cattle from three farms with tropical climate located in western Mexico. Animals were sampled twice a day, in the morning and noon. Gene expression was evaluated by quantitative polymerase chain reaction using probes marked with fluorescence. The MIXED procedure of SAS with repeated measures was used for all statistical analysis. Results: HSP60 gene expression differences were found for sex (p = 0.0349). HSP70 gene differences were detected for sampling hour (p = 0.0042), farm (p<0.0001), sex (p = 0.0476), and the interaction sampling hour×farm (p = 0.0002). Gene expression differences for HSP90 were observed for farm (p<0.0001) and year (p = 0.0521). HSP70 gene showed to be a better marker of heat stress than HSP60 and HSP90 genes. Conclusion: Expression of HSP70 gene in Simmental herds of the tropical region of western México was different during early morning and noon, but the expression of the HSP60 and HSP90 genes was similar. Identification of resilient animals to heat stress will be useful in the genetic improvement of the Simmental breed.
Current status and prospects of automatic sleep stages scoring: Review
Maksym Gaiduk,Ángel Serrano Alarcón,Ralf Seepold,Natividad Martínez Madrid 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.3
The scoring of sleep stages is one of the essential tasks in sleep analysis. Since a manual procedure requires considerable human and financial resources, and incorporates some subjectivity, an automated approach could result in several advantages. There have been many developments in this area, and in order to provide a comprehensive overview, it is essential to review relevant recent works and summarise the characteristics of the approaches, which is the main aim of this article. To achieve it, we examined articles published between 2018 and 2022 that dealt with the automated scoring of sleep stages. In the final selection for in-depth analysis, 125 articles were included after reviewing a total of 515 publications. The results revealed that automatic scoring demonstrates good quality (with Cohen's kappa up to over 0.80 and accuracy up to over 90%) in analysing EEG/EEG + EOG + EMG signals. At the same time, it should be noted that there has been no breakthrough in the quality of results using these signals in recent years. Systems involving other signals that could potentially be acquired more conveniently for the user (e.g. respiratory, cardiac or movement signals) remain more challenging in the implementation with a high level of reliability but have considerable innovation capability. In general, automatic sleep stage scoring has excellent potential to assist medical professionals while providing an objective assessment.
Juan I. del Río,Eduardo Pérez,David León,Ángel Martín,María D. Bermejo 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.97 No.-
The catalytic conversion of CO2 captured in aqueous media into formate was studied using aluminum-sourced hydrogenin a batch reaction system. To do so, themain ammonia-basedCO2absorption derivatives:ammoniumcarbamate,carbonate and bicarbonateandsodiumbicarbonatewere selectedasCO2source.Theperformance of the different species was determined under mild hydrothermal reaction conditions (120 C),using Pd/C 5 wt% catalyst. In these conditions, the formate yield and selectivity increase in the orderammonium bicarbonate < sodium bicarbonate < ammonium carbonate < ammonium carbamate. Ammo-nium bicarbonate and sodium bicarbonate reagents needed higher temperature (250 C) for an increasedyield. Results with ammonium carbamate as starting material indicate a significant effect of time andcatalyst content on formate yield, which ranged between 4 and 38%. Experiments with gaseous H2 showedthat a comparable yield with Al can be obtained at a similar level of pressure. The reutilization andcharacterization of the reaction solid, comprising exhausted aluminum and Pd/C catalyst, showed that thealuminum was not completely oxidized up to the 5th re-use, and Pd can play a reducing role through theformation of palladium hydride species. The process can be improved by operating at higher pressure andlower temperature, to avoid loss of yield by dehydration of formate.
Electrocatalytic reduction of CO2 with N/B co-doped reduced graphene oxide based catalysts
María Isabel Cerrillo,Carlos Jiménez,Miguel Ángel Ortiz,Rafael Camarillo,Jesusa Rincón,Fabiola Martínez 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-
Metal based materials are frequently used in electrocatalytic processes for the mitigation ofCO2 emissions, increasing the cost of the technology and the toxicity of the material. Metal-free catalystsappear as an interesting alternative. This work focusses on the synthesis of nitrogen and boron dopedreduced graphene oxide (rGO) for the electrocatalytic reduction of CO2 in gas phase in continuous operationmode in a PEM type cell. The main reaction products observed have been formic acid and CO, beingthe first one mainly formed. Results obtained with rGONB have been compared with the undoped rGOand with copper-based catalysts (Cu/rGO and Cu/rGONB). The non-metal doped material (rGONB) ismuch more active in the CO2 electrocatalytic reduction as compared with the undoped material (rGO). The catalytic activity of rGONB is very similar to those obtained with Cu/rGO and Cu/rGONB catalysts,pointing out rGONB as a very promising material for the electrocatalytic reduction of CO2. This is especiallyrelevant considering that rGONB has been tested in a relatively high geometric area (comparedwith most works in literature), in gas phase and in continuous operation mode, which is an importantstep to carry out the further scale-up of the process for industrial applications.
David Moro-Valdezate,Salvador Peiró,Elvira Buch-Villa,Antonio Caballero-Gárate,M. Dolores Morales-Monsalve,Ángel Martínez-Agulló,Félix Checa-Ayet,Joaquín Ortega-Serrano 한국유방암학회 2013 Journal of breast cancer Vol.16 No.1
Purpose: The objective of this study was to describe the evolution of health-related quality of life (HRQOL) in a cohort of breast cancer patients over 1 year after surgery and to analyse the predictive ability of HRQOL measurement instruments. Methods: Observational, multicenter and prospective study of a cohort of breast cancer patients, assessing HRQOL at 1, 6, and 12 months after surgery using three questionnaires: EuroQol-5D-3L, EORTC QLQ-C30, and EORTC QLQ-BR23. Results: A total of 364 women participated in the study. Visual Analogue Scale (VAS) scores from the EuroQol improved (1 month vs. 1 year: 70 vs. 80; p<0.0001); however, the EuroQol score showed no significant change (0.81 vs. 0.83; p=0.1323). In contrast, Global Health Status on the EORTC QLQ-C30 improved (66.67 vs. 100.00; p<0.0001), as did all of this instrument´s scales and most of its independent items. The EORTC QLQ-BR23 dimensions showed improvement, except for sexual functioning (100.00 vs. 86.67; p=0.0030) and future perspective (33.33 vs. 66.67; p<0.0001). Patients with good HRQOL outcomes at 1 month showed improved levels of HRQOL at 1 year; HRQOL measured at 1 month was predictive of HRQOL at 1 year. Conclusion: HRQOL improved during the follow-up period. Likewise, HRQOL measurement instruments can predict early HRQOL.
Guaranteed GNSS-based Road Charging Applications through User-Level Integrity
Audrey Mark,Joaquí,n Cosmen Schortmann,Miguel Á,ngel Martí,nez Olagü,e,Miguel Romay Merino 한국항해항만학회 2006 한국항해항만학회 학술대회논문집 Vol.2 No.-
Integrity plays a fundamental role in the feasibility of “liability critical” applications. Road charging, e.g. road tolling in urban zones or on highways, represents a series of liability critical applications where a guarantee in integrity could be a true enabler: being the mechanism that prevents the incorrect charging of users and enabling the advancement of these applications using GNSS such as Galileo and EGNOS that provide integrity mechanisms. However, the integrity of the end user position is not guaranteed by the EGNOS and Galileo integrity services alone as provided. Algorithms have been developed to supply a guarantee on the performance attainable at the user level through the provision of a horizontal protection level that responds to local user conditions such as multipath or interference. In addition, an application has been developed that implements road charging mechanisms based on the availability of user-level integrity. Results obtained show that the user-level integrity algorithms provided the required level of integrity guarantee and granularity of the horizontal protection levels necessary for executing urban and rural (highway) road charging. In addition, the road charging application developed shows that the current application domain requirements can be met through the provision of guaranteed integrity and that further reductions in the horizontal protection levels along with increased signal availability will enable future road charging modalities.