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Li, Qian,Kim, Minjeong,Liu, Ying,Yoo, ChangKyoo Elsevier 2018 Science of the Total Environment Vol.618 No.-
<P><B>Abstract</B></P> <P>Traffic-related pollution released a large amount of atmospheric polycyclic aromatic hydrocarbons (PAHs) which have severely influenced environmental safety and human health until now. However, the important issue of polycyclic aromatic hydrocarbon (PAH) emission from vehicle exhaust in urban populated areas has not been sufficiently investigated yet. This study focused on environmental behavior of vehicle exhaust PAHs (VEPAHs) and resultant health risk on local residents in urban populated areas. This study combined the multimedia fugacity models (Level III and Level IV) and the incremental lifetime cancer risk (ILCR) model, for analyzing the VEPAHs' environmental fate and related health risk on local residents in Zhengzhou of the central China. Regression models were applied to explore correlation between atmospheric concentration of VEPAHs and local pulmonary disease mortality rate. Our results demonstrate that the majority of VEPAH was sunk into the soil compartment in 2013, but the calculated BaP-equivalent concentrations of total VEPAHs in the air compartment exceeded the annual average standard limit of China (1ng/m<SUP>3</SUP>) yet. The human exposure routes of VEPAHs caused cancer risk in the following order: inhalation>dermal contact>ingestion.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PAH emissions from vehicle exhaust are evaluated using multimedia models. </LI> <LI> The ILCR model was used to evaluate the cancer risk for residents of Zhengzhou, China. </LI> <LI> Dynamic fugacity model and ILCR models elucidated the health problems of residents. </LI> <LI> Health effects are estimated for increased concentrations of VEPAHs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Ji Sun,Kim, Jang Hoon,Han, Yoo Kyong,Ma, Jin Yeul,Kim, Young Ho,Li, Wei,Yang, Seo Young Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.120 No.2
<P><B>Abstract</B></P> <P>Six diarylheptanoids (<B>1</B>–<B>6</B>) and two flavonoids (<B>7</B> and <B>8</B>) derived from <I>Alpinia officinarum</I> were evaluated for their ability to inhibit acetylcholinesterase. Compound <B>1</B> showed the highest degree of inhibition, with an IC<SUB>50</SUB> of approximately 2 μM, followed by moderate degrees of inhibition by <B>2</B>, <B>4</B> and <B>7</B>, with IC<SUB>50</SUB> values ranging from 20 to 40 μM. The remaining isolated compounds <B>3</B>, <B>5</B>, <B>6</B> and <B>8</B> had IC<SUB>50</SUB> values greater than 50 μM. Enzyme kinetic studies showed that the compounds with high or moderate activity were competitive inhibitors, anchored to the active site of acetylcholinesterase. In particular, compounds <B>1</B> and <B>2</B> were docked at slightly different positions from those occupied by <B>4</B> and <B>7</B>. Furthermore, molecular dynamics studies showed that compound <B>1</B> maintained its interactions with residues Thr74 and Phe295 throughout the simulation trajectory. Our findings suggest that compound <B>1</B> is a potential therapeutically relevant inhibitor of acetylcholinesterase.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Six diarylheptanoids (<B>1</B>–<B>6</B>) and two flavonoids (<B>7</B> and <B>8</B>) were isolated from <I>Alpinia officinarum</I>. </LI> <LI> Compound <B>1</B> showed acetylcholinesterase inhibitory activity with IC<SUB>50</SUB> value of approximately 2 μM. </LI> <LI> Compounds <B>1</B>, <B>2</B>, <B>4</B>, and <B>7</B> inhibited the catalytic reaction of acetylcholinesterase as competitive mode. </LI> <LI> Computational simulation study suggested the predicted binding position of the compound <B>1</B> with catalytic site of receptor. </LI> </UL> </P>
Kim, Dae Won,Hwang, In Koo,Lim, Soon Sung,Yoo, Ki-Yeon,Li, Hua,Kim, Young Sup,Kwon, Dae Young,Moon, Won Kuk,Kim, Dong-Woo,Won, Moo-Ho John Wiley Sons, Ltd. 2009 Phytotherapy research Vol.23 No.7
<P>Thee present study analysed the quantification of rutin in raw buckwheat extract (RBE) and germinated buckwheat extract (GBE) by high performance liquid chromatography (HPLC), and examined changes in body weight, systolic blood pressure (SBP) and nitrotyrosine (a marker for peroxynitrite formation) immunoreactivity in aortic endothelial cells in spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats after treatment with RBE and GBE for 5 weeks. In the HPLC study, RBE and GBE contained a mean content of rutin of 1.52 ± 0.21 and 2.92 ± 0.88 mg/g, respectively. In the 600 mg/kg GBE-treated group, SBP was lower than that in the 600 mg/kg RBE-treated group. The treatment with RBE and/or GBE significantly reduced oxidative damage in aortic endothelial cells by lowering nitrotyrosine immunoreactivity. These results suggest that GBE has an antihypertensive effect and may protect arterial endothelial cells from oxidative stress. Copyright © 2009 John Wiley & Sons, Ltd.</P>
LI, KUO CHU,HEO, KYUN,AMBADE, NITIN,KIM, MIN KYUNG,KIM, KYUNG-HEE,YOO, BYONG CHUL,YOO, HWA-SEUNG SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.3
<P>The Korean traditional medicine, HangAmDan (HAD), was developed in 1996 for use as an antitumor agent, and has since been modified to HAD?B (an altered form of HAD), in order to potentiate its therapeutic effects. In the present study, the effect of HAD?B on the proliferation and invasion of NIH:OVCAR?3 and SKOV?3 human ovarian cancer cell lines was investigated. In addition, the expression of major signal transduction molecules and changes in the proteome in these cells were measured. HAD?B treatment effectively induced a reduction in the levels of cell proliferation in serum?free conditioned media. However, unaltered levels of PARP and caspase?3 indicated that HAD?B does not reduce proliferation by inducing apoptotic cell death. Fluorescence?activated cell sorting analysis revealed no significant change in apoptosis following HAD-B treatment. Invasion assay results indicated a reduced rate of invasion following HAD?B treatment. HAD?B also influenced the expression of major signal transduction molecules; the phosphorylation of mTOR and AKT was reduced, while that of ERK was increased. Alterations in the proteomes of the two cell lines were investigated following HAD?B treatment. Among the 9 proteins with differential expression, heat?shock protein β?1 (HSP27) was downregulated in NIH:OVCAR?3 cells treated with HAD?B. The reduced expression of HSP27 was associated with human epidermal growth factor receptor 2 (Her2) downregulation in these cells. In conclusion, the results of the current proteome assessment suggest that HAD?B has the potential to suppress the proliferation and invasion of human ovarian cancer cells. HAD?B treatment of NIH:OVCAR?3 cells suppressed HSP27 expression and was also associated with Her2 downregulation.</P>
( Yoo Li Lim ),( Ki Tae Suk ),( Jung-Hwan Yoon ),( Moon Young Kim ),( Chang Wook Kim ),( Ja Kyung Kim ),( Hana Park ),( Seong Gyu Hwang ),( Byung Seok Lee ),( Sae Hwan Lee ),( Hong Soo Kim ),( Jae You 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has been suggested as an effective therapy for liver cirrhosis. The efficacy and safety of autologous BM-MSC transplantation in the treatment of alcoholic cirrhosis (AC) were investigated. Methods: Seventy-two patients with baseline biopsy-proven AC who had been alcohol-abstinent for more than 6 months underwent a multicenter, randomized, open-label, phase 2 trial. Patients were randomly assigned to three groups: one control group and two autologous BM-MSC groups that underwent either one-time or two-time hepatic arterial injections of 5×107 BM-MSCs 30 days after bone marrow aspiration. A follow-up biopsy was performed 6 months after enrollment and adverse events were monitored for 12 months. The primary endpoint was the improvement in the fibrosis-quantification based on Picrosirius-red staining. The secondary endpoints included liver function tests, Child-Pugh score, and the Model for End-stage Liver Disease score. Results: In terms of fibrosis-quantification (before vs. after), one-time and two-time BM-MSC groups were associated with 25% (19.5±9.5% vs. 14.5±7.1%) and 37% (21.1±8.9% vs. 13.2±6.7%) reductions in the proportion of collagen, respectively (P<0.001). In the inter-group comparison, two-time BM-MSC transplantation in comparison with one-time BM-MSC transplantation was not associated with improved results in fibrosis-quantification (P>0.05). The Child-Pugh scores of both BM-MSC groups (one-time: 7.6±1.0 vs. 6.3±1.3 and two-time: 7.8±1.2 vs. 6.8±1.6) were also significantly improved following BM-MSC transplantation (P<0.05). The proportion of patients with adverse events did not differ among the three groups. Conclusions: Autologous BM-MSC transplantation safely improved histologic fibrosis and liver function in patients with AC.