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Sun-Gil Do,Jun Hong Park,남윤이,김진봉,Jae-Yong Lee,Yang-Seok Oh,서준교 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.4
Components of silk including silk fibroin have long been used as anti-diabetic remedies in oriental medicine. However, detailed mechanisms underlying these antidiabetic effects remain unclear. In this study, we examined the anti-diabetic activity of silk fibroin hydrolysate (SFH) in C57BL/KsJ-db/db (db/db) mice, a well-known animal model of non-insulin dependent diabetes mellitus. When the db/db mice were administered SFH in drinking water for 6 weeks, hyperglycemia in the animals gradually disappeared and the level of glycosylated hemoglobin decreased, indicating that SFH plays important role in reducing the symptoms of diabetes. In addition, SFH-treated db/db mice exhibited improved glucose tolerance with increased plasma insulin levels. Immunohistochemical and morphological analyses showed that SFH up-regulated insulin production by increasing pancreatic β cell mass in the mice. In summary, our results suggest that SFH exerts anti-diabetic effects by increasing pancreatic β cell mass in a non-insulin dependent diabetes mellitus mouse model.
Occurrence and Ecology of Woolly Apple Aphid in Apple Orchards
Sun-Young Lee,Kyung-Hee Choi,Yun-Su Do,Changmann Yoon,Kyeong-Ho Chung,Gil-Hah Kim 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
Woolly apple aphid, Eriosoma lanigerum, one of the pests occurring in apple do damages on the branch and bastard slip nearby ground roots by sucking sap. Recently, seasonal population of this pest steadily increased but has scarcity the basic data relating to its ecology. This study was conducted to investigate the infested orchard ratio, environmental analysis of occurred orchard, seasonal population and parasite rate by Aphelinus mali, a natural enemy for woolly apple aphid, from 30 to 34 apple orchards, at 11 to 13 major apple producing areas in Gyeongsang-namdo and Gyeongsang-bukdo, Geolla-bukdo, and Chungchung-bukdo, during 2012 to 2013. It showed infested orchard ratio as about 35% and population density started to increase from mid-May, with its optimal density in late-June and increased again in late-September. This pest found in various rootstocks where infested orchards and could not found any significant pattern. The damage appeared in 9 to 35 year-old trees, severed rather old trees than younger trees. Also, orchards that did not eliminate bastard slip were showed high occurrence pattern. Parasite rates of Aphelinus mali showed the difference among investigated orchards but the rates showed generally increased pattern since early- July.
( Do Seon Song ),( Jong Young Choi ),( Sun Hong Yoo ),( Hee Yeon Kim ),( Myeong Jun Song ),( Si Hyun Bae ),( Seung Kew Yoon ),( Ho Jong Chun ),( Byung Gil Choi ),( Hae Giu Lee ) 대한소화기학회 2013 Gut and Liver Vol.7 No.1
Background/Aims: To determine if hepatocellular carcinoma refractory to conventional transarterial chemoembolization (TACE) responds to TACE with DC beads. Methods: Between July 2008 to June 2010, 435 patients underwent TACE. Of these, 10 patients who had tumors refractory to conventional TACE and who thus were treated with TACE with DC beads were enrolled in this study. The treatment response after TACE with DC beads was evaluated according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) and the Response Evaluation Criteria in Cancer of the Liver (RECICL). Results: Ten tumors were treated in 10 patients. Using the mRECIST and the RECICL, a complete response was observed in four (40%) of the tumors, and six tumors (60%) showed a partial response. Eight (80%) out of 10 HCCs showed delayed enhancement patterns upon angiography, and better responses were observed in these cases following DC bead treatment. The adverse effects of treatment with DC beads became tolerable. Conclusions: TACE with DC beads was effective for HCCs refractory to conventional TACE, and this treatment elicited a better response, especially when the tumors were small and showed a delayed enhancement pattern upon angiography. (Gut Liver 2013;7:89-95)
Sun Shin Yi,Hyun-Jin Kim,Seon-Gil Do,Yoon-Bok Lee,Hee Jin Ahn,In Koo Hwang,Yeo Sung Yoon 대한해부학회 2012 Anatomy & Cell Biology Vol.45 No.2
Arginine vasopressin (AVP) is a neuropeptide with vasoconstrictive, antidiuretic, cardiovascular regulative and hepatic glycogenolysis effects, that also affects other behaviors including modulating learning. A number of studies on AVP regulation have been conducted in various metabolic diseases (disorders). In this study, the immunoreactivities of AVP in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) and mRNA expressions in the hypothalamus were investigated by immunohistochemistry and quantitative real-time PCR (RT-qPCR) in stroke-prone spontaneously hypertensive rats at different ages (i.e., at postnatal months [PM] 1, 8, and 12). Blood glucose levels in the PM 8 group were higher than in the other groups. However, cresyl violet positive neurons were detected in the PVN and SON of all animals, and numbers of cresyl violet positive neurons were similar in all aged groups. In addition, AVP immunoreactivity was detected in the PVN and SON of all age groups, and AVP immunoreactivity and mRNA expression levels were found to be increased in proportion to age by immunohistochemistry and RT-qPCR. These results suggest that the diabetic condition is temporally generated after hypertension has developed. Furthermore, our findings suggest that increased AVP expressions in the hypothalamic PVN and SON are associated with hypertension by age.
Gil-Ho Yoo,Deok-Hyun Kim,Jin Yoo,Jong-Ho Yang,Sang-Woo Kim,Ki-Do Park,Min-Tae Kim,Sun-Hee Woo,Keun-Yook Chung 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.6
The impact of 1 pound of nitrous oxide (N₂O) on warming the atmosphere is almost 310 times that of 1 pound of carbon dioxide. Agricultural soil management is the largest source of N₂O emissions, accounting for about 73% of total N₂O emissions. This study was conducted to evaluate the nitrous oxide emission in the cultivation of soybean during the first year of No-tillage (NT) and Conventional-tillage (CT) practices, under the various conditions such as different kinds of fertilizers, soil temperature, and moisture level. In the experiment, we set CT and NT treatments into 4 different groups - control treatments (no fertilization), green manure treatments, chemical fertilizer treatments and organic manure treatments. In the case of chemical fertilizer treatments, N₂O emission of NT treatment was 7.78 to 22.59% lower than CT treatment. In organic manure treatment, N₂O emission of NT treatment was 6.62% higher than CT treatment in August. But In July and September, N₂O emission of NT treatment was 9.50% 28.38% lower than CT treatment, respectively. Soil temperature was correlated with N₂O emission positively. In the future, continued long-term research on influence of various environmental factors on the generation of N₂O and the economic value of no-till farming is required.
Gil, Tae Young,Lee, Do Kyung,Lee, Jung Min,Yoo, Eun Sun,Ryu, Kyung-Ha The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.6
Purpose: To evaluate the potential utility of $^{123}I$-metaiodobenzylguanine ($^{123}I$-MIBG) scintigraphy and $^{18}F$-fluorodeoxyglucose ($^{18}F$-FDG) positron emission tomography (PET) for the detection of primary and metastatic lesions in pediatric neuroblastoma (NBL) patients, and to determine whether $^{18}F$-FDG PET is as beneficial as $^{123}I$-MIBG imaging. Methods: We selected 8 NBL patients with significant residual mass after operation and who had paired $^{123}I$-MIBG and $^{18}F$-FDG PET images that were obtained during the follow-up. We retrospectively reviewed the clinical charts and the findings of 45 paired scans. Results: Both scans correlated relatively well with the disease status as determined by standard imaging modalities during follow-up; the overall concordance rates were 32/45 (71.1%) for primary tumor sites and 33/45 (73.3%) for bone-bone marrow (BM) metastatic sites. In detecting primary tumor sites, $^{123}I$-MIBG might be superior to $^{18}F$-FDG PET. The sensitivity of $^{123}I$-MIBG and $^{18}F$-FDG PET were 96.7% and 70.9%, respectively, and their specificity were 85.7% and 92.8%, respectively. $^{18}F$-FDG PET failed to detect 9 true NBL lesions in 45 follow-up scans (false negative rate, 29%) with positive $^{123}I$-MIBG. For bone-BM metastatic sites, the sensitivity of $^{123}I$-MIBG and $^{18}F$-FDG PET were 72.7% and 81.8%, respectively, and the specificity were 79.1% and 100%, respectively. $^{123}I$-MIBG scan showed higher false positivity (20.8%) than $^{18}F$-FDG PET (0%). Conclusion: $^{123}I$-MIBG is superior for delineating primary tumor sites, and $^{18}F$-FDG PET could aid in discriminating inconclusive findings on bony metastatic NBL. Both scans can be complementarily used to clearly determine discrepancies or inconclusive findings on primary or bone-BM metastatic NBL during follow-up.
Phosphoinositides Differentially Regulate Protrudin Localization through the FYVE Domain
Gil, Jung-Eun,Kim, Eui,Kim, Il-Shin,Ku, Bonsu,Park, Wei Sun,Oh, Byung-Ha,Ryu, Sung Ho,Cho, Wonhwa,Heo, Won Do American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.49
Yoo, Gil-Ho,Kim, Deok-Hyun,Yoo, Jin,Yang, Jong-Ho,Kim, Sang-Woo,Park, Ki-Do,Kim, Min-Tae,Woo, Sun-Hee,Chung, Keun-Yook 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.6
The impact of 1 pound of nitrous oxide ($N_2O$) on warming the atmosphere is almost 310 times that of 1 pound of carbon dioxide. Agricultural soil management is the largest source of $N_2O$ emissions, accounting for about 73% of total $N_2O$ emissions. This study was conducted to evaluate the nitrous oxide emission in the cultivation of soybean during the first year of No-tillage (NT) and Conventional-tillage (CT) practices, under the various conditions such as different kinds of fertilizers, soil temperature, and moisture level. In the experiment, we set CT and NT treatments into 4 different groups - control treatments (no fertilization), green manure treatments, chemical fertilizer treatments and organic manure treatments. In the case of chemical fertilizer treatments, $N_2O$ emission of NT treatment was 7.78 to 22.59% lower than CT treatment. In organic manure treatment, $N_2O$ emission of NT treatment was 6.62% higher than CT treatment in August. But In July and September, $N_2O$ emission of NT treatment was 9.50% 28.38% lower than CT treatment, respectively. Soil temperature was correlated with $N_2O$ emission positively. In the future, continued long-term research on influence of various environmental factors on the generation of $N_2O$ and the economic value of no-till farming is required.
Processed <i>Aloe vera</i> Gel Ameliorates Cyclophosphamide-Induced Immunotoxicity
Im, Sun-A,Kim, Ki-Hyang,Kim, Hee-Suk,Lee, Ki-Hwa,Shin, Eunju,Do, Seon-Gil,Jo, Tae Hyung,Park, Young In,Lee, Chong-Kil MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.11
<P>The effects of processed <I>Aloe vera</I> gel (PAG) on cyclophosphamide (CP)-induced immunotoxicity were examined in mice. Intraperitoneal injection of CP significantly reduced the total number of lymphocytes and erythrocytes in the blood. Oral administration of PAG quickly restored CP-induced lymphopenia and erythropenia in a dose-dependent manner. The reversal of CP-induced hematotoxicity by PAG was mediated by the functional preservation of Peyer’s patch cells. Peyer’s patch cells isolated from CP-treated mice, which were administered PAG, produced higher levels of T helper 1 cytokines and colony-stimulating factors (CSF) in response to concanavalin A stimulation as compared with those isolated from CP-treated control mice. PAG-derived polysaccharides directly activated Peyer’s patch cells isolated from normal mice to produce cytokines including interleukin (IL)-6, IL-12, interferon-γ, granulocyte-CSF, and granulocyte-macrophage-CSF. The cytokines produced by polysaccharide-stimulated Peyer’s patch cells had potent proliferation-inducing activity on mouse bone marrow cells. In addition, oral administration of PAG restored IgA secretion in the intestine after CP treatment. These results indicated that PAG could be an effective immunomodulator and that it could prevent CP-induced immunotoxic side effects.</P>