Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

Coevaporation에 의한 cd₁-xZn_(x)S 박막 제작 및 특성에 관한 연구

李載亨,李虎烈,朴鏞冠,申成浩,申載爀,朴光子 성균관대학교 1998 학술회의지원논문목록집 Vol.1998 No.-

In this paper, structural optical and electrical properties of Cd_(1-x)Zn_(x)S thin films prepared by coevaporation method were studied. Also, effects of ZnS mole ratio(x) to CdS on properties of thin film Cd_(1-x)Zn_(x)S/CdTe solar cells were investigated. When the ZnS mole ratio was less than 0.85, the crystal structure of Cd_(1-x)Zn_(x)S films was hexagonal with the c axis aligned perpendicular to the substrate. For x>0.85, however, the Cd_(1-x)Zn_(x)S films were grown with cubic zincblende structire. As the ZnS mole ratio increased the lattice constant of Cd_(1-x)Zn_(x)S films rapidly increased with ZnS mole ratio. The open circuit voltage of Cd₁xZnxS/CdTe solar cells increased with x due to reducing of the electron affinity difference between Cd₁xZnxS and CdTe films. However, the increase of series resistance due to the high resistivity of Cd_(1-x)Zn_(x)S films results on reducing conversion efficiency.

R.F. Magnetron Sputtering법으로 제조한 LaCoO₃박막의 가스감지 특성

신정호,김정규,박기철,전춘배,장재영 慶尙大學校 工科大學 自動化및컴퓨터應用技術硏究所 1998 自動化 및 컴퓨터應用技術 Vol.5 No.1

LaCoO₃(LCO) thin film sensors were fabricated on an alumina substrate by r.f. magnetron sputtering. By varying the annealing temperature of the LCO film from 600℃ to 1000℃, we investigated X-ray diffraction pattern, electrical properties, and gas sensing properties of the films. The crystallinity was improved and the activation energy was increased with increasing the annealing temperature. The sensitivities of the LCO films for NH₃ and CO gases were also increased with the annealing temperature. Sensing properties of LCO thin films were improved when the measuring temperature was 350℃ or more

鋼橋梁 下部플랜지 맞대기 鎔接이음부의 鎔入不足에 따른 疲勞擧動에 관한 硏究

신재철,한성호,정인수 충남대학교 산업기술연구소 1999 산업기술연구논문집 Vol.14 No.2

A major defective welding pattern in the steel bridges is identified as the lack of welding area due to the insufficient welding penetration. In this study is fatigue behavior and fatigue life of steel bridge under flange of weld insufficient of butt weld joint. Fatigue behavior and fatigue life test is minor's law and fracture analysis and nowaday, finite element method is used to many times. By considering the welding defect in the above, structural analysis is conducted to evaluate butt weld joint influence due to welding defect on the safety of steel bridges. The results indicate that, due to the insufficient welding penetration, the stress obtained in the analysis is over the allowable fatigue stress level, and its influence on safety of the bridges is significant

지삭의 양단이 단순고정된 화물삭도의 선로해석

신재균,최선호 영남대학교 공업기술연구소 1989 연구보고 Vol.17 No.1

A method of analyzing load-carrying ropeways is suggested in this study. Compared to to the ropeways for passengers whose tension at the one end of the main rope is given, load-carrying ropeways require different treatment because their main ropes are fixed at both ends. This difference makes the problem of analyzing load-carrying ropeways a statically indeterminate one and some iteraive solution technique seems to be inevitable. But, it is shown that this statically indeterminate problem can conceptually be reduced to a problem of solving a nonlinear algebraic equation in this study, and some numerical method such as Newton-Ropshon method can be applied successfully to solve the problem. Also, some example ropeways are analyzed after the proposed solution technique and the results are discussed.

LaCrO_(3) 후막의 가스 감도 특성

신정호,장재영,김정규,박기철 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

LaCrO_(3) thick film sensors were fabricated on an alumina substrate by screen printing method. The sensitivities for gases were investigated by varying the heat treatment temperatures of the films. The sensitivities of LaCrO_(3) thick film for Gallo and NH_(3) gases were better than for CO and NO gases. The best condition of heat treatment was 450℃ and the optimal operating temperature of LaCrO_(3) thick film for the highest sensitivity was 400℃. Sensitivities of LaCrO_(3) thick films about at 3000ppm for C_(4)H_(10) and NH_(3) gases were 85% and 95%, respectively.

웨이브렛 계수 Zero Crossings를 이용한 영상의 잡음제거 및 압축

신재호,이용준,은종숙,이성우 동국대학교 산업기술연구원 1997 산업기술논문집 Vol.10 No.-

윤곽선이나 에지같은 영상 데이터의 중요한 성분들은 웨이브렛 계수의 zero crossings를 통해 검출할 수 있다. 이런 방법은 영상의 패턴 인식에 관한 연구에서 sharp variation points를 검출하는데 사용되었다. 웨이브렛 변환과 zero-crossings를 거쳐 국부 극치의 위치를 검출하는데 이 방법을 적용하여서 영상의 잡음제거에 사용하도록 개선하였다. 더욱이 영상 데이터에서 전체 영상의 픽셀과 정보를 저장하는 대신, 대부분의 중요한 성분을 효과적으로 몇몇 국부 극치값으로 압축하였다. 그 결과 새로 개선된 기법은 패턴 인식 분야에서만 아니라 높은 압축률의 잡음 제거에도 사용될 수 있다. The important image data components such as contours and edges could be detected by zero crossings of wavelet coefficient. This method has been used for the studies on pattern recognition of images to detect sharp variation points. We have applied it to detection of the position of local maxima through zero-crossings and wavelet transform, so that it is improved to be used for noise-eliminating of image. In addition it could compress the image data into a few of local maxima which held the most of important component efficiently without saving All image pixels and information. As the result, the newly improved method could be implemented not merely for the field of pattern recognition but for that of noise removal at the higher compression ratio.

통신용 정류기 시스템의 모델링 및 제어기 설계

신병철,송의호,양재석 國立 昌原大學校 産業技術硏究所 1999 産技硏論文集 Vol.13 No.-

This paper deals with the design of controller which is used to rectifier for communication. Mathematical small-signal modeling and characteristic analysis are performed about DC/DC converter and three-phase AC/DC converter. Bode plots are obtained by the mathematical small-signal modeling. By the PSpice simulation, performance of the controller is proved respectively in line regulation and load.

동하중을 받는 FRAME 구조물의 확률유한요소해석 및 신뢰성해석

신재철,김진홍,정인수,한성호 충남대학교 산업기술연구소 2003 산업기술연구논문집 Vol.18 No.1

Most dynamic systems have various random properties in excitation and system parameters. Therefore, in this paper, reliability analysis for structural response is proposed fro the linear dynamic system with random properties in both excitation and system parameters. The system parameters and responses with random properties are modeled by the perturbation technique. A displacement and bending moment of frame structure is acquired in Stochastic Finite Element Method Program(SFEMP) and Dynamic Stochastic Finite Element Method Program(DSFEMP) using perturbation method, and Direct Monte Carlo Simulation Program(DMCSP) is used to verify and compare previous results. Comparing outputs of SFEMP and DSFEMP with them of DMCSP, it show that they are similar to each other. Also DMCSP need much time to analyze a complicated structure, but SFEMP and DSFEMP can reduce quite time. In this study, it is assumed that excitations, system parameters and response are Gaussian. The results of response for the analysis are compared to those of numerical simulation. Also the probability of failure are calculated for using Advanced First Order Second Moment(AFOSM) of the general reliability analysis method.

사례 기반 학습을 이용한 지능형 판매 지원 에이전트 시스템의 설계 및 구현

신하철,김재호,김기태 중앙대학교정보통신연구소 2000 정보통신연구소논문집 Vol.2 No.1

전자 카탈로그를 이용한 인터넷 정보의 접근은 일반화되고 있지만 수많은 정보의양과 다양성 때문에 고객이 원하는 효율적인 상품 검색을 방해하는 원인이 되고 있다. 또한 수시로 변경되는 상품 카탈로그를 처음 접근하는 고객이 원하는 상품 정보를 찾아내기란 쉬운 일이 아니다. 이러한 문제점들의 가장 근복적인 이유는 전문적인 상품 카탈로그가 다양한 속성들로 되어 있기 때문에 각 고객의 관심분야와 검색 습관은 같은 고객의 요구사항을 기존의 웹 브라우저만을 이용하여 만족시키지 못한데 기인된다. 본 논문에서는 이러한 문제를 해결하기 위해 사례 기반 학습 개념을 이용하여 각 고객의 관심 분야를 반영하고 고객 편의의 정보검색을 도와주는 지능형 판매 지원 시스템(Intelligence Sales support Agent System, ISAS)을 설계하였다. Although the access of internet information is generalized using electronic catalog, because of the number of amount and variety of information, the customers can't effectively search the merchandise that they need. Also it is difficult searching the merchandise information that the customer need, if they access merchandise catalog first. The reason of this problem is that the existing web browser is not satisfied the customer's requirement like their interests and search habits, because professional merchandise catalogs consist of variable attributes. In this paper, we designed Intelligence Sales support Agent System that reflects the customer's interests and assists the effective information search using case-based reasoning, to solve this problem.