방사선 치료를 받은 암환자에 대한 염색체 이상과 동위 효소에 관한 연구

김진영,김영진,김종봉 한국유전학회 1983 Genes & Genomics Vol.5 No.1

Dose response relationship between chromosome aberration and therapeutic irradiation was determined in peripheral lymphocytes obtained from cancer patients treated with therapeutic radiation. Enzyme activities and isozyme patterns as a biochemical genetic marker were also investigated in blood samples of cancer patients and normal group. Various types of structural aberrations of chromosome such as dicentrics, acentrics, ring chromosomes and chromatid breaks were observed in cancer patients. These types of aberrations were not usually observed in the normal cells. The frequencies of the structural aberrations ranged from 0.07 to 0.33 per cell according to the exposed doses. The incidence and prevalence of structural aberrations seen in cancer patients were consistently higher than those of control, suggesting the chromosomal effects of therapeutic irradiation. Isozyme patterns of cancer patients showed that enzyme activities and gene frequencies were found to be normal distribution except 6-Pgd isozyme. The heterozygosity of 6-Pgd in the cancer group was higher than that of healthy control.

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

大學綜合試驗 出題에 關한 硏究

卞烘圭,吳鎭坤,申鎔鎭,金泳喆,鄭求福,柳哲鍾,洪允杓 全北大學校 1977 論文集 Vol.19 No.-

The Comprehensive Examination for the undergraduate students is planned to adopt the Jeonbug National University for the purpose of enhancing the quality of its educational outputs. In order to effectively measure and evaluate the level of student progress toward the minimun standard as the students who have finished their general education and basic education for their major field study, the university has decided to make an item pool related to the subjects for the examination. This study is an attempt to make good items of five required courses among general education subjects which are Korean Language, English, Korean History, National Ethics. and Natural Science and are expected to be the subjects of the examination. Instead of making those items separately from the regular examination during the academic semesters, the university plans to collect and use good items from the usual mid-term and final examinations of those subjects. A key concern, in this study, therefore, is to analyze all the items used for the mid-term and final examinations of those subjects during the regular academic semesters. From the data of an about 100 sample in each subject at each time of total three tests, the difficulty index, discrimination index, the response rate of students on each item, and other general descriptive statistics are calculated and then good items are pooled for the future use for the Comprehensive Examination. Anhother important concern in this study is this study is given to the collection and analysis of controversial issues and problems on the process of operating the examination at other universities where the Comprehensive Examination is already adopted. The data from four institutions and from opinions of six participants of this study are used. The following main findidings are summarized : 1. The items have generally shown to be easy while the degree of discrimination is low. 2. Among the five subjects, Korean Language shows the highest rate of right answer (difficulty index) while English the strongest one in the discrimination index. 3. When comparing two types of test between the multiple choice and the short-answer, the latter seems to be powerful in both difficulty and discriminative. 4. The only one question of essay type test reveals clear limitations in scoring and evaluating students progress. 5. All items are constructed under the consideration of content-referenced base, not of the basis on behavioral aspect. 6. The analysis of issues and problems related to the Comprehensive Examination suggests that it is acceptable to test in terms of required subjects of general education and a few most basic subjects of major areas of study. 7. The examination can be functionally operated when it is held at the end of the first year of and before the beginning of the second year of the college years. The length of the examination is usally held from three to five hours. 8. Since the examination should be existed on the idea of criterion-referenced base rather than of norm-referenced one because of its testing the qualification of the entering behavior of students for the further study in their major field, the standard of the pass-and-failure should be set on at least 60 percent of correct answers in each subject. But there must be provided at least two additional opportunities for the make-up examination for those who failed in the first one. 9. A special committee must be established in order to deal with all the details related to the Comprehensive Examination.

알칼리환원수 음용이 급성 염증성장질환 생쥐 모델에 미치는 영향

김단,김동희,등영건,최주봉,이규재 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.2

알칼리환원수 (Alkaline Reduced Water: ARW)는 아시아를 비롯한 여러 나라에서 음용수로 사용되고 있으며 항산화효과와 장내이상발효 개선효과 등을 중심으로 안전성과 유효성의 검증이 이루어지고 있다. 본 연구에서는 알칼리환원수가 급성 염증성대장질환 (Inflammatory Bowel Disease: IBD) 동물모델에 미치는 영향을 알아보기 위해, ARW를 2주 동안 급이 시킨 후 4% DDS로 염증성 대장염을 유발시키고 대장의 길이와 조직병리학적 변화를 관찰하였다. 그 결과 대장의 길이와 육안적, 현미경적 질환점수의 수치가 대조군과 비교하여 유의한 차이를 나타내지 않았다. 이 결과는 DSS로 유도된 급성 염증성장질환 모델에서는 2주 동안의 ARW 급이가 개선효과를 나타내지 않았음을 말해준다. 그러나 ARW 가 장내환경을 개선시키고 위장관의 질환을 개선시키는 효과가 있음을 고려해볼 때 급성 IBD 동물모델이 ARW의 효과를 증명하기에 적합하지 않았거나 MARW의 급이기간이 장내환경을 개선할 만큼 충분히 길지 않았을 가능성을 추측해 볼 수 있다. 알칼리환원수의 장내이상발효 개선효과는 확인되고 있으나 그 기전은 아직까지 구체적으로 확인되어지지 않고 있다. 이번 연구결과에 의하면 인위적으로 유발시킨 급성 염증성 동물모델에서 ARW가 유의한 영향을 미치지 않았지만, 다른 장질환 모델을 이용한 효과 검증과 ARW의 장기 급이에 따른 효과, 그리고 ARW 가 장내환경에 미치는 작용기전에 대한 연구가 더 깊이 있게 이루어져야 할 것으로 사료된다. Alkaline reduced water (ARW) has been used for drinking widely in several countries of Asia. The safety and clinical effects of ARW has been reported including anti-oxidative effect and intestinal abnormal fermentation. To confirm the effect of ARW on DSS-induced acute inflammatory bowel disease (IBD) mouse model, we observed the length of total large intestine and the histopathological changes after supplying mineral induced-ARW (MARW) for 2 weeks and oral administration of 4% DSS (dextran sulfate sodium). As the result, the length of total large intestine and the disease scores by macro and microscopical access in the ARWsupplied group showed no significant differences compared with those in the control group. This result suggests that the supply of ARW for 2 weeks exerted no effect on amelioration in the DSS-induced acute IBD model. However, in consideration of the effect of ARW on the improvement of intestinal environment and gastrointestinal disease, this result seems that acute IBD animal model is not suitable or the period of ARW supply is not enough to prove the effect of ARW. The ameliorative effect of ARW on the intestinal abnormal fermentation has been confirmed by some researchers, but the precise mechanism also remain unclear. In conclusion, although MARW had no effect on the DSS-induced acute experimental colitis model, further studies on the verification of the effects of ARW by using other intestinal disease model and by long-term supply of ARW will be required. Also, It needs to clear the mechanism of ARW on the intestinal environment.

액체결정을 이용한 온도측정

김욱,고영주,이경진,김신 제주대학교 공과대학 첨단기술연구소 2003 尖端技術硏究所論文集 Vol.14 No.2

Temperature is one of the most important variables in thermal-hydraulic system. Many methods like, thermo couple, thermistor, semi-conduct sensor and so on have been divised for the temperature measurement. Recently optical method has attracted much interest due to its insensibility to electromagnetic environment. When liquid crystal film is attached to an object, its color changes sensitively as according to the temperature of the object. If a specific light is flashed on the film, the amount of light reflection depends on the color of the film. The purpose of this study is to develop an optical temperature measuring system using liquid crystal film.

加水分解 牛皮粉의 飼料的 價値에 관한 硏究

金大鎭,孟元在,高永杜 東亞大學校 大學院 1984 大學院論文集 Vol.9 No.-

Protein quality of hydrolyzed cattle skin meal was estimated by the pepsin-HCL digestion with various concentration and incubation time, and by chemical score to determine the limiting amino acids. Protein efficiency ratio(PER), net protein ratio(NPR) and net protein utilization(NPU) were also studied with chicks fed semipurified diet with and without supplementation of the limiting amino acids. Broiler chick growth trials were also conducted to determine the supplementation level of hydrolyzed cattle skin meal by replacing with soybean meal and feather meal. The results are summarized as follows: 1. Protein digestibility of hydrolyzed cattle skin meal was 66.31%, 80.69%, 83.72%, 84.65%, and 87.45%, respectively for 4, 8, 12, 16 and 20 hours incubation of 0.2% pepsin-HCl. Protein digestibility maintained above 80% after 8hours incubation and increased by increasing incubation time. 2. Protein digestibilities of hydrolyzed cattle skin meal incubated for 16 hours at 0.2%, 0.1%, 0.05%, 0.025%, and 0.0125% pepsin-HCl solution were 85.10%, 82.08%, 76.18%, 74.67% and 64.82%, respectively. 3. Chemical scores of methionine, isoleucine, threonine, leucine and histidine estimated based on NRC(1977) broiler(03 weeks) feeding standard were 27%, 38%, 44%, 48% and 51%, respectively 4. Growth rate, feed intake and feed conversion were improved by the addition of the limiting amino acids in the hydrolyzed cattle skin meal as compared with hydrolyzed cattle skin meal alone. 5. PER, NPR and NPU were also improved by the addition of the limiting amino acids. 6. Feed intake was not statistically significant upto 5% hydrolyzed cattle skin meal in the diet with was 100% replacement of hydrolyzed cattle skin meal with soybean meal and feather meal. Growth rate and feed conversion were not statistically significant at 3% but were significant 5% hydrolyzed cattle skin meal(p<0.05). These experiments were clearly indicated that hydrolyzed cattle skin meal could supplement in the diet upto 3% when mixed with 2 or 3 other protein sources.

氣管枝擴張症의 手術療法

金炯默,金源弼,兪鎭一,徐景弼,李寧均 醫藥係社 1955 綜合 醫學 Vol.12 No.11

기존 축열벽 시스템과 투명단열 축열벽 시스템의 열성능 평가 실험 연구

김병수,윤종호,윤용진,이진숙 대한건축학회 2003 대한건축학회논문집 Vol.19 No.10

TI-wall is an Mass-wall with TIM used instead of an usual single, double and triple glassed windows. The aim of this study is to analyze the thermal performance through Test-Cell of TI-wall in domestic climate. This study is carried out as follows: 1) Test-cells of TI-wall and Mass-wall are designed through the investigation of previous paper and work. The type of the TIM used in test-cell is small-celled(diameter 4㎜ and thickness 50㎜) capillary and cement brick(density 1500㎏/㎥) is used by thermal mass. 2) individual and combination test with various variants, such as thickness(190㎜, 380㎜) and surface absorption(60%, 95%) of thermal mass wall, measured for winter and spring, and the thermal effects are analyzed. Finally, as results indicated that the peak point time of the temperature of in-and-out surface is cut down approximately by an hour when the surface absorption of thermal mass wall is changed from 60% to 95% In case of applying for 1B(190㎜) in thickness of thermal mass wall. In case of applying for 2B(380㎜) in thickness of thermal mass wall, the temperature difference between in-and-out surface is showed about 23℃ in terms of Spring and Autumn. It means that the heat could not be delivered enough because the distance for heat transmission is too far. Therefore, in case of more than being 2B in thickness of thermal mass wall, it is not right for heating in Winter, Spring and Autumn. Experiment in term of su㎜er, the thermal mass wall is heated enough by outside temperature and solar radiation, the temperature difference between in-and-out surface is indicated 10℃. Also, inside temperature is sustained more than average 28C. Therefore, radical temperature rising will be released by changing its thickness, but the inside temperature still remains in high.

연료정책에 따른 대기오염 개선효과 분석에 관한 연구 : 대구지역을 중심으로

김차영,백성옥,박영규,최진수,장윤영 嶺南大學校 環境問題硏究所 1995 環境硏究 Vol.14 No.2

청정연료와 저유황유의 공급확대에 따른 대구지역의 대기오염 개선효과를 분석하기 위하여 향후 1996, 2001년 대구지역의 유종별, 소비부문별 소비량을 추정하고 이에 따른 아황산가스, 분진, 질소산화물 및 일산화탄소에 대한 배출량을 각각 산정하였다. 특히 향후 대구지역 대기중 아황산가스농도에 대하여 개정된 환경기준치의 달성가능성 여부를 연간 총배출량측면에서 검토한 결과 2001년의 아황산가스 배출량이 추정된 허용배출량 이하로 떨어질 것으로 나타나 저황유의 공급과 청정연료 사용의무화정책을 현재 계획대로 추진할 경우 아황산가스 농도는 대체로 환경기준을 충분히 달성할 수 있을 것으로 판단되었다. A study was carried out to evaluate the improvement of air quality in Taegu area in the years of 1996 and 2001 with the extended supply of cleaner fuels such as town gas and low sulfur fuel oil. The emission quantities of the air pollutants from the combustion of various fuel were estimated with respect to the sections of end-use in this area. With the implementation of the planned fuel policy to this area, the level of sulfur dioxide in the ambient air will satisfy the revised ambient air quality standard based on the yearly total quantity of the sulfur dioxide emission. If the fuel policy is implemented as scheduled, the attainability of the ambient air quality standard of sulfur dioxide will be possible as the total quantity of sulfur dioxide emission will be well below of that of the predicted value obtained under current fuel policy.

유기용제에 장기간 폭로된 근로자의 정신의학적 기능과 삶의 질

김석재,강순아,유지숙,국승희,윤진상,문재동,이형영 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 본 연구는 Y공단의 제조공정에서 저농도의 유기용제(solvent)에 장기간 노출된 근로자의 정신의학적 기능과 삶의 질을 평가하고자 하였다. 방법: 총 142명의 남성근로자 중 유기용제에 폭로된 군(이하 폭로군) 82명과 폭로되지 않는 군(이하 비폭로군) 60명에게 간이정신진단검사(Symptom Checklist-90-R, SCL-90-R), 인지 및 정신운동성검사 (Critical Flicker Fusion Threshold. CFFT; Choice Reaction Time, CRT;Compensatory Tracking Task, CTT;Digit-Symbol Substitution, DDS) 및 한국판 스미스클라인 비챰 삶의 질 척도(Korean version of the SmithKline Beecham 'Quality of Life' Scale, KvSBQOL) 등을 적용하였다. 두 군간의 비교는 평가치의 평균에 대해 t-검증을 하였고 또한 연령과 학력을 공변인으로한 공변량분석(ANCOVA)을 하였다. 결과: SCL-90-R의 9개 증상 차원과 3개 전체 지표 점수는 두 군이 각각 정상범위였다. 그러나 신체화 (Somatization, SOM), 우울(Depression, DEP), 적대감(Hostility, HOS), 공포불안(Phobic anx-iety, PHOB)의 증상차원과 전체심도지수(Global Severity Index, GSI), 표출증상합계(Positive Symptom Total, PST)의 전체 지표는 폭로군이 비폭로군보다 유의하게 높았다. 인지 및 정신운동성 검사와 삶의 질은 두 군간에 유의한 차이는 없었다. 결론: 이상의 결과는 유기용제가 허용치 이하일지라도 장기간 폭로되는 경우에는 정신의학적 문제를 다소 일으킬 수 있음을 시사하였다. 중심단어:유기용제·근로자·정신건강·정신운동성 기능·삶의 질. Objectives: The aim of this study was to evaluate the psychiatric function and quality of life of the chemical workers who had been exposed to long-term, low-level organic solvents in the Y industrial complex. Method: A total of 144 male workers, of whom 82 were in the exposed group and 60 in the unexposed-control group, were evaluated by using Symptom Checklist-90-R(SCL-90-R), series of neuropsychological tests(critical flicker fusion threshold, CFFT) ; choice reaction time, CRT ; compensatory tracking task, CTT) ; digit symbol substitution test, DSS), and the Korean version of the SmithKline Beecham Quality Of Life scale(KvSBQOL). For the statistical analyses, comparisons of the means of the two groups were performed for each variable with two-tailed t-test as well as ANCOVA including age and education as covariates. Results: For the SCL-90-R, the nine symptom scales and the three global indices were clinically within normal range in both groups. However, the scores on the symptom scales of 'somatization','depression','hostility' and 'phobic anxiety', and those on the global indices of 'global severity index' and 'positive symptom total', were significantly higher in the exposed group than in the unexposed group. In terms of the neuropsychological function and the quality of life, there wes no significant difference between the two groups. Conclusion: These findings suggested that the long-term eposure to mixed organic solvents, even at the low level below the permissible exposure limit, might induce some psychiatric problems. KEY WORDS: Organic solvent·Worker·Mental health·Psychomotor function·Quality of life.