http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Yul Hee Cho ),( Seok Hui Kang ),( Yaeni Kim ),( Myung Hyun Lee ),( Gun Hee An ),( Byung Ha Chung ),( Bum Soon Choi ),( Chul Woo Yang ),( Yong Soo Kim ),( Yeong Jin Choi ),( Cheol Whee Park ) 대한신장학회 2013 Kidney Research and Clinical Practice Vol.32 No.3
Background: Nephrotic syndrome (NS) and proteinuria are uncommon, often unrecognized manifestations of graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT). Only a few isolated case reports and case series involving smaller number of patients who developed NS after HSCT have been published. Methods: We reviewed the renal histopathological examination findings and clinical records of 15 patients who developed proteinuria after HSCT at Seoul and Yeouido St. Mary′s Hospital (Seoul, Korea). We also measured the anti-PLA2R antibodies (M-type phospholipase A2 receptor) in the serum samples from the seven patients at the time of renal biopsy. Results: All patients had GVHD. The most common indication for biopsy was proteinuria (41 g/day), with nine patients having nephrotic range proteinuria. The most common histopathological finding was membranous nephropathy (MN; n ¼ 12). Other findings were membranoproliferative glomerulonephritis, C1q nephropathy, and diabetic nephropathy. Eleven patients were treated with immunosuppressive agents, and three patients were treated only with angiotensin II receptor blocker. The overall response rate, including complete remission (urinary protein level o0.3 g/day) and partial remission (urinary protein level ¼ 0.31?3.4 g/day), was 73%. The mean follow-up period was 26 months, and none of the patients developed end-stage renal disease. All of the seven patients with MN had negative findings for anti-PLA2R antibodies, measured using an enzyme-linked immunosorbent assay kit. Conclusion: In this study the findings of 15 renal biopsies were analyzed and to our knowledge this is the largest clinicopathological study of GVHD-related biopsy-proven nephropathy. Approximately 80% of the patients were MN and 73% responded either partially or completely to immunosuppressive treatment. Currently, there is an increase in the incidence of GVHD-mediated renal disease, and therefore, renal biopsy is essential for diagnosing the nephropathy and preventing the progression of renal disease.
고 이소플라본 함유 콩잎의 저장 온도와 기간에 따른 영양학적 성분과 항산화 활성 변화
이희율 ( Hee Yul Lee ),이동희 ( Dong Hee Lee ),김수철 ( Su Cheol Kim ),조두용 ( Du Yong Cho ),조계만 ( Kye Man Cho ) 한국응용생명화학회(구 한국농화학회) 2020 Journal of Applied Biological Chemistry (J. Appl. Vol.63 No.4
본 연구는 고 이소플라본 함유 콩잎을 5, 25 및 55 ℃에서 180 일간 저장하면서 지방산, 아미노산, 무기질, 이소플라본, 총 phenolics, 총 flavonoids 및 라디칼 소거활성 변화를 확인하였다. 총 지방산 함량은 저장 기간에 따라 큰 차이를 보이지 않았다. 총 아미노산 함량은 저장 0일에 1313.81 mg/100 g에서 5, 25 및 55 ℃에서 180일째 각각 1776.15, 1693.93 및 1551.18 mg/100 g로 증가하였다. 총 무기질 함량은 저장 초기(51.65 mg/100 g)에 비해 5, 25 및 55 oC에서 180일째 각각 49.93, 50.20 및 61.21 mg/100 g로 검출되었다. 총 이소플라본 함량은 저장기간 중 비교적 큰 변화가 없었다. 55 ℃에서 180일 저장의 경우, glycosides와 aglycones은 각각 2195.13과 480.61 μg/g로 증가하였으며, malonylglycosides는 1289.48 μg/g로 감소하였다. 한편, 총 phenolics 및 총 flavonoids 함량은 0일 저장 시료에서 각각 9.31과 8.61 mg/g에서 180일째 각각 9.97과 9.30 mg/g으로 약간 증가하였고, 이에 상응하여 DPPH, ABTS 및 hydroxyl 라디칼 소거활성은 저장 0일째 각각 30.91, 55.98 및 23.27%에서 180일째 37.10, 62.54 및 30.95%로 증가하였다. This study investigated that change of the nutrients (including fatty acids, amino acids, and minerals) and total phenolic (TP), total flavonoid (TF), and isoflavone contents and antioxidant activities during the storage of soybean leaves containing high isoflavone contents at 5, 25, and 55 ℃ for 180 days. The contents of free amino acids were increased from 1313.81 mg/100 g at 0 day to 1776.15, 1693.93 and 1551.18 mg/ 100 g at 5, 25, and 55 ℃ storage for 180 days, respectively, but the values of fatty acids were little unchanged. The contents of minerals were detected from 51.65 mg/100 g (0 day) to 49.93 (5 ℃), 50.20 (25 ℃), and 61.21 (55 ℃) mg/100 g at 180 days, respectively. The levels of total isoflavones did not change during the storage periods. In case of storage at 55 ℃, the contents of glycosides (1347.78→2195.13 μg/g) and aglycones (342.79→ 480.61 μg/g) increased during storage, while the levels of malonylglycosides (2209.22→1289.48 μg/g) decreased. Also, the TP and TF contents were slightly increased from 9.31 and 8.61 mg/g at 0 day to 9.97 and 9.3 mg/g at 180 days, corresponding to the radical scavenging activities of 2,2-diphenyl-1-picrydrazyl, 2,4,6-azino-bis (3-ethylbenzthiazoline-6-sulphnoic acid), and hydroxyl increased from 30.91, 55.98 and 23.27% from 37.10, 62.54, and 30.95%, respectively.
증례 : 혈액종양 ; 슬관절 전이로 인한 통증이 초기 증상으로 발현된 대장암 1예
조율희 ( Yul Hee Cho ),장민옥 ( Min Ok Jang ),권희선 ( Hee Seon Kwon ),고윤호 ( Yoon Ho Ko ),강진형 ( Jin Hyoung Kang ),홍영선 ( Young Seon Hong ),이명아 ( Myung Ah Lee ) 대한내과학회 2011 대한내과학회지 Vol.80 No.3
저자들은 슬관절의 전이로 인한 증상이 내원 당시의 첫 증상이 되어 진단된 직장암 1예를 경험하였기에 이를 문헌고찰과 더불어 보고하는 바이다. Knee pain is rarely an initial symptom of colon cancer, because most bone metastases develop in the late stage of cancer. Therefore, patients with colorectal cancer usually present with gastrointestinal symptoms. Recently, we experienced a 46-year-old female with rectal cancer that presented as knee pain due to tibial metastasis without other organ metastasis. She was evaluated for knee pain and diagnosed with a rectal cancer after biopsies of the tibial and rectal masses. We report the first such case in Korea with a review of the literature. (Korean J Med 2011;80:352-355)
조성희(Sung-Hee Cho),백석흠(Seok-Heum Baek),이경영(Kyung-Young Lee),홍순혁(Soon-Hyeok Hong),조석수(Seok-Swoo Cho),장득열(Deuk-Yul Jang),주원식(Won-Sik Joo) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
This paper presents a method for considering fatigue life requirements in the optimal design of structures. The basic concept is to use the load history data combined with the finite element stresses of the structure and the material fatigue properties to calculate the fatigue life during the optimization process. Response surface methodology is used to construct response surface approximation for the fatigue life of structures with complex geometry and loading conditions. Thus, this study estimates fatigue life using rainflow counting and Palmgren-Miner method for variable amplitude loading and proposes response surface method for optimization. Response surface for fatigue life prediction is generated by D-optimal design method and is applied to optimal design of end beam by using fatigue life as constraints.
Anti-Angiogenic Activity of Mouse N-/C-terminal deleted Endostatin
Cho, Hee-Yeong,Kim, Woo-Jean,Lee, Sae-Won,Kim, Young-Mi,Choi, Eu-Yul,Park, Yong-Suk,Kwon, Young-Guen,Kim, Kyu-Won Korean Society for Biochemistry and Molecular Biol 2001 Journal of biochemistry and molecular biology Vol.34 No.3
Endostatin, a proteolytic fragment of collagen XVIII, is a potent inhibitor of angiogenesis and the growth of several primary tumors. However, the opinions on the activity of endostatin derivatives deleted N- or C- terminal are still controversial. In this regard, we produced mouse endostatin and its derivatives in the prokaryotic system, and studied their anti-tumor activity. The [$^3H$]-thymidine incorporation assay demonstrated that N-terminal deleted mouse endostatin, and a C- and N-terminal deleted mutant, effectively inhibited the proliferation of human umbilical vein endothelial cells (HUVECs). The biological activity of endostatin was also shown by its in vivo anti-angiogenic ability on the chorioallantoic membrane (CAM) of a chick embryo. Treatment of $200\;{\mu}g$ of mouse endostatin, or N-terminal deleted mouse endostatin, inhibited capillary formation of CAM 45 to 71%, which is comparative to a 80% effect of positive control, $1\;{\mu}g$ of retinoic acid. An in vivo mouse tumor growth assay showed that N-terminal deleted mouse endostatin, and the N-/C-terminal deleted mutant, significantly repressed the growth of B16F10 melanoma cells in mice as did the full-length mouse endostatin. According to these results, N-and N-/C-terminal deleted mouse endostatins are the potent inhibitors of tumor growth and angiogenesis.
Cho, Young-Suk,Kim, Chan Hyung,Ha, Tae-Sun,Lee, Sang Jin,Ahn, Hee Yul The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.2
Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant in Panax ginseng root, which has been used for prevention of illness in Korea. In this study, we investigated the mechanism(s) by which ginsenoside Rg2 may inhibit VCAM-1 and ICAM-1 expressions stimulated with lipopolysaccharide (LPS) in human umbilical vein endothelial cell (HUVEC). LPS increased VCAM-1 and ICAM-1 expression. Ginsenoside Rg2 prevented LPS-mediated increase of VCAM-1 and ICAM-1 expression. On the other hand, JSH, a nuclear factor kappa B (NF-${\kappa}B$) inhibitor, reduced both VCAM-1 and ICAM-1 expression stimulated with LPS. SB202190, inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), and wortmannin, phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, reduced LPS-mediated VCAM-1 but not ICAM-1 expression. PD98059, inhibitor of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) did not affect VCAM-1 and ICAM-1 expression stimulated with LPS. SP600125, inhibitor of c-Jun N-terminal kinase (JNK), reduced LPS-mediated ICAM-1 but not VCAM-1 expression. LPS reduced IkappaB${\alpha}$ ($I{\kappa}B{\alpha}$) expression, in a time-dependent manner within 1 hr. Ginsenoside Rg2 prevented the decrease of $I{\kappa}B{\alpha}$ expression stimulated with LPS. Moreover, ginsenoside Rg2 reduced LPS-mediated THP-1 monocyte adhesion to HUVEC, in a concentration-dependent manner. These data provide a novel mechanism where the ginsenoside Rg2 may provide direct vascular benefits with inhibition of leukocyte adhesion into vascular wall thereby providing protection against vascular inflammatory disease.
( Hee Yul Lee ),( Azizul Haque ),( Kye Man Cho ) 한국응용생명화학회(구 한국농화학회) 2020 Journal of Applied Biological Chemistry (J. Appl. Vol.63 No.4
This study aimed to investigate the change in physicochemical properties and lactic acid bacterial communities during kimchi fermentation at different temperatures (8, 15, and 25 ℃) using two molecular genetics approaches, multiplex polymerase chain reaction and 16S rRNA gene sequencing. The pH during fermentation at 8, 15, and 25 ℃ decreased from 6.17 on the initial fermentation day to 3.92, 3.79, and 3.48 after 54, 30, and 24 days of fermentation, respectively, while the acidity increased from 0.24% to 1.12, 1.35, and 1.54%, respectively. In particular, the levels of lactic acid increased from 3.74 g/L on the initial day (day 0) to 14.43, 20.60, and 27.69 g/L during the fermentation after 24, 18, and 12 days at 8, 15, and 25 ℃, respectively, after that the lactic acid concentrations decreased slowly. The predominance of lactic acid bacteria (LAB) in the fermented kimchi was dependent on fermentation stage and temperature: Lactobacillus sakei appeared during the initial stage and Leuconsotoc mesenteroides was observed during the optimum-ripening stage at 8, 15, and 25 ℃. Lac. sakei and Lactobacillus plantarum grew rapidly in kimchi produced at 8, 15, and 25 ℃. In addition, Weissella koreensis first appeared at days 12, 9, and 6 at 8, 15, and 25 ℃ of fermentation, respectively. This result suggests that LAB population dynamics are rather sensitive to environmental conditions, such as pH, acidity, salinity, temperature, and chemical factors including free sugar and organic acids.