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Youngkyung Kim,Eun-hye Kim,Kyu Sang Lee,Koeun Lee,Sung Ho Park,Sook Hyun Na,Cheolwoong Ko,Junesun Kim,Young Wook Yooon 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee joint inflammation was induced by intra-articular injection of monosodium iodoacetate (MIA, 8 mg/50 µl) and weight bearing percentage on right and left hindpaws during walking, paw withdrawal threshold to mechanical stimulation, and paw withdrawal latency to heat were measured to evaluate pain behavior. Intra-articular administration of RTX (0.03, 0.003 and 0.0003%) at 2 weeks after the induction of knee joint inflammation significantly improved reduction of weight bearing on the ipsilateral hindlimb and increased paw withdrawal sensitivity to mechanical and heat stimuli. The reduction of pain behavior persisted for 3~10 days according to each behavioral test. The MIA-induced increase in CGRP immunoreactivity in the spinal cord was decreased by RTX treatment in a dose-dependent manner. The present study demonstrated that a single intra-articular administration of RTX reduced pain behaviors for a relatively long time in an experimental model of OA and could normalize OA-associated changes in peptide expression in the spinal cord.
Kim, Youngkyung,Kim, Eun-hye,Lee, Kyu Sang,Lee, Koeun,Park, Sung Ho,Na, Sook Hyun,Ko, Cheolwoong,Kim, Junesun,Yooon, Young Wook The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee joint inflammation was induced by intra-articular injection of monosodium iodoacetate (MIA, $8mg/50{\mu}l$) and weight bearing percentage on right and left hindpaws during walking, paw withdrawal threshold to mechanical stimulation, and paw withdrawal latency to heat were measured to evaluate pain behavior. Intra-articular administration of RTX (0.03, 0.003 and 0.0003%) at 2 weeks after the induction of knee joint inflammation significantly improved reduction of weight bearing on the ipsilateral hindlimb and increased paw withdrawal sensitivity to mechanical and heat stimuli. The reduction of pain behavior persisted for 3~10 days according to each behavioral test. The MIA-induced increase in CGRP immunoreactivity in the spinal cord was decreased by RTX treatment in a dose-dependent manner. The present study demonstrated that a single intra-articular administration of RTX reduced pain behaviors for a relatively long time in an experimental model of OA and could normalize OA-associated changes in peptide expression in the spinal cord.
Kim, Junesun,Kim, Youngkyung,Hahm, Suk-Chan,Yoon, Young Wook The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2
Cholecystokinin is known to be involved in the modulation of nociception and to reduce the efficacy of morphine analgesia. This study investigated the effects of intrathecal administration of morphine and the cholecystokinin type B antagonist CI-988 on below-level neuropathic pain after spinal cord injury in rats. We also examined the interaction of morphine and CI-988 in the antinociceptive effect. Both morphine and CI-988 given individually increased the paw withdrawal threshold to mechanical stimulation in a dose-dependent manner. The combination of ineffective doses of intrathecally administered CI-988 and morphine produced significant analgesic effects and the combination of effective doses resulted in analgesic effects that were greater than the sum of the individual effects of each drug. Thus, morphine showed a synergistic interaction with CI-988 for analgesia of central neuropathic pain.
Kim, Bo-Bae,Kim, Minji,Park, Yun-Hee,Ko, Youngkyung,Park, Jun-Beom Cambridge Medical Publications Ltd 2017 The Journal of international medical research Vol.45 No.3
<P><B>Objective</B></P><P>Next-generation sequencing was performed to evaluate the effects of short-term application of dexamethasone on human gingiva-derived mesenchymal stem cells.</P><P><B>Methods</B></P><P>Human gingiva-derived stem cells were treated with a final concentration of 10<SUP>−7 </SUP>M dexamethasone and the same concentration of vehicle control. This was followed by mRNA sequencing and data analysis, gene ontology and pathway analysis, quantitative real-time polymerase chain reaction of mRNA, and western blot analysis of RUNX2 and β-catenin.</P><P><B>Results</B></P><P>In total, 26,364 mRNAs were differentially expressed. Comparison of the results of dexamethasone versus control at 2 hours revealed that 7 mRNAs were upregulated and 25 mRNAs were downregulated. The application of dexamethasone reduced the expression of RUNX2 and β-catenin in human gingiva-derived mesenchymal stem cells.</P><P><B>Conclusion</B></P><P>The effects of dexamethasone on stem cells were evaluated with mRNA sequencing, and validation of the expression was performed with qualitative real-time polymerase chain reaction and western blot analysis. The results of this study can provide new insights into the role of mRNA sequencing in maxillofacial areas.</P>
Kim, Young Ock,Kim, Youngkyung,Lee, Koeun,Na, Sae Won,Hong, Seon Pyo,Valan Arasu, Mariadhas,Yoon, Young Wook,Kim, Junesun Hindawi Publishing Corporation 2015 Evidence-based Complementary and Alternative Medic Vol.2015 No.-
<P>Spinal cord injury (SCI) results in permanent loss of motor function below the injured site. Neuroinflammatory reaction following SCI can aggravate neural injury and functional impairment. Ginseng is well known to possess anti-inflammatory effects. The present study investigated the neuroprotective effects of <I>Panax ginseng</I> C.A. Mayer (<I>P. ginseng</I>) after SCI. A spinal contusion was made at the T11-12 spinal cord in adult male Sprague-Dawley rats (<I>n</I> = 47) using the NYU impactor. Motor function was assessed using the Basso-Beattie-Bresnahan (BBB) score in <I>P. ginseng</I> (0.1, 0.5, 1, 3, and 5 mg/kg) or vehicle (saline) treated after SCI. We also assessed the protein expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) at the lesion site by western blot and then measured the cavity area using luxol fast blue/cresyl violet staining. <I>P. ginseng</I> treated group in SCI showed a significant improvement in locomotor function after the injury. The protein expression of COX-2 and iNOS at the lesion site and the cavity area were decreased following SCI by <I>P. ginseng</I> treatment. These results suggest that <I>P. ginseng</I> may improve the recovery of motor function after SCI which provides neuroprotection by alleviating posttraumatic inflammatory responses.</P>
산업체에서 제품 개발을 위한 감각과학의 활용과 소비자 연구
김영경(Youngkyung Kim) 한국식품과학회 2019 식품과학과 산업 Vol.52 No.1
Various sensory technologies have been used at different stages of product development. In this paper, the examples of sensory studies in teas and cosmetics were shown, and these could help to increase the contribution of sensory sciences to the development of products in the industry. In classical approach, descriptive analysis with trained panel and consumer acceptability test are very important to identify the sensory characteristics that drive consumer acceptability of products. Recently, some quick and easy sensory evaluation methods were introduced such as CATA (check-all-that-apply), sorting, and Napping<SUP>Ⓡ</SUP>, etc. to gather information about consumers’ perception of the sensory characteristics of products. Although there are many sensory methodologies available in the product development phase, the most important thing is that these have to be correctly selected and designed for target consumers, products, and research purposes in order to develop a successful product.
풍력발전사업 에너지생산량 산정 오차가 사업성지표에 미치는 영향 및 AHP를 이용한 중요인자 분석
김영경(Youngkyung Kim),장병만(Byungman Chang) 한국경영과학회 2013 經營 科學 Vol.30 No.2
Case studies are made to investigate the relationship between the accuracy of energy production estimation and project feasibility indicators such as rate of return on equity (ROE) and debt service coverage ratio (DSCR) for three wind farm projects. It is found out that 1% improvement in the accuracy of energy production estimation may enhance the ROE by more than 0.5% in the case of P95, thanks to improved financing terms. AHP survey shows that MCP correlation of measured in situ wind data with long term wind speed distribution and hands-on experiences of flow analysis are more important than other factors for more precise annual energy production estimation.