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Elastic Modulus of Osteoporotic Mouse Femur Based on Femoral Head Compression Test
Chon, Chang-soo,Yun, Hui-suk,Kim, Han Sung,Ko, Cheolwoong Hindawi 2017 Applied bionics and biomechanics Vol.2017 No.-
<P>A biomechanical test is a good evaluation method that describes the structural, functional, and pathological differences in the bones, such as osteoporosis and fracture. The tensile test, compression test, and bending test are generally performed to evaluate the elastic modulus of the bone using mice. In particular, the femoral head compression test is mainly used for verifying the osteoporosis change of the femoral neck. This study conducted bone mineral density analysis using in vivo microcomputed tomography (micro-CT) to observe changes in osteoporosis over time. It proposed a method of identifying the elastic modulus of the femur in the normal group (CON group) and the osteoporotic group (OVX group) through finite element analysis based on the femoral head compression test and also conducted a comparative analysis of the results. Through the femoral head compression test, it was verified that the CON group's ultimate and yield loads were significantly higher than those of the OVX group. It was considered that this result was caused by the fact that the bone mineral density change by osteoporosis occurred in the proximal end more often than in the femur diaphysis. However, the elastic modulus derived from the finite element analysis showed no significant difference between the two groups.</P>
Kim, Taemin,Seol, Dong Rim,Hahm, Suk-Chan,Ko, Cheolwoong,Kim, Eun-Hye,Chun, Keyoungjin,Kim, Junesun,Lim, Tae-Hong Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>The present study examined the analgesic effects of slow-releasing bupivacaine from hydrogel on chronic arthritic pain in rats. Osteoarthritis (OA) was induced by monosodium iodoacetate (MIA) injection into the right knee joint. Hydrogel (HG: 20, 30, and 50 <I>μ</I>L) and temperature-sensitive hydrogel containing bupivacaine (T-gel: 20, 30, and 50 <I>μ</I>L) were injected intra-articularly 14 days after MIA injection. Behavioral tests were conducted. The rats showed a significant decrease in weight load and paw withdrawal threshold (PWT). Intra-articular 0.5% bupivacaine (10 and 20 <I>μ</I>L) significantly reversed MIA-induced decreased PWT, with no effect on weight load. In normal rats, hydrogel did not produce significant changes in PWT but at 30 and 50 <I>μ</I>L slightly decreased weight bearing; T-gel did not cause any changes in both the weight load and PWT. In OA rats, T-gel at 20 <I>μ</I>L had a significant analgesic effect for 2 days, even though T-gel at 50 <I>μ</I>L further reduced the weight load, demonstrating that intra-articular T-gel (20 <I>μ</I>L) has long-lasting analgesic effects in OA rats. Thus, T-gel designed to deliver analgesics into the joint cavity could be an effective therapeutic tool in the clinical setting.</P>
폴리우레탄 폼의 모폴로지와 물리적 특성 사이의 관련성 연구
정민선(Minseon Jung),한세미(Semi Han),이진욱(Miseon Yang),고철웅(Cheolwoong Ko),변태민(Tae Min Byun),김백진(Baek-Jin Kim) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.2014 No.2
신발 내의 insole type의 족적수집 device용 센서 base와 core에 각각 폴리우레탄과 실리콘 소재를 심어 신체활동량 측정, 병증확인, 위치확인 등의 목적으로 적합한 소재 선정을 위한 물성 측정 결과를 알아보려고 한다. 이 중 폴리우레탄 소재가 여러 성질 중 충격흡수성과 표면 촉감이 우수한 특성을 갖고 신발이나 자동차내장재로서 사용되는 점을 보아 이를 주요 소재로 조사하였다. 본 연구에서는 PORON이라는 폴리우레탄 소재를 기준으로 여러 폴리우레탄 소재를 가지고 센서 소재에 대한 적합성을 확인하기 위해 형태학분석을 통해서 셀의 분포나 개수에 따라 영구압축 줄임률이나 복원특성에 어떠한 영향을 주는지 검토하였다.
Kim, Youngkyung,Kim, Eun-hye,Lee, Kyu Sang,Lee, Koeun,Park, Sung Ho,Na, Sook Hyun,Ko, Cheolwoong,Kim, Junesun,Yooon, Young Wook The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee joint inflammation was induced by intra-articular injection of monosodium iodoacetate (MIA, $8mg/50{\mu}l$) and weight bearing percentage on right and left hindpaws during walking, paw withdrawal threshold to mechanical stimulation, and paw withdrawal latency to heat were measured to evaluate pain behavior. Intra-articular administration of RTX (0.03, 0.003 and 0.0003%) at 2 weeks after the induction of knee joint inflammation significantly improved reduction of weight bearing on the ipsilateral hindlimb and increased paw withdrawal sensitivity to mechanical and heat stimuli. The reduction of pain behavior persisted for 3~10 days according to each behavioral test. The MIA-induced increase in CGRP immunoreactivity in the spinal cord was decreased by RTX treatment in a dose-dependent manner. The present study demonstrated that a single intra-articular administration of RTX reduced pain behaviors for a relatively long time in an experimental model of OA and could normalize OA-associated changes in peptide expression in the spinal cord.
Youngkyung Kim,Eun-hye Kim,Kyu Sang Lee,Koeun Lee,Sung Ho Park,Sook Hyun Na,Cheolwoong Ko,Junesun Kim,Young Wook Yooon 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee joint inflammation was induced by intra-articular injection of monosodium iodoacetate (MIA, 8 mg/50 µl) and weight bearing percentage on right and left hindpaws during walking, paw withdrawal threshold to mechanical stimulation, and paw withdrawal latency to heat were measured to evaluate pain behavior. Intra-articular administration of RTX (0.03, 0.003 and 0.0003%) at 2 weeks after the induction of knee joint inflammation significantly improved reduction of weight bearing on the ipsilateral hindlimb and increased paw withdrawal sensitivity to mechanical and heat stimuli. The reduction of pain behavior persisted for 3~10 days according to each behavioral test. The MIA-induced increase in CGRP immunoreactivity in the spinal cord was decreased by RTX treatment in a dose-dependent manner. The present study demonstrated that a single intra-articular administration of RTX reduced pain behaviors for a relatively long time in an experimental model of OA and could normalize OA-associated changes in peptide expression in the spinal cord.