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김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1
The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.
Young Beom Kwak,Yong Duk Lee,Jungdong Yu,Hye Hyun Yoo 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11
Anamorelin is s selective agonist of the non-peptide growth hormone secretagogues (GHs). The illegal use of “GHs” for their anabolic activity is strongly prohibited by World Anti-Doping Agency (WADA). However, the metabolism study of anamorelin for forensic evidence has not been done in human yet. In this study, the in vitro metabolism of anamorelin was investigated in human liver microsomes (HLM) using molecular networking (MN). As a result, a total of 17 metabolites (M1-M12) nodes in MN were structurally connected and elucidated based on MS¹, MS² and FMOs test (M1, demethylation; M2, demethylation and desaturation; M3a-b, hydroxylation; M4a-d, di-hydroxylation; M5a-c, hydroxylation and demethylation; M7, N-dealkylation; M8, N-dealkylation and demethylation; M9, N-dealkylation and desaturation; M10, N-oxidation; M11, N-oxidation and hydroxylation; M12, N-oxidation and demethylation). MN analysis additionally detected 12 metabolites which had not been reported previously.
Young Beom Kwak,Shaheed Ur Rehman,Hye Hyun Yoo 사단법인 한국질량분석학회 2023 Mass spectrometry letters Vol.14 No.3
Anabolic-androgenic steroids (AAS) are used illegally to enhance muscle development and increase strength and power. In this study, a reliable, and sensitive quantitative method was developed and validated using heptafluorobutyric acid anhydride (HFPA) derivatives for the simultaneous detection of prohibited AAS (testosterone [TS], boldenone [BD], 5α-estrane- 3β,17α-diol [EAD]) using gas chromatography-tandem mass spectrometry (GC-MS/MS). For processing the samples, solid phase extraction, methanolic hydrolysis, and liquid-liquid extraction were used. For detection using mass spectrometry, the mul- tiple reaction monitoring (MRM) mode was used with the electron ionization (EI) positive mode. The method was evaluated for selectivity, linearity, lower limit of quantification, intra- and inter-day precision, accuracy, and stability. The results showed that the method was accurate and reproducible for the quantitation of the three steroids. The developed method was finally applied to the analysis of a suspect gelding urine sample received from the Asian Quality Assurance Program (AQAP).
Young Beom Kwak,Jundong Yu,Hye Hyun Yoo 사단법인 한국질량분석학회 2022 Mass spectrometry letters Vol.13 No.4
Many therapeutic class drugs such as beta-blocker, corticosteroids, NSAIDs, etc are prohibited substances in the horse racing industry. Liquid chromatography-tandem mass spectrometry (LC–MS/MS) technology makes it possible to isolate drugs from interference, enables various drug analyses in complex biological samples due to its sensitive sensitivity, and has been successfully applied to doping control. In this paper, we describe a rapid and sensitive method based on solid-phase extraction (SPE) using solid phase cartridge and LC–MS/MS to screen for different class’s 35 drug targets in equine plasma. Plasma samples were pretreated by SPE with the NEXUS cartridge consisted non-polar carbon resin and minimum buffer sol- vent. Chromatographic separation of the analytes was performed on ACQUITY HSS C18 column (2.1 × 150 mm, 1.8 µm). The elution gradient was conducted with 5 mM ammonium formate (pH 3.0) in distilled water and 0.1% formic acid in acetonitrile at a flow rate of 0.25 mL/min. The selected reaction monitoring (SRM) mode was used for drug screening with multiple transitions in the positive ionization mode. The specificity, limit of detection, recovery, and stability was evaluated for validation. The method was found to be sensitive and reproducible for drug screening. The method was applied to plasma sample analysis for the proficiency test from the Association of Racing Chemist.