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Current status of whitening agents and their future in Japan
Tanaka, Yoshimasa,Masuda, Mitsuteru 한국유화학회 1998 한국응용과학기술학회지 Vol.15 No.3
Skin whitening agents, possible methods of controlling melanogenesis, and future considerations for skin whitening are discussed with respect to active ingredients and related substances in Japan.
Current status of whitening agents and their future in Japan
Yoshimasa Tanaka,Mitsuteru Masuda 한국유화학회 1998 한국응용과학기술학회지 Vol.15 No.3
Skin whitening agents, possible methods of controlling melanogenesis, and future considerations for skin whitening are discussed with respect to active ingredients and related substances in Japan.
( Yoshimasa Tanaka ),( Yasuaki Motomura ),( Kazuya Akahoshi ),( Risa Iwao ),( Keishi Komori ),( Naotaka Nakama ),( Takashi Osoegawa ),( Soichi Itaba ),( Masaru Kubokawa ),( Terumasa Hisano ),( Eikichi The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.3
Background/Aims: Colonic diverticular bleeding can stop spontaneously or be stopped by endoscopic hemostasis. We analyzed the clinical and colonoscopic features of patients with colonic diverticular bleeding to establish the predic-tive factors for rebleeding. Methods: A total of 111 patients (median age, 72 years) with colonic diverticular bleeding in Aso Iizuka Hospital between April 2007 and July 2010 were enrolled. Age, sex, body mass index (BMI), comorbid-ity, medication, location of bleeding, colonoscopic findings and hemostatic methods were analyzed retrospectively from the hospital records. Results: The most common sites of bleeding were the ascending (39.6%) and sigmoid (29.7%) colon. Overt rebleeding occurred in 30 patients (27.0%). Spontaneous hemostasis was seen in 81 patients (73.0%), and endoscopic hemostatic treatment was performed in 30 patients. The BMI in the patients with colonic diverticular rebleeding was significantly higher than in patients without rebleeding. Colonoscopic findings of actively bleeding or non-bleeding visible vessels in the responsible diverticula were more frequent in the group with rebleeding. Conclusions: A higher BMI and colonoscopic findings of actively bleeding or nonbleeding visible vessels can be used as predictive factors for colonic diverticular rebleeding. Patients with such findings should be carefully followed up after hemostasis of the initial colonic diverticular bleeding. (Gut Liver 2012;6:334-338)
DETECTING INFLUENTIAL SUBSETS IN REGRESSION ANALYSIS BY MEANS OF CLUSTER ANALYSIS
TANAKA, Yutaka,ODAKA, Yoshimasa,MOON, Sung Ho 高麗大學校統計硏究所 1992 應用統計 Vol.7 No.-
본 논문은 회귀분석에 있어서의 influential subsets의 탐색에 관하여 논한다. 이를 위하여 Moon, Yanagi and Tanaka(1992)에 의해 제안된 계층적 군집 알고리즘을 적용하였다. 이 알고리즘은 경험 영향력 함수(EIF)가 이용가능한 다변량 해석법에 있어서의 influential subsets을 탐색하기 위한 일반적인 방법의 하나로서 고안된 것이다. 또한 이를 위하여 일반화 영향력 함수(generalized influence function)를 유도하게 되며, 몇가지 유형의 영향력 측면 - 즉, 추정치와 추정치의 정도(精度)에 대한 영향 - 에서 정의되는 군집간의 유사성을 이용하였다. 이 논문의 주된 목적은 앞의 연구에 의한 알고리즘을 회귀분석에 적용하여 기존의 multiple case 진단법과의 결과 비교를 통하여 그것의 효율성을 논하는 데 있다.
Onigiri Esophagography as a Screening Test for Esophageal Motility Disorders
( Shohei Hamada ),( Eikichi Ihara ),( Kazumasa Muta ),( Masafumi Wada ),( Yoshitaka Hata ),( Hiroko Ikeda ),( Yoshimasa Tanaka ),( Haruei Ogino ),( Takatoshi Chinen ),( Yoshihiro Ogawa ) 대한소화기기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.1
Background/Aims No screening test for esophageal motility disorder (EMD) has been established, the objective of this study is to examine the potential usefulness of our newly developed “Onigiri esophagography” combined with an obstruction level (OL) classification system in screening for EMD. Methods A total of 102 patients with suspected EMDs who underwent both high-resolution manometry (HRM) and Onigiri esophagography between April 2017 and January 2019 were examined. The EMD diagnosis was performed based on the Chicago classification version 3.0 by HRM. Onigiri esophagography was performed using a liquid medium (barium sulfate) followed by a solid medium, which consisted of an Onigiri (a Japanese rice ball) with barium powder. The extent of medium obstruction was assessed by the OL classification, which was defined in a stepwise fashion from OL0 (no obstruction) to OL4 (severe obstruction). Results The patients with OL0 (32.3%), OL1 (50.0%), OL2 (88.0%), OL3 (100.0%), and OL4 (100.0%) were diagnosed EMDs by HRM. The area under the curve, as determined by a receiver operating characteristic analysis, for the OL classification was 0.86. Using the cutoff value of OL1, the sensitivity and specificity were 87.3% and 61.3%, respectively, while using a cutoff value of OL2, the sensitivity and specificity were 73.2% and 90.3%, respectively. Conclusion In conclusion, Onigiri esophagography combined with the OL classification system can be used as a screening test for EMDs with a cutoff value of OL1. (J Neurogastroenterol Motil 2022;28:43-52)
( Drug Therapy ),( Kazuhiko Nakamura ),( Kazuya Akahoshi ),( Toshiaki Ochiai ),( Keishi Komori ),( Kazuhiro Haraguchi ),( Munehiro Tanaka ),( Norimoto Nakamura ),( Yoshimasa Tanaka ),( Kana Kakigao ) The Editorial Office of Gut and Liver 2012 Gut and Liver Vol.6 No.4
Background/Aims: Antithrombotic/nonsteroidal antiinflammatory drug (NSAID) therapies increase the incidence of upper gastrointestinal bleeding. The features of hemorrhagic peptic ulcer disease in patients receiving antithrombotic/NSAID therapies were investigated. Methods: We investigated the medical records of 485 consecutive patients who underwent esophagogastroduodenoscopy and were diagnosed with hemorrhagic gastroduodenal ulcers. The patients treated with antithrombotic agents/NSAIDs were categorized as the antithrombotic therapy (AT) group (n=213). The patients who were not treated with antithrombotics/NSAIDs were categorized as the control (C) group (n=263). The clinical characteristics were compared between the groups. Results: The patients in the AT group were significantly older than those in the C group (p<0.0001). The hemoglobin levels before/without transfusion were significantly lower in the AT group (8.24±2.41 g/dL) than in the C group (9.44±2.95 g/dL) (p<0.0001). After adjusting for age, the difference in the hemoglobin levels between the two groups remained significant (p=0.0334). The transfusion rates were significantly higher in the AT group than in the C group (p=0.0002). However, the outcome of endoscopic hemostasis was similar in the AT and C groups. Conclusions: Patients with hemorrhagic peptic ulcers receiving antithrombotic/NSAID therapies were exposed to a greater risk of severe bleeding that required transfusion but were still treatable by endoscopy. (Gut Liver 2012;6:423-426)