마그네슘 풍부 해양미네랄 용액이 hairless 마우스의 아토피성 피부염에 미치는 영향

김동희,이규재,최주봉,이영미,윤양숙,김정례,장병수,양용석 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.3

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease that often has asthma and allergic rhinitis. Magnesium salts, the important component of minerals in Dead Sea water, are known to exhibit beneficial effects in inflammatory disease. Favorable effects of magnesium ions and sea water treated to the skin of patients with contact dermatitis have been reported. But histological and immunological investigations are insufficient. This study was performed to examine the inhibitory effect of magnesium-rich sea mineral water on the development of AD-like skin lesions in hairless mice. AD-like skin lesions are induced by the repeated application of 2,4-dinitrochlorobenzene (DNCB). Local application of magnesium-rich sea mineral water on hairless mice skin applied with DNCB inhibited the development of AD-like skin lesions as exemplified by a significant increase in skin hydration (p<0.01), and a decrease in epidermal water loss (p<0.01). Serum IgE level was also significantly decreased (p<0.01). These results suggest that magnesiumrich sea mineral water inhibits the development of DNCB-induced AD-like skin lesions in hairless mice. These observations indicate that magnesium-rich sea mineral water may be alternative and assistant substances for the management of AD. 아토피성 피부염은 주로 천식과 비염 등을 동반하는, 주위에서 흔히 볼 수 있는 만성 염증성 피부질환으로 유전학적, 환경적, 면역학적 요인이 복잡하게 연관되어 발병한다. 해수에 포함된 마그네슘염은 피부에 작용하여 피부장벽을 보호하는 것으로 알려지고 그에 대한 면역학적인 연구와 조직학적 연구는 아직 부족한 실정이다. 이번 연구에서는 피부염을 인위적으로 일으키는 hapten 형성물질인 DNCB를 hairless mice에 도포하여 아토피 피부염 동물 모델로 만든 후, 마그네슘이 다량 함유된 해양 미네랄수를 처리한 후 피부장벽에 미치는 영향을 관찰하였다. DNCB로 피부염을 유발한 hairless mice에 해양미네랄수를 국소적으로 도포하였을 때 유의한 피부수분함량이 증가와 경피수분손실의 감소를 확인하였다 (p<0.01). 피부측정에서 피부거칠기(skin roughness, p<0.05)와 스케일생성 (skin scaliness, p<0.01)은 실험군에서 유의한 개선효과를 나타내었으며 조직학적 검사에서도 피부손상지수의 유의한 감소 (p<0.01)와 비만세포와 (p<0.01) 호산구의 감소(p<0.05) 소견을 보였고 또한 혈청 IgE의 감소를 관찰할 수 있었다(p<0.01). 이상과 같이 마그네슘이 다량 함유된 해양 미네랄수 도포는 피부장벽의 손상을 줄이고 피부수분손실을 효과적으로 줄임으로 아토피성 피부염 증상 유발을 억제할수 있음을 확인하였다. 현재까지 아토피성 피부염의 관리를 위하여 세라마이드나 식물성 오일의 보습제가 주로 활용되고 있는 상황에서 부가적인 피부장벽의 보호를 위하여 탈염 해양 미네랄수의 활용이 가능할 것으로 판단되며 장기적으로 아토피 피부염치료의 대체, 혹은 보조적 물질로 활용될 수 있을 것으로 기대된다.

Risk factors and long-term prognosis of BCLC stage 0/A hepatocellular carcinoma for beyond milan recurrence after hepatectomy: A multicenter observational study

Zi-Han FENG,Ming-Da WANG,Li-Yang SUN,Xiao XU,Qing-Yu KONG,Zi-Xiang CHEN,Yong-Yi ZENG,Timothy M. PAWLIK,Wan Yee LAU,Feng SHEN,Zhong CHEN,Tian YANG 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

INTERFACIAL ENGINEERING FOR SOLUTION-PROCESSED METAL OXIDE BASED PEROVSKITE SOLAR CELLS

Feng Yang,Naying Jin,Yong-Sang Kim,Dong-Won Kang 한국신재생에너지학회 2017 AFORE Vol.2017 No.11

Prevalence and Age, Gender and Geographical Area Distribution of Esophageal Squamous Cell Carcinomas in North China from 1985 to 2006

Feng, Xiao-Shan,Yang, Yan-Tong,Gao, She-Gan,Ru, Yi,Wang, Gong-Ping,Zhou, Bo,Wang, Yu-Feng,Zhang, Peng-Fei,Li, Pu-Yu,Liu, Yong-Xuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Objective: To establish the prevalence and distribution profile of esophageal squamous cell carcinomas (ESCCs) over a 22-yr period in North China. Methods: Using endoscopy for primary diagnosis and histological analysis for the further confirmation, a total of 74,854 ESCC patients aged 20-89 between January 1985 and December 2006 were investigated to analyze the epidemiological profile including prevalence rates, distribution of age-of-onset, gender and geographical area of ESCC in Luoyang, the highest incidence area of North China. Results: A total of 4092 cases of ESCC were finally diagnosed among 74,854 patients who had their first endoscopies. The prevalence among males was higher than that among females (p<0.01), resulting in an overall male:female OR of 1.2 (95%CI, 1.2-1.3). The prevalence in rural areas was higher than in urban areas (p<0.01), resulting in an overall rural:urban OR of 2.6 (95%CI, 2.4-2.9). The rural:urban ORs and the 95% CI increased continuously from 2.6, 2.3-3.0 to 2.7, 2.2-3.3, respectively, for 4 consecutive periods during the 22-yr study period. Moreover, the median age of onset among females was higher than that among males (p<0.01). For both sexes and in both areas, the prevalence rates declined and the median age of onset rose for 4 consecutive periods in the 22-yrs time frame (p<0.01). Conculsions: These data reveal the epidemiological profile of ESCC in the area of North China, and suggest that urban areas and rural people account for a growing proportion of the ESCC patients although the prevalence of ESCC significantly declined and the median age-of-onset postponed over the 22-yrs period. Moreover, the prevalence status of ESCC in rural areas also underlines the need for public health initiatives aimed at reducing risk factors of this fatal disease.

Research on the motion characteristics of a trans-media vehicle when entering water obliquely at low speed

Yong-li Li,Jin-fu Feng,Jun-hua Hu,Jian Yang 대한조선학회 2018 International Journal of Naval Architecture and Oc Vol.10 No.2

This paper proposes a single control strategy to solve the problem of trans-media vehicle difficult control. The proposed control strategy is just to control the vehicle's air navigation, but not to control the underwater navigation. The hydrodynamic model of a vehicle when entering water obliquely at low speed has been founded to analyze the motion characteristics. Two methods have been used to simulate the vehicle entering water in the same condition: numerical simulation method and theoretical model solving method. And the results of the two methods can validate the hydrodynamic model founded in this paper. The entering water motion in the conditions of different velocity, different angle, and different attack angle has been simulated by this hydrodynamic model and the simulation has been analyzed. And the change rule of the vehicle's gestures and position when entering water has been obtained by analysis. This entering water rule will guide the follow-up of a series of research, such as the underwater navigation, the exiting water process and so on.

Laser-processing of transparent solid materials for advanced photonic device applications

Feng Zhu,Rui Yang,Lei Wang,Yong-Sen Yu,Qi-Dai Chen,Hong-Bo Sun 한국생산제조학회 2012 한국생산제조시스템학회 학술발표대회 논문집 Vol.2012 No.10

We demonstrate the laser processing for fabrication of advanced photonic devices including fiber gratings and high transmittance biomimetic windows. The fiber gratings, including fiber Bragg gratings (FBGs) and long period fiber gratings (LPFGs), are fabricated in non-sensitized standard telecom single-mode fiber by femtosecond (fs) laser, making them hightemperature (1000 ℃) stable. The FBG written by fs laser combined with phase mask method is used for monitoring the thermal effect in fs laser interaction with silica glass. The peak temperature of the thermal impulse is estimated about 4800 ℃, which decays to around 500 ℃ in the pulse interval for irradiation of 1.1 mJ at repetition rate of 1 kHz. When the pulse energy and repetition rate increase in the fabrication process of FBGs, the fs-laser-induced grating regions extend from the fiber core to the cladding?air boundary due to the laser self-focusing. With the help of selective chemical etching of the laser modified grating regions, a microhole array structured FBG is formed, which is demonstrated in the application of simultaneous sensing for refractive index (RI) and temperature. For the fs laser direct writing of LPFGs, the period is 100 μm, making the total length of the LPFG only 5 mm. The LPFGs can couple the guided mode to high-order cladding modes of second-order diffraction, resulting in a high RI sensitivity of 5265 nm/RI unit in the RI range of 1.433 ∼ 1.443 and a low-temperature sensitivity of ?15.52 pm/℃ from 20 ℃ to 500 ℃. In addition, the high transmittance biomimetic windows are produced by direct laser interference ablation. The interfered laser beams are introduced into the surface of a bare optical substrate, where structured surfaces consisting of a micropillar array are produced by the multiple exposure of the two-beam interference ablation. As an example of the application, zinc sulfide substrates are processed with this technology.

HIGHLY ENHANCED PERFORMANCE OF INVERTED POLYMER SOLAR CELLS USING PENTACENE

Feng YANG,Eung-Kyu PARK,Jae-Hyoung KIM,Yong-Sang KIM 한국신재생에너지학회 2014 AFORE Vol.2014 No.-

Pentacene-assisted planarization of photo-active layers for high performance tandem organic photovoltaics

Yang, Feng,Kang, Dong-Won,Kim, Yong-Sang Elsevier 2018 SOLAR ENERGY -PHOENIX ARIZONA THEN NEW YORK- Vol.163 No.-

<P><B>Abstract</B></P> <P>In organic tandem solar cells, the morphology of the photo-active layers is not usually stable when their fabrication processes are made with several thermal treatments. Here, we report pentacene-assisted planar tandem organic photovoltaic device based on the active layers of poly(3-hexylthiophene) (P3HT) and (6,6)-phenyl C61-butyric acid methyl ester (PCBM), fabricated in air-ambient. An additive of pentacene was introduced into the active layers of the bottom sub-cells for planarization on their surfaces. The surface morphology of pentacene-based active layer was maintained to be flat from 80 to 160 °C, and allowed for fabricating the planar active layers and interconnecting layer of tandem devices against thermal treatment. State-of-the-art homo-tandem organic solar cells were achieved with an average power conversion efficiency (PCE) of 3.5%, while their best single junction solar cells of P3HT:PCBM achieved a PCE of 3.2%. We showed the first application of high performance tandem organic photovoltaics with three times of high temperature annealing processes at 160 °C. Our work demonstrates a practical way to design highly efficient tandem organic solar cells with other powerful and well-chosen bandgap energy active layers during thermal treatments.</P> <P><B>Highlights</B></P> <P> <UL> <LI> State-of-the-art homo-tandem organic solar cells were made in air-ambient. </LI> <LI> Surface of pentacene-added absorber was morphologically stable at 160 °C. </LI> <LI> Stable tandem cell against high temperature annealing three times at 160 °C. </LI> <LI> Homo-tandem solar cells increase PCE by 10% more than the best single cell. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Development and validation of risk score for predicting spontaneous rupture of hepatocellular carcinoma

Feng Ye,Di Ma,Xiao-Yong Gong,Yu-Chen Yang,Yong-Jun Chen 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.5

Purpose: Spontaneous rupture is a potentially serious complication of liver cancer. A risk score was developed and validated for predicting spontaneous rupture based on a retrospective study. Methods: Multiple logistic regression analysis was used to study the relationship between clinical variables and spontaneous rupture. The independent rupture predictors were converted into a score based on the odds ratio. Predicted attributes of the developed scores were then verified using a dataset in 2019. Results: The incidence of spontaneous rupture was 5.5% from 2002 to 2019. A 10-point score (α-FP of ≥400 μg/L, 1; protrusion from liver surface, 2; ascites, 3; tumor size of >5 cm, 4) was derived for prediction of rupture and area under the receiver-operating characteristic curve was 0.9 (95% confidence interval, 0.87–0.92). When applying a cutoff value of 5 points or more, the specificity was 0.87 and the sensitivity was 0.84. A validation cohort consisting of 202 hepatocellular carcinoma patients reproduces the predictive, identification, and calibration characteristics. The observed rate of spontaneous rupture according to risk stratification of the score was 0.6% for those with a score of 0–4, 21.6% for a score of 5–7, and 36.4% for a score of 8–10 in the validation cohort. Conclusion: Here, based on routine clinical data, we determine the factors that affect prognosis and propose an effective tool for predicting spontaneous rupture, which may be useful in guiding priority treatment of high-risk patients or clinical routine preventive treatment.

FE MODEL UPDATING OF ROTOR SHAFT USING OPTIMIZATION TECHNIQUES

Yong Han Kim(김용한),Fu Zhou Feng,Bo-Suk Yang(양보석) 한국소음진동공학회 2003 한국소음진동공학회 학술대회논문집 Vol.2003 No.11