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P-85 Inflammatory pseudotumor of the lung with extensive metastasis
( Yong Jun Jang ),( Jae Seok Jeong ),( So Ri Kim ),( Seung Yong Park ),( Yeong Hun Choe ),( Yong Chul Lee ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Inflammatory pseudotumors (IPTs) are rare benign diseases entity of uncertain etiology and involve almost all major organs including the lung. IPTs tend to infiltrate into adjacent tissues, however, limited information exists on the IPTs initially manifesting with distant metastasis. A 66-year-old male presented with cough and hemoptysis for 3 weeks. Chest X-ray showed right hilar enlargement and contrast-enhanced chest computed tomography (CT) showed a mass in the right lower lobe (RLL) with enlargement of lymph nodes (LNs) involving mediastinum and both supraclavicular areas. Transthoracic needle biopsy for the RLL mass revealed that the biopsy samples showed proliferation of plasma cells, fibroblasts and simultaneous infiltration of various inflammatory cells and there was no evidence of malignant cells. Excisional biopsy for right supraclavicular LN and bone biopsy of thoracic vertebra also revealed chronic inflammation, which suggests the infiltration of IPT. Collectively, the patient was diagnosed with metastatic IPT and treated with macrolide and anti-inflammatory drugs including glucocorticoids based on previous reports.
( Yeong Hun Choe ),( Min Suk Kim ),( Mi Hee Kang ),( Yu Jeong Oh ),( Yoon Chae Lee ),( Seung Yong Park ),( So Ri Kim ),( Seoung Ju Park ),( Heung Bum Lee ),( Yong Chul Lee ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.0
Background: It is known that the prevalence and social burden related to chronic obstructive pulmonary disease is increasing. Previous survey published at 2008 demonstrated that 13.4% of subjects aged over 40 years had airflow obstruction (FEV1/FVC <0.7) in Korean population. However, current status of prevalence and characteristics of elderly who have obstruction airway disease (OAD) is not well investigated yet. Methods: A total of 2566 adults (1109 of male and 1457 of female; mean age 73.4±6.4) were included from public health survey during 3 years. Pulmonary function was measured by portable flow-volume device. A standard questionnaire (CAT score), smoking status, respiratory symptoms such as cough, sputum, dyspnea, and comorbid illness were collected. Results: The prevalence of person with OAD which was defined as FEV1/FVC <0.7 was 18.5% (Male 29.2%, Female 10.4%). Mean FEV1 change was -33mL per year in both men and women. There was significant correlation between age and prevalence of OAD. Former or current smoking was significantly more common in group of OAD. Among persons with OAD, 56.2% have FEV1 below 80% of predicted. The proportion of person according to GOLD stage A-D was 50.6%, 37.9%, 4.6%, and 6.9% respectively. Comparing GOLD stage A with B, persons with GOLD stage B were tent to have low BMI and comorbid illness such as hypertension and diabetes. In multivariate analysis, factors associated with higher CAT score in OAD were advanced COPD stage, history of smoking, and female gender. Conclusions: Our data indicate that the prevalence of COPD in elderly is still high and large number of person is undiagnosed and untreated.
Endobronchial mucormycosis successfully treated with bronchoscopic cryotherapy: A case report
( Yeong Hun Choe ),( Yong Chul Lee ),( Seung Yong Park ),( Jae Seok Jeong ),( So Ri Kim ) 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Endobronchial mucormycosis is devastating fungal disease and a major threat in immunocompromised patients. The mortality rate is high, and surgical debridement of necrotic tissue along with antifungal therapy is required for cure. However, there are so many hurdles to apply the surgical resection as a therapeutic strategy. We describe a case of endobronchial mucormycosis in a liver transplant recipient who was successfully treated with bronchoscopic cryotherapy and liposomal amphotericin B. Given that there is extremely little information on mucormycosis treated with bronchoscopic cryotherapy so far, the current experience has valuable clinical significance suggesting that bronchoscopic cryotherapy with antifungal treatment can be a promising alternative therapeutic approach for endobronchial mucormycosis, especially in cases of mucormycosis that surgery may not be feasible due to various factors such as the extent and location of the lesions and poor medical condition of the patient.
( Yeong Hun Choe ),( Min Suk Kim ),( Mi Hee Kang ),( Yu Jeong Oh ),( Yoon Chae Lee ),( Seung Yong Park ),( So Ri Kim ),( Seoung Ju Park ),( Heung Bum Lee ),( Yong Chul Lee ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: It is known that the prevalence and social burden related to chronic obstructive pulmonary disease is increasing. Previous survey published at 2008 demonstrated that 13.4% of subjects aged over 40 years had airfiow obstruction (FEV1/FVC <0.7) in Korean population. However, current status of prevalence and characteristics of elderly who have obstruction airway disease (OAD) is not well investigated yet. Methods: A total of 2566 adults (1109 of male and 1457 of female; mean age 73.4±6.4) were included from public health survey during 3 years. Pulmonary function was measured by portable fiow-volume device. A standard questionnaire (CAT score), smoking status, respiratory symptoms such as cough, sputum, dyspnea, and comorbid illness were collected. Results: The prevalence of person with OAD which was defined as FEV1/FVC <0.7 was 18.5% (Male 29.2%, Female 10.4%). Mean FEV1 change was -33mL per year in both men and women. There was significant correlation between age and prevalence of OAD. Former or current smoking was significantly more common in group of OAD. Among persons with OAD, 56.2% have FEV1 below 80% of predicted. The proportion of person according to GOLD stage A-D was 50.6%, 37.9%, 4.6%, and 6.9% respectively. Comparing GOLD stage A with B, persons with GOLD stage B were tent to have low BMI and comorbid illness such as hypertension and diabetes. In multivariate analysis, factors associated with higher CAT score in OAD were advanced COPD stage, history of smoking, and female gender. Conclusions: Our data indicate that the prevalence of COPD in elderly is still high and large number of person is undiagnosed and untreated.
인간 면역결핍 바이러스 감염자와 비감염자에서 발생한 주폐포자충 폐렴의 임상 양상 비교
최준용 ( Choe Jun Yong ),이꽃실 ( Lee Kkoch Sil ),박윤수 ( Park Yun Su ),조정호 ( Jo Jeong Ho ),한상훈 ( Han Sang Hun ),최석훈 ( Choe Seog Hun ),진범식 ( Jin Beom Sig ),박윤선 ( Park Yun Seon ),장경희 ( Jang Gyeong Hui ),송영구 ( 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.55 No.4
하행 대동맥류 파열 산모에서 응급 제왕절개술과 병행된 대동맥류 교정술
최철훈 ( Choe Cheol Hun ),김영아 ( Kim Yeong A ),서용수 ( Seo Yong Su ),최성진 ( Choe Seong Jin ),양순하 ( Yang Sun Ha ),김종화 ( Kim Jong Hwa ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.9
Aortic aneurysms are extremely uncommon in women under age 40 and are rarely encountered by obstetricians. Various physiologic changes of pregnancy appear to make pregnancy a risky situation of rupture of an aortic aneurysm and pregnancy is discouraged in
Kim, So Ri,Yoon, Ha‐,Yong,Jin, Gong Yong,Choe, Yeong Hun,Park, Seung Yong,Lee, Yong Chul Wiley-Blackwells 2016 Thoracic cancer Vol.7 No.4
<P><B>Abstract</B></P><P>Melanoma is a cutaneous malignant neoplasm of melanocytes. Primary malignant melanoma (MM) of the lung is very rare. Although previous reports have described the radiologic features of pulmonary MM, its rarity means that many factors are unknown. Thus, radiologic diagnosis is very difficult. Furthermore, there is little information regarding diagnostic application and/or the usefulness of [<SUP>18</SUP>F]‐fluorine‐2‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography‐computed tomography (FDG‐PET‐CT) for primary pulmonary MM. A 69‐year‐old patient with a productive cough lasting three weeks was admitted to our hospital. Chest CT showed a large single mass with a multi‐lobulated margin and homogeneous enhancement in the right upper lobe, which was subsequently diagnosed as a primary pulmonary MM with multiple metastases. On PET‐CT images, the pulmonary mass and multiple bone lesions showed very increased uptakes of FDG. Considering that pulmonary metastasis from a mucocutaneous melanoma is the main differential diagnosis of primary pulmonary MM, systemic assessment of the whole body is more important than for other types of lung malignancies. This report introduces PET‐CT as a useful diagnostic modality for pulmonary MM, especially in cases of distant multiple metastases.</P>
( Yong Chul Lee ),( Jae Seok Jeong ),( So Ri Kim ),( Hae Jin Park ),( Kyeong Hwa Park ),( Navin Ray ),( Yeong Hun Choe ),( Seung Yong Park ) 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Respiratory fungal exposure is associated with severe allergic lung inflammation. NLRP3 inflammasome and phosphoinositide 3-kinase (PI3K)-δ in airway epithelium are involved in various inflammatory processes. We previously reported that fungus- induced activation of PI3K-δ in airway epithelium leads to generation of mitochondrial reactive oxygen species (mtROS), thereby being involved in the corticosteroid resistance in fungal allergy model. In this study, we performed in vitro experiments using normal human bronchial epithelial (NHBE) cells to investigate the role of PI3K-δ in modulating NLRP3 inflammasome activation against fungal exposure, especially focusing on mtROS. We also checked NLRP3 expression in lung tissues from allergic bronchopulmonary aspergillosis (ABPA) patients. NLRP3, caspase-1, and ASC and their cytoplasmic co-localization were increased in Af-stimulated NHBE cells. Furthermore, mature IL-1β were increased in Af-stimulated NHBE cells. Notably, Af-induced increases of NLRP3 inflammasome components and their co-localizations were lowered by a potent PI3K-δ inhibitor or PI3K-δ specific siRNA. This modulatory role of PI3K-δ was mediated through the regulation of mtROS generation. In human lung tissue specimens, NLRP3 in ABPA patients was increased compared to that in disease control (idiopathic pulmonary fibrosis) or healthy controls. These findings suggest that fungi-induced activation of NLRP3 inflammasome in airway epithelium may be modulated by PI3K-δ, which is mediated partly through the regulation of mtROS.