Transient Hiatal Separation During Straight Leg Raise Can Predict Reflux Burden in Gastroesophageal Reflux Disease Patients With Ineffective Esophageal Motility

Wei-Yi Lei,Shu-Wei Liang,Taher Omari,Wei-Chuan Chang,Ming-Wun Wong,Jui-Sheng Hung,Chih-Hsun Yi,Tso-Tsai Liu,Lin Lin,C Prakash Gyawali,Chien-Lin Chen 대한소화기 기능성질환∙운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.4

Background/Aims Straight leg raise (SLR) can be utilized to evaluate the integrity of the esophagogastric junction during high-resolution manometry (HRM). We aim to assess the value of transient hiatal separation during SLR in symptomatic reflux patients. Methods Consecutive reflux patients undergoing esophageal HRM and pH monitoring were included. Transient hiatal separation was defined by a ≥ 1 cm separation between the lower esophageal sphincter and crural diaphragm during SLR. We compared esophageal motor patterns and reflux monitoring parameters between patients with normal, transiently abnormal and consistently abnormal esophagogastric junction morphology during SLR. Results Of 85 (56.3% female, mean age: 46.7 ± 12.3 years) completed SLR, esophagogastric junction morphology was normal in 31 (36.5%), transient hiatal separation in 19 (22.3%), and consistently hiatal hernia in 35 (41.2%). The values of total acid exposure time (P = 0.016), longest acid reflux episodes (P = 0.024), and DeMeester scores (P = 0.016) were higher in hiatal hernia compared to patients with non-transient hiatal separation, but there were no differences between those with and without transient hiatal separation. Within ineffective esophageal motility, the presence of transient hiatal separation during SLR significantly associated with a higher total acid exposure time (P = 0.014), higher DeMeester scores (P = 0.019), higher total acid reflux events (P = 0.037), and higher longest acid reflux episodes (P = 0.006). Conclusion Our work suggests that SLR may have value as a provocative test during HRM, and future outcome studies are warranted to elucidate the clinical relevance of motor abnormalities depicted from SLR.

Effects of Codeine on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility: Studies Using High-resolution Manometry

Wei-Yi Lei,Tso-Tsai Liu,Wei-Chuan Chang,Chih-Hsun Yi,Jui-Sheng Hung,Ming-Wun Wong,Shu-Wei Liang,Lin Lin,Chien-Lin Chen 대한소화기 기능성질환∙운동학회 2024 Journal of Neurogastroenterology and Motility (JNM Vol.30 No.1

Background/AimsThis study aims to evaluate the effects of acute codeine administration on primary and secondary esophageal peristalsis in patients with ineffective esophageal motility (IEM). MethodsEighteen IEM patients (8 women; mean age 37.8 years, range 23-64 years) were enrolled in the study. The patients underwent high-resolution manometry exams, consisting of 10 single wet swallows, multiple rapid swallows, and ten 20 mL rapid air injections to trigger secondary peristalsis. All participants completed 2 separate sessions, including acute administration of codeine (60 mg) and placebo, in a randomized order. ResultsCodeine significantly increased the distal contractile integral (566 ± 81 mmHg∙s∙cm vs 247 ± 36 mmHg∙s∙cm, P = 0.001) and shortened distal latency (5.7 ± 0.2 seconds vs 6.5 ± 0.1 seconds, P < 0.001) for primary peristalsis compared with these parameters after placebo treatment. The mean total break length decreased significantly after codeine treatment compared with the length after placebo (P = 0.003). Codeine significantly increased esophagogastric junction-contractile integral (P = 0.028) but did not change the 4-second integrated relaxation pressure (P = 0.794). Codeine significantly decreased the frequency of weak (P = 0.039) and failed contractions (P = 0.009), resulting in increased frequency of normal primary peristalsis (P < 0.136). No significant differences in the ratio of impaired multiple rapid swallows inhibition and parameters of secondary peristalsis were detected. ConclusionsIn IEM patients, acute administration of codeine increases contraction vigor and reduces distal latency of primary esophageal peristalsis, but has no effect on secondary peristalsis. Future studies are required to further elucidate clinical relevance of these findings, especially in the setting of gastroesophageal reflux disease with IEM.

Concurrent Weekly Docetaxel Chemotherapy in Combination with Radiotherapy for Stage III and IVA-B Nasopharyngeal Carcinoma

Wei, Wei-Hong,Cai, Xiu-Yu,Xu, Tao,Zhang, Guo-Yi,Wu, Yong-Feng,Feng, Wei-Neng,Lin, Li,Deng, Yan-Ming,Lu, Qiu-Xia,Huang, Zhe-Li Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Background and Purpose: Cisplatin is the most common chemotherapeutic agent for loco-regionally advanced nasopharyngeal carcinoma (NPC); however, toxicity is a limiting factor for some patients. We retrospectively compared the efficacy and toxicity of weekly docetaxel-based and cisplatin-based concurrent chemoradiotherapy in loco-regionally advanced NPC. Methods and Materials: Eighty-four patients with Stage III and IVA-B NPCs, treated between 2007 and 2008, were retrospectively analyzed. Thirty received weekly docetaxel-based concurrent chemotherapy, and 43 were given weekly cisplatin-based concurrent chemotherapy. Radiotherapy was administered using a conventional technique (seven weeks, 2.0 Gy per fraction, total dose 70-74 Gy) with 6-8 Gy boosts for some patients with locally advanced disease. Results: Median follow-up time was 42.3 months (range, 8.6-50.8 months). There were no significant differences in the 3-year loco-regional failure-free survival (85.6% vs. 92.3%; p=0.264), distant failure-free survival (87.0% vs. 92.5%; p=0.171), progression-free survival (85.7% vs. 88.4%; p=0.411) or overall survival (86.5% vs. 92.5%, p=0.298) of patients treated concurrently with docetaxel or cisplatin. Severe toxicity was not common in either group. Conclusions: Weekly docetaxel-based concurrent chemoradiotherapy is potentially effective and has a tolerable toxicity; however, further investigations are required to determine if docetaxel is superior to cisplatin for advanced stage NPC.

Esophageal Bolus Domain Pressure and Peristalsis Associated With Experimental Induction of Esophagogastric Junction Outflow Obstruction

( Wei-yi Lei ),( Taher Omari ),( Tso-tsai Liu ),( Ming-wun Wong ),( Jui-sheng Hung ),( Chih-hsun Yi ),( Shu-wei Liang ),( Charles Cock ),( Chien-lin Chen ) 대한소화기기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.1

Background/Aims Intrabolus pressures are important for esophageal bolus transport and may detect obstructed bolus flow. This study measured the effect esophageal outflow obstruction experimentally induce by a leg-lift protocol. Methods Twenty-five gastroesophageal reflux disease patients referred for esophageal manometry and a normal motility diagnosis were included. Supine liquid swallows were tested. Leg-lift protocol generated esophageal outflow obstruction by increasing abdominal pressure. Esophageal pressure topography and intrabolus pressure metrics were calculated. These included, (1) mid-domain bolus distension pressure during esophageal emptying (DPE, mmHg) and (2) ramp pressure (mmHg/sec), generated by compression of the bolus between the peristaltic contraction and esophagogastric junction (EGJ). Results EGJ relaxation pressure was increased by leg-lift from 13 (11-17) to 19 (14-30) mmHg (P < 0.005) and distal contractile integral also increased from 1077 (883-1349) to 1620 (1268-2072) mmHgㆍcmㆍsec (P < 0.001) as a physiological response to obstruction. All bolus pressures were increased by leg lift; DPE increased from 17 (15-20) to 27 (19-32) mmHg (P < 0.001), and ramp pressure increased from 3 (1-4) to 5 (2-9) mmHg/sec (P < 0.05). Conclusion Measuring pressures within the intrabolus domain can quantify changes related to obstruction to outflow and may serve as adjunct measures for confirming a diagnosis EGJ outflow obstruction. (J Neurogastroenterol Motil 2022;28:62-68)

Flatbands and Emergent Ferromagnetic Ordering in Fe3Sn2 Kagome Lattices

Lin, Zhiyong,Choi, Jin-Ho,Zhang, Qiang,Qin, Wei,Yi, Seho,Wang, Pengdong,Li, Lin,Wang, Yifan,Zhang, Hui,Sun, Zhe,Wei, Laiming,Zhang, Shengbai,Guo, Tengfei,Lu, Qingyou,Cho, Jun-Hyung,Zeng, Changgan,Zhan American Physical Society 2018 Physical Review Letters Vol.121 No.9

Courage Store II

( Lin Rui-lin ),( He Xin-hua ),( Chen Guan-ting ),( Chen Jia-ling ),( Jua Wei-ting ),( Lin Yen-chun ),( Yuan Zheng-xing ),( Lin Yi-ru ) 한국기초조형학회 2018 한국기초조형학회 작품집 Vol.2018 No.2

Controlled Release of Clenbuterol from a Hydroxyapatite Carrier for the Treatment of Alzheimer’s Disease

Yi-Wen Lin,Chih-Hsiang Fang,Ya-Jyun Liang,Ching-Yun Yang,Wei-Ting Kuo,Feng-Huei Lin 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Alzheimer’s disease is a neurodegenerative disorder, and Aβ aggregation is considered to be the central process implicated in its pathogenesis. Current treatments are faced by challenges such as serious side effects and reduced drug bioavailability. In this study, we developed a drug delivery system for intramuscular injection that uses cellular activity to achieve constant and long-term drug release. Methods Synthesized mesoporous hydroxyapatite (SHAP) was prepared via co-precipitation, and hydrophobic surface modification using stearic acid was then used to load clenbuterol by physical absorption, thus creating the drug delivery system. Clenbuterol release was achieved through cellular activity, with macrophage uptake triggering lysosome/endosome disruption, cytoplasmic release, extracellular exocytosis, and subsequent systemic circulation. Results We found that clenbuterol-loaded SHAP enabled sustained release for more than 2 weeks and effectively modulated inflammation, reduced Aβ oligomer-induced toxicity, and prevented Aβ aggregation. Conclusions Our findings suggest that treatment with clenbuterol loaded in this SHAP delivery system could be a promising strategy for treating Alzheimer’s disease.

2022 Taiwan clinical multicenter expert consensus and recommendations for thyroid radiofrequency ablation

Wei-Che Lin,Wen-Chieh Chen,Pei-Wen Wang,Yi-Chia Chan,Yen-Hsiang Chang,Harn-Shen Chen,Szu-Tah Chen,Wei-Chih Chen,Kai-Lun Cheng,Shun-Yu Chi,Pi-Ling Chiang,Chen-Kai Chou,Feng-Fu Chou,Shun-Chen Huang,Feng 대한초음파의학회 2023 ULTRASONOGRAPHY Vol.42 No.3

Radiofrequency ablation (RFA) is a minimally invasive management strategy that has been widely applied for benign and recurrent malignant thyroid lesions as an alternative to surgery in Taiwan. Members of academic societies for specialists in interventional radiology, endocrinology, and endocrine surgery collaborated to develop the first consensus regarding thyroid RFA in Taiwan. The modified Delphi method was used to reach a consensus. Based on a comprehensive review of recent and valuable literature and expert opinions, the recommendations included indications, pre-procedural evaluations, procedural techniques, post-procedural monitoring, efficacy, and safety, providing a comprehensive review of the application of RFA. The consensus effectively consolidates advice regarding thyroid RFA in clinical practice for local experts.

콤팩트시티의 공유 업무 공간 특성에 관한 연구 -Wework 프로젝트를 중심으로-

웨이이린 ( Wei Yi Lin ),홍관선 ( Hong Kwan ) 한국기초조형학회 2020 기초조형학연구 Vol.21 No.6

도시가 급속도로 발전함으로 인해 도시에서는 상대적으로 많은 자원 환경의 문제가 발생하고 있다. 자원의 과도한 사용 및 환경오염 등이 도시환경 문제의 주요 원인이라는 사실을 연구 배경으로 삼아 자원 절약과 환경개선을 위해 기존 도시의 공유 공간 구축과 도시 재생 실현을 제안한다. 본 논문의 연구 목적은 콤팩트 시티의 공유 공간 조성을 통해 원도시의 자연환경 문제를 완화하는데 있다. Wework프로젝트의 대표적 사례를 선택해 공유 업무 공간의 서로 다른 특성의 수량 분석하고 중요도를 구분하였다. 또한 전문가들을 대상으로 설문조사를 실시하여 조사 결과와 사례분석 결과를 중요도 추세 도표로 요악하였고, 그 도표를 근거로 미래의 콤팩트 시티 공유 공간 조성에 디자인적 영감을 제공하고자 한다. 연구 방법은 콤팩트 시티 개념을 근거로 이론적 고찰과 관련 특성을 추출해 정리한다. 또한 공유의 개념에 대해 이론적 고찰 및 서로 다른 공유 공간에 존재하는 특성을 정리한다. 이를 토대로 양자관계를 찾아 ‘공유 공간’과 ‘콤팩트 시티’의 연관성을 찾아내고, 콤팩트 시티의 공유 공간의 특성을 정리하며 특성에 따른 사례를 분석한다. 분석에 근거한 도표의 사례 소결의 결과, 중요도가 높은 특성은 접근성(B), 개방성(G), 교류성(J), 우연성(K)과 가변성(M)으로 나타났으며, 중요도의 일반적인 특성은 복합성(C)과 편리성(D)으로 나타났다. 또한 중요도가 낮은 특성은 개별성(H), 영역성(I), 놀이성(L)과 중심성(N)으로 나타났고, 관련성이 없는 특성은 고밀성(A), 사회성(E)과 경제성(F)으로 나타났다. 서로 다른 중요도는 콤팩트 시티에서의 공유 업무 공간 디자인에서의 활용 가치를 나타낸다. 중요도가 높은 것은 필수적 특성으로 공유 업무 공간의 디자인에서 필요하며, 중요도가 일반적이거나 낮은 특성은 보조역할으로 공간을 구체적으로 디자인할 때 최적화와 보완을 도우며, 관련성이 없는 특성은 무시해도 무방하다. 본 연구의 결론이 앞으로 콤팩트 도시의 공유 업무 공간 설계에 참고 자료로 활용될 수 있기를 기대한다. With the rapid development of cities, relative resource and environmental problems will follow. Based on the fact that excessive use of resources and environmental pollution are the main causes of urban environmental problems, we propose to build a Shared Space in existing cities and realize urban regeneration to save resources and improve the environment. The purpose of the research is to alleviate the resource and environmental problems of the original city by building a Compact City Shared Space. This paper selects representative cases of the Wework project and divides the importance by analyzing the number of characteristics in different spaces in the Shared Office Space. At the same time, it conducts a questionnaire survey of experts, and summarizes the survey results and case analysis results into an importance trend chart. Come to a conclusion, hoping to provide certain design inspiration for the future construction of a Compact City Shared Space. The research method is to analyze the concepts and characteristics of Compact City and Shared Space, find out the relationship between the two, analyze the relationship between ‘Shared Space’ and ‘Compact City’, and summarize the characteristics of Compact City’s Shared Space. According to the results of the analysis, organize the chart to get the case summary, the characteristics are divided according to the importance evaluation level, the high importance are proximity(B), openness(G), communication(J), contingency(K) and variability(M), and the general importance are complexity(C) and convenience(D). The low importance are individuality(H), territoriality(I), entertainment(L) and centrality(N), and non-relevant features are high-density(A) and sociality(E) And economy(F). Different importance levels represent the value of utilization in the design of shared workspaces in Compact Cities. Taking this result as a conclusion, we hope to provide value in the design of Shared Office Space in the future.

콤팩트 시티 교통 공공공간과 심리적 암시에 관한 연구 - 지하철역을 중심으로 -

웨이이린 ( Wei Yi Lin ),홍관선 ( Hong Kwan ) 한국기초조형학회 2019 한국기초조형학회 학술발표논문집 Vol.2019 No.1