盛明巴蜀文人楊慎對孔明的批評

楊釗(Yang Zhao) 동아인문학회 2017 동아인문학 Vol.39 No.-

Yang Shen had made many comments on Kong Ming, which can be seen in his works, poems, poetic criticisms and “the Whole Shu Yiwenzhi”. Yang Shen mainly focused on the analysis of hot issues such as the moral and utilitarian achievements, the academic and governance abilities of Kong Ming. Yang Shen’s purpose in comments on Kong Ming aimed was to admire for former worthies and educate the future generation, not pedantically to look for quotes in order to embellish his writings.

楊愼 《全蜀藝文志》 編輯的文化背景考論

楊釗(Yang Zhao) 중국어문학연구회 2016 중국어문학논집 Vol.0 No.98

Yang Shen, in the introduction to “Arts and Literatures History of the Whole Shu nation”, provided that the cultural background of editting this book was to “carry forward the fragrance of the Si Zi, and write the Su nation’s history”. Thus the selected works in this book were not only the literatural ones but also those that reflected the Bashu’s history and academic thoughts. Meanwhile, he had self-consciously assumed the responsibilities of the inheritance of the rural culture and encouraging the backwards through editting the book. Yang Shen and his son had carried forward the local culture through the following three aspects, that is, to devote much attention to the nation’ history, to praise the local loyal bachelors and to place emphasize on the moral education.Besides, Yang Shen and his son had taken great pains to discuss these issues and carry out the social pracitice.

MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis

Yang Yang,Rongfang Qiu,Qiaoyou Weng,Ziwei Xu,Jingjing Song,Siyu Zhao,Miaomiao Meng,Dengke Zhang,Chunli Kong,Hailin Wang,Min Xu,Zhongwei Zhao,Jiansong Ji 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3

Purpose Mixed-lineage leukemia protein 4 (MLL4/KMT2D) is a histone methyltransferase, and its mutation has been reported to be associated with a poor prognosis in many cancers, including lung cancer. We investigated the function of MLL4 in lung carcinogenesis. Materials and Methods RNA sequencing (RNA-seq) in A549 cells transfected with control siRNA or MLL4 siRNA was performed. Also, we used EdU incorporation assay, colony formation assays, growth curve analysis, transwell invasion assays, immunohistochemical staining, and in vivo bioluminescence assay to investigate the function of MLL4 in lung carcinogenesis. Results We found that MLL4 expression was downregulated in non–small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues and tended to decrease with disease stage progression. We analyzed the transcriptomes in control and MLL4- deficient cells using high-throughput RNA deep sequencing (RNA-seq) and identified a cohort of target genes, such as SOX2, ATF1, FOXP4, PIK3IP1, SIRT4, TENT5B, and LFNG, some of which are related to proliferation and metastasis. Our results showed that low expression of MLL4 promotes NSCLC cell proliferation and metastasis and is required for the maintenance of NSCLC stem cell properties. Conclusion Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for NSCLC therapy.

論錢穆對漢代『春秋』學的硏究

楊兆貴 ( Yang¸ Zhao Gui ),趙殷尙 ( Cho¸ Eun Sang ) 한국중국학회 2021 중국학보 Vol.97 No.-

錢穆對秦漢史、漢代經學研究飮譽學林, 影響很大。他這兩方面的論著大多已逾半世紀, 在出土文獻日益增多、研究方法多元化等學風下, 他的論著有哪些價值?對當代相關研究有什麼影響?筆者結合他這兩方面的研究, 聚焦他的漢代『春秋』學, 以見他治學、見解之一斑。 要探討他對漢代『春秋』學的看法, 則先簡介他對『春秋』及三傳的看法。他與傳統主張孔子作『春秋』的看法相同, 並從史學肯定『春秋』、『左傳』的史學價值。他認為漢代經學今古文之別是王官學與百家言之殊, 而非文字古今之異。這是他論漢代經今古文最具特色的部分。他撰『孔子與春秋』一文, 著重闡釋『公羊』學的精神, 強調孔子『春秋』以百家言而成為新的王官學。他在不同時期對『公羊』學與董仲舒的評價不同。他認為漢儒多通古今, 因此治『春秋』者多能兼採三傳或兩傳之義、說。他又指出, 『春秋』學與漢代思想尤其是災異說、禪讓說、禮制說有密切的關係。 Prof. Qian Mu has a great influence on the honorary scholars of Qin and Han history and Han dynasty studies. Most of his works in these two areas have been over half a century. With the increasing number of unearthed documents and diversified research methods, what is the value of his works? And what is the impact on contemporary related research? This essay combines his research in these two areas and focuses on his study of Chun Qiu in the Han Dynasty, so as to see his academic research methods and insights. To explore his views on the study of Chun Qiu in the Han Dynasty, the first part of the essay introduces his views on Chun Qiu and the three ‘Zhuan’. He is the same as the traditional view that Confucius wrote Chun Qiu, and affirmed the historical value of Chun Qiu and Zuo Zhuan from his historiography. He believes that the difference between modern and ancient literatures in Han dynasty is the difference between Ancient Official Document and Philosophers, rather than the difference between ancient and modern writing. He wrote the article Confucius and Chun Qiu, focusing on explaining the spirit of school of Gong Yang, emphasizing that Confucius' Chun Qiu became a new official ideology with the philosophical thought in Han China. He had different evaluations of Gong Yang and Dong Zhongshu in different periods. He believes that the Han scholars are mostly integrated with the ancient and modern literatures, so most of them who studied Chun Qiu can adopt the meaning and theories of the three or two ‘Zhuan’ at the same time. He also pointed out that the study of Chun Qiu has a close relationship with the thoughts of the Han Dynasty, especially the theory of catastrophe, concession, and etiquette.

Effects of Aqueous Extract of Schizandra Chinensis Fruit on Cadmium-Induced Change of Monoamine Neurotransmitters in Rats

Zhao, Zheng Lin,Zhao, Guang Wen,Li, Li,Li, Meng Quan,Guan, Li Xin,Yang, Xu Dong,Li, Hou Zhong,Lin, Feng,Lee, Jong-Rok,Zhao, Rong Jie Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.1

The effects of aqueous extract of Schizandra Chinensis Fruit (AESC) on cadmium-induced changes of monoamine neurotransmitters in the different brain regions of adult rats were investigated. Male rats were received intraperitoneal (i.p.) administration of CdCl2 (0.6 mg/kg/d) for 21 days and sacrificed 7 days after the last administration. Concentrations of norepinephrine (NE), dopamine (DA) in striatum and serotonin (5-HT), 5-hydroxyindole acetic acid (5-HIAA) in cortex were measured by HPLC. There were significant decreases of NE, DA, 5-HT and 5-HIAA in Cd intoxicated rats (P < 0.05), while pretreatment with AESC (20 mg/kg/d or 60 mg/kg/d, p.o., 30 min before $CdCl_2$) greatly inhibited the decrease of monoamine transmitters, respectively (P < 0.05). Also, AESC significantly increased the reduction of glutathione contents and superoxide dismutase activities in cortex induced by $CdCl_2$. These results suggest that AESC ameliorates Cd-induced depletion of monoamine neurotransmitters in brain through its antioxidant activity.

Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes

Zhao Junxiong,Wu Qian,Yang Ting,Nie Liangui,Liu Shengquan,Zhou Jia,Chen Jian,Jiang Zhentao,Xiao Ting,Yang Jun,Chu Chun 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important cause of myocardial fibrosis. The purpose of this study was to investigate the effect of gaseous signal molecule sulfur dioxide (SO2) on diabetic myocardial fibrosis and its internal regulatory mechanism. Masson and TUNEL staining, Western-blot, transmission electron microscopy, RT-qPCR, immunofluorescence staining, and flow cytometry were used in the study, and the interstitial collagen deposition, autophagy, apoptosis, and changes in phosphatidylinositol 3-kinase (PI3K)/AKT pathways were evaluated from in vivo and in vitro experiments. The results showed that diabetic myocardial fibrosis was accompanied by cardiomyocyte apoptosis and down-regulation of endogenous SO2-producing enzyme aspartate aminotransferase (AAT)1/2. However, exogenous SO2 donors could up-regulate AAT1/2, reduce apoptosis of cardiomyocytes induced by diabetic rats or high glucose, inhibit phosphorylation of PI3K/AKT protein, up-regulate autophagy, and reduce interstitial collagen deposition. In conclusion, the results of this study suggest that the gaseous signal molecule SO2 can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.

Joint FrFT‐FFT basis compressed sensing and adaptive iterative optimization for countering suppressive jamming

Yang Zhao,Chaoxuan Shang,Zhuangzhi Han,Yuanwei Yin,Ning Han,Hui Xie 한국전자통신연구원 2019 ETRI Journal Vol.41 No.3

Accurate suppressive jamming is a prominent problem faced by radar equipment. It is difficult to solve signal detection problems for extremely low signal to noise ratios using traditional signal processing methods. In this study, a joint sensing dictionary based compressed sensing and adaptive iterative optimization algorithm is proposed to counter suppressive jamming in information domain. Prior information of the linear frequency modulation (LFM) and suppressive jamming signals are fully used by constructing a joint sensing dictionary. The jamming sensing dictionary is further adaptively optimized to perfectly match actual jamming signals. Finally, through the precise reconstruction of the jamming signal, high detection precision of the original LFM signal is realized. The construction of sensing dictionary adopts the Pei type fast fractional Fourier decomposition method, which serves as an efficient basis for the LFM signal. The proposed adaptive iterative optimization algorithm can solve grid mismatch problems brought on by undetermined signals and quickly achieve higher detection precision. The simulation results clearly show the effectiveness of the method.

Robust MAVE for single-index varying-coefficient models

Zhao Yang,Yue Lili,Li Gaorong 한국통계학회 2022 Journal of the Korean Statistical Society Vol.51 No.4

In this paper, a robust, efficient and easily implemented estimation procedure for single-index varying-coefficient models is proposed by combining minimum average variance estimation (MAVE) with exponential squared loss. The merit of the proposed method is robust against outliers or heavy-tailed error distributions while asymptotically efficient as the original MAVE under the normal error case. A practical minorization–maximization algorithm is proposed for implementation. Under some regularity conditions, asymptotic distributions of the resulting estimators are derived. Simulation studies and a real data example are conducted to examine the finite sample performance of the proposed method. Both theoretical and empirical findings confirm that our proposed method works very well.

Current covariance analysis-based open-circuit fault diagnosis for voltage-source-inverter-fed vector-controlled induction motor drives

Yang, Huanwen,Zhou, Yang,Zhao, Jin The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.2

In recent years, a faulty leg is mostly replaced by a healthy leg for current fault-tolerant control of power converters, and its fault diagnosis only needs to confirm the fault leg. For fault-tolerant control, this paper proposed a real-time, robust and accurate diagnosis method for the legs of insulated gate bipolar transistor open-circuit faults in the pulse-width-modulated voltage source inverters for vector-controlled induction motors based on three-phase current. The covariance of three-phase current is used to diagnose and locate faults by analyzing the correlation between them, and its performance is explained specifically under both health condition and fault conditions. The proposed method is simple and no additional current or voltage sensors are required. The fault diagnosis time is about half a current cycle. Experiments are conducted and the obtained results demonstrate the effectiveness and merit of the proposed method.

Multivariate Analysis of the Prognosis of 37 Chondrosarcoma Patients

Yang, Zheng-Ming,Tao, Hui-Min,Ye, Zhao-Ming,Li, Wei-Xu,Lin, Nong,Yang, Di-Sheng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Objective: The current study aimedto screen for possible factors which affect prognosis of chondrosarcoma. Methods: Thirty seven cases were selected and analyzed statistically. The patients received surgical treatment at our hospital between December 2005 and March 2008. All of them had complete follow-up data. The survival rates were calculated by univariate analysis using the Kaplan-Meier method and tested by Log-rank. ${\chi}^2$ or Fisher exact tests were carried out for the numeration data. The significant indexes after univariate analysis were then analyzed by multivariate analysis using COX regression model. Based on the literature, factors of gender, age, disease course, tumor location, Enneking grades, surgical approaches, distant metastasis and local recurrence were examined. Results: Univariate analysis showed that there were significant differences in Enneking grades, surgical approaches and distant metastasis related to the patients' 3-year survival rate after surgery (P<0.001). No significant difference was not found in gender, age, disease course, tumor location or local recurrence (P>0.05). Multivariate analysis showed that Enneking grade (P=0.007) and surgical approaches (P=0.010) were independent factors affecting the prognosis of chondrosarcoma, but distant metastasis was not (P=0.942). Conclusion: Enneking grades, surgical approaches and distant metastasis are risk factors for prognosis of chondrosarcoma, among which the former two are independent factors.