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( Xinhui Wang ),( Xiaoli Liu ),( Zhibo Dang ),( Lihua Yu ),( Yuyong Jiang ),( Xianbo Wang ),( Zhiyun Yang ) 대한간학회 2020 Gut and Liver Vol.14 No.2
Background/Aims: Studies have shown that nucleos(t)ide analogue (NA) treatment can reduce the risk of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients, but it is unclear which NA is most effective. We performed a meta-analysis and systematic review comparing the efficacies of NAs in CHB patients. Methods: We searched literature databases for randomized controlled trials (RCTs) and observational studies that analyzed the hepatic biochemical response, virological response, seroconversion rate, drug resistance rate, and HCC incidence rate in CHB patients treated with NAs. Meta-analyses were performed with RevMan and Stata/SE software. Results: Twelve cohort studies and one RCT were selected, in which entecavir (ETV), lamivudine (LAM), telbivudine (LdT), and/or tenofovir disoproxil fumarate (TDF) were evaluated in CHB patients. The meta-analysis showed that ETV was superior to LAM with regard to the HCC incidence (p<0.001), biochemical response (p=0.001), virological response (p=0.02), and drug resistance (p<0.001), and ETV was superior to LdT with regard to the virological response (p<0.001) and drug resistance (p<0.001). We found no significant difference between ETV and TDF with regard to the HCC incidence (p=0.08), biochemical response (p=0.39), virological response (p=0.31), serological conversion (p=0.38), or drug resistance (p=0.95). NA-treated patients with pre-existing cirrhosis had a 5.49 times greater incidence of HCC than those without cirrhosis (p<0.001). Conclusions: ETV or TDF should be used for long-term first-line monotherapy in CHB patients according to the current guidelines. Standardized protocols are needed for future studies of ETV and TDF to facilitate conclusive comparisons. Patients with cirrhosis are at significantly elevated risk for HCC, despite the benefits of NA treatment. (Gut Liver 2020;14:232-247)
Wang, Xinhui,Ren, Hongyang,Zhan, Yi 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1
The structure of microbial communities in a typical Italian-style salami, including bacterial and fungal diversity, was investigated by high-throughput sequencing technology. A total of 6 phyla, 7 classes, 19 orders, 20 families and 28 genera were obtained from 16S rDNA sequences, and a total of 2 phyla, 4 classes, 4 orders, 5 families, 10 genera and 12 Species were obtained from 18S rDNA sequences. The core microbiota was composed of Staphylococcaceae, representing up to 97.52% of the total 16S rRNA, and Penicillium digitatum, accounting for 99.74% of the total classified 18S rRNA. Lactobacillales and Saccharomycetales were detected with a quite low proportion of 1.71 and 0.007%, respectively. This study contributes to the knowledge of the microbial diversity involved in salami and presents high-throughput sequencing as a useful tool to evaluate microbial diversity and monitor the food-borne pathogens in fermented sausage.
Xinhui Wang,Hongyang Ren,Yi Zhang 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.1
The structure of microbial communities in a typical Italian-style salami, including bacterial and fungal diversity, was investigated by high-throughput sequencing technology. A total of 6 phyla, 7 classes, 19 orders, 20 families and 28 genera were obtained from 16S rDNA sequences, and a total of 2 phyla, 4 classes, 4 orders, 5 families, 10 genera and 12 Species were obtained from 18S rDNA sequences. The core microbiota was composed of Staphylococcaceae, representing up to 97.52% of the total 16S rRNA, and Penicillium digitatum, accounting for 99.74% of the total classified 18S rRNA. Lactobacillales and Saccharomycetales were detected with a quite low proportion of 1.71 and 0.007%, respectively. This study contributes to the knowledge of the microbial diversity involved in salami and presents high-throughput sequencing as a useful tool to evaluate microbial diversity and monitor the food-borne pathogens in fermented sausage.
Bacthing Auditing of Data in Multicloud Storage
Zhihua Xia,Xinhui Wang,Xingming Sun,Yafeng Zhu,Peng Ji,Jin Wang 보안공학연구지원센터 2014 International Journal of Database Theory and Appli Vol.7 No.6
Cloud storage enables users to outsource their data to cloud servers and enjoy the on-demand services. However, this new paradigm also introduces integrity threats toward user’ outsourced data. This paper develops an efficient auditing mechanism, which support batch auditing for multiple data files in multi-cloud environment. By constructing a sequence-enforced Merkle Hash Tree, the proposed protocol can resist the replace attack. By using the bilinear map, the proposed protocol achieves stateless and transparent verification. By putting the computation of intermediate values of the verification on cloud servers, our method can greatly reduce the computing burden of the auditor. The performance analysis proves the good efficiency of the proposed protocol.
Electroconvulsive Therapy on Severe Obsessive-Compulsive Disorder Comorbid Depressive Symptoms
Xiaohui Liu,Xinhui Xie,Hong Cui,Qiang Wei,Ying Wang,Keyong Wang,Chen Wang,Chunyan Zhu 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.2
Electroconvulsive therapy (ECT) is not currently used as a first-line treatment for obsessive-compulsive disorder (OCD). However, several related case reports have demonstrated that ECT seems to be effective for severe OCD, especially when first-line therapies have failed. In this study, we describe the courses, detailed parameters, effects, and follow-up information relating to three patients with severe OCD who were treated by modified bifrontal ECT after their first-line anti-OCD treatments pharmacotherapy, behavioral therapy, and cognitive behavioral therapy failed. The number of ECT procedures administered in each case is as follows: Case 1, eight; Case 2, three; and Case 3, four. In all three cases, the patients’ depressive symptoms improved considerably after the ECT procedures. In addition, the condition of all three patients’ OCD significantly improved and remained stable at regular follow-ups. ECT may play an effective role in treating severe OCD.
Electroconvulsive Therapy on Severe Obsessive-Compulsive Disorder Comorbid Depressive Symptoms
Xiaohui Liu,Hong Cui,Qiang Wei,Ying Wang,Keyong Wang,Chen Wang,Chunyan Zhu,Xinhui Xie 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.2
Electroconvulsive therapy (ECT) is not currently used as a first-line treatment for obsessive-compulsive disorder (OCD). However, several related case reports have demonstrated that ECT seems to be effective for severe OCD, especially when first-line therapies have failed. In this study, we describe the courses, detailed parameters, effects, and follow-up information relating to three patients with severe OCD who were treated by modified bifrontal ECT after their first-line anti-OCD treatments pharmacotherapy, behavioral therapy, and cognitive behavioral therapy failed. The number of ECT procedures administered in each case is as follows: Case 1, eight; Case 2, three; and Case 3, four. In all three cases, the patients’ depressive symptoms improved considerably after the ECT procedures. In addition, the condition of all three patients’ OCD significantly improved and remained stable at regular follow-ups. ECT may play an effective role in treating severe OCD.
Remote control system based on the internet and machine vision for tracked vehicles
Shuai Wang,Shubing Zhang,Ruoding Ma,E. Jin,Xinhui Liu,He Tian,Ruipeng Yang 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.3
A remote control system based on the Internet and machine vision is designed in this study for tracked vehicles. The system consists of remote monitoring, remote control, and visual navigation subsystems. The on-board computer receives control commands issued by the monitoring center and controls the speed and steering angle of the tracked vehicles. The front camera collects navigation line information, and the collected image is processed by filtering, gray processing, binarization processing, and interference elimination to obtain the center point coordinates of the navigation line. Proportional-integral-derivative (PID), fuzzy PID, and neural network control algorithms are compared based on the distance and angle deviations of the preview point to control the operation of tracked vehicles through simulation. The Internet remote control system with the fuzzy PID control algorithm is then tested on a tracked vehicle. Experimental results indicate that the trajectory of the tracked vehicle fits the navigation path well.
Guanyu Zhang,Xinhui Liu,Shuai Wang,Guoqiang Wang 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.2
This study analyzes resistances to sinking, steering bulldozer, steering friction, running, climbing, inertia, and wind and considered the offsetting effects of instantaneous center of speed and center of mass based on the sinkage method proposed by Bekker. The purpose of the analysis is to show the calculation method for the driving power of crawlers under different working conditions. The influence of several performance factors were analyzed to calculate the steering performance of a dumping machine with heavy double crawler. The performance factors include steering radius, offset mass, width-to-length ratio, crawler width wider than the interior and lateral, caterpillar gauge in crawler drive, drive power, and steering torque friction. These factors are involved in driving wheels at a crawler speed of 3.33 RPM. The law of operation for heavy crawlers under different working conditions is obtained by performing a real vehicle test. The results of this test are compared with the theoretical calculations to verify correctness. Such a test provides important theoretical basis for theoretical modeling and for analyzing the performance of large crawlers running on soft ground.