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Ngoan Thi Nguyen,Dai Lam Tran,Duc Cuong Nguyen,Thai Loc Nguyen,Thi Cham Ba,Binh Hai Nguyen,Thi Duong Ba,Nam Hong Pham,Dzung Tuan Nguyen,Thai Hoa Tran,Gia Dien Pham 한국물리학회 2015 Current Applied Physics Vol.15 No.11
Nanocomposites containing two or more functional constituents are attractive candidates for advanced nanomaterials. In this study, multifunctional Ag/Fe3O4-CS nanocomposites were successfully prepared, using chitosan as a stabilizing and cross-linking agent. The as-synthesized nanocomposites were characterized by Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Energy-dispersive X-ray spectroscopy (EDS), UVevisible spectrophotometer (UVeVis) and vibrating sample magnetometer (VSM). The results demonstrated that Ag/Fe3O4-CS composite nanoparticles (NPs) were composed of parent components, Fe3O4 and Ag NPs, which were uniformly dispersed in the chitosan matrix. The hybrid NPs exhibited strong antibacterial property against Pseudomonas aeruginosa. With high magnetization value (67 emu/g), the synthesized Ag/Fe3O4-CS composite can be easily separated or recycled in potential biomedical applications. Furthermore, the results showed that the multicomponent hybrid nanostructures appeared to be the promising material for local hyperthermia, which can be used as thermoseeds for localized hyperthermia treatment of cancers.
Bioinformatic identification and expression analysis of the chicken B cell lymphoma (BCL) gene
Van Thai Than,Ha Thi Thanh Tran,Duc Viet Ly,Hoang Vu Dang,Minh Nam Nguyen,Anh Duc Truong 한국유전학회 2019 Genes & Genomics Vol.41 No.10
Background B cell lymphoma (BCL) families play an important role in apoptosis as a growth factor, cell death programming, cytokine expression and immune-related genes expression. Objectives In this study, to investigate the roles of BCLs, we performed genome-wide identification, expression and functional analyses of the BCL family in chicken. Methods Chicken BCLs genes were identified and analyzed by using bioinformatics approach. Expression profiles and Hierarchical cluster analysis of the BCLs genes in different chicken tissues were obtained from the genome-wide RNA-seq in the GEO, and Cluster and Java Treeview, respectively. Results A total of 16 BCLs genes were identified from the chicken genome, which could be further classified into five distinct groups in the phylogenetic tree. On the other hand, the interaction among BCLs proteins and between BCLs proteins with NF-κB subunits are limited, indicating that the remaining the functions of BCLs protein could be investigated in chicken. Moreover, KEGG pathway analysis indicated that BCL gene family was involved in regulation of apoptotic and immune response. Finally, BCL gene family was differentially expressed in chicken tissues, pathogen infection and growth stages of early chicken early embryo. Conclusion This study provides significant insights into the potential functions of BCLs in chicken, including the regulation of apoptosis, cell death and expression of immune-related genes.
Fabrication and Characteristics of Fully-sprayed ZnO/CdS/CuInS2 Solar Cells
Tran Thanh Thai,Nguyen Duc Hieu,Luu Thi Lan Anh,Pham Phi Hung,Vo Thach Son,Vu Thi Bich 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.9
This paper reports the successful fabrication of deposited Glass/ZnO/CdS/CuInS<sub>2</sub> solar cells with superstrate structure using Full Spray Pyrolysis Deposition (FSPD). The structure, optical and electrical properties of the constituent layers are investigated. It is observed that the CuInS<sub>2</sub> (CIS) film deposited from starting solution with [Cu]/[In] = 1.1, and Al-doped CuInS<sub>2</sub> (CIAS) film deposited from solution with [Cu]/[In] = 1.0, [Al]/[In] = 0.12, and using sulfurization process exhibited the best crystallites with tetragonal structure. The optical band gap of the CIAS film is obtained as 1.49 eV. Some physical properties of both ZnO, and CdS thin films are also studied. The parameters of the cells obtained are V<sub>OC</sub> = 425 mV, J<sub>SC</sub> = 14.02 mA/cm<sup>2</sup>, FF = 28.75% and efficiency of 1.71%. The results in our experiment show that FSPD is a potential technique to prepare solar cells based on CIS absorbers in a superstrate structure with low cost and high performance.
Do Van Cong,Nguyen Thi Thu Trang,Nguyen Vu Giang,Tran Huu Trung,Nguyen Thuy Chinh,Mai Duc Huynh,Thai Hoang,Jun Seo Park(박준서) 한국고분자학회 2016 폴리머 Vol.40 No.3
This study describes the preparation and characterization of nanocomposites obtained by melt-mixing of poly (ethylene-co-vinyl acetate) (EVA), polylactic acid (PLA), and TiO₂ nanoparticles (TNPs) via three different methods of direct mixing, one-step, and two-step methods. Vinyltrimethoxysilane was used as a surface modifier for the TNPs. The one-step method showed the best suitability for the preparation of EVA/PLA/TiO₂ nanocomposites. The increase in torque and the adhesion of the TNPs with EVA/PLA matrix in these nanocomposites showed enhanced interfacial interactions between EVA, PLA chains, and TNPs. The tensile strength, Young’s modulus, dynamic storage modulus, and thermooxidative stability of the one-step prepared nanocomposites were higher than those of two other nanocomposites and that of the EVA/PLA blend, reaching maximum values at 2.0 wt% of TNPs.
Evaluation of Various Escherichia coli Strains for Enhanced Lycopene Production
( Jun Ren ),( Junhao Shen ),( Thi Duc Thai ),( Min-gyun Kim ),( Seung Ho Lee ),( Wonseop Lim ),( Dokyun Na ) 한국미생물생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.7
Lycopene is a carotenoid widely used as a food and feed supplement due to its antioxidant, anti-inflammatory, and anti-cancer functions. Various metabolic engineering strategies have been implemented for high lycopene production in Escherichia coli, and for this purpose it was essential to select and develop an E. coli strain with the highest potency. In this study, we evaluated 16 E. coli strains to determine the best lycopene production host by introducing a lycopene biosynthetic pathway (crtE, crtB, and crtI genes cloned from Deinococcus wulumuqiensis R12 and dxs, dxr, ispA, and idi genes cloned from E. coli). The 16 lycopene strain titers diverged from 0 to 0.141 g/l, with MG1655 demonstrating the highest titer (0.141 g/l), while the SURE and W strains expressed the lowest (0 g/l) in an LB medium. When a 2 × YTg medium replaced the MG1655 culture medium, the titer further escalated to 1.595 g/l. These results substantiate that strain selection is vital in metabolic engineering, and further, that MG1655 is a potent host for producing lycopene and other carotenoids with the same lycopene biosynthetic pathway.
Vo Minh Hoang Do,Long Giang Bach,Diem-Huong Nguyen Tran,Van Du Cao,Thi Nhu Quynh Nguyen,Duc Thuan Hoang,Van Cuong Ngo,Dai Hai Nguyen,Thai Thanh Hoang Thi 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.2
Polyamidoamine (PAMAM) dendrimer is emerging as an effective nanocarrier for delivering anticancer drugs. Still, unmodified PAMAM dendrimer is hardly used in vivo because of unsatisfied drug release, high tendency of interfering with cellular membranes, and rapid clearance by reticuloendothelial system. In this study, low generation polyamidoamine (PAMAM) dendrimer G3.0 is developed and surface modified with methoxypolyethylene glycol (PAMAM G3.0-mPEG) to overcome its limitations. Specifically, PAMAM G3.0 conjugated with mPEG at different ratios are investigated to effectively eliminate its charge-associated toxicity, in which PAMAM G3.0-mPEG- 8 is chosen for oxaliplatin (OX) loading. Results reveal that OX-loaded PAMAM G3.0-mPEG-8 has desirable size, good entrapment efficiency, and sustained release with minimum drug leakage. In addition, Resazurin assay indicates that the toxicity of loaded OX is reduced as compared to free drug but still maintain substantially anticancer activity on HeLa cells, suggesting the potential application of PAMAM G3.0-mPEG-8 for OX delivery in cancer therapy.