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Prognostic value of FDG PET/CT during radiotherapy in head and neck cancer patients
Kim, Suzy,Oh, Sowon,Kim, Jin Soo,Kim, Yu Kyeong,Kim, Kwang Hyun,Oh, Do Hoon,Lee, Dong-Han,Jeong, Woo-Jin,Jung, Young Ho The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.2
Purpose: To evaluate the prognostic value of $^{18}F$-fluorodeoxyglucose positron-emission tomography (FDG PET) with computed tomography (CT) before and during radiotherapy (RT) in patients with head and neck cancer. Methods: Twenty patients with primary head and neck squamous cell carcinoma were enrolled in this study, of whom 6 had oropharyngeal cancer, 10 had hypopharyngeal cancer, and 4 had laryngeal cancer. Fifteen patients received concurrent cisplatin and 2 received concurrent cetuximab chemotherapy. FDG PET/CT was performed before RT and in the 4th week of RT. The parameters of maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis (TLG) of the primary tumor were measured, and the prognostic significance of each was analyzed with the Cox proportional hazards model. Results: Higher TLG (>19.0) on FDG PET/CT during RT was a poor prognostic factor for overall survival (OS) (p = 0.001) and progression-free survival (PFS) (p = 0.007). In the multivariate analysis, TLG during RT as a continuous variable was significantly associated with OS and PFS rate (p = 0.023 and p = 0.016, respectively). Tumor response worse than partial remission at 1 month after RT was another independent prognostic factor for PFS (p = 0.024). Conclusions: Higher TLG of the primary tumor on FDG PET/CT during RT was a poor prognostic factor for OS and PFS in patients with head and neck cancer.
Suzy Kim,MD,PhD,So Won Oh,MD,PhD,Jin Soo Kim,MD,PhD,Ki Hwan Kim,MD,PhD,Yu Kyeong Kim,MD,PhD 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.4
Purpose: To evaluate the predictive value of the early response of 18F-flurodeoxyglucose positron emission tomography (FDG PET) during concurrent chemoradiotherapy (CCRT) for locally advanced non-small cell lung cancer (NSCLC). Materials and Methods: FDG PET was performed before and during CCRT for 13 NSCLC patients. Maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured and the changes were calculated. These early metabolic changes were compared with the standard tumor response by computed tomograms (CT) one month after CCRT. Results: One month after the completion of CCRT, 9 patients had partial response (PR) of tumor and 4 patients had stable disease. The percent changes of SUVmax (%ΔSUVmax) were larger in responder group than in non-responder group (55.7% ± 15.6% vs. 23.1% ± 19.0%, p = 0.01). The percent changes of SUVmean (%ΔSUVmean) were also larger in responder group than in non-responder group (54.4% ± 15.9% vs. 22.3% ± 23.0%, p = 0.01). The percent changes of MTV (%ΔMTV) or TLG (%ΔTLG) had no correlation with the tumor response after treatment. All the 7 patients (100%) with %ΔSUVmax ≥ 50% had PR, but only 2 out of 6 patients (33%) with %ΔSUVmax < 50% had PR after CCRT (p = 0.009). Likewise, all the 6 patients (100%) with %ΔSUVmean ≥ 50% had PR, but only 3 out of 7 patients (43%) with %ΔSUVmean < 50% had PR after CCRT (p = 0.026). Conclusion: The degree of metabolic changes measured by PET-CT during CCRT was predictive for NSCLC tumor response after CCRT.
The Effects of Integrative Tasks on Speaking Performances of Korean EFL Learners
Suzy Kim 한국영어어문교육학회 2020 영어어문교육 Vol.26 No.4
This paper explored the effect of an integrative task on speaking performances of Korean EFL learners by shedding light on relationships between reading, writing and speaking. Fifty-one freshmen of college enrolled in a required class participated in this study. Over a treatment period of 14 weeks, the experimental group were provided with writing basic skills and writing tasks connected to reading. Meanwhile, the students of the control group were given journal articles for reading and practice exercises for comprehension. A pre and posttest, which consisted of three questions including describing, narrating, and problem-solving speaking tasks, and survey were administered and t-test was utilized for the analysis. As a result, the students who were involved in the integrative task showed significant differences in improvement of their L2 speaking proficiency. Both high and low level students in the treatment group also benefited from the integrative tasks in terms of speaking proficiencies. In addition, the analyses of the survey revealed that the students of the experimental group perceived the integrative tasks as a useful tool for enhancing speaking proficiency of L2. The findings imply that writing, reading and speaking are co-related and the integrative tasks can lead to promote L2 speaking ability.
Kim, Suzy,Oh, So Won,Kim, Jin Soo,Kim, Ki Hwan,Kim, Yu Kyeong The Korean Society for Radiation Oncology 2014 Radiation Oncology Journal Vol.32 No.4
Purpose: To evaluate the predictive value of the early response of $^{18}F$-flurodeoxyglucose positron emission tomography (FDG PET) during concurrent chemoradiotherapy (CCRT) for locally advanced non-small cell lung cancer (NSCLC). Materials and Methods: FDG PET was performed before and during CCRT for 13 NSCLC patients. Maximum standardized uptake value ($SUV_{max}$), mean standardized uptake value ($SUV_{mean}$), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured and the changes were calculated. These early metabolic changes were compared with the standard tumor response by computed tomograms (CT) one month after CCRT. Results: One month after the completion of CCRT, 9 patients had partial response (PR) of tumor and 4 patients had stable disease. The percent changes of $SUV_{max}$ ($%{\Delta}SUV_{max}$) were larger in responder group than in non-responder group ($55.7%{\pm}15.6%$ vs. $23.1%{\pm}19.0%$, p = 0.01). The percent changes of $SUV_{mean}$ ($%{\Delta}SUV_{mean}$) were also larger in responder group than in non-responder group ($54.4%{\pm}15.9%$ vs. $22.3%{\pm}23.0%$, p = 0.01). The percent changes of MTV ($%{\Delta}MTV$) or TLG ($%{\Delta}TLG$) had no correlation with the tumor response after treatment. All the 7 patients (100%) with $%{\Delta}SUV_{max}{\geq}50%$ had PR, but only 2 out of 6 patients (33%) with $%{\Delta}SUV_{max}$ < 50% had PR after CCRT (p = 0.009). Likewise, all the 6 patients (100%) with $%{\Delta}SUV_{mean}{\geq}50%$ had PR, but only 3 out of 7 patients (43%) with $%{\Delta}SUV_{mean}$ < 50% had PR after CCRT (p = 0.026). Conclusion: The degree of metabolic changes measured by PET-CT during CCRT was predictive for NSCLC tumor response after CCRT.
Suzy Kim,Kyubo Kim,Eui Kyu Chie,Sun Whe Kim,Yung-Jue Bang,Sung Whan Ha 한국간담췌외과학회 2011 한국간담췌외과학회지 Vol.15 No.3
Backgrounds/Aims: To investigate survival rates and prognostic factors of patients with gallbladder cancer who were treated with surgery and postoperative radiation therapy. Methods: Seventeen gallbladder cancer patients who received surgery and postoperative radiotherapy from October 1989 to April 1998 were included in this retrospective study. Five patients had stage II, 8 patients had stage III, and 4 patients had stage IV disease according to the 1997 American Joint Committee on Cancer (AJCC) staging. All patients received ≥40 Gy of postoperative radiotherapy with a daily dose of 2.0 Gy/fraction and 15 patients received concurrent chemotherapy. An analysis was performed for the endpoints of overall and disease-free survival. Results: Of the 17 patients, 13 had no residual disease (R0), 1 had microscopic residual disease (R1), and 3 had macroscopic residual disease (R2) after surgery. Among patients with no residual disease, 4 had locoregional recurrences during the follow-up period. One patient with microscopic residual disease had local recurrence. The 5-year overall survival rate was 38.2%. The median overall survival time was 21 months and the median disease-free survival time was 12 months. Old age (≥60 years old), female gender, a high pathological stage (≥IVA), and the presence of residual disease after surgery were significant prognostic factors for disease-free survival. Conclusions: Despite a high proportion of patients with advanced disease and macroscopic residual disease, the prognosis of gallbladder patients who had postoperative radiotherapy is encouraging. Additional investigation to improve the loco-regional control of gallbladder cancer patients with adverse prognostic factors is warranted. (Korean J Hepatobiliary Pancreat Surg 2011;15:152-156)
Kim, Miyoung,Kim, Hanna,Ryu, Jeonghyun,Jo, Suzy,Lee, Guemsan,Ryu, Mi Heon,Kim, Hyungwoo,Cho, Su In Medknow PublicationsMedia Pvt Ltd 2014 Pharmacognosy magazine Vol.10 No.38
<P><B>Background:</B></P><P>The slough shed of <I>Cryptotympana atrata</I> Fabricius is widely used to treat skin diseases in China, Japan, and Korea.</P><P><B>Objective:</B></P><P>To investigate the anti-inflammatory effects of <I>C. atrata</I> on contact dermatitis.</P><P><B>Materials and Methods:</B></P><P>We investigated the effects of <I>C. atrata</I> methanol extract (MECA) on ear swelling, histophathological changes and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mice.</P><P><B>Results:</B></P><P>Topical application of MECA effectively inhibited enlargement of ear swelling (30 and 100 μ/ear, <I>P</I> < 0.05; 300 μg/ear, <I>P</I> < 0.01). MECA treatment also inhibited hyperplasia, spongiosis (100 and 300 μg/ear, <I>P</I> < 0.001), and immune cell infiltration (30 μg/ear, <I>P</I> < 0.05; 100 and 300 μg/ear, <I>P</I> < 0.001) induced by DNFB. In addition, treatment with MECA suppressed the increase in the levels of TNF-α (<I>P</I> < 0.05), IFN-g (3, 100 μg/ear, <I>P</I> < 0.05; 300 μg/ear, <I>P</I> < 0.01), and IL-6 (100 μg/ear, <I>P</I> < 0.05; 300 μg/ear, <I>P</I> < 0.01) production.</P><P><B>Conclusion:</B></P><P>These data suggest that MECA has the potential for use in the treatment of inflammatory skin diseases, including CD. Moreover, the results presented herein indicate that anti-inflammatory actions of MECA are mediated by decreasing production of TNF-α, IFN-γ, and IL-6 in inflamed tissues.</P>