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인슐린의존형 당뇨병환자에서 임신중 병발한 당뇨병성 케톤산증 1예
이성근,신영구,이성규,정윤석,이관우,김현만,김행수 아주대학교 1997 아주의학 Vol.2 No.2
저자등은 인슐린의존형 당뇨병환자에서 임신중에 병발한 당뇨병성 케톤산증을 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. IDDM is an autoimmune disease resulted from beta cell destruction and insulin deficiency, and developed mostly in children and puberty. Ketoaddosis remains one of the most senous complications that can occur in the pregnant diabetic. A 26-year-old woman, gravida 1, para 0, was admitted at 32 weeks gestation because of fever lasted for 6 days. She had been treated with insulin pump during the pregnancy. Blood sugar was well controlled before admission, and the etiology of her ketoacidosis was urinary tract infection and no insulin-intake. DKA was treated with fluids and intravenous insulin. Urinary tract infection was treated with antibiotics, based on culture test. Healthy newbom was later delivered by cesarean section due to fetal distress. We experienced a case of DKA in pregnant woman and report it with a review on literature.
초미분말 석회석 현탁액을 이용한 전자산업 폐수 불소이온 제거연구
박현수 ( Hyeon Soo Park ),박연수 ( Yeon Soo Park ),정구일 ( Goo Ill Jung ),김재우 ( Jae Woo Kim ),조영민 ( Young Min Jo ) 한국공업화학회 2018 공업화학 Vol.29 No.3
본 연구에서는 전자산업폐수에 함유되어 있는 불소성분을 제거하기 위하여 미세 침강성 석회석을 적용해보고자 하였다. 석회석의 입자크기는 평균 0.96 μm이었으며, 질량 기준으로 70%가 함유된 수용액상의 pH는 10이었다. 현탁액의 침강속도는 2 mL/hr로 나타났다. 본 연구의 시험용 석회석 수용액은 폐수 중화와 불소이온 제거능력 면에서 기존의 액상소석회와 동등 이상의 성능을 보여주었다. 추가적인 알칼리 증량제의 투입양에 따라 pH 7에 도달할 수 있는 시험용 칼슘원의 양은 기존의 석회수보다 적었다. 또한 불화수소로 고정시킬 수 있는 양도 미분말 석회석이 석회수보다 큰 것으로 나타났다. 또한, Minteq 평형모델링으로부터 다양한 불소와 칼슘화합물 형성이 예상되었다. This study attempted to utilize ultrafine precipitated calcium carbonate for fluoride removal from the wastewater of electronics industries. An average particle size of the calcium carbonate was 0.96 μm, and pH of the aqueous slurry was 10 with 70% in mass. The suspension solution showed approximately 2 mL/hr of the sedimentation rate. The present calcium carbonate solution could be comparable to the conventional aqueous calcium source, Ca(OH)<sub>2</sub>, for the neutralization and removal of fluoride ions. Depending on the amount of an additional alkali source, less amounts of test Ca-source slurries were required to reach the solution pH of 7.0 than that of using the aqueous calcium hydroxide. It was also found from XRD analysis that more calcium fluoride precipitates were formed by the addition of calcium carbonate solution rather than that of calcium hydroxide. In addition, Minteq equilibrium modelling estimated various ion complexes of fluoride and calcium in this process.
Prenatal diagnosis by direct DNA analysis in facioscapulohumeral muscular dystrophy (FSHD) families
Soo Kyung Choi,Je Hyeon Lee,Bong Yoon Kim,Hyung Goo Kim,Eun Hee Cho,Hyun Mee Ryu,Young Joe Kim 대한의학유전학회 1998 대한의학유전학회지 Vol.2 No.1
Facloscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant neuromuscular disorder which has been clinically shown to cause progressive weakness and result in atrophy of the facial muscles, shoulder girdle and upper arm muscles. The responsible gene for the FSHD has been located on chromosome 4q35-qter. The probes p13E-11 and pFR-1 detect DNA rearrangements associated with FSHD as under 28 kb DNA fragment in genomic southern analysis digested with EcoPⅠ and the fragment contains 3.3 kb KpnⅠ tandem repeats. In this study, 4 fetuses with, a family history of FSHD were analysed by genomic southern hybridization analysis with probes to determine whether they carried the deleted region. Of the 4 fetuses, three of them had mothers who were FSHD patients and the other one had a father affected with FSHD. After 10-11 weeks of gestation, we performed chorionic villi sampling and extracted DNA from uncultured and cultured tissue cells for the direct DNA analysis. The result of the southern analysis showed two fetuses having received about 15-18 kb of deleted genes from the father and the mother respectively, and found to be FSHD patients. The other two fetuses were shown to have two normal alleles from the parents and found to be normal. Two pregnancies which were determined to be normal were carried to term delivering two healthy babies.
Goo, Bonhyuk,Kim, Sung-Jin,Kim, Eun-Jung,Nam, Dongwoo,Lee, Hyun-Jong,Kim, Jae-Soo,Park, Yeon-Cheol,Baek, Yong-Hyeon,Nam, Sang-Soo,Seo, Byung-Kwan Williams & Wilkins Co 2018 Medicine Vol.97 No.50
<P><B>Abstract</B></P><P><B>Background:</B></P><P>A lumbar herniated intervertebral disc (LHIVD) is a common problem that usually causes low back pain and radiating pain. The effectiveness of Bosinji, one of the herbal medicines used for low back pain and radiating pain in patient with LHIVD, has been reported in several studies; however, little clinical evidence is available owing to the methodological limitations in previous studies. Hence, the present study aims to establish the clinical evidence regarding the efficacy and safety of Bosinji in improving pain, function, and quality of life in LHIVD patients.</P><P><B>Method/design:</B></P><P>This is a multicenter, open-label, randomized, controlled, and equivalence trial with 2 parallel arms. A total of 74 patients who have low back pain and radiating pain due to LHIVD will be recruited and randomly allocated to the experimental group and control group. The patients in the experimental group and control group will take 2.5 g of Bosinji granule (1.523 g of Bosinji extract) or Loxonin tablet (60 mg of loxoprofen) 3 times a day for 6 weeks. Additionally, both groups will receive the same acupuncture treatment once a week for 6 weeks as a concurrent treatment. Changes in the 100-mm visual analogue scale (VAS) for low back pain after 6 weeks from baseline will be assessed as the primary outcome. Furthermore, the 100-mm VAS for radiating pain, Oswestry disability index (ODI), Roland–Morris disability questionnaire (RMDQ), EuroQol 5 Dimensions 5 Levels (EQ-5D-5L), global perceived effect (GPE), and deficiency syndrome of kidney index (DSKI) will be used to evaluate secondary outcomes. Outcomes will be assessed at baseline and at 3, 6, and 10 weeks after screening. For the safety evaluation, laboratory examinations including complete blood count, liver function test, renal function test, blood coagulation test, inflammation test, and urine analysis will be conducted before and after taking the medications.</P><P><B>Discussion:</B></P><P>The results of this trial will be used to establish clinical evidence regarding the use of Bosinji with acupuncture treatment in the treatment of patients with LHIVD.</P><P><B>Trial registration number:</B></P><P>NCT03386149 (clinicaltrials.gov) and KCT0002848 (Clinical Research Information Service of the Republic of Korea).</P>
Goo, Bonhyuk,Jeong, Seong-Mok,Kim, Jong-Uk,Park, Yeon-Cheol,Seo, Byung-Kwan,Baek, Yong-Hyeon,Yook, Tae-Han,Nam, Sang-Soo Williams & Wilkins Co 2019 Medicine Vol.98 No.7
<P><B>Abstract</B></P><P><B>Background:</B></P><P>The sequelae of Bell's palsy cause critical problem in facial appearance, as well as social and psychological problems in the patient's life. The aim of the present study is to establish clinical evidence of thread-embedding acupuncture (TEA) in the treatment of sequelae of Bell's palsy.</P><P><B>Method/Design:</B></P><P>This is a patient-assessor blinded, randomized, sham-controlled trial with two parallel arms. Fifty-six patients aged 19–65 years, who have experienced sequelae of Bell's palsy for >3 months, will be recruited and screened using the eligibility criteria. After screening, they will be randomly allocated to a TEA group or a sham TEA (STEA) group. Both groups will receive TEA or STEA treatment on ten predefined acupoints once a week for 8 weeks. Additionally, both groups will receive the same acupuncture treatment twice a week for 8 weeks as a concurrent treatment. Changes in the Facial Disability Index over 8 weeks will be assessed as the primary outcome. Furthermore, the House-Brackmann Grade, Facial Nerve Grading System 2.0, Sunnybrook Facial Grading System, facial stiffness score, lip mobility score, and treatment satisfaction score will be measured and analyzed as secondary outcomes. All outcomes will be assessed at baseline and at 4 and 8 weeks after screening.</P><P><B>Discussion:</B></P><P>The results from this trial will help establish clinical evidence regarding the efficacy and safety of TEA in the treatment of patients with sequelae of Bell's palsy.</P><P><B>Trial registration number:</B></P><P>KCT0002557 (Clinical Research Information Service of the Republic of Korea).</P>
Plasma Resistin Concentrations are Elevated in Individuals with Type 2 Diabetes Mellitus
( Jun Goo Kang ),( Young Min Cho ),( Jae Hyeon Kim ),( Hye Seung Jung ),( Byung Soo Youn ),( Kang Yeol Yu ),( Hong Je Park ),( Kyong Soo Park ),( Seong Yeon Kim ),( Hong Kyu Lee ) 대한비만학회 2003 대한비만학회 학술대회 Vol.2003 No.-
Jun Hyeon Cho,Hari Krishna Upreti,You Cheon Song,Woon Goo Ha,hambhu Prasad Khatiwada,Jong He e Lee,Ji Yoon Lee,Un Sang Yeo,Dong Soo Park,Hang Won Kang 한국육종학회 2012 한국육종학회지 Vol.44 No.2
For QTL analysis of agronomic traits based on cultivation of low and high altitude locations, BC1 F5 181 lines were developed from a cross of Tongil type Gayabyeo and japonica Chhomrong originated from Nepal. Plant materials were grown in both of low altitude area of Milyang, Korea and high altitude area of Khumaltar, Nepal. In QTLs analysis, a total of 42 QTLs were detected in days to flowering, culm length, panicle length, number of panicles/hill, panicle exertion, and spikelet ripening ratio. Although many of the QTLs were coincided between the two locations of Korea and Nepal, several QTLs were revealed as location specific in high altitude area of Khumaltar. Especially, the regions harboring marker RM489-RM14281 on chromo- some 3, RM5642-RM19049 on chromosome 5, and RM2854-RM6696 on chromosome 12 where QTLs were clustered and coincided between the two locations are considered as positive target regions for environmental independent traits. Furthermore, high rate of location specific QTLs such as panicle exertion and spikelet ripening ratio could be considered carefully for understanding the mechanism of cold tolerance based on cultivation of different altitude location.