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      • SCIESCOPUSKCI등재

        Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia

        Sharif, Ahsan,Ahmed, Ejaz,Malik, Abdul,Riaz, Naheed,Afza, Nighat,Nawaz, Sarfraz Ahmad,Arshad, Muhammad,Shah, Muhammad Raza,Chaudhary, Muhammad Iqbal The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.7

        Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with $\beta$-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.

      • Cloud Computing Security Models, Architectures, Issues and Challenges

        Muhammad Alyas Shahid,Muhammad Sharif 한국산학기술학회 2015 SmartCR Vol.5 No.6

        Cloud computing a new recently emerged environment for the hosting and delivery of IT services over a network typically includes on-demand, reliable, customized, self service computing environment guarantees dynamic access and quality of service for end users. This computing paradigm introduces many changes with flexible and dynamically scalable pools of often virtualized resources. With these multitudinous benefits and characteristics, a cloud system can prospectively perk up information technology and encourage business to work on, and invest in new alternate computing system. It offers a quick start, flexibility, scalability and cost-effectiveness for hosting and expanding resources but new threats and opportunities for exploitation are introduced requiring essential values and control policies to guide the protection and safety of systems and data. The cloud computing environment also provides opportunities to share resources, information and services among the peoples of the world. With all the advantages of cloud computing, there are a few limitations with respect to data security and quality of service, because this environment brings new security issues, challenges and threats. Management must understand and analyze the risks of this new and emerging paradigm of cloud in order to protect and secure the system, resources and data from exploitation. This paper focuses on cloud computing Security Models, Security Architecture, risks, issues, threats and challenges of security to any cloud computing environment.

      • KCI등재

        Dengue Virus Serotypes Circulating in Khyber Pakhtunkhwa Province, Pakistan, 2013-2015

        Muhammad Suleman,Rani Faryal,Muhammad Masroor Alam,Salmaan Sharif,Shahzad Shaukat,Uzma Bashir Aamir,Adnan Khurshid,Mehar Angez,Massab Umair,Mian Muhammad Sufian,Yasir Arshad,Syed Sohail Zahoor Zaidi 대한진단검사의학회 2017 Annals of Laboratory Medicine Vol.37 No.2

        From 2013 to 2015, the National Institute of Health, Pakistan, received 1,270 blood samples of suspected dengue cases reported from inpatient and outpatient departments of various hospitals in Khyber Pakhtunkhwa (KPK) province. In this study, we determined the circulating dengue virus (DENV) serotypes using real-time reverse transcriptase (RT)-PCR to understand the serotype-based epidemiology of DENV. All four serotypes (DENV-1 [6%], DENV-2 [33%], DENV-3 [47%], and DENV-4 [0.1%]) were found circulating during the study period. Our findings suggest the need for an active surveillance system coupled with the laboratory diagnosis, especially in the chronic endemic areas of the country. Public awareness programs are needed for effective control and prevention of outbreaks in the future.

      • KCI등재

        On the Physical Properties of the Plane Symmetric Self-Similar Solution

        Muhammad Sharif,Sehar Aziz 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.47 No.3

        This paper discusses some of the physical properties of plane symmetric self-similar solutions of the first kind (i.e., homothetic solutions). We are interested in calculating the expansion, the acceleration, the rotation, the shear tensor, the shear invariant, and the expansion rate (given by Raychaudhuri’s equation). We check these properties both in co-moving and non-co-moving coordinates (only in the radial direction). Further, the singularity structure of such solutions will be explored. This analysis provides some interesting features of self-similar solutions.

      • SCOPUSKCI등재

        Wild Mushrooms: A Potential Source of Nutritional and Antioxidant Attributes with Acceptable Toxicity

        Sharif, Sumaira,Shahid, Muhammad,Mushtaq, Muhammad,Akram, Sumia,Rashid, Ayoub The Korean Society of Food Science and Nutrition 2017 Preventive Nutrition and Food Science Vol.22 No.2

        This paper describes in detail proximate composition, nutritional profile, phytochemical constituents, antioxidant activities, antimicrobial potential, and antihemolytic activity (towards human erythrocytes) of various fractions of wild Ganoderma lucidum. Proximate analysis established that wild G. lucidum comprises about $87.02{\pm}5.45%$ of moisture, and the remaining part is a rich source of proteins ($8.59{\pm}0.37%$), crude fiber ($54.21{\pm}1.2%$), and carbohydrate (35.16%) with smaller fat content (3.33 %). Similarly, phytochemical screening revealed the presence of flavonoids ($217.51{\pm}0.30mg/g$), ascorbic acid ($116{\pm}7.32mg/g$), phenolics ($360.72{\pm}34.07mg/g$), ${\beta}$-carotenes ($0.42{\pm}0.04{\mu}g/g$), and lycopene ($0.05{\pm}0.00{\mu}g/g$). Extracts of wild G. lucidum in various solvents provided first line protection against Escherichia coli and Pasteurella multocida in the order of ethyl acetate> ethanol> methanol> n-hexane> water. Furthermore, aqueous and methanolic extracts of wild G. lucidum were found to be safe towards human erythrocytes. Overall, wild mushroom (G. lucidum) was found to be a good source of dietary supplements, antimicrobial and antioxidant agents in the pursuance of its commercial utilization in food and pharmaceutical industries.

      • KCI등재

        Five-Dimensional Perfect Fluid Collapse with the Cosmological Constant

        Muhammad Sharif,Zahid Ahmad 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.4

        This paper is devoted to the study of a five-dimensional spherically symmetric perfect fluid collapse with a positive cosmological constant. We take a five-dimensional spherically symmetric metric in the interior region and a five-dimensional Schwarzschild-de Sitter metric in the exterior region. The junction conditions between the interior and the exterior spacetimes are derived. By assuming that the energy density and the pressure satisfy the weak energy condition, we discuss the solution for the interior spacetime with a perfect fluid for both the marginally bound and the non-marginally bound cases. We investigate the apparent horizons and their physical significance and conclude that the cosmological constant slows down the collapse of matter and, hence, limits the size of the black hole. This analysis generalizes four-dimensional perfect fluid collapse. The energy density is found to diverge faster in five dimensions than in four dimensions, indicating faster collapse here. Also, the cosmological horizon and the black hole horizon have larger proper areas than they do in four dimensions. This paper is devoted to the study of a five-dimensional spherically symmetric perfect fluid collapse with a positive cosmological constant. We take a five-dimensional spherically symmetric metric in the interior region and a five-dimensional Schwarzschild-de Sitter metric in the exterior region. The junction conditions between the interior and the exterior spacetimes are derived. By assuming that the energy density and the pressure satisfy the weak energy condition, we discuss the solution for the interior spacetime with a perfect fluid for both the marginally bound and the non-marginally bound cases. We investigate the apparent horizons and their physical significance and conclude that the cosmological constant slows down the collapse of matter and, hence, limits the size of the black hole. This analysis generalizes four-dimensional perfect fluid collapse. The energy density is found to diverge faster in five dimensions than in four dimensions, indicating faster collapse here. Also, the cosmological horizon and the black hole horizon have larger proper areas than they do in four dimensions.

      • KCI등재

        Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia

        Ahsan Sharif,Ejaz Ahmed,Abdul Malik,Naheed Riaz,Nighat Afza,Sarfraz Ahmad Nawaz,Muhammad Arshad,Muhammad Raza Shah,Muhammad Iqbal Choudhary 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.7

        Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with β-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.

      • SCIESCOPUS

        TinyOS-New Trends, Comparative Views, and Supported Sensing Applications: A Review

        Amjad, Muhammad,Sharif, Muhammad,Afzal, Muhammad Khalil,Sung Won Kim IEEE 2016 IEEE SENSORS JOURNAL Vol.16 No.9

        <P>The wireless sensor network (WSN) is an interesting area for modern day research groups. Tiny sensor nodes are deployed in a diversity of environments but with limited resources. Scarce resources compel researchers to employ an operating system that requires limited memory and minimum power. Tiny operating system (TinyOS) is a widely used operating system for sensor nodes, which provides concurrency and flexibility while adhering to the constraints of scarce resources. Comparatively, TinyOS is considered to be the most robust, innovative, energy-efficient, and widely used operating system in sensor networks. This paper looks at the state-of-the-art TinyOS and the different dimensions of its design paradigm, programming model, execution model, scheduling algorithms, concurrency, memory management, hardware support platforms, and other features. The addition of different features in TinyOS makes it the operating system of choice for WSNs. Sensing nodes with TinyOS seem to show more flexibility in supporting diverse types of sensing applications.</P>

      • Arsenic removal by natural and chemically modified water melon rind in aqueous solutions and groundwater

        Shakoor, Muhammad Bilal,Niazi, Nabeel Khan,Bibi, Irshad,Shahid, Muhammad,Sharif, Fakhra,Bashir, Safdar,Shaheen, Sabry M.,Wang, Hailong,Tsang, Daniel C.W.,Ok, Yong Sik,Rinklebe, Jö,rg Elsevier 2018 The Science of the total environment Vol.645 No.-

        <P><B>Abstract</B></P> <P>Contamination of groundwater with toxic arsenic (As) has become an emerging health and environmental problem around the world, which has seen significant attention amongst the scientists for development of new sorbents to remediate As-contaminated water. Here, we explored the arsenate (As(V)) and arsenite (As(III)) sorption to natural water melon rind (WMR), xanthated WMR and citric acid-modified WMR in aqueous solutions, and determined potential of the most potent sorbent for As removal in groundwater. Xanthated WMR (X-WMR) showed relatively higher As(V) and As(III) removal than the citric acid modified WMR (CA-WMR) and natural WMR. The maximum As(III) (99%) and As(V) (98%) removal was obtained at pH 8.2 and 4.6, respectively, by X-WMR at 4 mg L<SUP>−1</SUP> initial As(V) and As(III) concentrations and sorbent dose of 1 g L<SUP>−1</SUP>. Langmuir isotherm model best fitted (<I>R</I> <SUP> <I>2</I> </SUP> of up to 0.96) the data both for As(III) and As(V) sorption to X-WMR. Sorption kinetics of As(V) and As(III) was well described (<I>R</I> <SUP> <I>2</I> </SUP> of up to 0.99) by the pseudo second-order model on surface of the X-WMR. Thermodynamic investigations revealed that As(V) and As(III) sorption was endothermic and spontaneous. The FTIR spectroscopy depicted the presence of different surface function groups (OH, COOH, S-bearing (C=S, S=O and S–S)) which were involved in As(V) and As(III) sequestration on the sorbents examined here. Significantly, X-WMR showed (up to 49%) greater As(III) and As(V) sorption than that of natural WMR. Our results demonstrated that X-WMR efficiently removed 94%–100% (<I>n</I> = 16) of As from As-contaminated drinking well water which possessed detectable concentrations of some anions (e.g., SO<SUB>4</SUB>, CO<SUB>3</SUB>, HCO<SUB>3</SUB>). This study highlights that the X-WMR has potential to remove As, notably As(III), from solutions and drinking water, and might be utilized as a reactive medium for the treatment of As-contaminated water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Water melon rind (WMR) was tested for arsenic removal potential from water. </LI> <LI> Xanthated WMR removed up to 99% of As(III)/As(V) in solutions. </LI> <LI> Langmuir and pseudo second-order models provided the best fits for As(III) and As(V). </LI> <LI> FTIR spectra showed arsenic sequestration with surface functional groups of sorbents. </LI> <LI> Xanthated WMR successfully removed 94–100% arsenic from drinking well water. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

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