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      • KCI등재

        Optimality of Linear MIMO Detection for 5G Systems via 1-Opt Local Search

        Khurshid Kiran,Khan Adnan Ahmed,Siddiqui Muhammad Haroon,Hadi M. Usman,Rashid Imran,Imran Muhammad 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.2

        Multiple input multiple output (MIMO) symbol detection problem belongs to non-deterministic polynomial acceptable hard combinatorial optimization (CO) class. One of the key trials in design of MIMO scheme is to develop a low complexity detection algorithm without much compromise in performance. Detection approaches proposed in the literature can be split into non-linear and linear algorithms. Vertical Bell-Labs Layered Space Time (V-BLAST) and Sphere Decoder (SD) are non-linear methods used for extracting transmitted data; whereas, Zero-Forcing (ZF) and Minimum Mean Square Error (MMSE) detections are comparatively in complex and eff ectual linear techniques. In this work, the heuristic 1-Opt local search method used for solving computationally hard combinatorial optimization problems is applied to the ZF and MMSE detection algorithms. First, simple MIMO decoding using ZF and MMSE is accomplished to fi nd the estimated symbol then the transmitted symbol is calculated using the heuristic 1-opt approach by means of the estimated symbol. Simulation results demonstrate that 1-opt search when applied to the ZF and MMSE displays better bit error rate (BER) performance than the simple ZF and MMSE detectors. It is also verifi ed through simulations that the proposed 1-Opt based detectors display better BER performance as compared to the complex nonlinear VBLAST and SD at considerably reduced complexity. Hence, the proposed detectors are appropriate for eff ective hardware implementations.

      • Ki67 Index in Breast Cancer: Correlation with Other Prognostic Markers and Potential in Pakistani Patients

        Haroon, Saroona,Hashmi, Atif Ali,Khurshid, Amna,Kanpurwala, Muhammad Adnan,Mujtuba, Shafaq,Malik, Babar,Faridi, Naveen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7

        Introduction: Breast cancer aggressiveness can be correlated with proliferation status of tumor cells, which can be ascertained with tumor grade and Ki67 indexing. However due to lack of reproducibility, the ASCO do not recommend routine use of Ki67 in determining prognosis in newly diagnosed breast cancers. We therefore aimed to determine associations of the Ki67 index with other prognostic markers like tumor size, grade, lymph node metastasis, ER, PR and HER2neu status. Methods: A total of 194 cases of newly diagnosed breast cancer were included in the study. Immunohistochemical staining for ER, PR, HER2neu and Ki67 was performed by the DAKO envision method. Associations of the Ki67 index with other prognostic factors were evaluated both as continuous and categorical variables. Results: Mean age of the patients was 51.7 years (24-90). Mean Ki67 index was 26.9% (1-90). ER, PR, HER2neu positivity was noted in 90/194 cases (46.4%), 74/194 cases (38.1%) and 110/194 cases (56.70%) respectively. Significant association was found between Ki67 and tumor grade, PR, HER2neu positivity and lymph node status, but no link was apparent with ER positivity and tumor size. There wasan inverse relation between Ki67 index and PR positivity, whereas a direct correlation was seen with HER2neu positivity. However, high Ki67 (>30%) was associated with decreased HER2neu positivity as compared to intermediate Ki67 (16-30%). The same trend was established with lymph node metastasis. Conclusion: Our study indicates that with high grade tumors, clinical utility of ki67 is greater in combination with other prognostic markers because we found that tumors with Ki67 higher than 30% have better prognostic profile compared to tumors with intermediate Ki67 level, as reflected by slightly lower frequency of lymph node metastasis and HER2neu expression. Therefore we suggest that Ki67 index should be categorized into high, intermediate and low groups when considering adjuvant chemotherapy and prognostic stratification.

      • KCI등재

        Dengue Virus Serotypes Circulating in Khyber Pakhtunkhwa Province, Pakistan, 2013-2015

        Muhammad Suleman,Rani Faryal,Muhammad Masroor Alam,Salmaan Sharif,Shahzad Shaukat,Uzma Bashir Aamir,Adnan Khurshid,Mehar Angez,Massab Umair,Mian Muhammad Sufian,Yasir Arshad,Syed Sohail Zahoor Zaidi 대한진단검사의학회 2017 Annals of Laboratory Medicine Vol.37 No.2

        From 2013 to 2015, the National Institute of Health, Pakistan, received 1,270 blood samples of suspected dengue cases reported from inpatient and outpatient departments of various hospitals in Khyber Pakhtunkhwa (KPK) province. In this study, we determined the circulating dengue virus (DENV) serotypes using real-time reverse transcriptase (RT)-PCR to understand the serotype-based epidemiology of DENV. All four serotypes (DENV-1 [6%], DENV-2 [33%], DENV-3 [47%], and DENV-4 [0.1%]) were found circulating during the study period. Our findings suggest the need for an active surveillance system coupled with the laboratory diagnosis, especially in the chronic endemic areas of the country. Public awareness programs are needed for effective control and prevention of outbreaks in the future.

      • KCI등재

        Impact of salicylic acid and calcium chloride on quality attributes of peach stored at refrigeration temperature

        Nosheen Khalid,Shehla Sammi,Sumaira Miskeen,Imran Khan,Inam-u-llah,Muhammad Liaquat,Khurshid Anwar,Adnan Khan,Abdul Majeed Shah,Abdul Sattar Shah,Awatif Abid Mohammed Al-Judaibi,하재원,Muhammad Jahangir 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.9

        Salicylic acid (SA) in different concentration were used to assess its individual effect as well as combined impact with 3% calcium chloride (CaCl2) on Swat No. 8 variety of peach stored at refrigerated temperature (6 ± 2 °C) for 21 days. Interestingly, the results revealed that applying 2 mmol L−1 SA with 3% CaCl2 maintained maximum nutritional value and least decay percent (44.1%) as compared to other treatments during storage. Moreover, this combination also exhibited significant weight loss and chilling injury at 6 ± 2 °C whereas increased levels of total phenolic, flavonoids, tannin, alkaloid, ascorbic acid, and antioxidant activity were observed as compared to other treatments. The combination treatment (2 mmol L−1 SA with 3% CaCl2) maintained other sensory attributes of peach fruit during refrigerated storage, therefore, its commercial use was recommended to store peach fruit for up to three weeks without any significant nutritional and physical loss.

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