http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia
Sharif, Ahsan,Ahmed, Ejaz,Malik, Abdul,Riaz, Naheed,Afza, Nighat,Nawaz, Sarfraz Ahmad,Arshad, Muhammad,Shah, Muhammad Raza,Chaudhary, Muhammad Iqbal The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.7
Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with $\beta$-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.
Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia
Ahsan Sharif,Ejaz Ahmed,Abdul Malik,Naheed Riaz,Nighat Afza,Sarfraz Ahmad Nawaz,Muhammad Arshad,Muhammad Raza Shah,Muhammad Iqbal Choudhary 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.7
Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with β-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.
( Ahsan Naveed ),( Yeong-bin Baek ),( Mahmoud Soliman ),( Muhammad Sharif ),( Sang-ik Park ),( Mun-il Kang ) 한국동물위생학회 2021 韓國家畜衛生學會誌 Vol.44 No.4
Species A rotaviruses (RVAs) replicate and assemble their immature particles within electron dense compartments known as viroplasms, where lipid droplets (LDs) interact with the viroplasm and facilitate viral replication. Despite the importance of LD formation in the life cycle of RVAs, the upstream molecules modulating LD formation remain unclear. This study aimed to find out the role of sterol regulatory element-binding proteins (SREBPs) in reprogramming of LD formation after RVA infection. Here, we demonstrate that RVA infection reprograms the sterol regulatory element-binding proteins (SREBPs)-dependent lipogenic pathways in virus-infected cells, and that both SREBP-1 and -2 transactivated genes, which are involved in fatty acid and cholesterol biosynthesis, are essential for LD formation. Our results showed that pharmacological inhibition of SREBPs using AM580 and betulin and inhibition of their downstream cholesterol biosynthesis (simvastatin for HMG-CoA reductase) and fatty acid enzymes (TOFA) negatively modulated the intracellular triacylglycerides and cholesterol levels and their resulting LD and viroplasm formations. Interestingly, pharmacological inhibition of SREBPs significantly reduced RVA protein synthesis, genome replication and progeny production. This study identified SREBPs-mediated lipogenic reprogramming in RVA-infected host cells, which facilitates virus replication through LD formation and its interaction with viroplasms, suggesting that SREBPs can be a potential target for the development of efficient and affordable therapeutics against RVA infection.
Waqar Nasir,Munawar Ali Munawar,Ejaz Ahmed,Ahsan Sharif,Saeed Ahmed,Amjad Ayub,Misbahul Ain Khan,Faizul Hassan Nasim 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.10
In this study, twenty-one arylaminoquinoxalinone derivatives were synthesized and their antibacterial activities against Staphylococci aureus, Pseudomonas aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi, and Shigella pneumoniae were evaluated relative to known antibiotics; augmentin, ampicillin, and chloramphenicol. The insecticidal activities of the prepared compounds were also investigated against Tribolium castaneum using permethrin as a standard insecticide. The derivatives were synthesized using both conventional and microwave techniques. Their structures were confirmed using spectral techniques and elemental analysis.
Mohammad Manjur ALAM,Md. ALAUDDIN,Mohd Yasin SHARIF,Evana Nusrat DOOTY,Syed Md. Hasib AHSAN,Mustafa Manir CHOWDHURY 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.9
Educational institutions play a critical role in national development through the advancement of skilled human resources and intellectual society. The number of higher educational institutions (HEIs) is increasing significantly in Bangladesh. Students have a number of options from which to select their preferred educational institutions. Hence, HEIs should think about the quality of services they provide to students. The objective of this study is to measure students’ satisfaction and university reputation through service quality (SQ) in a private higher educational institution (PriHEI) in Bangladesh. Primary data was collected from 270 students of International Islamic University Chittagong (IIUC), Bangladesh, through a simple random sampling technique. In this study, data was analyzed through descriptive statistics, correlation, measurement model using confirmatory factor analyses, and structural equation modeling (SEM). The results showed that transport services have indirect but medical and physical facilities have both direct and indirect significant effects on overall students’ satisfaction. Further, the administrative services and research facilities have significant indirect effects on overall students’ satisfaction. Finally, the results of structural equation modeling (SEM) confirm that the reputation of the university is directly associated with overall students’ satisfaction.