Size effect on nanomechanical properties of ZnO cones using in situ transmission electron microscopy

Shao-Hui Kang,Te-Hua Fang,Tao-Hsing Chen,Ching-Hong Kuo 한국물리학회 2013 Current Applied Physics Vol.13 No.8

Nanoscale fracture and strain-induced structure variation of ZnO nanocones are determined using in situ transmission electron microscopy compression experiments. For the single-crystalline nanocones with diameters of 100-300 nm, the Young’s modulus is in the range of 7.7-48 GPa and the ultimate tensile strength is in the range of 2.4-4.3%. The Young’s modulus and tensile strength increase with decreasing diameter. Here, we report the nanogenerator of ZnO nanocones can be used mechanical energy to output 90 nW/mm2

Replication of butterfly wing microstructures using molding lithography

Shao-Hui Kang,Tzu-Yao Tai,Te-Hua Fang 한국물리학회 2010 Current Applied Physics Vol.10 No.2

This study employed a soft lithography technique to fabricate a polydimethylsiloxane (PDMS) replica of the multi-layered scales on the upper surface of a Morpho butterfly. The bionic photonic crystal microstructure of the replicated scales was examined using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The absorptivity, reflectivity and fluorescent characteristics of the wing were measured. The results showed that the microstructural and optical characteristics of the replicated wing qualitatively agree with those of the actual wing. The contact angle for the natural wing structure and the replicated wing were about 143˚ and 120˚, respectively. As a result, it can be inferred that the soft lithography technique employed in this study represents a viable approach for the mass production of artificial photonic crystal structures for a variety of commercial applications, including optical elements for computing and communications purposes, photonic integrated circuits, anti-counterfeiting mechanisms, and so forth.

The Synthesis and Preliminary Activity Assay In Vitro of Peptide-like Derivatives as APN Inhibitors

Shao-hua Li,Hui-ming Huang,Fang Xiong,Guo-gang Tu,Gang Li 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

Both the aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis. A series of novel peptide-like derivatives were designed and synthesized as antitumor agents. Their structures were confirmed by IR, MS, and 1H-NMR. These compounds exhibited potent inhibitory activities against APN and low activity against MMP in vitro. The derivatives with methoxy group show better activities than those with other substituted group and could be used as lead compounds for exploring new APN inhibitors in the future.

Effect of nitrogen doping on nanomechanical and surface properties of silicon film

Te-Hua Fang,Win-Jin Chang,Shao-Hui Kang,Jia-Hung Liou 한국물리학회 2009 Current Applied Physics Vol.9 No.6

The effect of nitrogen ion implantation on the nanomechanical properties of single crystal Si was evaluated by means of a conventional Vickers indentation and nanoindentation tests. The images of Si surfaces before and after nitrogen implantation were observed and their average surface roughnesses were measured by an atomic force microscope (AFM), while the changes in the morphology and microstructure of the single crystal Si by N implantation were examined by field emission scanning electron microscope (SEM) and X-ray diffractometer (XRD). In addition, the hydrophilic/hydrophobic surface property of the N-doping Si film was determined from the measurement of water contact angle by the sessile drop technique. Furthermore, the effects of the doping energy on the surface contact angle and the surface roughness and the Vickers hardness of the film are also investigated. The effect of nitrogen ion implantation on the nanomechanical properties of single crystal Si was evaluated by means of a conventional Vickers indentation and nanoindentation tests. The images of Si surfaces before and after nitrogen implantation were observed and their average surface roughnesses were measured by an atomic force microscope (AFM), while the changes in the morphology and microstructure of the single crystal Si by N implantation were examined by field emission scanning electron microscope (SEM) and X-ray diffractometer (XRD). In addition, the hydrophilic/hydrophobic surface property of the N-doping Si film was determined from the measurement of water contact angle by the sessile drop technique. Furthermore, the effects of the doping energy on the surface contact angle and the surface roughness and the Vickers hardness of the film are also investigated.

Optical and physical characteristics of In-doped ZnO nanorods

Te-Hua Fang,Shao-Hui Kang 한국물리학회 2010 Current Applied Physics Vol.10 No.4

In this paper the effect of indium dopants on structure, optical, electrical and mechanical properties of ZnO nanorods are studied. The average surface potentials and the surface currents of ZnO:In nanorods were 0.25–0.84 mV and 2.2–200 MΩ-cm, respectively. The turn-on threshold field for the vertical ZnO nanorods was around 2–16 V ㎛-1. Emission current densities of 3.3–911.4 mA cm-2 were obtained for an electrical field of 60–160 V ㎛-1. The photoluminescence (PL) spectrum measured at 15–300 K showed that the intensity of the peak at 2.06 eV increased with decreasing temperature, while the peak at 2.06 eV further red shifted and the peak at 3.39 eV blue shifted.

Indentation deformation of mesoporous anodic aluminum oxide

Te-Hua Fang,Tong Hong Wang,Shao-Hui Kang,Cheng-Hsin Chuang 한국물리학회 2009 Current Applied Physics Vol.9 No.4

Mechanical properties of anodic aluminum oxides (AAO) were achieved by means of a scanning electron microscope (SEM), an atomic force microscope (AFM), and indentation measurements. A two-step anodized mesoporous anodic aluminum oxide was successfully fabricated vertically and hollowly. Both microindentation and nanoindentation were carried out. Localized pop-in can be found during nanoindentation due to the collapse of the beneath cylindrical structures. Over a certain load, microindentation may induce radial cracks from the indented edge to outward of the AAO. The underside of the indented AAO sample was milled to figure out the structural changes. Mechanical properties of anodic aluminum oxides (AAO) were achieved by means of a scanning electron microscope (SEM), an atomic force microscope (AFM), and indentation measurements. A two-step anodized mesoporous anodic aluminum oxide was successfully fabricated vertically and hollowly. Both microindentation and nanoindentation were carried out. Localized pop-in can be found during nanoindentation due to the collapse of the beneath cylindrical structures. Over a certain load, microindentation may induce radial cracks from the indented edge to outward of the AAO. The underside of the indented AAO sample was milled to figure out the structural changes.

The Synthesis and Preliminary Activity Assay In Vitro of Peptide-like Derivatives as APN Inhibitors

Li, Shao-Hua,Li, Gang,Huang, Hui-Ming,Xiong, Fang,Liu, Cheng-Mei,Tu, Guo-Gang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

Both the aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis. A series of novel peptide-like derivatives were designed and synthesized as antitumor agents. Their structures were confirmed by IR, MS, and $^1H$-NMR. These compounds exhibited potent inhibitory activities against APN and low activity against MMP in vitro. The derivatives with methoxy group show better activities than those with other substituted group and could be used as lead compounds for exploring new APN inhibitors in the future.

Immobilization of lipase onto aminopropyl-functionalized MSU-H type mesoporous silica and esterification

Wei Hua Yu,Han Bin Zhao,Dong Shen Tong,Chun Hui Zhou,Ping Shao 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.8

Candida rugosa lipase (CRL) was immobilized on an aminopropyl-functionalized MSU-H type mesoporous silica (AFMS) through physical adsorption and a covalent cross-linking. It was evaluated as a class of biocatalysts in the esterification of conjugated linoleic acid (CLA) isomers with ethanol. AFMS materials with varied content of aminopropyl were prepared by a simple co-condensation at near neutral pH condition. Introduction of aminopropyl chains and CRL molecules onto the AFMS supports was confirmed by Fourier transform infrared (FT-IR) spectra. CRL was immobilized on the AFMS through electrostatic and covalent interactions. The covalently cross-linked CRL gave a loading amount of 34.3mg CRL/g-support and a hydrolytic activity of 2471.5U/g-catalyst. It exhibited high operational stability and remained 23.9-27.5% of total esterification in 32 h consecutive four runs in the esterification of CLA with ethanol. Moreover, the immobilized CRLs catalyzed 2.8-3.8 times of esterification of cis-(c)9, trans-(t)11- CLA faster than that of t10, c12-CLA.

書評 : 口述史的佳作 -評習賢德敎授撰寫的<<警察與二二八事件>>

( Jie Hou ),( Shao Hui Hua ) 중국사학회 2014 中國史硏究 Vol.88 No.-

2012年7月, 習賢德敎授撰寫的『警察與二二八事件』一書在臺灣由時英出版社出版, 引起筆者的關注. 早在2006年筆者訪學於臺灣大學時, 曾和習敎授有過短暫交往. 2008年筆者訪學世新大學舍我紀念館期間, 與習敎授學術交流增多, 逐漸瞭解他是一位曾在新聞界打□多年, 後又轉向學界, 透過勤苦治學, 取得諸多成績的成大事者. 俗話說"十年磨一劍". 『警察與二二八事件』一書可以說是現爲臺灣輔仁大學大□傳播學硏究所副敎授兼新聞傳播學系主任和傳播學院行政副院長的習賢德敎授花費大量心血完成的精心之作. 在10多年前, 他卽開始拜訪1945年10月赴臺灣接收警務幷親歷"二二八事件"的國民黨中央警校臺灣幹部訓練班(以下簡稱"台幹班")的菁英, 幷完成了珍貴的口述史著作. 2007年, 習賢德敎授憑藉這部口述史的學術硏究成果--『二二八口述歷史補遺: 中央警校台幹班的集體記憶』一書獲得了美國紐約第15屆"萬人傑新聞文化奬", 頒奬委員會認定該書的價値在於"澄淸歷史疑點, 揭開事實眞相". 『警察與二二八事件』正是在上述一書的基礎上經過著者的逐段考據幷進行增補後出版發行的, 是近年來硏究和再認識"二二八事件"的一部口述史佳作.

Combination of Tumor Volume and Epstein-Barr Virus DNA Improved Prognostic Stratification of Stage II Nasopharyngeal Carcinoma in the Intensity Modulated Radiotherapy Era: A Large-Scale Cohort Study

Qiu-Yan Chen,Shao-Yan Guo,Lin-Quan Tang,Tong-Yu Lu,Bo-Lin Chen,Qi-Yu Zhong,Meng-Sha Zou,Qing-Nan Tang,Wen-Hui Chen,Shan-Shan Guo,Li-Ting Liu,Yang Li,Ling Guo,Hao-Yuan Mo,Rui Sun,Dong-Hua Luo,Chong Zha 대한암학회 2018 Cancer Research and Treatment Vol.50 No.3

Purpose Little is known about combination of the circulating Epstein-Barr viral (EBV) DNA and tumor volume in prognosis of stage II nasopharyngeal carcinoma (NPC) patients in the intensity modulated radiotherapy (IMRT) era. We conducted this cohort study to evaluate the prognostic values of combining these two factors. Materials and Methods By Kaplan-Meier, we compare the differences of survival curves between 385 patients with different EBV DNA or tumor volume levels, or with the combination of two biomarkers mentioned above. Results Gross tumor volume of cervical lymph nodes (GTVnd, p < 0.001) and total tumor volume (GTVtotal, p < 0.001) were both closely related to pretreatment EBV DNA, while gross tumor volume of nasopharynx (GTVnx, p=0.047) was weakly related to EBV DNA. EBV DNA was significantly correlated with progress-free survival (PFS, p=0.005), locoregional-free survival (LRFS, p=0.039), and distant metastasis-free survival (DMFS, p=0.017), while GTVtotal, regardless of GTVnx and GTVnd, had a significant correlation with PFS and LRFS. The p-values of GTVtotal for PFS and LRFS were 0.008 and 0.001, respectively. According to GTVtotal and pretreatment EBV DNA level, patients were divided into a low-risk group (EBV DNA 0 copy/mL, GTVtotal < 30 cm3; EBV DNA 0 copy/mL, GTVtotal  30 cm3; or EBV DNA > 0 copy/mL, GTVtotal < 30 cm3) and a high-risk group (EBV DNA > 0 copy/mL, GTVtotal  30 cm3). When patients in the low-risk group were compared with those in the high-risk group, 3-year PFS (p=0.003), LRFS (p=0.010), and DMFS (p=0.031) rates were statistically significant. Conclusion Pretreatment plasma EBV DNA and tumor volume were both closely correlated with prognosis of stage II NPC patients in the IMRT era. Combination of EBV DNA and tumor volume can refine prognosis and indicate for clinical therapy.