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- 저자 : ( Seung Cheo Shim ) (검색결과 3 건)
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Kye, Yoon-Chul,Park, Sung-Moo,Shim, Byoung-Shik,Firdous, Jannatul,Kim, Girak,Kim, Han Wool,Ju, Young-Jun,Kim, Cheol Gyun,Cho, Chong-Su,Kim, Dong Wook,Cho, Jae Ho,Song, Man Ki,Han, Seung Hyun,Yun, Cheo Elsevier 2019 Acta Biomaterialia: structure-property-function re Vol.90 No.-
<P><B>Abstract</B></P> <P>Developing effective mucosal subunit vaccine for the <I>Streptococcus pneumoniae</I> has been unsuccessful mainly because of their poor immunogenicity with insufficient memory T and B cell responses. We thus address whether such limitation can be overcome by introducing effective adjuvants that can enhance immunity and show here that polysorbitol transporter (PST) serves as a mucosal adjuvant for a subunit vaccine against the <I>Streptococcus pneumoniae</I>. Pneumococcal surface protein A (PspA) with PST adjuvant induced protective immunity against <I>S. pneumoniae</I> challenge, especially long-term T and B cell immune responses. Moreover, we found that the PST preferentially induced T helper (Th) responses toward Th2 or T follicular helper (Tfh) cells and, importantly, that the responses were mediated through antigen-presenting cells via activating a peroxisome proliferator-activated receptor gamma (PPAR-γ) pathway. Thus, these data indicate that PST can be used as an effective and safe mucosal vaccine adjuvant against <I>S. pneumoniae</I> infection.</P> <P><B>State of Significance</B></P> <P>In this study, we suggested the nanoparticle forming adjuvant, PST works as an effective adjuvant for the pneumococcal vaccine, PspA. The PspA subunit vaccine together with PST adjuvant efficiently induced protective immunity, even in the long-term memory responses, against <I>Streptococcus pneumoniae</I> lethal challenge. We found that PspA with PST adjuvant induced dendritic cell activation followed by follicular helper T cell responses through PPAR-γ pathway resulting long-term memory antibody-producing cells. Consequently, in this paper, we suggest the mechanism for safe nanoparticle forming subunit vaccine adjuvant against pneumococcal infection.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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( Jin Kyung Oh ),( Jae Hyeong Park ),( Seung Cheo Shim ),( In Seol Yoo ),( Seong Wook Kang ),( Su Jin Yoo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality among patients with connective tissue disease (CTD). Although the incidence of PAH in CTD patients is higher than that of normal population, the true incidence of PAH in Korean patients with CTD is still unknown. Methods: We performed two sessions of echocardiographic screening in cooperation with rheumatologic department in a tertiary hospital. In each session, we enrolled up to 20 patients with CTD and performed echocardiographic study by an experienced examiner. The possibility of PAH is determined by the estimation of pulmonary arterial pressure by tricuspid regurgitation (TR) maximal velocity (TR Vmax >3. 0m/sec). After the screening, the patients with possible PAH were recommended to undergo cardiac catheterization to confi rm the diagnosis. Results: We screened total 30 patients with CTD (27 females, mean age 51±14 years old). Of them, 22 patients had systemic sclerosis (SSc), 6 had systemic lupus erythematosis (SLE) and 2 had Raynaud`s phenomenon. They showed normal left ventricular function and no evidence of signifi cant valvular heart disease. After echocardiographic screening, possible PAH was detected in 9 patients (30%). The incidence of possible PAH was 36% in SSc (8 of 22 patients) and 17 % in SLE (1 of 6 patients). We confi rmed PAH with cardiac catheterization in 4 of 9 patients and started to treat disease specifi c vasodilator therapy in them. Conclusions: We performed two sessions of echocardiographic screening of PAH with cooperation with rheumatology department. The incidence of possible PAH was 37% in SSc and 17% in SLE. To fi nd exact incidence of PAH in CTD patients, more large numbers of patients in many centers will be needed.
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Chuel Kyu Kim,Dae Youn Hwang,Byoung Guk Kim,Seung Wan Jee,Yong Kyu Kim,Sun Bo Shim,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Byoung Chun Lee,Jin Hee Park,Se Heon Lee,Jung Sik Cho,Hyoung Jin Kim,Byoung Cheo 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.3
It has been required to manage the laboratory animals with systemic and scientific manner and to develop the animal models for human diseases, according to the development of new drugs based on the research of gene function and irredeemable diseases activated by National Dynamic Project of 21th Century on Life and Health. It is also necessary to accredit with high quality of laboratory animals for evaluating the safety and validity of foods and drugs, which are directly connected to human health. The aim of this study was to search current status on genetically engineered animals in order to enhance the scientific trusts of these animals to advanced level, and thus providing the book guiding us how to manage and breed the genetically engineered animals. To accomplish this, 107 researchers were selected to ask for current status of genetic engineered animals to 35 questions including the area of management, patent, and law-regulation. We concluded that (ⅰ) there are the total of 146 genetically engineered animals and the total of 29 patents in the country, (ⅱ) the 64 different embryos from mouse, pig, dog, and wolf are stocked, and (ⅲ) it is being prepared to publish a guide book on the basis of these results. Thus, these results raised a possibility that guide book provides a good opportunity to experts acting in the field of evaluating toxicants and of testing drugs as a guideline. It is also possible to use as fundamental materials to establish national policy on the laboratory and genetic engineered animals, and to generate Laboratory Animal Law, which is being review by members of National Assembly.
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