아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

A Reverie for Fire and Death in “Little Gidding”

( Seong¸ Chang-gyu ) 동국대학교 영어권문화연구소 2014 영어권문화연구 Vol.7 No.2

The study aims to suggest that both T. S. Eliot and Gaston Bachelard are concerned with archetypal imagery and reverie for the four elements, and they have comparison to their creations and processes of poetic images. Especially, “Little Gidding,” the fourth poem in Four Quartets deals with fire or flame images and cosmic order, psychoanalysis or poetics of fire by Bachelard, also deals with fire images such as Phoenix and Prometheus, so this paper compares and analyzes two poets' poetry in the poem because their ways to develop from reverie of fire, to the consciousness for time and history, to the meditation for order of cosmos, works of both authors are comparably analogous. Eliot grasps the still point on rotating world as pure, high and sacred culmination, so finally reaches the instance that a human encounters God's love. He also materializes God's love with the fire image and regards it as the glory that we can obtain by conquering humane desires and affections. If the fire is a symbol of God's love, the rose is a symbol of humane love and death. That means the instance combining humane love and death into the fire of anguish, transcendence and purgation. This is considered as the ultimate vision in Dante's Paradiso, the intersection of the time and the timeless of Eliot, and the reverberation or transformation of being in Bachelard's poetics. As new literary images, creation of images is possible to participate in our beings, and as readers, we can experiences the kind of reverberation that give the energy of an origin to being.

Cultural and Domestic Memory in Seamus Heaney’s Bog Poems

( Seong¸ Chang-gyu ),( Kim¸ Chong-kyen ) 동국대학교 영어권문화연구소 2016 영어권문화연구 Vol.9 No.2

This paper deals with Seamus Heaney's bog poems and the meaning of cultural memory. He delves into the bog, examines its past and history, develops its present situation and negotiates between the present and past, not missing its originality. In fact, the bog poems suggest different reconstructions of the same event, different ways of remembering or recalling memory traces. And memory emerges from these negotiations and strategies as a range of processes of recovery. The person remembering an object can enter into the unknown. So, it is a creative or interpretative process of narrating memory traces in terms of the context of retrieval, rather than an archaeological process of revealing discrete or complete memories. It is also a means of representing the ongoing trace of the past or the presence of the past, rather than of discovering a finished past. In the context, poems such as “Kinship,” “The Tollund Man,” “The Bog Queen” and “The Grauballe Man” can be applicable to memorial images of Irish bog. Heaney's attitude to the past has changed radically in the bog poems. The poet's attitude to the past is so subdued and private, as exemplified by the inclusion his wife in the peaceful pastoral scene. Irish history and memory is considered to be originated and completed on a domestic dimension rather than a national dimension.

BTA 드릴링에 있어서 모터 전류를 이용한 절삭이상상태 감시에 관한 연구

장성규,장성화,전언찬 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.2

In the tube-seat working of heat exchanger using BTA drilling among the deep hole drilling process, this paper analyses the property about the tool breakage monitoring in the deep hole drilling as detect the current signal of main spindle motor and analyse the change of cutting force through the experiment for the workability measurement in the low-carbon steel and stainless. We obtain the following conclusions through this experiments. 1) We could detect the current of AC spindle motor through the indirect measuring system of cutting force without using the tool dynamometer. 2) We could observe the change of cutting force and tool breakage monitoring by detecting only the main spindle motor current in the deep hole drilling machine. 3) We could sufficiently observe tool breakage monitoring with detecting the main spindle motor current in BTA drilling process of deep hole drilling machine. 4) We could observe that the limit value approaches 20kg-cm in the 0.4mm range of flank wear.

무증상 갑상선기능저하증 환자에서 Thyroxine 치료에 따른 혈청 지질 및 아포지단백의 변화

조보연,신찬수,김원배,고창순,김성연,박혜영,박건상,이홍규,박형규,김숙경 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.1

Background: Subclinical hypothyroidism(SCH) is a common biochemical abnormality which can be found in routine screening tests of thyroid function. We are increasingly faced with the question of whether its an indication for thyroxine replacement therapy. The effect of thyroxine replacement on lipid profile in SCH has aroused a great interest because of an association of overt hypothyroidism(OVH) with hyperlipidemia and increased risk of coronary artery disease. Method: We prospectively evaluated the changes in lipids and apoproteins before and after thyroxine replacement therapy in 23 patients with SCH and in 37 patients with OVH. We measured serum total cholesterol and triglyceride using autoanalyzer, high density lipoprotein(HDL) chole-sterol by dextran sulfate method, Apo A1 and Apo B by immunonephelometric assay. Results: Thyroxine replacement therapy significantly decreased total cholesterol, low density lipoprotein(LDL) cholesterol and apo B levels, but did not affect the level of triglyceride, HDL cholesterol or apo AI in patients with OVH. In SCH, thyroxine replacement therapy with the doses to normalize serum TSH concentrations also decreased significantly the level of cholesterol and LDL cholesterol albeit apo B levels did not change. Moreover, in most of patients with OVH (11 of 12) and in all of patients with SCH(5 of 5) who had had hyperchlesterolemia before treatment, thyroxine replament normalized their cholesterol and LDL cholesterol levels. Conclusion: In regard to the beneficial changes in blood lipid levels, patients with SCH should be treated, especially in cases who have other risk factors for the development of atherosclerosis. If thyroxine replacement only will reduce the incidence of coronary artery disease in SCH remains to be elucidated by long-term prospective studies(J Kor Soc Endocrinol 11:41-51, 1996).

Balance in Movement from Earthly Roots to Airy Imagination in Seamus Heaney’s Poems

( Seong¸ Chang-gyu ) 동국대학교 영어권문화연구소 2015 영어권문화연구 Vol.8 No.2

This study is to figure out elemental images and the balance with nature & culture in Seamus Heaney's poems. In his whole work, we can find poetic process from earthly images to airy images, which can relate to Bachelard's four element theory. The correlation between nature and culture, between place and language, between earthy rootedness and airy imagination can perform a key role in Heaney's poem, especially bog poems such as “The Tollund Man”, “Bogland” etc. The bogland as a wet center or combination with earth and water, can relate to richness and feminine productivity with sorrowful Irish history. The elemental images are applied to Heaney's poems in order to distinguish between his earthy phase and airy phase. The earthy phase with water and downward movement are found until North, and the new airy phase with light and upward movement are found from Field Work. Though his poems reveal unfair Irish history through victims beneath the bogland, he also reflects the present daily lives and elemental materiality with Irish natural landscape on them, yet never avoiding the past culture.

日中時間 變動에 따른 白鼠의 生理變化에 對한 補肝湯 瀉肝湯의 影響에 關한 硏究

金成圭,洪茂昌,金完熙 慶熙大學校韓醫科大學韓醫學硏究所 1986 慶熙韓醫大論文集 Vol.9 No.-

Deep Hole Drilling에서 절삭유가 가공성에 미치는 영향에 관한 연구

장성규,이충일,전언찬,장성화 東亞大學校 大學院 1998 大學院論文集 Vol.23 No.-

This work deals with o investigation of the influence of various additives to a base stock cutting fluid in order to develop a better deep hole drilling. This investigation has been aimed at development of an oil which gives a maximum cutting efficiency and a minimum wear rate of the tool and the guiding pads. The purpose of this study is to analyze how guide pad of tools, workpiece and the change of contained quantity of the extremen pressure additive i cutting fluids have effects on the hole over size of cutting hole, surface foughness of workpiece, wear rates of guide pad and roundness during the deep hole machining of SM55C with solid BTA drill by using BTA drilling system through experiment. Conclusion reached is as follows. 1)It has been proved that contained quantity of sulphyr more affects machinability than that of extreme pressure additive of chlorine in BTA drilling during deep hole drilling. 2)The range of 1.5~2.0% of sulphur quantity is suitable to machinability for workpiece in BTA drilling. 3)The wear of guide pad is affeted by the quantity of extreme pressure additive of chlorine.

한국인 쯔쯔가무시병 환자에서 사이토카인 유전자의 다양성 조사

장우임,김수연,위성헌,김태규 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Scrub typhus is caused by Orientia tsutsugamushi and can become severe and potentially life-threatening. It is suggested that specific host factors can modify the host response during O. tsutsugamushi infection. It is known that susceptibility and outcome of infectious disease are associated with genetic polymorphisms of some cytokines. Materials and Methods: Peripheral blood of 144 patients who were diagnosed with scrub typhus and of 311 unrelated healthy subjects were collected. A diagnosis of scrub typhus was made upon demonstration of a fourfold rise in antibody titer to O. tsutsugamushi in paired serum specimens in an indirect immunofluorescent (IFA) test. Genomic DNAs were extracted from peripheral mononuclear cells and genotypings for IL-1 (-511C/T), IL-1β (+3953T/C), IL-2 (-330T/G), IL-4 (-590C/T), IL-4R(-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A) and TNF-α (-308G/A) were performed simultaneously using PCR-SSP (sequence specific polymorphisms) assay. Results: The frequency of IL-1 (-511T/T) (OR=0.53, P<0.01) and IL-2 (-330T/T) (OR=0.56, P<0.01) were significantly decreased, but that of IL-2(-330G/G) (OR=4.49, P<0.01) was increased, in the scrub typhus patients compared to the healthy controls. And, there were no statistically significant differences in the genetic polymorphisms of IL-4 (-590C/T), IL-4Rα (-1902G/A), IL-10 (-1082G/A), IL-10 (-819C/T), TNF-α (-238G/A), TNF-α (-308G/A) genes, in the scrub typhus patients compared to the unrelated healthy controls. Conclusions: Cytokine polymorphisms in the IL-1 (-511T/T) and the IL-2 genes may influence the host response to O. tsutsugamushi.

BTA드릴에 의한 심공가공에서 구멍의 정밀도 향상에 관한 연구

장성규,전언찬 동아대학교 생산기술연구소 2000 生産技術硏究所硏究論文集 Vol.5 No.1

When the deep hole drilling with BTA drill, there are serious problems such as accuracy of diameter (deflection, hole over size), surface roughness to inhibit the required qualities. With the purpose of the accuracy improvement in deep hole drilling, we investigated the influence of the drilled hole accuracy and the cutting resistance of materials that occurred as the variation of the cutting condition after deep hole drilling with BTA drill on SM55C. And we obtained the following results. 1) The burnishing torque is closed upon 26% of the cutting torque in a single edge BTA drill or multi-edge BTA drill. The multi-edge BTA drill is better dispersed the cutting torque than the single edge BTA drill. 2) In hole over size, the drilling accuracy according to the drilled length is best improved under the condition of V=70m/min, f=0.15mm/rev in the multi-edge BTA drill. Values of hole over size are then about 25μm on 0∼0.5m, about 0μm on 10∼20m, and about-l5μm on over 20 m. 3) The surface roughness is distributed 9.1∼10.9 μm in the single edge BTA drill and 3.28∼6.3 μm in the multi-edge BTA drill. And the surface roughness is irrelated to the cutting speed.