http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Seokyung Kim ) (검색결과 53 건)
- 무료
- 기관 내 무료
- 유료
-
Kim, Ryul,Keam, Bhumsuk,Hahn, Seokyung,Ock, Chan-Young,Kim, Miso,Kim, Tae Min,Kim, Dong-Wan,Heo, Dae Seog Elsevier 2019 Clinical lung cancer Vol.20 No.5
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>This study aimed to comprehensively review the available evidence regarding the efficacy of first-line pembrolizumab for advanced/metastatic non–small-cell lung cancer (NSCLC), and to compare pembrolizumab monotherapy versus pembrolizumab plus chemotherapy versus chemotherapy alone.</P> <P><B>Materials and Methods</B></P> <P>A search of the PubMed, EMBASE, and Cochrane Library databases was performed in July 2018, and abstracts from the American Society of Clinical Oncology meetings (2015-2018) were reviewed. Summaries of the results were pooled using a random-effect model to determine the pooled hazard ratio (HR) for progression-free survival (PFS), overall survival (OS), and their 95% confidence intervals (CIs). A network meta-analysis was used to indirectly compare pembrolizumab monotherapy with pembrolizumab plus chemotherapy.</P> <P><B>Results</B></P> <P>A total of 4 relevant phase III trials comprising 2754 patients were identified. Pembrolizumab (with or without chemotherapy) led to significant improvements in OS and PFS, irrespective of the programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS). In particular, for the subgroup with PD-L1 TPS ≥ 50%, the HR of PFS was 0.49 (95% CI, 0.32-0.76; <I>P</I> = .001), and that of OS was 0.57 (95% CI, 0.45-0.73; <I>P</I> < .001). In terms of PFS, pembrolizumab plus chemotherapy was superior to pembrolizumab monotherapy with an HR of PFS 0.52 (95% CI, 0.27-0.99; <I>P</I> = .048) for the subgroup with PD-L1 TPS ≥ 50%.</P> <P><B>Conclusions</B></P> <P>For patients with NSCLC with PD-L1 TPS ≥ 50%, pembrolizumab plus chemotherapy has a better PFS than pembrolizumab monotherapy in this meta-analysis. To confirm this finding, a prospective phase III trial that directly compares the treatments is warranted.</P>
-
Kim, Bohyoung,Lee, Kyoung Ho,Kim, Kil Joong,Mantiuk, Rafal,Hahn, Seokyung,Kim, Tae Jung,Kim, Young Hoon American Roentgen Ray Society, etc.] 2008 American Journal of Roentgenology Vol.190 No.2
<P>OBJECTIVE: The objective of our study was to determine whether peak signal-to-noise ratio (PSNR) and a perceptual quality metric (High-Dynamic Range Visual Difference Predictor [HDR-VDP]) can predict the presence of perceptible artifacts in Joint Photographic Experts Group (JPEG) 2000-compressed chest CT images. MATERIALS AND METHODS: One hundred chest CT images were compressed to 5:1, 8:1, 10:1, and 15:1. Five radiologists determined if the original and compressed images were identical (negative response) or different (positive response). The correlation between the results for each metric and the number of readers with positive responses was evaluated using Spearman's rank correlation test. Using the pooled readers' responses as the reference standard, we performed receiver operating characteristic (ROC) analysis to determine the cutoff values balancing sensitivity and specificity and yielding 100% sensitivity in each metric. These cutoff values were then used to estimate the visually lossless thresholds for the compressions for the 100 original images, and the accuracy of the estimates of two metrics was compared (McNemar test). RESULTS: The correlation coefficients were -0.918 and 0.925 for PSNR and the HDR-VDP, respectively. The areas under the ROC curves for the two metrics were 0.983 and 0.984, respectively (p = 0.11). The PSNR and HDR-VDP accurately predicted the visually lossless threshold for 69% and 72% of the 100 images (p = 0.68), respectively, at the cutoff values balancing sensitivity and specificity and for 43% and 47% (p = 0.22), respectively, at the cutoff values reaching 100% sensitivity. CONCLUSION: Both metrics are promising in predicting the perceptible compression artifacts and therefore can potentially be used to estimate the visually lossless threshold.</P>
-
( Seokyung Kim ),( Joo-hyuk Son ),( Tae-wook Kong ),( Jiheum Paek ),( Suk-joon Chang ),( Hee-sug Ryu ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: The aim of the study was to evaluate risk factors associated with lymph node (LN) metastasis in FIGO stage I-IIIC endometrioid carcinoma patients according to lymphovascular space invasion (LVSI) status. Methods: A total of 338 FIGO stage I-IIIC patients with endometrioid histology between March 2000 and February 2018 were included. All patients received complete staging procedures including pelvic and para-aortic lymphadenectomy and were surgically staged according to the 2009 FIGO staging system. The patients were divided into LVSI-negative and LVSI-positive groups. Risk factors for LN metastasis were analyzed in LVSI-negative and LVSI-positive groups, respectively. Results: Fifty-eight patients (17.2%) were LVSI-positive and 280 (82.8%) were LVSI-negative. LVSI-positive patients were significantly older (p = 0.001) and showed higher CA-125 value (p < 0.001), more advanced stage (p < 0.001), poorer differentiation (p < 0.001), higher frequency of ≥50% myometrial invasion, and cervical stromal invasion (p < 0.001), and LN metastasis (p < 0.001) than LVSI-negative patients. In LVSI-negative group, positive peritoneal cytology (p = 0.020, OR = 27.708, 95% CI = 3.433-223.664) and ≥50% myometrial invasion (p = 0.043, OR = 8.777, 95% CI = 1.069-63.323) were significantly associated with LN metastasis. In LVSI-positive group, CA-125 ≥35 IU/mL (p = 0.020, OR = 4.303, 95% CI = 1.256-14.739) and cervical stromal invasion (p=0.022, OR = 3.939, 95% CI = 1.219-12.728) was significantly related to LN metastasis. Conclusion: In the cases that the nodal status has not been assessed surgically in clinically early-stage endometrioid adenocarcinoma, both LVSI-negative patients with ≥50% myometrial invasion or positive cytology and LVSI-positive patients with CA-125 ≥35 IU/mL or cervical stromal invasion are likely to have more lymphatic metastasis from primary tumor. Therefore, these patients may be a reasonable candidate for systematic lymphadenectomy.
-
( Seokyung Kim ),( Dong Wook Kwak ),( Hyun Ji Bae ),( Keun Yeok Seo ),( Moon Young Kim ),( You Jung Han ),( Hyun Mee Ryu ),( Jin Hoon Chung ) 대한주산의학회 2023 Perinatology Vol.34 No.4
Objective: To evaluate fetal biparietal diameter (BPD) between 11 and 14 weeks of gestation in pregnant Korean women after in vitro fertilization (IVF) and to construct reference charts for estimating gestational age (GA). Methods: Data of Korean women with singleton pregnancies who conceived after IVF and underwent sonography between 11 and 14 weeks of gestation were retrospectively collected. BPD was measured from the outer to the inner edge of the parietal bone in a transverse plane. GA was calculated by adding 14 to the number of days between dates of oocyte retrieval and ultrasound scan. Fractional polynomial regression model was fitted to estimate GA in relation to BPD. Results: BPD measurements were obtained for 960 fetuses. The BPD of Korean pregnancies was similar to previously described estimations at 12 weeks of gestation. However, it tended to be greater with advancing GA than those of non-Hispanic whites, non-Hispanic blacks, and Hispanics based on the Eunice Kennedy Shriver National Institute of Child Health and Human Development fetal growth studies. The best-fit equation for estimating GA from BPD was GA (day)=89.5684- (1.4667×BPD)+(0.0635×BPD<sup>2</sup>) with standard deviation=-0.4532+ (0.1007×BPD). Conclusion: Ethnic differences may exist in fetal BPD during the first trimester. The described chart can improve the accuracy of estimating GA in pregnant Korean women.
-
Kim, Young Hoon,Lee, Kyoung Ho,Park, Seong Ho,Kim, Hyung-Ho,Hahn, Seokyung,Park, Do Joong,Lee, Hye Seung Radiological Society of North America 2009 Radiology Vol.250 No.3
<P>PURPOSE: To determine the added value of multiplanar reformation (MPR) images combined with computed tomographic (CT) images in staging of T4 gastric cancers. MATERIALS AND METHODS: The institutional review board approved this retrospective study and waived informed consent. One hundred forty-nine consecutive patients (99 men [age range, 33-85 years; mean age, 63.1 years] and 50 women [age range, 30-85 years; mean age, 57.1 years]; age range, 30-85 years; mean age, 61.1 years) with pathologically and/or surgically confirmed T3 (n = 110) or T4 tumors (n = 39), with invasion of the transverse colon or mesocolon (n = 23), pancreas (n = 16), diaphragm (n = 4), liver (n = 3), and/or spleen (n = 1) were included. Two experienced radiologists independently reviewed 4-mm-thick transverse CT images and, 10 weeks later, reviewed both transverse CT and additional coronal and sagittal MPR images to assess tumor invasion in each of the aforementioned five adjacent organs. Receiver operating characteristic (ROC) analyses and weighted kappa statistics were obtained to evaluate reader performance and agreement in identifying tumor invasion. RESULTS: With addition of MPR images, the area under the ROC curve (AUC) led to a significant increase in the prediction of adjacent organ invasion in per-organ analyses (0.88 vs 0.95 for reader 1 [P = .01], 0.88 vs 0.98 for reader 2 [P < .001]) and identification of T4 tumors in per-patient analyses (0.79 vs 0.91 for reader 1 [P = .006], 0.78 vs 0.96 for reader 2 [P < .001]). In the five analyzed organs, AUC was significantly increased in regard to invasion of the transverse colon or mesocolon and pancreas; separate analysis was not performed for the diaphragm, liver, and spleen because of the small number of true invasions. Interobserver agreement increased in per-organ (kappa = 0.43 vs 0.67) and per-patient (kappa = 0.42 vs 0.62) analyses. CONCLUSION: Adding MPR images to transverse CT images improves the capability for distinguishing T3 from T4 gastric cancer and prediction of adjacent organ invasion. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/2502071872/DC1.</P>
-
Kim, Chi Heon,Chung, Chun Kee,Kim, Myo Jeong,Choi, Yunhee,Kim, Min-Jung,Hahn, Seokyung,Shin, Sukyoun,Jong, Jong-myung,Lee, Jun Ho Lippincott Williams & Wilkins 2018 Spine Vol.43 No.8
<P>Conclusion. The choice of surgical method might not always be consistent with cost-effectiveness strategies, and a high proportion of medium-sized hospitals may be responsible for this change.</P>
-
Kang, Seokyung,Lee, Junghee,Ryu, Seungmi,Kwon, Yeji,Kim, Kyung-Hun,Jeong, Dae Hong,Paik, Seung R.,Kim, Byung-Soo American Chemical Society 2017 Chemistry of materials Vol.29 No.8
<P>Cell-mediated nanoparticle delivery has been proposed for an effective cancer therapy. However, there are limitations in loading nanoparticles within cells as the internalized nanoparticles cause cytotoxicity and leak out of the cells via exocytosis. Here, we introduce hybrid sheets composed of gold nanoparticles (AuNPs) and graphene oxide (GO), which stably adhere to the cell surface and exhibit a remarkable photothermal effect. To form AuNP/GO sheets in which GO is sandwiched between two AuNP monolayers, AuNPs are coated with alpha-synuclein protein and subsequently adsorbed onto GO sheets. Attaching AuNP/GO sheets to the tumor-tropic mesenchymal stem cell (MSC) surface enhances the loading efficiency of AuNPs in MSCs by avoiding the cytotoxicity and exocytosis issues. Furthermore, the tight packing of AuNPs on microscaled GO sheets enhances the photothermal effect via strong plasmon coupling between AuNPs. The injection of AuNP/GO sheet-attached MSCs into tumor-bearing mice significantly improves the photothermal therapeutic efficacy by delivering larger amounts of AuNPs to the tumor and generating higher heat at the tumor region compared to injection of AuNP-internalized MSCs. The system of attaching AuNP/GO hybrid sheets to the tumor-tropic cell surface may be an effective platform for cancer therapy.</P>
-
김철(Kim Chul),경서경(Kyung Seokyung),조우석(Oh Myungwon),오명원(Cho Wooseok),김병선(Kim Byungseon) 한국태양에너지학회 2009 한국태양에너지학회 학술대회논문집 Vol.- No.-
South Korea having military power within the 10th in world ranking is the biggest single institution among public institutions in Korea and comprises force of over seven hundred thousand soldiers. However, outworn equipments and efficiency problem have issued. So, this study is to search the distribution state of new-renewable energy and to analyze application plan on the basis of interview with a official in charge in military. Analysis process is the first, classify surveyed military facilities into troops and the geographical factor. Second, classify a scale and type of facilities that new-renewable energy is supplied. Third, find consideration facts on the basis of interview with a official in charge. On the results of the survey, new-renewable energy applied to the military facility is photovoltaic, solar heat, wind power and geo-thermal energy. Also, divide military into the army, navy, air force and marine, visit 14 units and analyze the official's opinion. This study will deduce LCCA(Life cycle cost analysis) considered expenses for the installation and maintenance, and will be basic research that suggest an appropriate new-renewable energy model in military.
-
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
