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Yang, Seung-Jip,Son, Jin Kyung,Hong, Sang Jun,Lee, Na-Eun,Shin, Du Yeon,Park, Sang Hoon,An, Seong Beom,Sung, Young Chul,Park, Jae Berm,Yang, Heung-Mo,Kim, Sung Joo Elsevier 2018 Biochemical and biophysical research communication Vol.504 No.1
<P><B>Abstract</B></P> <P>Mesenchymal stromal cells (MSCs) isolated from numerous tissues including human fetal tissue are currently used in cell therapy and regenerative medicine. Among fetal tissues, the umbilical cord (UC) is one of the sources for both MSCs and endothelial cells (ECs). To establish ectopic vascularized bone tissue formation, UC-derived MSCs and ECs were isolated. UC-MSCs expressing human BMP-2 (hBMP-2-MSCs) were generated using an adenoviral system to promote bone formation. These cells were then transplanted with Matrigel into the subcutaneous tissue of an immune deficient NSG mouse, and bone tissue was analyzed after several weeks. The osteogenic differentiation ability of MSCs was elevated by transduction of the hBMP-2 expressing adenoviral system, and vascularization of bone tissue was enhanced by human umbilical vein endothelial cells (HUVEC). In this study, our results provide evidence that MSCs and HUVECs from human umbilical cord are suitable cells to investigate bone tissue engineering. The results also suggest that the co-transplantation of hBMP2-MSCs and HUVECs may be a simple and efficient strategy for improving tissue generation and angiogenesis in bone tissue engineering using stem cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MSCs and ECs from human UC were stably isolated and characterized. </LI> <LI> Generate hBMP-2 expressing hUC-MSCs using adenoviral system. </LI> <LI> Ectopic vascularized bone formation via transplantation of hBMP-2-MSCs and HUVECs. </LI> <LI> hBMP-2 and HUVECs enhance ossification and vascular structure formation. </LI> </UL> </P>
Reconstituting Human Cutaneous Regeneration in Humanized Mice under Endothelial Cell Therapy
Yang, Heung-Mo,Choi, Jong-Jin,Kim, Ha-Na,Yang, Seung Jip,Park, Soon-Jung,Kang, Changhee,Chung, Hyung-Min,Lee, Man Ryul,Kim, Sung Joo,Moon, Sung-Hwan Elsevier 2019 The Journal of investigative dermatology Vol.139 No.3
Marinopyrones A-D, α-pyrones from marine-derived actionmycetes of the family Nocardiopsaceae
( Jihye Lee ),( Chulkyeong Han ),( Tae Gu Lee ),( Jungwook Chin ),( Hyukjae Choi ),( Wonjae Lee ),( Man Jeong Paik ),( Dong Hwan Won ),( Gyusang Jeong ),( Jaeyoung Ko ),( Yeo Joon Yoon ),( Sang Jip Na 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Two actinomycetes, a member of the rare halophilic genus Streptomonospora and a Nocardiopsis sp. (Nocardiopsaceae), strains CNQ-082 and CNQ-675, respectively. were isolated from marine sediments collected off shore near La Jolla. California. HPLC-UV guided fractionations of the extracts of these strains yielded marinopyrones A-D (1-4), the structures of which were elucidated by interpretation of 10 and 20 NMR and HRMS spectroscopic data. Oxidative ozonation, followed by conversion of the acid product to an α-naphthyl amide, provided the absolute configuration at the chiral center on the side-chain. Marinopyrones A-D were examined for the inhibitory activity on nitric oxide production in LPS-activated mouse macrophage cells (RAW 264.7); marinopyrone D (4) was inhibitory with an IC<sub>50</sub> value of 13 I``M. To our knowledge, marinopyrones A-C are only the second reported natural products from the rare halophi-lic genus Streptomonospora.