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Marinopyrones A-D, α-pyrones from marine-derived actionmycetes of the family Nocardiopsaceae
( Jihye Lee ),( Chulkyeong Han ),( Tae Gu Lee ),( Jungwook Chin ),( Hyukjae Choi ),( Wonjae Lee ),( Man Jeong Paik ),( Dong Hwan Won ),( Gyusang Jeong ),( Jaeyoung Ko ),( Yeo Joon Yoon ),( Sang Jip Na 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Two actinomycetes, a member of the rare halophilic genus Streptomonospora and a Nocardiopsis sp. (Nocardiopsaceae), strains CNQ-082 and CNQ-675, respectively. were isolated from marine sediments collected off shore near La Jolla. California. HPLC-UV guided fractionations of the extracts of these strains yielded marinopyrones A-D (1-4), the structures of which were elucidated by interpretation of 10 and 20 NMR and HRMS spectroscopic data. Oxidative ozonation, followed by conversion of the acid product to an α-naphthyl amide, provided the absolute configuration at the chiral center on the side-chain. Marinopyrones A-D were examined for the inhibitory activity on nitric oxide production in LPS-activated mouse macrophage cells (RAW 264.7); marinopyrone D (4) was inhibitory with an IC<sub>50</sub> value of 13 I``M. To our knowledge, marinopyrones A-C are only the second reported natural products from the rare halophi-lic genus Streptomonospora.
Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.
( Dongyup Hahn ),( Dong Hwan ),( Bora Mun ),( Hiyoung Kim ),( Chulkyeong Han ),( Weihong Wang ),( Taeho Chun ),( Sunhee Park ),( Dajeong Yoon ),( Hyukjae Choi ),( Sang Jip Nam ),( Merrick Ekins ),( Ju 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM. ⓒ2013 Elsevier Ltd. All rights reserves.